{
  "schema": "nmd-vcell-candidate-dmd-truth-boundary/1.0",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "candidate_count": 21,
  "measured_dmd_candidate_perturbation_response_count": 0,
  "candidate_level_dmd_pathway_prediction_count": 0,
  "records": [
    {
      "gene": "CPEB1",
      "action": "Verify expression",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-06",
      "gap_label": "Expression feasibility is not verified in the intended model",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "DNAAF3",
      "action": "Verify expression",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-06",
      "gap_label": "Expression feasibility is not verified in the intended model",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "EPS8L1",
      "action": "Verify expression",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-06",
      "gap_label": "Expression feasibility is not verified in the intended model",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "ZFP69B",
      "action": "Verify expression",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-06",
      "gap_label": "Expression feasibility is not verified in the intended model",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "INTS13",
      "action": "Risk/context review",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-08",
      "gap_label": "Safety and dependency context blocks escalation",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "NAGLU",
      "action": "Risk/context review",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-08",
      "gap_label": "Safety and dependency context blocks escalation",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "RAC3",
      "action": "Risk/context review",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-08",
      "gap_label": "Safety and dependency context blocks escalation",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "RNASEH2C",
      "action": "Risk/context review",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-08",
      "gap_label": "Safety and dependency context blocks escalation",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "RNF8",
      "action": "Risk/context review",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-08",
      "gap_label": "Safety and dependency context blocks escalation",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "WDR4",
      "action": "Risk/context review",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-08",
      "gap_label": "Safety and dependency context blocks escalation",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "ZNF236",
      "action": "Risk/context review",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-08",
      "gap_label": "Safety and dependency context blocks escalation",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "MON1A",
      "action": "Muscle-context assay",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-02",
      "gap_label": "Independent muscle-context perturbation is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "ZNF133",
      "action": "Muscle-context assay",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-02",
      "gap_label": "Independent muscle-context perturbation is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "ADAM10",
      "action": "Computational replication",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-07",
      "gap_label": "Independent computational replication is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "CALR",
      "action": "Computational replication",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-07",
      "gap_label": "Independent computational replication is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "DDX19B",
      "action": "Computational replication",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-07",
      "gap_label": "Independent computational replication is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "DNM1",
      "action": "Computational replication",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-07",
      "gap_label": "Independent computational replication is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "EHMT2",
      "action": "Computational replication",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-07",
      "gap_label": "Independent computational replication is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "LMO2",
      "action": "Computational replication",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-07",
      "gap_label": "Independent computational replication is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "MPHOSPH6",
      "action": "Computational replication",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-07",
      "gap_label": "Independent computational replication is absent",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    },
    {
      "gene": "GFOD2",
      "action": "Provisional hold \u00b7 external report not yet audited",
      "highest_supported_level": "L2_observed_same_context_perturbation",
      "gap_code": "GAP-09",
      "gap_label": "External quantitative evidence has not been imported and audited",
      "measured_dmd_candidate_perturbation_response": "0",
      "candidate_level_dmd_pathway_prediction": "0",
      "current_claim": "governed hypothesis; no DMD candidate response truth"
    }
  ],
  "claim_boundary": "Measured DMD-gene induction and correction are distinct from candidate-gene responses. All 21 candidates remain unmeasured in DMD perturbation context."
}