{
  "schema": "nmd-vcell-research-os/3.0",
  "scientific_release": "Evidence Release 2026.08",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "interface_build": "EA-20260817-57",
  "information_architecture": {
    "workbench": [
      "Explore",
      "Research Question",
      "Virtual Cell",
      "Experiments",
      "Models"
    ],
    "evidence_archive": [
      "Datasets",
      "Registry",
      "Releases",
      "API",
      "Schemas",
      "Checksums"
    ],
    "publications": [
      "Manuscripts",
      "Figures",
      "Review objects",
      "Analysis packets"
    ]
  },
  "research_question": {
    "object_schema": "nmd-vcell-research-question/1.0",
    "object_id_pattern": "Q:{DISEASE}:{CELL_STATE}:{PERTURBATION}:{TARGET}:{TIME}:{ENDPOINT}",
    "required": [
      "disease",
      "cell_state",
      "perturbation",
      "target",
      "time",
      "endpoint"
    ],
    "example": {
      "question_id": "Q:DMD:DIFFERENTIATING_MYOBLAST:CRISPRI:ZNF133:48H:FUSION",
      "disease": "DMD",
      "cell_state": "differentiating_myoblast",
      "perturbation": "CRISPRi",
      "target": "ZNF133",
      "time": "48H",
      "endpoint": "FUSION",
      "lifecycle": "DRAFT_DEVICE_LOCAL"
    },
    "persistence": "Device-local browser storage; no server registration or external authority is implied."
  },
  "state_dictionary": {
    "evidence": [
      "Observed",
      "Contextual",
      "Conflicted",
      "Missing"
    ],
    "computability": [
      "Bounded",
      "Calibratable",
      "Validated"
    ],
    "lifecycle": [
      "Draft",
      "Registered",
      "Running",
      "Measured",
      "Released"
    ],
    "outcome": [
      "Supportive",
      "Null",
      "Toxic",
      "Discordant",
      "Failed QC"
    ],
    "audit_only_code_families": [
      "G",
      "L",
      "R",
      "P",
      "GAP"
    ]
  },
  "lifecycle_tracks": {
    "truth_generation": [
      "Scientific question",
      "Frozen Study",
      "Registered Study",
      "Experiment",
      "Outcome",
      "Truth Dataset",
      "Evidence transition",
      "Model eligibility review"
    ],
    "prediction_validation": [
      "Eligible ModelRun",
      "Frozen Prediction",
      "Registered validation study",
      "Experiment",
      "Outcome",
      "Prediction error",
      "Calibration assessment",
      "Model update"
    ]
  },
  "claim_boundary": "A Research Question organizes existing evidence and the next action. It does not create a prediction, registration, measured outcome or therapeutic claim."
}