{
  "readiness_schema": "nmd-vcell-disease-prediction-readiness/1.0",
  "resource_release": "v1.0.0-database-resource",
  "model_release": "ridge-safe-v2.3",
  "benchmark_protocol": "repeated-fold-v2.2",
  "current_level": "P0_prediction_infrastructure_only",
  "recommended_next_level": "P1_research_use_dmd_perturbation_response_prediction",
  "clinical_level_status": "P2_clinical_prediction_locked",
  "platform_claim_state": "P0_prediction_infrastructure_ready_P1_unvalidated_P2_locked",
  "allowed_current_claims": [
    "static prediction-registration schema and empty registry are available",
    "same-HepG2 perturbation-response benchmark is auditable",
    "future prospective outcomes can be linked without overwriting predictions",
    "evidence gaps and abstention requirements are explicit"
  ],
  "locked_claims": [
    "validated DMD disease predictor",
    "therapeutic response predictor",
    "clinical decision-support platform",
    "treatment-prioritization engine"
  ],
  "levels": [
    {
      "level": "P0",
      "label": "Prediction infrastructure only",
      "status": "PASS",
      "claim_allowed": "registry, schema, benchmark and abstention infrastructure exist"
    },
    {
      "level": "P1",
      "label": "Research-use DMD perturbation-response prediction",
      "status": "LOCKED_PENDING_EXTERNAL_VALIDATION",
      "claim_allowed": "none in this release"
    },
    {
      "level": "P2",
      "label": "Clinical disease prediction or decision support",
      "status": "LOCKED_NOT_IN_SCOPE",
      "claim_allowed": "none"
    }
  ],
  "gate_summary": {
    "governed_hypotheses": 21,
    "observed_hepg2_perturbation": 21,
    "external_myoblast_context_assessed": 9,
    "independent_muscle_or_dmd_perturbation_replication": 0,
    "therapeutic_or_clinical_validation": 0,
    "prediction_registered": 0,
    "outcome_measured": 0
  },
  "p1_required_before_unlock": [
    "frozen DMD/dystrophin-deficient human myogenic or neuromuscular perturbation dataset",
    "train/validation/external-test partition declared before model fitting",
    "donor, isogenic-pair or perturbation unit of analysis declared",
    "negative, positive and rescue/control definitions predeclared",
    "primary functional endpoint and transcriptomic secondary endpoints frozen",
    "baseline models, calibration, uncertainty intervals and abstention policy benchmarked",
    "out-of-distribution detection and failure-mode taxonomy frozen",
    "prospective prediction cards timestamped before outcome access",
    "outcome board populated without relabelling failed or abstained predictions"
  ],
  "p2_required_before_unlock": [
    "clinical intended-use statement",
    "independent external clinical validation",
    "decision-impact or workflow evaluation protocol",
    "bias, safety, monitoring and human-oversight plan",
    "regulatory and ethics review appropriate to intended use"
  ],
  "minimum_validation_boundary": "No P1 or P2 prediction claim can be made until independent disease-relevant perturbation data, prospective registration, external test results, calibration, uncertainty, OOD and abstention analyses are frozen.",
  "reporting_alignment": [
    "TRIPOD+AI-style model reporting fields are required before a P1 prediction claim",
    "DECIDE-AI/SPIRIT-AI/CONSORT-AI-style clinical evaluation fields are not triggered until a clinical workflow is proposed"
  ],
  "empty_registry_semantics": "Zero registered predictions and zero measured outcomes mean no qualifying prediction/outcome object exists; this is not a negative validation result."
}