{
  "contract_schema": "nmd-vcell-task-contract/1.0",
  "task_contract_id": "NMD-B1-DMD-MATCHED-PERTURBATION-DRAFT",
  "status": "DRAFT_NOT_REGISTERED_OUTCOME_MISSING",
  "legacy_status": "DRAFT_NOT_REGISTERED_TRUTH_MISSING",
  "scientific_question": "Can a frozen model predict a candidate-conditioned response in a previously unseen DMD biological donor and disease-relevant myogenic state?",
  "disease": "DMD",
  "donor_policy": "Hold out complete biological donors; cells are never independent donor replicates.",
  "cell_state": "Disease-relevant human myogenic state; exact maturation state must be frozen before registration.",
  "perturbation": "Candidate intervention identity and modality must be frozen; no healthy-myoblast or HepG2 substitution.",
  "dose": "Prespecified per intervention; missing until the experimental protocol is registered.",
  "time": "Prespecified baseline and post-intervention time points; missing until the experimental protocol is registered.",
  "readout": [
    "transcriptomic response",
    "cell-state distribution",
    "at least one disease-relevant functional endpoint"
  ],
  "target_quantity": [
    "perturbation-specific delta",
    "response direction",
    "population shift",
    "functional response"
  ],
  "split_policy": "Donor-disjoint first; perturbation, cell-state, batch and disease overlap reported separately.",
  "metric_bundle": [
    "RMSE/MAE",
    "signed delta correlation",
    "DE-gene recovery",
    "pathway recovery",
    "distribution distance",
    "calibration/coverage",
    "functional endpoint"
  ],
  "prohibited_claims": [
    "clinical efficacy",
    "treatment recommendation",
    "patient digital twin",
    "DMD prediction before matched truth exists"
  ],
  "current_outcome_state": "MATCHED_DMD_CANDIDATE_RESPONSE_OUTCOME_MISSING",
  "current_truth_state": "MATCHED_DMD_CANDIDATE_RESPONSE_TRUTH_MISSING"
}