{
  "manifest_schema": "nmd-vcell-external-source-manifest/1.0",
  "object_id": "SRC:GSE293514:EA-20260817-57:STAGE-B0",
  "accession": "GSE293514",
  "doi": "10.1038/s41467-025-67583-x",
  "sources": [
    {
      "supplement": 1,
      "file": "Supplementary_Data_1_human_myogenesis_signatures.xlsx",
      "official_file": "41467_2025_67583_MOESM3_ESM.xlsx",
      "sha256": "e539f9212042cb3cab40a8458dfea2669093d5a5c4b0f64fc550beed2f35dbaa",
      "role": "seven-donor unperturbed human-myogenesis GSEA reference",
      "size_bytes": 220485,
      "observed_sha256": "e539f9212042cb3cab40a8458dfea2669093d5a5c4b0f64fc550beed2f35dbaa",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM3_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "GSEA, TOP up-regulated genes",
          "rows": 1523,
          "columns": 30
        },
        {
          "sheet": "GSEA, TOP down-regulated genes",
          "rows": 623,
          "columns": 30
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 2,
      "file": "Supplementary_Data_2_MyoCRISPR_library.xlsx",
      "official_file": "41467_2025_67583_MOESM4_ESM.xlsx",
      "sha256": "362806fb11b2798733bb54f8f34b4454f0870aa2de4e487ce7e5aebd20d3ee82",
      "role": "MyoCRISPR library membership and guide sequences",
      "size_bytes": 988152,
      "observed_sha256": "362806fb11b2798733bb54f8f34b4454f0870aa2de4e487ce7e5aebd20d3ee82",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM4_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "gRNAs in MyoCRISPR Library",
          "rows": 21397,
          "columns": 10
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 3,
      "file": "Supplementary_Data_3_fitness_depletion_hits.xlsx",
      "official_file": "41467_2025_67583_MOESM5_ESM.xlsx",
      "sha256": "94bf24a63e2740402a56e313c2e8335ddd45b32d8ad0c43fe34d7d95893b1267",
      "role": "myoblast fitness-depletion hit reference",
      "size_bytes": 117046,
      "observed_sha256": "94bf24a63e2740402a56e313c2e8335ddd45b32d8ad0c43fe34d7d95893b1267",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM5_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "myoblast fitness screen hits",
          "rows": 421,
          "columns": 34
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 4,
      "file": "Supplementary_Data_4_fitness_enrichment_hits.xlsx",
      "official_file": "41467_2025_67583_MOESM6_ESM.xlsx",
      "sha256": "75afb7b025927e1c42bbed8776c13e6a549e792e72a2dc34e2b896c30f12de07",
      "role": "myoblast fitness-enrichment hit reference",
      "size_bytes": 19628,
      "observed_sha256": "75afb7b025927e1c42bbed8776c13e6a549e792e72a2dc34e2b896c30f12de07",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM6_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "Sheet1",
          "rows": 49,
          "columns": 32
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 5,
      "file": "Supplementary_Data_5_fusion_hits.xlsx",
      "official_file": "41467_2025_67583_MOESM7_ESM.xlsx",
      "sha256": "b362439cbec443265aa157c4630a9721d553d9d687fee1e7d1a5eed1374467e2",
      "role": "gene-level split-toxin fusion-screen statistics",
      "size_bytes": 774760,
      "observed_sha256": "b362439cbec443265aa157c4630a9721d553d9d687fee1e7d1a5eed1374467e2",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM7_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "MyoCRISPR_Fusion_Gene_summary",
          "rows": 7198,
          "columns": 14
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 6,
      "file": "Supplementary_Data_6_individual_validation.xlsx",
      "official_file": "41467_2025_67583_MOESM8_ESM.xlsx",
      "sha256": "c3d425e8d577cf4fb7bfdf26591c74a540b98aac005a521624fe56aee4e5fea6",
      "role": "individually tested fusion-screen hits and guide identities",
      "size_bytes": 15603,
      "observed_sha256": "c3d425e8d577cf4fb7bfdf26591c74a540b98aac005a521624fe56aee4e5fea6",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM8_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "Sheet1",
          "rows": 344,
          "columns": 3
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 7,
      "file": "Supplementary_Data_7_disease_mouse_phenotype_hits.xlsx",
      "official_file": "41467_2025_67583_MOESM9_ESM.xlsx",
      "sha256": "31b7f8322a8b2a3c2d012ed28b499819f171b414072ace42e06e6e5e7f6dbbe1",
      "role": "human disease and mouse phenotype annotations for fusion hits",
      "size_bytes": 27647,
      "observed_sha256": "31b7f8322a8b2a3c2d012ed28b499819f171b414072ace42e06e6e5e7f6dbbe1",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM9_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "Sheet1",
          "rows": 42,
          "columns": 9
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 8,
      "file": "Supplementary_Data_8_cluster_markers.xlsx",
      "official_file": "41467_2025_67583_MOESM10_ESM.xlsx",
      "sha256": "e865b1c0dd062381d4e048e42fce1ceed935d2bb8d35dbb7de4ecda4671ce1e6",
      "role": "CROP-seq cell-cluster differential-expression markers",
      "size_bytes": 16580240,
      "observed_sha256": "e865b1c0dd062381d4e048e42fce1ceed935d2bb8d35dbb7de4ecda4671ce1e6",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM10_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "marker_genes_fdr",
          "rows": 395081,
          "columns": 5
        }
      ],
      "bundled_in_public_site": false
    },
    {
      "supplement": 9,
      "file": "Supplementary_Data_9_myogenesis_signature.xlsx",
      "official_file": "41467_2025_67583_MOESM11_ESM.xlsx",
      "sha256": "f793c02d54d0c5cf24e475d8fc2ac94a8e9cf3b8e027780af0ac6282ea348823",
      "role": "395-gene myoblast-versus-myocyte signature used for MDS",
      "size_bytes": 29176,
      "observed_sha256": "f793c02d54d0c5cf24e475d8fc2ac94a8e9cf3b8e027780af0ac6282ea348823",
      "sha256_verified": true,
      "source_url": "https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41467-025-67583-x/MediaObjects/41467_2025_67583_MOESM11_ESM.xlsx",
      "workbook_shape": [
        {
          "sheet": "Myogenesis_signature_genes",
          "rows": 396,
          "columns": 6
        }
      ],
      "bundled_in_public_site": false
    }
  ],
  "all_sha256_verified": true,
  "raw_files_bundled": false,
  "claim_boundary": "This is an observed healthy-human-myoblast functional perturbation network with a published named-module subset and qualitative grouped CROP-seq state edges. It is not a DMD perturbation network, not a candidate-level expression response atlas, and not a trained virtual-cell predictor."
}
