{"matrix_schema":"nmd-vcell-gene-prediction-readiness-matrix/1.0","interface_build":"EA-20260817-57","resource_release":"v1.2.0-measured-dmd-evidence","evidence_freeze":"2026-08-03","matrix_scope":"gene_level_prediction_maturity_management_not_a_prediction_score","level_order":["R0","R1","R2","R3","R4"],"level_definitions":{"R0":{"label":"R0 · evidence annotation only","plain_language":"The current release can describe the gene and evidence gaps, but cannot use it as a prediction substrate.","machine_definition":"No eligible observed perturbation response is available for this gene in the released perturbation universe.","current_state":"not_prediction_ready","next_upgrade_required":"Add a governed perturbation response or direct disease-relevant experimental evidence.","unlocks":"Evidence review and experiment planning only."},"R1":{"label":"R1 · non-DMD perturbation substrate","plain_language":"The gene has an observed perturbation in a non-DMD context; it can support hypothesis triage, not DMD response prediction.","machine_definition":"Observed same-processed-context HepG2 perturbation exists, but no qualifying muscle-context bridge is available.","current_state":"hypothesis_triage_ready_not_dmd_prediction_ready","next_upgrade_required":"Add a muscle-context or DMD-background perturbation endpoint with frozen analysis rules.","unlocks":"Same-context model audit and next-experiment design."},"R2":{"label":"R2 · muscle-context bridge evidence","plain_language":"The gene has non-DMD perturbation evidence plus muscle-context screening evidence, but still lacks DMD-context perturbation outcome.","machine_definition":"Observed HepG2 perturbation and external myogenic screen evidence are both present; independent DMD perturbation replication is absent.","current_state":"context_bridge_ready_dmd_prediction_locked","next_upgrade_required":"Run an independent DMD/control myogenic perturbation with predeclared molecular, state and functional endpoints.","unlocks":"Priority experiment design and DMD perturbation outcome-gap tracking."},"R3":{"label":"R3 · DMD perturbation outcome available","plain_language":"A matched DMD-context perturbation outcome exists and can be reserved for prospective model validation.","machine_definition":"Independent disease-relevant myogenic perturbation outcome is frozen with leakage-safe grouping and outcome metadata.","current_state":"target_state_locked_no_current_records","next_upgrade_required":"Calibrate a DMD-response model with uncertainty, abstention and external test reporting.","unlocks":"Research-use DMD response prediction evaluation, not clinical use."},"R4":{"label":"R4 · calibrated DMD prediction model","plain_language":"A calibrated, externally tested DMD response model exists for this task.","machine_definition":"Training, validation, external testing, calibration, uncertainty, OOD and abstention analyses are all frozen for the DMD task.","current_state":"target_state_locked_no_current_records","next_upgrade_required":"Maintain prospective outcome registration and external replication before any clinical wording.","unlocks":"Bounded research-use DMD prediction claims only when the platform gate also unlocks P1."}},"current_maximum_observed_level":"R2_context_bridge_ready_dmd_prediction_locked","level_counts":{"R0":17900,"R1":12,"R2":9,"R3":0,"R4":0},"calibrated_dmd_prediction_ready_count":0,"dmd_perturbation_outcome_ready_count":0,"dmd_perturbation_truth_ready_count":0,"claim_boundary":"Prediction readiness is a maturity annotation and does not emit a disease-response prediction, target rank, therapeutic claim or clinical recommendation.","record_fields":["gene","prediction_readiness_code","prediction_readiness_label","gene_evidence_tier_code","highest_supported_level","highest_assessed_level","decision_blocking_gap_code","next_upgrade_required","supports_calibrated_dmd_prediction"],"record_count":17921,"records":[["A1BG","R0","R0 · evidence annotation only","G1","L1_resource_record","L1_resource_record","GAP-01","Add a governed perturbation response or direct disease-relevant experimental evidence.",false],["A1BG-AS1","R0","R0 · evidence annotation only","G1","L1_resource_record","L1_resource_record","GAP-01","Add a governed perturbation response or direct disease-relevant experimental evidence.",false],["A2M","R0","R0 · evidence annotation only","G1","L1_resource_record","L1_resource_record","GAP-01","Add a governed perturbation response or direct disease-relevant experimental evidence.",false],["A2M-AS1","R0","R0 · evidence annotation only","G1","L1_resource_record","L1_resource_record","GAP-01","Add 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