{"ZADH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZADH2","identifiers":{"approved_symbol":"ZADH2","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZADH2","release_manifest":"api/v1.1/release_manifest.json"}},"ZAN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZAN","identifiers":{"aliases":[],"approved_symbol":"ZAN","ensembl_gene_id":"ENSG00000146839","hgnc_id":"HGNC:12857","ncbi_gene_id":7455,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZAN","release_manifest":"api/v1.1/release_manifest.json"}},"ZAP70":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZAP70","identifiers":{"aliases":["ZAP-70","STD"],"approved_symbol":"ZAP70","ensembl_gene_id":"ENSG00000115085","hgnc_id":"HGNC:12858","ncbi_gene_id":7535,"previous_symbols":["SRK"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZAP70","release_manifest":"api/v1.1/release_manifest.json"}},"ZAR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZAR1","identifiers":{"aliases":["Z3CXXC6"],"approved_symbol":"ZAR1","ensembl_gene_id":"ENSG00000182223","hgnc_id":"HGNC:20436","ncbi_gene_id":326340,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZAR1","release_manifest":"api/v1.1/release_manifest.json"}},"ZAR1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZAR1L","identifiers":{"aliases":["Z3CXXC7"],"approved_symbol":"ZAR1L","ensembl_gene_id":"ENSG00000189167","hgnc_id":"HGNC:37116","ncbi_gene_id":646799,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZAR1L","release_manifest":"api/v1.1/release_manifest.json"}},"ZBBX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBBX","identifiers":{"aliases":["FLJ23049"],"approved_symbol":"ZBBX","ensembl_gene_id":"ENSG00000169064","hgnc_id":"HGNC:26245","ncbi_gene_id":79740,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZBBX","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED1","identifiers":{"aliases":["TRAMP","KIAA0785","DREF","hDREF"],"approved_symbol":"ZBED1","ensembl_gene_id":"ENSG00000214717","hgnc_id":"HGNC:447","ncbi_gene_id":9189,"previous_symbols":["ALTE"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBED1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED3","identifiers":{"aliases":["MGC15435"],"approved_symbol":"ZBED3","ensembl_gene_id":"ENSG00000132846","hgnc_id":"HGNC:20711","ncbi_gene_id":84327,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBED3","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED3-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED3-AS1","identifiers":{"aliases":["lnc13728"],"approved_symbol":"ZBED3-AS1","ensembl_gene_id":"ENSG00000250802","hgnc_id":"HGNC:44188","ncbi_gene_id":728723,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBED3-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED4","identifiers":{"aliases":["KIAA0637"],"approved_symbol":"ZBED4","ensembl_gene_id":"ENSG00000100426","hgnc_id":"HGNC:20721","ncbi_gene_id":9889,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBED4","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED5","identifiers":{"aliases":["Buster1"],"approved_symbol":"ZBED5","ensembl_gene_id":"ENSG00000236287","hgnc_id":"HGNC:30803","ncbi_gene_id":58486,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBED5","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED5-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED5-AS1","identifiers":{"aliases":[],"approved_symbol":"ZBED5-AS1","ensembl_gene_id":"ENSG00000247271","hgnc_id":"HGNC:48646","ncbi_gene_id":729013,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBED5-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED6","identifiers":{"aliases":[],"approved_symbol":"ZBED6","ensembl_gene_id":"ENSG00000257315","hgnc_id":"HGNC:33273","ncbi_gene_id":100381270,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBED6","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED6CL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED6CL","identifiers":{"approved_symbol":"ZBED6CL","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZBED6CL","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED8","identifiers":{"aliases":["Buster3"],"approved_symbol":"ZBED8","ensembl_gene_id":"ENSG00000221886","hgnc_id":"HGNC:30804","ncbi_gene_id":63920,"previous_symbols":["C5orf54","FAM200C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZBED8","release_manifest":"api/v1.1/release_manifest.json"}},"ZBED9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBED9","identifiers":{"approved_symbol":"ZBED9","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZBED9","release_manifest":"api/v1.1/release_manifest.json"}},"ZBP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBP1","identifiers":{"aliases":["dJ718J7.3","DLM1","DLM-1","DAI"],"approved_symbol":"ZBP1","ensembl_gene_id":"ENSG00000124256","hgnc_id":"HGNC:16176","ncbi_gene_id":81030,"previous_symbols":["C20orf183"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBP1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB1","identifiers":{"aliases":["KIAA0997","ZNF909"],"approved_symbol":"ZBTB1","ensembl_gene_id":"ENSG00000126804","hgnc_id":"HGNC:20259","ncbi_gene_id":22890,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB10","identifiers":{"aliases":["RINZF","FLJ12752"],"approved_symbol":"ZBTB10","ensembl_gene_id":"ENSG00000205189","hgnc_id":"HGNC:30953","ncbi_gene_id":65986,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB10","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB11","identifiers":{"aliases":["ZNF-U69274","ZNF913"],"approved_symbol":"ZBTB11","ensembl_gene_id":"ENSG00000066422","hgnc_id":"HGNC:16740","ncbi_gene_id":27107,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB11","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB11-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB11-AS1","identifiers":{"aliases":[],"approved_symbol":"ZBTB11-AS1","ensembl_gene_id":"ENSG00000256628","hgnc_id":"HGNC:48573","ncbi_gene_id":100009676,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZBTB11-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB12","identifiers":{"aliases":["G10","NG35","D6S59E"],"approved_symbol":"ZBTB12","ensembl_gene_id":"ENSG00000204366","hgnc_id":"HGNC:19066","ncbi_gene_id":221527,"previous_symbols":["C6orf46"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZBTB12","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB14","identifiers":{"aliases":["ZNF478"],"approved_symbol":"ZBTB14","ensembl_gene_id":"ENSG00000198081","hgnc_id":"HGNC:12860","ncbi_gene_id":7541,"previous_symbols":["ZFP161"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB14","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB16","identifiers":{"aliases":["PLZF"],"approved_symbol":"ZBTB16","ensembl_gene_id":"ENSG00000109906","hgnc_id":"HGNC:12930","ncbi_gene_id":7704,"previous_symbols":["ZNF145"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB16","detailed_audit_record":"gene/ZBTB16/audit","legacy_api_record":"api/v1/genes/ZBTB16.json","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB17","identifiers":{"aliases":["MIZ1","pHZ-67"],"approved_symbol":"ZBTB17","ensembl_gene_id":"ENSG00000116809","hgnc_id":"HGNC:12936","ncbi_gene_id":7709,"previous_symbols":["ZNF151","ZNF60"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB17","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB18","identifiers":{"aliases":["C2H2-171","TAZ-1","RP58"],"approved_symbol":"ZBTB18","ensembl_gene_id":"ENSG00000179456","hgnc_id":"HGNC:13030","ncbi_gene_id":10472,"previous_symbols":["ZNF238"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB18","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB2","identifiers":{"aliases":["KIAA1483","ZNF437","bA351K16.2"],"approved_symbol":"ZBTB2","ensembl_gene_id":"ENSG00000181472","hgnc_id":"HGNC:20868","ncbi_gene_id":57621,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB2","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB20","identifiers":{"aliases":["ODA-8S","DKFZp566F123","DPZF"],"approved_symbol":"ZBTB20","ensembl_gene_id":"ENSG00000181722","hgnc_id":"HGNC:13503","ncbi_gene_id":26137,"previous_symbols":["ZNF288"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZBTB20","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB20-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB20-AS1","identifiers":{"aliases":[],"approved_symbol":"ZBTB20-AS1","ensembl_gene_id":"ENSG00000241560","hgnc_id":"HGNC:40640","ncbi_gene_id":100131117,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB20-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB20-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB20-AS2","identifiers":{"aliases":[],"approved_symbol":"ZBTB20-AS2","ensembl_gene_id":"ENSG00000241295","hgnc_id":"HGNC:42421","ncbi_gene_id":100506673,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZBTB20-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB20-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB20-AS3","identifiers":{"aliases":[],"approved_symbol":"ZBTB20-AS3","ensembl_gene_id":"ENSG00000239946","hgnc_id":"HGNC:42422","ncbi_gene_id":104413890,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZBTB20-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB20-AS4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB20-AS4","identifiers":{"aliases":[],"approved_symbol":"ZBTB20-AS4","ensembl_gene_id":"ENSG00000242767","hgnc_id":"HGNC:42423","ncbi_gene_id":100874131,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB20-AS4","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB20-AS5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB20-AS5","identifiers":{"aliases":[],"approved_symbol":"ZBTB20-AS5","ensembl_gene_id":"ENSG00000242290","hgnc_id":"HGNC:52841","ncbi_gene_id":101929754,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB20-AS5","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB21","identifiers":{"aliases":["KIAA1227"],"approved_symbol":"ZBTB21","ensembl_gene_id":"ENSG00000173276","hgnc_id":"HGNC:13083","ncbi_gene_id":49854,"previous_symbols":["ZNF295"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB21","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB22","identifiers":{"aliases":["BING1","ZNF297A","fruitless","fru","ZBTB22A"],"approved_symbol":"ZBTB22","ensembl_gene_id":"ENSG00000236104","hgnc_id":"HGNC:13085","ncbi_gene_id":9278,"previous_symbols":["ZNF297"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB22","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB24","identifiers":{"aliases":["KIAA0441","BIF1","PATZ2"],"approved_symbol":"ZBTB24","ensembl_gene_id":"ENSG00000112365","hgnc_id":"HGNC:21143","ncbi_gene_id":9841,"previous_symbols":["ZNF450"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB24","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB25","identifiers":{"aliases":["KUP"],"approved_symbol":"ZBTB25","ensembl_gene_id":"ENSG00000089775","hgnc_id":"HGNC:13112","ncbi_gene_id":7597,"previous_symbols":["ZNF46","C14orf51"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB25","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB26","identifiers":{"aliases":[],"approved_symbol":"ZBTB26","ensembl_gene_id":"ENSG00000171448","hgnc_id":"HGNC:23383","ncbi_gene_id":57684,"previous_symbols":["ZNF481"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB26","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB3","identifiers":{"aliases":["FLJ23392"],"approved_symbol":"ZBTB3","ensembl_gene_id":"ENSG00000185670","hgnc_id":"HGNC:22918","ncbi_gene_id":79842,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB3","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB32":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB32","identifiers":{"aliases":["TZFP","FAZF","FAXF","Rog","ZNF538","mynn"],"approved_symbol":"ZBTB32","ensembl_gene_id":"ENSG00000011590","hgnc_id":"HGNC:16763","ncbi_gene_id":27033,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB32","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB33":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB33","identifiers":{"aliases":["ZNF-kaiso","kaiso","WUGSC:H_DJ525N14.1","KAISO","ZNF348"],"approved_symbol":"ZBTB33","ensembl_gene_id":"ENSG00000177485","hgnc_id":"HGNC:16682","ncbi_gene_id":10009,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB33","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB34":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB34","identifiers":{"aliases":["KIAA1993","MGC24652","ZNF918"],"approved_symbol":"ZBTB34","ensembl_gene_id":"ENSG00000177125","hgnc_id":"HGNC:31446","ncbi_gene_id":403341,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB34","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB37":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB37","identifiers":{"aliases":["MGC2629","ZNF908"],"approved_symbol":"ZBTB37","ensembl_gene_id":"ENSG00000185278","hgnc_id":"HGNC:28365","ncbi_gene_id":84614,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB37","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB38":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB38","identifiers":{"aliases":["FLJ35036","CIBZ","ZNF921","PPP1R171"],"approved_symbol":"ZBTB38","ensembl_gene_id":"ENSG00000177311","hgnc_id":"HGNC:26636","ncbi_gene_id":253461,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB38","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB39":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB39","identifiers":{"aliases":["KIAA0352","ZNF922"],"approved_symbol":"ZBTB39","ensembl_gene_id":"ENSG00000166860","hgnc_id":"HGNC:29014","ncbi_gene_id":9880,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB39","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB4","identifiers":{"aliases":["KIAA1538","KAISO-L1","ZNF903"],"approved_symbol":"ZBTB4","ensembl_gene_id":"ENSG00000174282","hgnc_id":"HGNC:23847","ncbi_gene_id":57659,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZBTB4","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB40":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB40","identifiers":{"aliases":["KIAA0478","ZNF923"],"approved_symbol":"ZBTB40","ensembl_gene_id":"ENSG00000184677","hgnc_id":"HGNC:29045","ncbi_gene_id":9923,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZBTB40","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB41":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB41","identifiers":{"aliases":["FRBZ1","FLJ36199","DKFZp686C06120","ZNF924"],"approved_symbol":"ZBTB41","ensembl_gene_id":"ENSG00000177888","hgnc_id":"HGNC:24819","ncbi_gene_id":360023,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB41","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB42":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB42","identifiers":{"aliases":["ZNF925"],"approved_symbol":"ZBTB42","ensembl_gene_id":"ENSG00000179627","hgnc_id":"HGNC:32550","ncbi_gene_id":100128927,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB42","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB43":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB43","identifiers":{"aliases":["KIAA0414","ZNF-X","FLJ22470","ZBTB22B"],"approved_symbol":"ZBTB43","ensembl_gene_id":"ENSG00000169155","hgnc_id":"HGNC:17908","ncbi_gene_id":23099,"previous_symbols":["ZNF297B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZBTB43","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB44":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB44","identifiers":{"aliases":["HSPC063","ZNF851"],"approved_symbol":"ZBTB44","ensembl_gene_id":"ENSG00000196323","hgnc_id":"HGNC:25001","ncbi_gene_id":29068,"previous_symbols":["BTBD15"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZBTB44","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB44-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB44-DT","identifiers":{"aliases":[],"approved_symbol":"ZBTB44-DT","ensembl_gene_id":"ENSG00000175773","hgnc_id":"HGNC:54265","ncbi_gene_id":646383,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB44-DT","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB45":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB45","identifiers":{"aliases":["FLJ14486"],"approved_symbol":"ZBTB45","ensembl_gene_id":"ENSG00000119574","hgnc_id":"HGNC:23715","ncbi_gene_id":84878,"previous_symbols":["ZNF499"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB45","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB46":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB46","identifiers":{"aliases":["FLJ13502","RINZF","BZEL"],"approved_symbol":"ZBTB46","ensembl_gene_id":"ENSG00000130584","hgnc_id":"HGNC:16094","ncbi_gene_id":140685,"previous_symbols":["ZNF340","BTBD4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB46","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB46-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB46-AS1","identifiers":{"aliases":[],"approved_symbol":"ZBTB46-AS1","ensembl_gene_id":"ENSG00000231208","hgnc_id":"HGNC:40753","ncbi_gene_id":101928604,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB46-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB47":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB47","identifiers":{"aliases":["KIAA1190","DKFZp434N0615"],"approved_symbol":"ZBTB47","ensembl_gene_id":"ENSG00000114853","hgnc_id":"HGNC:26955","ncbi_gene_id":92999,"previous_symbols":["ZNF651"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB47","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB48":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB48","identifiers":{"aliases":["ZNF855","TZAP"],"approved_symbol":"ZBTB48","ensembl_gene_id":"ENSG00000204859","hgnc_id":"HGNC:4930","ncbi_gene_id":3104,"previous_symbols":["HKR3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB48","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB49":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB49","identifiers":{"aliases":["FLJ38559"],"approved_symbol":"ZBTB49","ensembl_gene_id":"ENSG00000168826","hgnc_id":"HGNC:19883","ncbi_gene_id":166793,"previous_symbols":["ZNF509"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB49","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB5","identifiers":{"aliases":["KIAA0354"],"approved_symbol":"ZBTB5","ensembl_gene_id":"ENSG00000168795","hgnc_id":"HGNC:23836","ncbi_gene_id":9925,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB5","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB6","identifiers":{"aliases":["ZID"],"approved_symbol":"ZBTB6","ensembl_gene_id":"ENSG00000186130","hgnc_id":"HGNC:16764","ncbi_gene_id":10773,"previous_symbols":["ZNF482"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB6","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB7A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB7A","identifiers":{"aliases":["FBI-1","LRF","DKFZp547O146","pokemon","ZNF857A"],"approved_symbol":"ZBTB7A","ensembl_gene_id":"ENSG00000178951","hgnc_id":"HGNC:18078","ncbi_gene_id":51341,"previous_symbols":["ZBTB7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB7A","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB7B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB7B","identifiers":{"aliases":["ZBTB15","c-Krox","hcKrox","ZNF857B","vGAF","ThPOK"],"approved_symbol":"ZBTB7B","ensembl_gene_id":"ENSG00000160685","hgnc_id":"HGNC:18668","ncbi_gene_id":51043,"previous_symbols":["ZFP67"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB7B","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB7C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB7C","identifiers":{"aliases":["ZNF857C"],"approved_symbol":"ZBTB7C","ensembl_gene_id":"ENSG00000184828","hgnc_id":"HGNC:31700","ncbi_gene_id":201501,"previous_symbols":["ZBTB36"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB7C","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB8A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB8A","identifiers":{"aliases":["BOZF1","FLJ90065","ZNF916A"],"approved_symbol":"ZBTB8A","ensembl_gene_id":"ENSG00000160062","hgnc_id":"HGNC:24172","ncbi_gene_id":653121,"previous_symbols":["ZBTB8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB8A","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB8OS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB8OS","identifiers":{"approved_symbol":"ZBTB8OS","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB8OS","release_manifest":"api/v1.1/release_manifest.json"}},"ZBTB9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZBTB9","identifiers":{"aliases":["MGC23166","ZNF919"],"approved_symbol":"ZBTB9","ensembl_gene_id":"ENSG00000213588","hgnc_id":"HGNC:28323","ncbi_gene_id":221504,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZBTB9","release_manifest":"api/v1.1/release_manifest.json"}},"ZC2HC1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC2HC1A","identifiers":{"aliases":["CGI-62"],"approved_symbol":"ZC2HC1A","ensembl_gene_id":"ENSG00000104427","hgnc_id":"HGNC:24277","ncbi_gene_id":51101,"previous_symbols":["C8orf70","FAM164A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC2HC1A","release_manifest":"api/v1.1/release_manifest.json"}},"ZC2HC1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC2HC1B","identifiers":{"aliases":["dJ468K18.5"],"approved_symbol":"ZC2HC1B","ensembl_gene_id":"ENSG00000118491","hgnc_id":"HGNC:21174","ncbi_gene_id":153918,"previous_symbols":["FAM164B","C6orf94"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC2HC1B","release_manifest":"api/v1.1/release_manifest.json"}},"ZC2HC1C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC2HC1C","identifiers":{"aliases":[],"approved_symbol":"ZC2HC1C","ensembl_gene_id":"ENSG00000119703","hgnc_id":"HGNC:20354","ncbi_gene_id":79696,"previous_symbols":["C14orf140","FAM164C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC2HC1C","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H10","identifiers":{"aliases":["FLJ14451"],"approved_symbol":"ZC3H10","ensembl_gene_id":"ENSG00000135482","hgnc_id":"HGNC:25893","ncbi_gene_id":84872,"previous_symbols":["ZC3HDC10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H10","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H11A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H11A","identifiers":{"aliases":["KIAA0663"],"approved_symbol":"ZC3H11A","ensembl_gene_id":"ENSG00000058673","hgnc_id":"HGNC:29093","ncbi_gene_id":9877,"previous_symbols":["ZC3HDC11A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H11A","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H12A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H12A","identifiers":{"aliases":["FLJ23231","MCPIP1","Regnase-1"],"approved_symbol":"ZC3H12A","ensembl_gene_id":"ENSG00000163874","hgnc_id":"HGNC:26259","ncbi_gene_id":80149,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H12A","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H12B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H12B","identifiers":{"aliases":["MCPIP2"],"approved_symbol":"ZC3H12B","ensembl_gene_id":"ENSG00000102053","hgnc_id":"HGNC:17407","ncbi_gene_id":340554,"previous_symbols":["CXorf32"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H12B","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H12C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H12C","identifiers":{"aliases":["KIAA1726","MCPIP3"],"approved_symbol":"ZC3H12C","ensembl_gene_id":"ENSG00000149289","hgnc_id":"HGNC:29362","ncbi_gene_id":85463,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H12C","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H12D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H12D","identifiers":{"aliases":["dJ281H8.1","MCPIP4"],"approved_symbol":"ZC3H12D","ensembl_gene_id":"ENSG00000178199","hgnc_id":"HGNC:21175","ncbi_gene_id":340152,"previous_symbols":["C6orf95"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H12D","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H13","identifiers":{"aliases":["DKFZp434D1812","Xio"],"approved_symbol":"ZC3H13","ensembl_gene_id":"ENSG00000123200","hgnc_id":"HGNC:20368","ncbi_gene_id":23091,"previous_symbols":["KIAA0853"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H13","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H14","identifiers":{"aliases":["FLJ11806","UKp68","NY-REN-37"],"approved_symbol":"ZC3H14","ensembl_gene_id":"ENSG00000100722","hgnc_id":"HGNC:20509","ncbi_gene_id":79882,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H14","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H15","identifiers":{"aliases":["DFRP1","LEREPO4"],"approved_symbol":"ZC3H15","ensembl_gene_id":"ENSG00000065548","hgnc_id":"HGNC:29528","ncbi_gene_id":55854,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H15","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H18","identifiers":{"aliases":["NHN1"],"approved_symbol":"ZC3H18","ensembl_gene_id":"ENSG00000158545","hgnc_id":"HGNC:25091","ncbi_gene_id":124245,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZC3H18","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H3","identifiers":{"aliases":["KIAA0150"],"approved_symbol":"ZC3H3","ensembl_gene_id":"ENSG00000014164","hgnc_id":"HGNC:28972","ncbi_gene_id":23144,"previous_symbols":["ZC3HDC3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H3","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H4","identifiers":{"aliases":["KIAA1064"],"approved_symbol":"ZC3H4","ensembl_gene_id":"ENSG00000130749","hgnc_id":"HGNC:17808","ncbi_gene_id":23211,"previous_symbols":["C19orf7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H4","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H6","identifiers":{"aliases":["FLJ41410","FLJ45877","KIAA2035"],"approved_symbol":"ZC3H6","ensembl_gene_id":"ENSG00000188177","hgnc_id":"HGNC:24762","ncbi_gene_id":376940,"previous_symbols":["ZC3HDC6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZC3H6","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H7A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H7A","identifiers":{"aliases":["HSPC055","FLJ20318"],"approved_symbol":"ZC3H7A","ensembl_gene_id":"ENSG00000122299","hgnc_id":"HGNC:30959","ncbi_gene_id":29066,"previous_symbols":["ZC3HDC7","ZC3H7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H7A","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H7B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H7B","identifiers":{"aliases":["RoXaN","FLJ13787","DKFZp434K0920","KIAA1031"],"approved_symbol":"ZC3H7B","ensembl_gene_id":"ENSG00000100403","hgnc_id":"HGNC:30869","ncbi_gene_id":23264,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H7B","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3H8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3H8","identifiers":{"aliases":["Fliz1"],"approved_symbol":"ZC3H8","ensembl_gene_id":"ENSG00000144161","hgnc_id":"HGNC:30941","ncbi_gene_id":84524,"previous_symbols":["ZC3HDC8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3H8","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3HAV1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3HAV1","identifiers":{"aliases":["ZAP","FLB6421","FLJ13288","MGC48898","ZC3HDC2","ZC3H2","PARP13","ARTD13"],"approved_symbol":"ZC3HAV1","ensembl_gene_id":"ENSG00000105939","hgnc_id":"HGNC:23721","ncbi_gene_id":56829,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3HAV1","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3HAV1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3HAV1L","identifiers":{"aliases":["MGC14289"],"approved_symbol":"ZC3HAV1L","ensembl_gene_id":"ENSG00000146858","hgnc_id":"HGNC:22423","ncbi_gene_id":92092,"previous_symbols":["C7orf39"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZC3HAV1L","release_manifest":"api/v1.1/release_manifest.json"}},"ZC3HC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC3HC1","identifiers":{"aliases":["NIPA"],"approved_symbol":"ZC3HC1","ensembl_gene_id":"ENSG00000091732","hgnc_id":"HGNC:29913","ncbi_gene_id":51530,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC3HC1","release_manifest":"api/v1.1/release_manifest.json"}},"ZC4H2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZC4H2","identifiers":{"aliases":["HCA127"],"approved_symbol":"ZC4H2","ensembl_gene_id":"ENSG00000126970","hgnc_id":"HGNC:24931","ncbi_gene_id":55906,"previous_symbols":["KIAA1166","WWS","MCS","MRXS4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZC4H2","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC10","identifiers":{"aliases":["FLJ20094"],"approved_symbol":"ZCCHC10","ensembl_gene_id":"ENSG00000155329","hgnc_id":"HGNC:25954","ncbi_gene_id":54819,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC10","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC12","identifiers":{"aliases":["FLJ16123","SIZN","SIZN1","PNMA7A"],"approved_symbol":"ZCCHC12","ensembl_gene_id":"ENSG00000174460","hgnc_id":"HGNC:27273","ncbi_gene_id":170261,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZCCHC12","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC14","identifiers":{"aliases":["BDG29","MGC14139"],"approved_symbol":"ZCCHC14","ensembl_gene_id":"ENSG00000140948","hgnc_id":"HGNC:24134","ncbi_gene_id":23174,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC14","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC17","identifiers":{"aliases":["PS1D","HSPC251","pNO40"],"approved_symbol":"ZCCHC17","ensembl_gene_id":"ENSG00000121766","hgnc_id":"HGNC:30246","ncbi_gene_id":51538,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC17","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC18","identifiers":{"aliases":["SIZN2","PNMA7B"],"approved_symbol":"ZCCHC18","ensembl_gene_id":"ENSG00000166707","hgnc_id":"HGNC:32459","ncbi_gene_id":644353,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC18","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC2","identifiers":{"aliases":["FLJ20281","KIAA1744","FLJ20222"],"approved_symbol":"ZCCHC2","ensembl_gene_id":"ENSG00000141664","hgnc_id":"HGNC:22916","ncbi_gene_id":54877,"previous_symbols":["C18orf49"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC2","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC24","identifiers":{"aliases":["FLJ90798","Z3CXXC8"],"approved_symbol":"ZCCHC24","ensembl_gene_id":"ENSG00000165424","hgnc_id":"HGNC:26911","ncbi_gene_id":219654,"previous_symbols":["C10orf56"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC24","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC3","identifiers":{"aliases":["dJ1103G7.7"],"approved_symbol":"ZCCHC3","ensembl_gene_id":"ENSG00000247315","hgnc_id":"HGNC:16230","ncbi_gene_id":85364,"previous_symbols":["C20orf99"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC3","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC4","identifiers":{"aliases":["HSPC052","FLJ23024","ZGRF4"],"approved_symbol":"ZCCHC4","ensembl_gene_id":"ENSG00000168228","hgnc_id":"HGNC:22917","ncbi_gene_id":29063,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC4","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC7","identifiers":{"aliases":["FLJ22611","AIR1"],"approved_symbol":"ZCCHC7","ensembl_gene_id":"ENSG00000147905","hgnc_id":"HGNC:26209","ncbi_gene_id":84186,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC7","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC8","identifiers":{"aliases":["DKFZp434E2220"],"approved_symbol":"ZCCHC8","ensembl_gene_id":"ENSG00000033030","hgnc_id":"HGNC:25265","ncbi_gene_id":55596,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC8","release_manifest":"api/v1.1/release_manifest.json"}},"ZCCHC9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCCHC9","identifiers":{"aliases":["DKFZp761J139","PPP1R41"],"approved_symbol":"ZCCHC9","ensembl_gene_id":"ENSG00000131732","hgnc_id":"HGNC:25424","ncbi_gene_id":84240,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCCHC9","release_manifest":"api/v1.1/release_manifest.json"}},"ZCRB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCRB1","identifiers":{"aliases":["MADP-1","MADP1","RBM36","ZCCHC19","SNRNP31"],"approved_symbol":"ZCRB1","ensembl_gene_id":"ENSG00000139168","hgnc_id":"HGNC:29620","ncbi_gene_id":85437,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZCRB1","release_manifest":"api/v1.1/release_manifest.json"}},"ZCWPW1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCWPW1","identifiers":{"aliases":["FLJ10057","DKFZp434N0510","ZCW1"],"approved_symbol":"ZCWPW1","ensembl_gene_id":"ENSG00000078487","hgnc_id":"HGNC:23486","ncbi_gene_id":55063,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCWPW1","release_manifest":"api/v1.1/release_manifest.json"}},"ZCWPW2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZCWPW2","identifiers":{"aliases":["ZCW2"],"approved_symbol":"ZCWPW2","ensembl_gene_id":"ENSG00000206559","hgnc_id":"HGNC:23574","ncbi_gene_id":152098,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZCWPW2","release_manifest":"api/v1.1/release_manifest.json"}},"ZDBF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDBF2","identifiers":{"aliases":["FLJ45338","KIAA1571"],"approved_symbol":"ZDBF2","ensembl_gene_id":"ENSG00000204186","hgnc_id":"HGNC:29313","ncbi_gene_id":57683,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZDBF2","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC1","identifiers":{"aliases":["HSU90653","ZNF377"],"approved_symbol":"ZDHHC1","ensembl_gene_id":"ENSG00000159714","hgnc_id":"HGNC:17916","ncbi_gene_id":29800,"previous_symbols":["C16orf1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC1","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC11","identifiers":{"aliases":["ZNF399","FLJ13153"],"approved_symbol":"ZDHHC11","ensembl_gene_id":"ENSG00000188818","hgnc_id":"HGNC:19158","ncbi_gene_id":79844,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC11","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC11B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC11B","identifiers":{"aliases":[],"approved_symbol":"ZDHHC11B","ensembl_gene_id":"ENSG00000206077","hgnc_id":"HGNC:32962","ncbi_gene_id":653082,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC11B","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC12","identifiers":{"aliases":["ZNF400","FLJ14524"],"approved_symbol":"ZDHHC12","ensembl_gene_id":"ENSG00000160446","hgnc_id":"HGNC:19159","ncbi_gene_id":84885,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC12","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC13","identifiers":{"aliases":["FLJ10852","FLJ10941","HIP14L"],"approved_symbol":"ZDHHC13","ensembl_gene_id":"ENSG00000177054","hgnc_id":"HGNC:18413","ncbi_gene_id":54503,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC13","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC14","identifiers":{"aliases":["FLJ20984","NEW1CP"],"approved_symbol":"ZDHHC14","ensembl_gene_id":"ENSG00000175048","hgnc_id":"HGNC:20341","ncbi_gene_id":79683,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC14","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC15","identifiers":{"aliases":["FLJ31812","MRX91","DHHC15"],"approved_symbol":"ZDHHC15","ensembl_gene_id":"ENSG00000102383","hgnc_id":"HGNC:20342","ncbi_gene_id":158866,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC15","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC16","identifiers":{"aliases":["APH2"],"approved_symbol":"ZDHHC16","ensembl_gene_id":"ENSG00000171307","hgnc_id":"HGNC:20714","ncbi_gene_id":84287,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZDHHC16","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC17","identifiers":{"aliases":["HIP14","HYPH","KIAA0946"],"approved_symbol":"ZDHHC17","ensembl_gene_id":"ENSG00000186908","hgnc_id":"HGNC:18412","ncbi_gene_id":23390,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZDHHC17","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC18","identifiers":{"aliases":["DKFZp667O2416"],"approved_symbol":"ZDHHC18","ensembl_gene_id":"ENSG00000204160","hgnc_id":"HGNC:20712","ncbi_gene_id":84243,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC18","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC19","identifiers":{"aliases":["MGC33345"],"approved_symbol":"ZDHHC19","ensembl_gene_id":"ENSG00000163958","hgnc_id":"HGNC:20713","ncbi_gene_id":131540,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZDHHC19","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC2","identifiers":{"aliases":["ZNF372","DHHC2"],"approved_symbol":"ZDHHC2","ensembl_gene_id":"ENSG00000104219","hgnc_id":"HGNC:18469","ncbi_gene_id":51201,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC2","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC20","identifiers":{"aliases":["FLJ25952","DHHC20"],"approved_symbol":"ZDHHC20","ensembl_gene_id":"ENSG00000180776","hgnc_id":"HGNC:20749","ncbi_gene_id":253832,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC20","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC21","identifiers":{"aliases":["HSPC097","DNZ1","DHHC21"],"approved_symbol":"ZDHHC21","ensembl_gene_id":"ENSG00000175893","hgnc_id":"HGNC:20750","ncbi_gene_id":340481,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZDHHC21","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC23","identifiers":{"aliases":["MGC42530"],"approved_symbol":"ZDHHC23","ensembl_gene_id":"ENSG00000184307","hgnc_id":"HGNC:28654","ncbi_gene_id":254887,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC23","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC24","identifiers":{"aliases":[],"approved_symbol":"ZDHHC24","ensembl_gene_id":"ENSG00000174165","hgnc_id":"HGNC:27387","ncbi_gene_id":254359,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC24","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC3","identifiers":{"aliases":["ZNF373","GODZ","DHHC3"],"approved_symbol":"ZDHHC3","ensembl_gene_id":"ENSG00000163812","hgnc_id":"HGNC:18470","ncbi_gene_id":51304,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC3","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC4","identifiers":{"aliases":["FLJ10479","ZNF374"],"approved_symbol":"ZDHHC4","ensembl_gene_id":"ENSG00000136247","hgnc_id":"HGNC:18471","ncbi_gene_id":55146,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC4","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC5","identifiers":{"aliases":["KIAA1748","ZNF375","DHHC5"],"approved_symbol":"ZDHHC5","ensembl_gene_id":"ENSG00000156599","hgnc_id":"HGNC:18472","ncbi_gene_id":25921,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC5","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC6","identifiers":{"aliases":["ZNF376","FLJ21952"],"approved_symbol":"ZDHHC6","ensembl_gene_id":"ENSG00000023041","hgnc_id":"HGNC:19160","ncbi_gene_id":64429,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC6","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC7","identifiers":{"aliases":["FLJ10792","ZNF370","FLJ20279","SERZ-B","SERZ1","DHHC7"],"approved_symbol":"ZDHHC7","ensembl_gene_id":"ENSG00000153786","hgnc_id":"HGNC:18459","ncbi_gene_id":55625,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.0092891,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC7","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC8","identifiers":{"aliases":["ZNF378","KIAA1292","DHHC8"],"approved_symbol":"ZDHHC8","ensembl_gene_id":"ENSG00000099904","hgnc_id":"HGNC:18474","ncbi_gene_id":29801,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC8","release_manifest":"api/v1.1/release_manifest.json"}},"ZDHHC9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZDHHC9","identifiers":{"aliases":["ZNF379","CGI-89","ZNF380","DHHC9"],"approved_symbol":"ZDHHC9","ensembl_gene_id":"ENSG00000188706","hgnc_id":"HGNC:18475","ncbi_gene_id":51114,"previous_symbols":["ZDHHC10","CXorf11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZDHHC9","release_manifest":"api/v1.1/release_manifest.json"}},"ZEB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZEB1","identifiers":{"aliases":["BZP","ZEB","AREB6","NIL-2-A","Zfhep","Zfhx1a","FECD6"],"approved_symbol":"ZEB1","ensembl_gene_id":"ENSG00000148516","hgnc_id":"HGNC:11642","ncbi_gene_id":6935,"previous_symbols":["TCF8","PPCD3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZEB1","release_manifest":"api/v1.1/release_manifest.json"}},"ZEB1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZEB1-AS1","identifiers":{"aliases":[],"approved_symbol":"ZEB1-AS1","ensembl_gene_id":"ENSG00000237036","hgnc_id":"HGNC:42354","ncbi_gene_id":220930,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZEB1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZEB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZEB2","identifiers":{"aliases":["KIAA0569","SIP-1","SIP1"],"approved_symbol":"ZEB2","ensembl_gene_id":"ENSG00000169554","hgnc_id":"HGNC:14881","ncbi_gene_id":9839,"previous_symbols":["ZFHX1B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZEB2","release_manifest":"api/v1.1/release_manifest.json"}},"ZEB2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZEB2-AS1","identifiers":{"aliases":["ZEB2NAT"],"approved_symbol":"ZEB2-AS1","ensembl_gene_id":"ENSG00000238057","hgnc_id":"HGNC:37149","ncbi_gene_id":100303491,"previous_symbols":["ZEB2AS","ZEB2-AS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZEB2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZER1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZER1","identifiers":{"aliases":["ZYG","Hzyg"],"approved_symbol":"ZER1","ensembl_gene_id":"ENSG00000160445","hgnc_id":"HGNC:30960","ncbi_gene_id":10444,"previous_symbols":["C9orf60","ZYG11BL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZER1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAND1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAND1","identifiers":{"aliases":["FLJ14007"],"approved_symbol":"ZFAND1","ensembl_gene_id":"ENSG00000104231","hgnc_id":"HGNC:25858","ncbi_gene_id":79752,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAND1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAND2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAND2A","identifiers":{"aliases":["AIRAP"],"approved_symbol":"ZFAND2A","ensembl_gene_id":"ENSG00000178381","hgnc_id":"HGNC:28073","ncbi_gene_id":90637,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAND2A","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAND2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAND2B","identifiers":{"aliases":["AIRAPL"],"approved_symbol":"ZFAND2B","ensembl_gene_id":"ENSG00000158552","hgnc_id":"HGNC:25206","ncbi_gene_id":130617,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAND2B","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAND3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAND3","identifiers":{"aliases":["FLJ13222"],"approved_symbol":"ZFAND3","ensembl_gene_id":"ENSG00000156639","hgnc_id":"HGNC:18019","ncbi_gene_id":60685,"previous_symbols":["TEX27"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAND3","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAND4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAND4","identifiers":{"aliases":["FLJ40185"],"approved_symbol":"ZFAND4","ensembl_gene_id":"ENSG00000172671","hgnc_id":"HGNC:23504","ncbi_gene_id":93550,"previous_symbols":["ANUBL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAND4","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAND5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAND5","identifiers":{"aliases":["ZFAND5A"],"approved_symbol":"ZFAND5","ensembl_gene_id":"ENSG00000107372","hgnc_id":"HGNC:13008","ncbi_gene_id":7763,"previous_symbols":["ZNF216","ZA20D2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAND5","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAND6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAND6","identifiers":{"aliases":["ZFAND5B","AWP1"],"approved_symbol":"ZFAND6","ensembl_gene_id":"ENSG00000086666","hgnc_id":"HGNC:30164","ncbi_gene_id":54469,"previous_symbols":["ZA20D3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAND6","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAS1","identifiers":{"aliases":["HSUP1","HSUP2"],"approved_symbol":"ZFAS1","ensembl_gene_id":"ENSG00000177410","hgnc_id":"HGNC:33101","ncbi_gene_id":441951,"previous_symbols":["C20orf199","NCRNA00275","ZNFX1-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZFAS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFAT","identifiers":{"aliases":["KIAA1485"],"approved_symbol":"ZFAT","ensembl_gene_id":"ENSG00000066827","hgnc_id":"HGNC:19899","ncbi_gene_id":57623,"previous_symbols":["ZNF406","ZFAT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFAT","release_manifest":"api/v1.1/release_manifest.json"}},"ZFC3H1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFC3H1","identifiers":{"aliases":["MGC23401","KIAA0546","CSRC2"],"approved_symbol":"ZFC3H1","ensembl_gene_id":"ENSG00000133858","hgnc_id":"HGNC:28328","ncbi_gene_id":196441,"previous_symbols":["PSRC2","CCDC131"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFC3H1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFHX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFHX2","identifiers":{"aliases":["KIAA1762","KIAA1056","ZFH-5"],"approved_symbol":"ZFHX2","ensembl_gene_id":"ENSG00000136367","hgnc_id":"HGNC:20152","ncbi_gene_id":85446,"previous_symbols":["ZNF409"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFHX2","release_manifest":"api/v1.1/release_manifest.json"}},"ZFHX2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFHX2-AS1","identifiers":{"aliases":["LncZFHX2"],"approved_symbol":"ZFHX2-AS1","ensembl_gene_id":"ENSG00000157306","hgnc_id":"HGNC:52658","ncbi_gene_id":109729160,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFHX2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFHX3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFHX3","identifiers":{"aliases":["ZNF927","FLJ26184"],"approved_symbol":"ZFHX3","ensembl_gene_id":"ENSG00000140836","hgnc_id":"HGNC:777","ncbi_gene_id":463,"previous_symbols":["ATBF1","C16orf47"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFHX3","release_manifest":"api/v1.1/release_manifest.json"}},"ZFHX4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFHX4","identifiers":{"aliases":["ZFH4","FLJ20980"],"approved_symbol":"ZFHX4","ensembl_gene_id":"ENSG00000091656","hgnc_id":"HGNC:30939","ncbi_gene_id":79776,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFHX4","release_manifest":"api/v1.1/release_manifest.json"}},"ZFHX4-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFHX4-AS1","identifiers":{"aliases":[],"approved_symbol":"ZFHX4-AS1","ensembl_gene_id":"ENSG00000253661","hgnc_id":"HGNC:44165","ncbi_gene_id":100192378,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFHX4-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP1","identifiers":{"aliases":["PITA","FLJ34243","ZNF475"],"approved_symbol":"ZFP1","ensembl_gene_id":"ENSG00000184517","hgnc_id":"HGNC:23328","ncbi_gene_id":162239,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP14","identifiers":{"aliases":["KIAA1559","ZNF531"],"approved_symbol":"ZFP14","ensembl_gene_id":"ENSG00000142065","hgnc_id":"HGNC:29312","ncbi_gene_id":57677,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP14","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP2","identifiers":{"aliases":["FLJ21628","ZNF751"],"approved_symbol":"ZFP2","ensembl_gene_id":"ENSG00000198939","hgnc_id":"HGNC:26138","ncbi_gene_id":80108,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP2","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP28","identifiers":{"aliases":["KIAA1431","mkr5"],"approved_symbol":"ZFP28","ensembl_gene_id":"ENSG00000196867","hgnc_id":"HGNC:17801","ncbi_gene_id":140612,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP28","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP3","identifiers":{"aliases":["FLJ30726","ZNF752"],"approved_symbol":"ZFP3","ensembl_gene_id":"ENSG00000180787","hgnc_id":"HGNC:12861","ncbi_gene_id":124961,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP3","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP30","identifiers":{"aliases":["ZNF745","KIAA0961"],"approved_symbol":"ZFP30","ensembl_gene_id":"ENSG00000120784","hgnc_id":"HGNC:29555","ncbi_gene_id":22835,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP30","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP36":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP36","identifiers":{"aliases":["TIS11","G0S24","TTP","NUP475"],"approved_symbol":"ZFP36","ensembl_gene_id":"ENSG00000128016","hgnc_id":"HGNC:12862","ncbi_gene_id":7538,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP36","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP36L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP36L1","identifiers":{"aliases":["Berg36","ERF1","TIS11B","cMG1"],"approved_symbol":"ZFP36L1","ensembl_gene_id":"ENSG00000185650","hgnc_id":"HGNC:1107","ncbi_gene_id":677,"previous_symbols":["BRF1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP36L1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP36L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP36L2","identifiers":{"aliases":["ERF2","TIS11D"],"approved_symbol":"ZFP36L2","ensembl_gene_id":"ENSG00000152518","hgnc_id":"HGNC:1108","ncbi_gene_id":678,"previous_symbols":["BRF2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP36L2","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP37":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP37","identifiers":{"aliases":["ZNF906"],"approved_symbol":"ZFP37","ensembl_gene_id":"ENSG00000136866","hgnc_id":"HGNC:12863","ncbi_gene_id":7539,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP37","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP41":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP41","identifiers":{"aliases":["FLJ38705","FLJ00028","ZNF753"],"approved_symbol":"ZFP41","ensembl_gene_id":"ENSG00000181638","hgnc_id":"HGNC:26786","ncbi_gene_id":286128,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP41","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP62":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP62","identifiers":{"aliases":["FLJ34231","ZET","ZNF755"],"approved_symbol":"ZFP62","ensembl_gene_id":"ENSG00000196670","hgnc_id":"HGNC:23241","ncbi_gene_id":643836,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP62","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP64":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP64","identifiers":{"aliases":["FLJ10734","dJ831D17.1","FLJ12628","dJ548G19.1"],"approved_symbol":"ZFP64","ensembl_gene_id":"ENSG00000020256","hgnc_id":"HGNC:15940","ncbi_gene_id":55734,"previous_symbols":["ZNF338"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP64","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP69":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP69","identifiers":{"aliases":["ZKSCAN23A","FLJ16030","ZFP69A","ZSCAN54A"],"approved_symbol":"ZFP69","ensembl_gene_id":"ENSG00000187815","hgnc_id":"HGNC:24708","ncbi_gene_id":339559,"previous_symbols":["ZNF642"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP69","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP69B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP69B","identifiers":{"aliases":["ZKSCAN23B","FLJ34293","ZSCAN54B"],"approved_symbol":"ZFP69B","ensembl_gene_id":"ENSG00000187801","hgnc_id":"HGNC:28053","ncbi_gene_id":65243,"previous_symbols":["ZNF643"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L2_observed_same_context_perturbation","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":81},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"verify_expression","current_display_label":"Verify expression","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":3,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-06","label":"Expression feasibility is not verified in the intended model"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-03 DMD-relevant functional validation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":0.155208,"depmap_median_gene_effect":-0.1074611086158024,"moderate_dependency_flag":false,"observed_counteralignment":0.0563412545485794},"summary":"Priority A · validate first; observed DMD-prior counteralignment 0.0563; observed cells 81; integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP69B","detailed_audit_record":"gene/ZFP69B/audit","legacy_api_record":"api/v1/genes/ZFP69B.json","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP82":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP82","identifiers":{"aliases":["MGC45380","KIAA1948"],"approved_symbol":"ZFP82","ensembl_gene_id":"ENSG00000181007","hgnc_id":"HGNC:28682","ncbi_gene_id":284406,"previous_symbols":["ZNF545"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP82","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP90":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP90","identifiers":{"aliases":["KIAA1954","NK10","ZNF756"],"approved_symbol":"ZFP90","ensembl_gene_id":"ENSG00000184939","hgnc_id":"HGNC:23329","ncbi_gene_id":146198,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP90","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP91":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP91","identifiers":{"aliases":["PZF","ZNF757"],"approved_symbol":"ZFP91","ensembl_gene_id":"ENSG00000186660","hgnc_id":"HGNC:14983","ncbi_gene_id":80829,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP91","release_manifest":"api/v1.1/release_manifest.json"}},"ZFP92":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFP92","identifiers":{"aliases":["ZNF897"],"approved_symbol":"ZFP92","ensembl_gene_id":"ENSG00000189420","hgnc_id":"HGNC:12865","ncbi_gene_id":139735,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFP92","release_manifest":"api/v1.1/release_manifest.json"}},"ZFPL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFPL1","identifiers":{"aliases":["D11S750","MCG4"],"approved_symbol":"ZFPL1","ensembl_gene_id":"ENSG00000162300","hgnc_id":"HGNC:12868","ncbi_gene_id":7542,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFPL1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFPM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFPM1","identifiers":{"aliases":["PRDM18","FOG1","FOG","ZNF89A"],"approved_symbol":"ZFPM1","ensembl_gene_id":"ENSG00000179588","hgnc_id":"HGNC:19762","ncbi_gene_id":161882,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZFPM1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFPM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFPM2","identifiers":{"aliases":["PRDM19","FOG2","hFOG-2","ZNF89B"],"approved_symbol":"ZFPM2","ensembl_gene_id":"ENSG00000169946","hgnc_id":"HGNC:16700","ncbi_gene_id":23414,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFPM2","release_manifest":"api/v1.1/release_manifest.json"}},"ZFPM2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFPM2-AS1","identifiers":{"aliases":["SCAT3"],"approved_symbol":"ZFPM2-AS1","ensembl_gene_id":"ENSG00000251003","hgnc_id":"HGNC:50698","ncbi_gene_id":102723356,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZFPM2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFR","identifiers":{"aliases":["ZFR1","SPG71"],"approved_symbol":"ZFR","ensembl_gene_id":"ENSG00000056097","hgnc_id":"HGNC:17277","ncbi_gene_id":51663,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFR","release_manifest":"api/v1.1/release_manifest.json"}},"ZFR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFR2","identifiers":{"aliases":[],"approved_symbol":"ZFR2","ensembl_gene_id":"ENSG00000105278","hgnc_id":"HGNC:29189","ncbi_gene_id":23217,"previous_symbols":["KIAA1086"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZFR2","release_manifest":"api/v1.1/release_manifest.json"}},"ZFX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFX","identifiers":{"aliases":["ZNF926"],"approved_symbol":"ZFX","ensembl_gene_id":"ENSG00000005889","hgnc_id":"HGNC:12869","ncbi_gene_id":7543,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFX","release_manifest":"api/v1.1/release_manifest.json"}},"ZFX-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFX-AS1","identifiers":{"aliases":[],"approved_symbol":"ZFX-AS1","ensembl_gene_id":"ENSG00000234230","hgnc_id":"HGNC:40617","ncbi_gene_id":100873922,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFX-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFY":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFY","identifiers":{"aliases":["ZNF911"],"approved_symbol":"ZFY","ensembl_gene_id":"ENSG00000067646","hgnc_id":"HGNC:12870","ncbi_gene_id":7544,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZFY","release_manifest":"api/v1.1/release_manifest.json"}},"ZFY-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFY-AS1","identifiers":{"aliases":[],"approved_symbol":"ZFY-AS1","ensembl_gene_id":"ENSG00000233070","hgnc_id":"HGNC:38798","ncbi_gene_id":107987337,"previous_symbols":["ZFYAS","ZFY-AS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFY-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE1","identifiers":{"aliases":["DFCP1","KIAA1589","TAFF1","PPP1R172"],"approved_symbol":"ZFYVE1","ensembl_gene_id":"ENSG00000165861","hgnc_id":"HGNC:13180","ncbi_gene_id":53349,"previous_symbols":["ZNFN2A1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE1","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE16","identifiers":{"aliases":["KIAA0305","PPP1R69"],"approved_symbol":"ZFYVE16","ensembl_gene_id":"ENSG00000039319","hgnc_id":"HGNC:20756","ncbi_gene_id":9765,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE16","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE19","identifiers":{"aliases":["FLJ14840","ANCHR","MPFYVE"],"approved_symbol":"ZFYVE19","ensembl_gene_id":"ENSG00000166140","hgnc_id":"HGNC:20758","ncbi_gene_id":84936,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE19","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE21","identifiers":{"aliases":["MGC2550","ZF21"],"approved_symbol":"ZFYVE21","ensembl_gene_id":"ENSG00000100711","hgnc_id":"HGNC:20760","ncbi_gene_id":79038,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE21","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE26","identifiers":{"aliases":["KIAA0321"],"approved_symbol":"ZFYVE26","ensembl_gene_id":"ENSG00000072121","hgnc_id":"HGNC:20761","ncbi_gene_id":23503,"previous_symbols":["SPG15"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE26","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE27","identifiers":{"aliases":["FLJ32919","SPG33"],"approved_symbol":"ZFYVE27","ensembl_gene_id":"ENSG00000155256","hgnc_id":"HGNC:26559","ncbi_gene_id":118813,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE27","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE28","identifiers":{"aliases":["KIAA1643","lst-2"],"approved_symbol":"ZFYVE28","ensembl_gene_id":"ENSG00000159733","hgnc_id":"HGNC:29334","ncbi_gene_id":57732,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE28","release_manifest":"api/v1.1/release_manifest.json"}},"ZFYVE9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZFYVE9","identifiers":{"aliases":["SMADIP","SARA","PPP1R173"],"approved_symbol":"ZFYVE9","ensembl_gene_id":"ENSG00000157077","hgnc_id":"HGNC:6775","ncbi_gene_id":9372,"previous_symbols":["MADHIP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZFYVE9","release_manifest":"api/v1.1/release_manifest.json"}},"ZG16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZG16","identifiers":{"aliases":["hZG16","JCLN1","ZG16A"],"approved_symbol":"ZG16","ensembl_gene_id":"ENSG00000174992","hgnc_id":"HGNC:30961","ncbi_gene_id":653808,"previous_symbols":["JCLN"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZG16","release_manifest":"api/v1.1/release_manifest.json"}},"ZG16B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZG16B","identifiers":{"aliases":["HRPE773","PRO1567","JCLN2"],"approved_symbol":"ZG16B","ensembl_gene_id":"ENSG00000162078","hgnc_id":"HGNC:30456","ncbi_gene_id":124220,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZG16B","release_manifest":"api/v1.1/release_manifest.json"}},"ZGLP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZGLP1","identifiers":{"aliases":["GLP1","GLP-1","GATAD3"],"approved_symbol":"ZGLP1","ensembl_gene_id":"ENSG00000220201","hgnc_id":"HGNC:37245","ncbi_gene_id":100125288,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZGLP1","release_manifest":"api/v1.1/release_manifest.json"}},"ZGPAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZGPAT","identifiers":{"aliases":["dJ583P15.3","MGC44880","FLJ14972","ZC3HDC9","ZC3H9","GPATC6","GPATCH6","ZIP"],"approved_symbol":"ZGPAT","ensembl_gene_id":"ENSG00000197114","hgnc_id":"HGNC:15948","ncbi_gene_id":84619,"previous_symbols":["KIAA1847"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZGPAT","release_manifest":"api/v1.1/release_manifest.json"}},"ZGRF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZGRF1","identifiers":{"aliases":["FLJ11331"],"approved_symbol":"ZGRF1","ensembl_gene_id":"ENSG00000138658","hgnc_id":"HGNC:25654","ncbi_gene_id":55345,"previous_symbols":["C4orf21"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZGRF1","release_manifest":"api/v1.1/release_manifest.json"}},"ZHX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZHX1","identifiers":{"aliases":[],"approved_symbol":"ZHX1","ensembl_gene_id":"ENSG00000165156","hgnc_id":"HGNC:12871","ncbi_gene_id":11244,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZHX1","release_manifest":"api/v1.1/release_manifest.json"}},"ZHX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZHX2","identifiers":{"aliases":["KIAA0854"],"approved_symbol":"ZHX2","ensembl_gene_id":"ENSG00000178764","hgnc_id":"HGNC:18513","ncbi_gene_id":22882,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZHX2","release_manifest":"api/v1.1/release_manifest.json"}},"ZHX3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZHX3","identifiers":{"aliases":["KIAA0395"],"approved_symbol":"ZHX3","ensembl_gene_id":"ENSG00000174306","hgnc_id":"HGNC:15935","ncbi_gene_id":23051,"previous_symbols":["TIX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZHX3","release_manifest":"api/v1.1/release_manifest.json"}},"ZIC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZIC1","identifiers":{"aliases":["ZIC","ZNF201"],"approved_symbol":"ZIC1","ensembl_gene_id":"ENSG00000152977","hgnc_id":"HGNC:12872","ncbi_gene_id":7545,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZIC1","release_manifest":"api/v1.1/release_manifest.json"}},"ZIC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZIC4","identifiers":{"aliases":[],"approved_symbol":"ZIC4","ensembl_gene_id":"ENSG00000174963","hgnc_id":"HGNC:20393","ncbi_gene_id":84107,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZIC4","release_manifest":"api/v1.1/release_manifest.json"}},"ZIK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZIK1","identifiers":{"aliases":["ZNF762"],"approved_symbol":"ZIK1","ensembl_gene_id":"ENSG00000171649","hgnc_id":"HGNC:33104","ncbi_gene_id":284307,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZIK1","release_manifest":"api/v1.1/release_manifest.json"}},"ZIM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZIM2","identifiers":{"aliases":["ZNF656"],"approved_symbol":"ZIM2","ensembl_gene_id":"ENSG00000269699","hgnc_id":"HGNC:12875","ncbi_gene_id":23619,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZIM2","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN1","identifiers":{"aliases":["KOX18","PHZ-37","ZSCAN33"],"approved_symbol":"ZKSCAN1","ensembl_gene_id":"ENSG00000106261","hgnc_id":"HGNC:13101","ncbi_gene_id":7586,"previous_symbols":["ZNF139","ZNF36"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZKSCAN1","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN2","identifiers":{"aliases":["FLJ23199","ZSCAN34"],"approved_symbol":"ZKSCAN2","ensembl_gene_id":"ENSG00000155592","hgnc_id":"HGNC:25677","ncbi_gene_id":342357,"previous_symbols":["ZNF694"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZKSCAN2","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN2-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN2-DT","identifiers":{"aliases":["CTD-2547G23.4"],"approved_symbol":"ZKSCAN2-DT","ensembl_gene_id":"ENSG00000274925","hgnc_id":"HGNC:53912","ncbi_gene_id":112577464,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZKSCAN2-DT","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN3","identifiers":{"aliases":["Zfp47","ZF47","ZSCAN35"],"approved_symbol":"ZKSCAN3","ensembl_gene_id":"ENSG00000189298","hgnc_id":"HGNC:13853","ncbi_gene_id":80317,"previous_symbols":["ZNF306","ZNF309"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZKSCAN3","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN4","identifiers":{"aliases":["p373c6.1","P1P373C6","FLJ32136","ZSCAN36"],"approved_symbol":"ZKSCAN4","ensembl_gene_id":"ENSG00000187626","hgnc_id":"HGNC:13854","ncbi_gene_id":387032,"previous_symbols":["ZNF307","ZNF427"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZKSCAN4","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN5","identifiers":{"aliases":["ZNF914","ZSCAN37"],"approved_symbol":"ZKSCAN5","ensembl_gene_id":"ENSG00000196652","hgnc_id":"HGNC:12867","ncbi_gene_id":23660,"previous_symbols":["ZFP95"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZKSCAN5","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN7","identifiers":{"aliases":["FLJ12738","ZSCAN39"],"approved_symbol":"ZKSCAN7","ensembl_gene_id":"ENSG00000196345","hgnc_id":"HGNC:12955","ncbi_gene_id":55888,"previous_symbols":["ZNF64","ZNF448","ZNF167"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZKSCAN7","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN7-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN7-AS1","identifiers":{"aliases":["RP11-944L7.4"],"approved_symbol":"ZKSCAN7-AS1","ensembl_gene_id":"ENSG00000236869","hgnc_id":"HGNC:53964","ncbi_gene_id":112840933,"previous_symbols":["ZNF197-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZKSCAN7-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZKSCAN8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZKSCAN8","identifiers":{"aliases":["LD5-1","ZSCAN40"],"approved_symbol":"ZKSCAN8","ensembl_gene_id":"ENSG00000198315","hgnc_id":"HGNC:12983","ncbi_gene_id":7745,"previous_symbols":["ZNF192"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZKSCAN8","release_manifest":"api/v1.1/release_manifest.json"}},"ZMAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMAT1","identifiers":{"aliases":["KIAA1789"],"approved_symbol":"ZMAT1","ensembl_gene_id":"ENSG00000166432","hgnc_id":"HGNC:29377","ncbi_gene_id":84460,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMAT1","release_manifest":"api/v1.1/release_manifest.json"}},"ZMAT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMAT2","identifiers":{"aliases":["FLJ31121","hSNU23","Snu23"],"approved_symbol":"ZMAT2","ensembl_gene_id":"ENSG00000146007","hgnc_id":"HGNC:26433","ncbi_gene_id":153527,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMAT2","release_manifest":"api/v1.1/release_manifest.json"}},"ZMAT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMAT3","identifiers":{"aliases":["WIG1","MGC10613","FLJ12296","WIG-1","PAG608"],"approved_symbol":"ZMAT3","ensembl_gene_id":"ENSG00000172667","hgnc_id":"HGNC:29983","ncbi_gene_id":64393,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMAT3","release_manifest":"api/v1.1/release_manifest.json"}},"ZMAT4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMAT4","identifiers":{"aliases":["FLJ13842"],"approved_symbol":"ZMAT4","ensembl_gene_id":"ENSG00000165061","hgnc_id":"HGNC:25844","ncbi_gene_id":79698,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZMAT4","release_manifest":"api/v1.1/release_manifest.json"}},"ZMAT5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMAT5","identifiers":{"aliases":["SNRNP20"],"approved_symbol":"ZMAT5","ensembl_gene_id":"ENSG00000100319","hgnc_id":"HGNC:28046","ncbi_gene_id":55954,"previous_symbols":["ZC3H19"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMAT5","release_manifest":"api/v1.1/release_manifest.json"}},"ZMIZ1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMIZ1","identifiers":{"aliases":["RP11-519K18.1","KIAA1224","FLJ13541","hZIMP10","Zimp10","MIZ"],"approved_symbol":"ZMIZ1","ensembl_gene_id":"ENSG00000108175","hgnc_id":"HGNC:16493","ncbi_gene_id":57178,"previous_symbols":["RAI17"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMIZ1","release_manifest":"api/v1.1/release_manifest.json"}},"ZMIZ1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMIZ1-AS1","identifiers":{"aliases":[],"approved_symbol":"ZMIZ1-AS1","ensembl_gene_id":"ENSG00000224596","hgnc_id":"HGNC:27433","ncbi_gene_id":283050,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZMIZ1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZMIZ2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMIZ2","identifiers":{"aliases":["KIAA1886","hZIMP7","ZIMP7","DKFZp761I2123","NET27"],"approved_symbol":"ZMIZ2","ensembl_gene_id":"ENSG00000122515","hgnc_id":"HGNC:22229","ncbi_gene_id":83637,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMIZ2","release_manifest":"api/v1.1/release_manifest.json"}},"ZMPSTE24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMPSTE24","identifiers":{"aliases":["FACE-1","Ste24p","STE24","HGPS","PRO1"],"approved_symbol":"ZMPSTE24","ensembl_gene_id":"ENSG00000084073","hgnc_id":"HGNC:12877","ncbi_gene_id":10269,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMPSTE24","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYM1","identifiers":{"aliases":["FLJ23151","MYM"],"approved_symbol":"ZMYM1","ensembl_gene_id":"ENSG00000197056","hgnc_id":"HGNC:26253","ncbi_gene_id":79830,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYM1","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYM2","identifiers":{"aliases":["RAMP","FIM","MYM"],"approved_symbol":"ZMYM2","ensembl_gene_id":"ENSG00000121741","hgnc_id":"HGNC:12989","ncbi_gene_id":7750,"previous_symbols":["ZNF198"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYM2","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYM3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYM3","identifiers":{"aliases":["ZNF198L2","DXS6673E","KIAA0385","MYM"],"approved_symbol":"ZMYM3","ensembl_gene_id":"ENSG00000147130","hgnc_id":"HGNC:13054","ncbi_gene_id":9203,"previous_symbols":["ZNF261"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYM3","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYM4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYM4","identifiers":{"aliases":["KIAA0425","ZNF198L3","MYM"],"approved_symbol":"ZMYM4","ensembl_gene_id":"ENSG00000146463","hgnc_id":"HGNC:13055","ncbi_gene_id":9202,"previous_symbols":["ZNF262"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYM4","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYM4-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYM4-AS1","identifiers":{"aliases":[],"approved_symbol":"ZMYM4-AS1","ensembl_gene_id":"ENSG00000227409","hgnc_id":"HGNC:40624","ncbi_gene_id":100861513,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYM4-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYM5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYM5","identifiers":{"aliases":["ZNF198L1","MYM"],"approved_symbol":"ZMYM5","ensembl_gene_id":"ENSG00000132950","hgnc_id":"HGNC:13029","ncbi_gene_id":9205,"previous_symbols":["ZNF237"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYM5","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYM6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYM6","identifiers":{"aliases":["ZNF198L4","MYM","Buster2","ZBED7","KIAA1353"],"approved_symbol":"ZMYM6","ensembl_gene_id":"ENSG00000163867","hgnc_id":"HGNC:13050","ncbi_gene_id":9204,"previous_symbols":["ZNF258"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYM6","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYND10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYND10","identifiers":{"aliases":["BLU","CILD22","DNAAF7"],"approved_symbol":"ZMYND10","ensembl_gene_id":"ENSG00000004838","hgnc_id":"HGNC:19412","ncbi_gene_id":51364,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZMYND10","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYND11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYND11","identifiers":{"aliases":["BS69","BRAM1"],"approved_symbol":"ZMYND11","ensembl_gene_id":"ENSG00000015171","hgnc_id":"HGNC:16966","ncbi_gene_id":10771,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYND11","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYND12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYND12","identifiers":{"aliases":["DKFZp434N2435"],"approved_symbol":"ZMYND12","ensembl_gene_id":"ENSG00000066185","hgnc_id":"HGNC:21192","ncbi_gene_id":84217,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYND12","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYND15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYND15","identifiers":{"aliases":["DKFZp434N127"],"approved_symbol":"ZMYND15","ensembl_gene_id":"ENSG00000141497","hgnc_id":"HGNC:20997","ncbi_gene_id":84225,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYND15","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYND19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYND19","identifiers":{"aliases":["MIZIP"],"approved_symbol":"ZMYND19","ensembl_gene_id":"ENSG00000165724","hgnc_id":"HGNC:21146","ncbi_gene_id":116225,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYND19","release_manifest":"api/v1.1/release_manifest.json"}},"ZMYND8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZMYND8","identifiers":{"aliases":["RACK7","KIAA1125"],"approved_symbol":"ZMYND8","ensembl_gene_id":"ENSG00000101040","hgnc_id":"HGNC:9397","ncbi_gene_id":23613,"previous_symbols":["PRKCBP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZMYND8","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF10","identifiers":{"aliases":["KOX1"],"approved_symbol":"ZNF10","ensembl_gene_id":"ENSG00000256223","hgnc_id":"HGNC:12879","ncbi_gene_id":7556,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF10","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF100":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF100","identifiers":{"aliases":[],"approved_symbol":"ZNF100","ensembl_gene_id":"ENSG00000197020","hgnc_id":"HGNC:12880","ncbi_gene_id":163227,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF100","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF101":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF101","identifiers":{"aliases":["HZF12","DKFZp570I0164"],"approved_symbol":"ZNF101","ensembl_gene_id":"ENSG00000181896","hgnc_id":"HGNC:12881","ncbi_gene_id":94039,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF101","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF106":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF106","identifiers":{"aliases":["ZNF474","SH3BP3"],"approved_symbol":"ZNF106","ensembl_gene_id":"ENSG00000103994","hgnc_id":"HGNC:12886","ncbi_gene_id":64397,"previous_symbols":["ZFP106"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF106","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF107":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF107","identifiers":{"aliases":["ZFD25","smap-7"],"approved_symbol":"ZNF107","ensembl_gene_id":"ENSG00000196247","hgnc_id":"HGNC:12887","ncbi_gene_id":51427,"previous_symbols":["ZNF588"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF107","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF112":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF112","identifiers":{"aliases":[],"approved_symbol":"ZNF112","ensembl_gene_id":"ENSG00000062370","hgnc_id":"HGNC:12892","ncbi_gene_id":7771,"previous_symbols":["ZFP112","ZNF228"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF112","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF114":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF114","identifiers":{"aliases":["MGC17986"],"approved_symbol":"ZNF114","ensembl_gene_id":"ENSG00000178150","hgnc_id":"HGNC:12894","ncbi_gene_id":163071,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF114","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF117":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF117","identifiers":{"aliases":["HPF9","H-plk"],"approved_symbol":"ZNF117","ensembl_gene_id":"ENSG00000152926","hgnc_id":"HGNC:12897","ncbi_gene_id":51351,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF117","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF12","identifiers":{"aliases":["KOX3","GIOT-3"],"approved_symbol":"ZNF12","ensembl_gene_id":"ENSG00000164631","hgnc_id":"HGNC:12902","ncbi_gene_id":7559,"previous_symbols":["ZNF325"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF12","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF121":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF121","identifiers":{"aliases":["ZHC32","ZNF20"],"approved_symbol":"ZNF121","ensembl_gene_id":"ENSG00000197961","hgnc_id":"HGNC:12904","ncbi_gene_id":7675,"previous_symbols":["D19S204"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF121","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF124":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF124","identifiers":{"aliases":["HZF16","HZF-16"],"approved_symbol":"ZNF124","ensembl_gene_id":"ENSG00000196418","hgnc_id":"HGNC:12907","ncbi_gene_id":7678,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF124","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF131":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF131","identifiers":{"approved_symbol":"ZNF131","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF131","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF132":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF132","identifiers":{"aliases":["pHZ-12"],"approved_symbol":"ZNF132","ensembl_gene_id":"ENSG00000131849","hgnc_id":"HGNC:12916","ncbi_gene_id":7691,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF132","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF133":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF133","identifiers":{"aliases":["pHZ-13","pHZ-66"],"approved_symbol":"ZNF133","ensembl_gene_id":"ENSG00000125846","hgnc_id":"HGNC:12917","ncbi_gene_id":7692,"previous_symbols":["ZNF150"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":84},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.003533,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"muscle_assay","current_display_label":"Muscle-context assay","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":2,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-02","label":"Independent muscle-context perturbation is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-03 DMD-relevant functional validation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":4.55781,"depmap_median_gene_effect":-0.0375505223925062,"moderate_dependency_flag":false,"observed_counteralignment":0.0638177433316608},"summary":"Priority A · validate first; observed DMD-prior counteralignment 0.0638; observed cells 84; integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF133","detailed_audit_record":"gene/ZNF133/audit","legacy_api_record":"api/v1/genes/ZNF133.json","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF134":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF134","identifiers":{"aliases":["pHZ-15"],"approved_symbol":"ZNF134","ensembl_gene_id":"ENSG00000213762","hgnc_id":"HGNC:12918","ncbi_gene_id":7693,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF134","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF135":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF135","identifiers":{"aliases":["pHZ-17"],"approved_symbol":"ZNF135","ensembl_gene_id":"ENSG00000176293","hgnc_id":"HGNC:12919","ncbi_gene_id":7694,"previous_symbols":["ZNF61","ZNF78L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF135","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF136":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF136","identifiers":{"aliases":["pHZ-20"],"approved_symbol":"ZNF136","ensembl_gene_id":"ENSG00000196646","hgnc_id":"HGNC:12920","ncbi_gene_id":7695,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF136","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF138":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF138","identifiers":{"aliases":["pHZ-32"],"approved_symbol":"ZNF138","ensembl_gene_id":"ENSG00000197008","hgnc_id":"HGNC:12922","ncbi_gene_id":7697,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF138","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF14","identifiers":{"aliases":["KOX6","GIOT-4"],"approved_symbol":"ZNF14","ensembl_gene_id":"ENSG00000105708","hgnc_id":"HGNC:12924","ncbi_gene_id":7561,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF14","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF140":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF140","identifiers":{"aliases":["pHZ-39"],"approved_symbol":"ZNF140","ensembl_gene_id":"ENSG00000196387","hgnc_id":"HGNC:12925","ncbi_gene_id":7699,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF140","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF141":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF141","identifiers":{"aliases":["pHZ-44"],"approved_symbol":"ZNF141","ensembl_gene_id":"ENSG00000131127","hgnc_id":"HGNC:12926","ncbi_gene_id":7700,"previous_symbols":["D4S90"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF141","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF142":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF142","identifiers":{"aliases":["KIAA0236","pHZ-49"],"approved_symbol":"ZNF142","ensembl_gene_id":"ENSG00000115568","hgnc_id":"HGNC:12927","ncbi_gene_id":7701,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF142","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF143":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF143","identifiers":{"aliases":["SBF","pHZ-1","STAF"],"approved_symbol":"ZNF143","ensembl_gene_id":"ENSG00000166478","hgnc_id":"HGNC:12928","ncbi_gene_id":7702,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF143","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF146":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF146","identifiers":{"aliases":["OZF"],"approved_symbol":"ZNF146","ensembl_gene_id":"ENSG00000167635","hgnc_id":"HGNC:12931","ncbi_gene_id":7705,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF146","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF148":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF148","identifiers":{"aliases":["BERF-1","ZBP-89","BFCOL1","HT-BETA","ZFP148","pHZ-52"],"approved_symbol":"ZNF148","ensembl_gene_id":"ENSG00000163848","hgnc_id":"HGNC:12933","ncbi_gene_id":7707,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF148","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF154":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF154","identifiers":{"aliases":["pHZ-92"],"approved_symbol":"ZNF154","ensembl_gene_id":"ENSG00000179909","hgnc_id":"HGNC:12939","ncbi_gene_id":7710,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF154","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF155":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF155","identifiers":{"aliases":["pHZ-96"],"approved_symbol":"ZNF155","ensembl_gene_id":"ENSG00000204920","hgnc_id":"HGNC:12940","ncbi_gene_id":7711,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF155","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF157":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF157","identifiers":{"aliases":["HZF22"],"approved_symbol":"ZNF157","ensembl_gene_id":"ENSG00000147117","hgnc_id":"HGNC:12942","ncbi_gene_id":7712,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF157","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF16","identifiers":{"aliases":["KOX9"],"approved_symbol":"ZNF16","ensembl_gene_id":"ENSG00000170631","hgnc_id":"HGNC:12947","ncbi_gene_id":7564,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF16","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF160":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF160","identifiers":{"aliases":["HZF5","F11","KR18","HKr18","FLJ00032","KIAA1611"],"approved_symbol":"ZNF160","ensembl_gene_id":"ENSG00000170949","hgnc_id":"HGNC:12948","ncbi_gene_id":90338,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF160","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF165":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF165","identifiers":{"aliases":["ZSCAN7","CT53"],"approved_symbol":"ZNF165","ensembl_gene_id":"ENSG00000197279","hgnc_id":"HGNC:12953","ncbi_gene_id":7718,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF165","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF169":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF169","identifiers":{"aliases":["MGC51961"],"approved_symbol":"ZNF169","ensembl_gene_id":"ENSG00000175787","hgnc_id":"HGNC:12957","ncbi_gene_id":169841,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF169","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF17","identifiers":{"aliases":["HPF3","KOX10","KIAA1947","FLJ40864","FLJ46058","FLJ46615"],"approved_symbol":"ZNF17","ensembl_gene_id":"ENSG00000186272","hgnc_id":"HGNC:12958","ncbi_gene_id":7565,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF17","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF174":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF174","identifiers":{"aliases":["ZSCAN8"],"approved_symbol":"ZNF174","ensembl_gene_id":"ENSG00000103343","hgnc_id":"HGNC:12963","ncbi_gene_id":7727,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF174","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF175":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF175","identifiers":{"aliases":["OTK18"],"approved_symbol":"ZNF175","ensembl_gene_id":"ENSG00000105497","hgnc_id":"HGNC:12964","ncbi_gene_id":7728,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF175","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF177":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF177","identifiers":{"aliases":[],"approved_symbol":"ZNF177","ensembl_gene_id":"ENSG00000188629","hgnc_id":"HGNC:12966","ncbi_gene_id":7730,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF177","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF18","identifiers":{"aliases":["ZKSCAN6","KOX11","HDSG1","Zfp535","ZNF535","ZSCAN38"],"approved_symbol":"ZNF18","ensembl_gene_id":"ENSG00000154957","hgnc_id":"HGNC:12969","ncbi_gene_id":7566,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF18","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF180":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF180","identifiers":{"aliases":["HHZ168"],"approved_symbol":"ZNF180","ensembl_gene_id":"ENSG00000167384","hgnc_id":"HGNC:12970","ncbi_gene_id":7733,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF180","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF181":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF181","identifiers":{"aliases":["HHZ181","MGC44316"],"approved_symbol":"ZNF181","ensembl_gene_id":"ENSG00000197841","hgnc_id":"HGNC:12971","ncbi_gene_id":339318,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF181","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF182":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF182","identifiers":{"aliases":["KOX14","HHZ150","Zfp182"],"approved_symbol":"ZNF182","ensembl_gene_id":"ENSG00000147118","hgnc_id":"HGNC:13001","ncbi_gene_id":7569,"previous_symbols":["ZNF21"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF182","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF184":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF184","identifiers":{"aliases":[],"approved_symbol":"ZNF184","ensembl_gene_id":"ENSG00000096654","hgnc_id":"HGNC:12975","ncbi_gene_id":7738,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF184","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF185":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF185","identifiers":{"aliases":["SCELL"],"approved_symbol":"ZNF185","ensembl_gene_id":"ENSG00000147394","hgnc_id":"HGNC:12976","ncbi_gene_id":7739,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF185","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF189":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF189","identifiers":{"aliases":[],"approved_symbol":"ZNF189","ensembl_gene_id":"ENSG00000136870","hgnc_id":"HGNC:12980","ncbi_gene_id":7743,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF189","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF19","identifiers":{"aliases":["KOX12","MGC51021"],"approved_symbol":"ZNF19","ensembl_gene_id":"ENSG00000157429","hgnc_id":"HGNC:12981","ncbi_gene_id":7567,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF19","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF195":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF195","identifiers":{"aliases":[],"approved_symbol":"ZNF195","ensembl_gene_id":"ENSG00000005801","hgnc_id":"HGNC:12986","ncbi_gene_id":7748,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF195","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF197":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF197","identifiers":{"aliases":["P18","D3S1363E","ZKSCAN9","ZSCAN41"],"approved_symbol":"ZNF197","ensembl_gene_id":"ENSG00000186448","hgnc_id":"HGNC:12988","ncbi_gene_id":10168,"previous_symbols":["ZNF166"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF197","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF2","identifiers":{"aliases":["A1-5","ZNF661","Zfp661"],"approved_symbol":"ZNF2","ensembl_gene_id":"ENSG00000275111","hgnc_id":"HGNC:12991","ncbi_gene_id":7549,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF2","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF20","identifiers":{"aliases":["KOX13"],"approved_symbol":"ZNF20","ensembl_gene_id":"ENSG00000132010","hgnc_id":"HGNC:12992","ncbi_gene_id":7568,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF20","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF200":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF200","identifiers":{"aliases":[],"approved_symbol":"ZNF200","ensembl_gene_id":"ENSG00000010539","hgnc_id":"HGNC:12993","ncbi_gene_id":7752,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF200","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF202":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF202","identifiers":{"aliases":["ZKSCAN10","ZSCAN42"],"approved_symbol":"ZNF202","ensembl_gene_id":"ENSG00000166261","hgnc_id":"HGNC:12994","ncbi_gene_id":7753,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF202","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF205":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF205","identifiers":{"aliases":["Zfp13"],"approved_symbol":"ZNF205","ensembl_gene_id":"ENSG00000122386","hgnc_id":"HGNC:12996","ncbi_gene_id":7755,"previous_symbols":["ZNF210"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF205","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF207":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF207","identifiers":{"aliases":["BuGZ"],"approved_symbol":"ZNF207","ensembl_gene_id":"ENSG00000010244","hgnc_id":"HGNC:12998","ncbi_gene_id":7756,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF207","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF208":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF208","identifiers":{"aliases":["PMIDP","ZNF95"],"approved_symbol":"ZNF208","ensembl_gene_id":"ENSG00000160321","hgnc_id":"HGNC:12999","ncbi_gene_id":7757,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF208","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF211":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF211","identifiers":{"aliases":["ZNF-25","CH2H2-25"],"approved_symbol":"ZNF211","ensembl_gene_id":"ENSG00000121417","hgnc_id":"HGNC:13003","ncbi_gene_id":10520,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF211","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF212":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF212","identifiers":{"aliases":["C2H2-150"],"approved_symbol":"ZNF212","ensembl_gene_id":"ENSG00000170260","hgnc_id":"HGNC:13004","ncbi_gene_id":7988,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF212","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF213":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF213","identifiers":{"aliases":["CR53","ZKSCAN21","ZSCAN53"],"approved_symbol":"ZNF213","ensembl_gene_id":"ENSG00000085644","hgnc_id":"HGNC:13005","ncbi_gene_id":7760,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF213","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF213-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF213-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF213-AS1","ensembl_gene_id":"ENSG00000263072","hgnc_id":"HGNC:50505","ncbi_gene_id":100507458,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF213-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF214":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF214","identifiers":{"aliases":[],"approved_symbol":"ZNF214","ensembl_gene_id":"ENSG00000149050","hgnc_id":"HGNC:13006","ncbi_gene_id":7761,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF214","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF215":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF215","identifiers":{"aliases":["ZKSCAN11","ZSCAN43"],"approved_symbol":"ZNF215","ensembl_gene_id":"ENSG00000149054","hgnc_id":"HGNC:13007","ncbi_gene_id":7762,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF215","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF217":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF217","identifiers":{"aliases":["ZABC1"],"approved_symbol":"ZNF217","ensembl_gene_id":"ENSG00000171940","hgnc_id":"HGNC:13009","ncbi_gene_id":7764,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF217","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF219":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF219","identifiers":{"aliases":[],"approved_symbol":"ZNF219","ensembl_gene_id":"ENSG00000165804","hgnc_id":"HGNC:13011","ncbi_gene_id":51222,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF219","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF22","identifiers":{"aliases":["KOX15","HKR-T1","ZNF422","Zfp422"],"approved_symbol":"ZNF22","ensembl_gene_id":"ENSG00000165512","hgnc_id":"HGNC:13012","ncbi_gene_id":7570,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF22","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF221":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF221","identifiers":{"aliases":[],"approved_symbol":"ZNF221","ensembl_gene_id":"ENSG00000159905","hgnc_id":"HGNC:13014","ncbi_gene_id":7638,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF221","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF222":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF222","identifiers":{"aliases":[],"approved_symbol":"ZNF222","ensembl_gene_id":"ENSG00000159885","hgnc_id":"HGNC:13015","ncbi_gene_id":7673,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF222","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF223":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF223","identifiers":{"aliases":[],"approved_symbol":"ZNF223","ensembl_gene_id":"ENSG00000178386","hgnc_id":"HGNC:13016","ncbi_gene_id":7766,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF223","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF224":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF224","identifiers":{"aliases":["BMZF-2","KOX22"],"approved_symbol":"ZNF224","ensembl_gene_id":"ENSG00000267680","hgnc_id":"HGNC:13017","ncbi_gene_id":7767,"previous_symbols":["ZNF255","ZNF27"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF224","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF225":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF225","identifiers":{"aliases":[],"approved_symbol":"ZNF225","ensembl_gene_id":"ENSG00000256294","hgnc_id":"HGNC:13018","ncbi_gene_id":7768,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF225","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF226":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF226","identifiers":{"aliases":[],"approved_symbol":"ZNF226","ensembl_gene_id":"ENSG00000167380","hgnc_id":"HGNC:13019","ncbi_gene_id":7769,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF226","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF227":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF227","identifiers":{"aliases":[],"approved_symbol":"ZNF227","ensembl_gene_id":"ENSG00000131115","hgnc_id":"HGNC:13020","ncbi_gene_id":7770,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF227","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF229":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF229","identifiers":{"aliases":[],"approved_symbol":"ZNF229","ensembl_gene_id":"ENSG00000278318","hgnc_id":"HGNC:13022","ncbi_gene_id":7772,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF229","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF23","identifiers":{"aliases":["KOX16","Zfp612","ZNF612"],"approved_symbol":"ZNF23","ensembl_gene_id":"ENSG00000167377","hgnc_id":"HGNC:13023","ncbi_gene_id":7571,"previous_symbols":["ZNF359"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF23","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF230":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF230","identifiers":{"aliases":["FDZF2"],"approved_symbol":"ZNF230","ensembl_gene_id":"ENSG00000159882","hgnc_id":"HGNC:13024","ncbi_gene_id":7773,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF230","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF232":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF232","identifiers":{"aliases":["ZSCAN11"],"approved_symbol":"ZNF232","ensembl_gene_id":"ENSG00000167840","hgnc_id":"HGNC:13026","ncbi_gene_id":7775,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF232","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF233":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF233","identifiers":{"aliases":["FLJ38032"],"approved_symbol":"ZNF233","ensembl_gene_id":"ENSG00000159915","hgnc_id":"HGNC:30946","ncbi_gene_id":353355,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF233","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF234":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF234","identifiers":{"aliases":["HZF4"],"approved_symbol":"ZNF234","ensembl_gene_id":"ENSG00000263002","hgnc_id":"HGNC:13027","ncbi_gene_id":10780,"previous_symbols":["ZNF269"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF234","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF235":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF235","identifiers":{"aliases":["HZF6","ANF270"],"approved_symbol":"ZNF235","ensembl_gene_id":"ENSG00000159917","hgnc_id":"HGNC:12866","ncbi_gene_id":9310,"previous_symbols":["ZNF270","ZFP93"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF235","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF236":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF236","identifiers":{"aliases":[],"approved_symbol":"ZNF236","ensembl_gene_id":"ENSG00000130856","hgnc_id":"HGNC:13028","ncbi_gene_id":7776,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L2_observed_same_context_perturbation","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":202},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"risk_review","current_display_label":"Risk/context review","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":4,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-08","label":"Safety and dependency context blocks escalation"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-03 DMD-relevant functional validation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":2.00686,"depmap_median_gene_effect":-0.2963978265299027,"moderate_dependency_flag":true,"observed_counteralignment":0.0596269867166334},"summary":"Priority A · validate first; observed DMD-prior counteralignment 0.0596; observed cells 202; integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF236","detailed_audit_record":"gene/ZNF236/audit","legacy_api_record":"api/v1/genes/ZNF236.json","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF236-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF236-DT","identifiers":{"aliases":[],"approved_symbol":"ZNF236-DT","ensembl_gene_id":"ENSG00000264278","hgnc_id":"HGNC:53779","ncbi_gene_id":100131655,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF236-DT","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF239":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF239","identifiers":{"aliases":["MOK2","HOK-2"],"approved_symbol":"ZNF239","ensembl_gene_id":"ENSG00000196793","hgnc_id":"HGNC:13031","ncbi_gene_id":8187,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF239","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF24","identifiers":{"aliases":["ZSCAN3","Zfp191","KOX17"],"approved_symbol":"ZNF24","ensembl_gene_id":"ENSG00000172466","hgnc_id":"HGNC:13032","ncbi_gene_id":7572,"previous_symbols":["ZNF191"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF24","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF248":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF248","identifiers":{"aliases":["bA162G10.3"],"approved_symbol":"ZNF248","ensembl_gene_id":"ENSG00000198105","hgnc_id":"HGNC:13041","ncbi_gene_id":57209,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF248","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF25","identifiers":{"aliases":["KOX19","FLJ31890","Zfp9"],"approved_symbol":"ZNF25","ensembl_gene_id":"ENSG00000175395","hgnc_id":"HGNC:13043","ncbi_gene_id":219749,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF25","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF250":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF250","identifiers":{"aliases":["MGC9718","ZFP647"],"approved_symbol":"ZNF250","ensembl_gene_id":"ENSG00000196150","hgnc_id":"HGNC:13044","ncbi_gene_id":58500,"previous_symbols":["ZNF647"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF250","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF251":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF251","identifiers":{"aliases":[],"approved_symbol":"ZNF251","ensembl_gene_id":"ENSG00000198169","hgnc_id":"HGNC:13045","ncbi_gene_id":90987,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF251","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF252P-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF252P-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF252P-AS1","ensembl_gene_id":"ENSG00000255559","hgnc_id":"HGNC:27821","ncbi_gene_id":286103,"previous_symbols":["C8orf77"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZNF252P-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF253":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF253","identifiers":{"aliases":["BMZF-1","FLJ90391"],"approved_symbol":"ZNF253","ensembl_gene_id":"ENSG00000256771","hgnc_id":"HGNC:13497","ncbi_gene_id":56242,"previous_symbols":["ZNF411"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF253","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF254":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF254","identifiers":{"aliases":["HD-ZNF1","BMZF-5"],"approved_symbol":"ZNF254","ensembl_gene_id":"ENSG00000213096","hgnc_id":"HGNC:13047","ncbi_gene_id":9534,"previous_symbols":["ZNF91L","ZNF539"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF254","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF256":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF256","identifiers":{"aliases":["BMZF-3"],"approved_symbol":"ZNF256","ensembl_gene_id":"ENSG00000152454","hgnc_id":"HGNC:13049","ncbi_gene_id":10172,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF256","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF257":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF257","identifiers":{"aliases":["BMZF-4"],"approved_symbol":"ZNF257","ensembl_gene_id":"ENSG00000197134","hgnc_id":"HGNC:13498","ncbi_gene_id":113835,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF257","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF26","identifiers":{"aliases":["KOX20","FLJ20755"],"approved_symbol":"ZNF26","ensembl_gene_id":"ENSG00000198393","hgnc_id":"HGNC:13053","ncbi_gene_id":7574,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF26","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF260":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF260","identifiers":{"aliases":["ozrf1","Zfp260"],"approved_symbol":"ZNF260","ensembl_gene_id":"ENSG00000254004","hgnc_id":"HGNC:13499","ncbi_gene_id":339324,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF260","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF263":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF263","identifiers":{"aliases":["FPM315","ZKSCAN12","ZSCAN44"],"approved_symbol":"ZNF263","ensembl_gene_id":"ENSG00000006194","hgnc_id":"HGNC:13056","ncbi_gene_id":10127,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF263","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF264":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF264","identifiers":{"aliases":["KIAA0412"],"approved_symbol":"ZNF264","ensembl_gene_id":"ENSG00000083844","hgnc_id":"HGNC:13057","ncbi_gene_id":9422,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF264","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF266":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF266","identifiers":{"aliases":["HZF1"],"approved_symbol":"ZNF266","ensembl_gene_id":"ENSG00000174652","hgnc_id":"HGNC:13059","ncbi_gene_id":10781,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF266","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF267":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF267","identifiers":{"aliases":["HZF2"],"approved_symbol":"ZNF267","ensembl_gene_id":"ENSG00000185947","hgnc_id":"HGNC:13060","ncbi_gene_id":10308,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF267","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF268":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF268","identifiers":{"aliases":["HZF3"],"approved_symbol":"ZNF268","ensembl_gene_id":"ENSG00000090612","hgnc_id":"HGNC:13061","ncbi_gene_id":10795,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF268","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF273":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF273","identifiers":{"aliases":["HZF9"],"approved_symbol":"ZNF273","ensembl_gene_id":"ENSG00000198039","hgnc_id":"HGNC:13067","ncbi_gene_id":10793,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF273","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF274":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF274","identifiers":{"aliases":["ZKSCAN19","ZSCAN51"],"approved_symbol":"ZNF274","ensembl_gene_id":"ENSG00000171606","hgnc_id":"HGNC:13068","ncbi_gene_id":10782,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF274","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF275":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF275","identifiers":{"aliases":[],"approved_symbol":"ZNF275","ensembl_gene_id":"ENSG00000063587","hgnc_id":"HGNC:13069","ncbi_gene_id":10838,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF275","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF276":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF276","identifiers":{"aliases":["MGC45417","ZNF477","CENPZ","CENP-Z","ZADT"],"approved_symbol":"ZNF276","ensembl_gene_id":"ENSG00000158805","hgnc_id":"HGNC:23330","ncbi_gene_id":92822,"previous_symbols":["ZFP276"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF276","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF277":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF277","identifiers":{"aliases":["NRIF4"],"approved_symbol":"ZNF277","ensembl_gene_id":"ENSG00000198839","hgnc_id":"HGNC:13070","ncbi_gene_id":11179,"previous_symbols":["ZNF277P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF277","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF28","identifiers":{"aliases":["KOX24","DKFZp781D0275"],"approved_symbol":"ZNF28","ensembl_gene_id":"ENSG00000198538","hgnc_id":"HGNC:13073","ncbi_gene_id":7576,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF28","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF280A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF280A","identifiers":{"aliases":["3'OY11.1","ZNF636"],"approved_symbol":"ZNF280A","ensembl_gene_id":"ENSG00000169548","hgnc_id":"HGNC:18597","ncbi_gene_id":129025,"previous_symbols":["ZNF280","SUHW1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF280A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF280B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF280B","identifiers":{"aliases":["5'OY11.1","ZNF632"],"approved_symbol":"ZNF280B","ensembl_gene_id":"ENSG00000275004","hgnc_id":"HGNC:23022","ncbi_gene_id":140883,"previous_symbols":["ZNF279","SUHW2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF280B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF280C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF280C","identifiers":{"aliases":["FLJ20095","ZNF633","ZPET"],"approved_symbol":"ZNF280C","ensembl_gene_id":"ENSG00000056277","hgnc_id":"HGNC:25955","ncbi_gene_id":55609,"previous_symbols":["SUHW3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF280C","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF280D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF280D","identifiers":{"aliases":["FLJ20086","ZNF634"],"approved_symbol":"ZNF280D","ensembl_gene_id":"ENSG00000137871","hgnc_id":"HGNC:25953","ncbi_gene_id":54816,"previous_symbols":["SUHW4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF280D","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF281":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF281","identifiers":{"aliases":["ZBP-99"],"approved_symbol":"ZNF281","ensembl_gene_id":"ENSG00000162702","hgnc_id":"HGNC:13075","ncbi_gene_id":23528,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF281","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF282":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF282","identifiers":{"aliases":["HUB1"],"approved_symbol":"ZNF282","ensembl_gene_id":"ENSG00000170265","hgnc_id":"HGNC:13076","ncbi_gene_id":8427,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF282","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF283":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF283","identifiers":{"aliases":[],"approved_symbol":"ZNF283","ensembl_gene_id":"ENSG00000167637","hgnc_id":"HGNC:13077","ncbi_gene_id":284349,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF283","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF284":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF284","identifiers":{"aliases":["DKFZp781F1775"],"approved_symbol":"ZNF284","ensembl_gene_id":"ENSG00000186026","hgnc_id":"HGNC:13078","ncbi_gene_id":342909,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF284","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF285":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF285","identifiers":{"aliases":[],"approved_symbol":"ZNF285","ensembl_gene_id":"ENSG00000267508","hgnc_id":"HGNC:13079","ncbi_gene_id":26974,"previous_symbols":["ZNF285A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF285","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF286A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF286A","identifiers":{"aliases":["KIAA1874"],"approved_symbol":"ZNF286A","ensembl_gene_id":"ENSG00000187607","hgnc_id":"HGNC:13501","ncbi_gene_id":57335,"previous_symbols":["ZNF286"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF286A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF287":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF287","identifiers":{"aliases":["ZKSCAN13","ZSCAN45"],"approved_symbol":"ZNF287","ensembl_gene_id":"ENSG00000141040","hgnc_id":"HGNC:13502","ncbi_gene_id":57336,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF287","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF292":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF292","identifiers":{"aliases":["KIAA0530","ZFP292","bA393I2.3","Zn-15","Zn-16"],"approved_symbol":"ZNF292","ensembl_gene_id":"ENSG00000188994","hgnc_id":"HGNC:18410","ncbi_gene_id":23036,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF292","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF295-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF295-AS1","identifiers":{"aliases":["PRED87"],"approved_symbol":"ZNF295-AS1","ensembl_gene_id":"ENSG00000237232","hgnc_id":"HGNC:23130","ncbi_gene_id":150142,"previous_symbols":["C21orf121","NCRNA00318"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF295-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF296":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF296","identifiers":{"aliases":[],"approved_symbol":"ZNF296","ensembl_gene_id":"ENSG00000170684","hgnc_id":"HGNC:15981","ncbi_gene_id":162979,"previous_symbols":["ZNF342"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF296","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF3","identifiers":{"aliases":["A8-51","KOX25","PP838","FLJ20216","HF.12","Zfp113"],"approved_symbol":"ZNF3","ensembl_gene_id":"ENSG00000166526","hgnc_id":"HGNC:13089","ncbi_gene_id":7551,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF3","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF30","identifiers":{"aliases":["KOX28","DKFZp686N19164","FLJ20562"],"approved_symbol":"ZNF30","ensembl_gene_id":"ENSG00000168661","hgnc_id":"HGNC:13090","ncbi_gene_id":90075,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF30","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF300":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF300","identifiers":{"aliases":[],"approved_symbol":"ZNF300","ensembl_gene_id":"ENSG00000145908","hgnc_id":"HGNC:13091","ncbi_gene_id":91975,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF300","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF302":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF302","identifiers":{"aliases":["ZNF327","ZNF135L","ZNF140L"],"approved_symbol":"ZNF302","ensembl_gene_id":"ENSG00000089335","hgnc_id":"HGNC:13848","ncbi_gene_id":55900,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF302","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF304":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF304","identifiers":{"aliases":[],"approved_symbol":"ZNF304","ensembl_gene_id":"ENSG00000131845","hgnc_id":"HGNC:13505","ncbi_gene_id":57343,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF304","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF311":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF311","identifiers":{"aliases":[],"approved_symbol":"ZNF311","ensembl_gene_id":"ENSG00000197935","hgnc_id":"HGNC:13847","ncbi_gene_id":282890,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF311","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF316":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF316","identifiers":{"aliases":["MZF-3","ENST00000305834"],"approved_symbol":"ZNF316","ensembl_gene_id":"ENSG00000205903","hgnc_id":"HGNC:13843","ncbi_gene_id":100131017,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF316","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF317":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF317","identifiers":{"aliases":[],"approved_symbol":"ZNF317","ensembl_gene_id":"ENSG00000130803","hgnc_id":"HGNC:13507","ncbi_gene_id":57693,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF317","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF318":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF318","identifiers":{"aliases":["HRIHFB2436","ZFP318"],"approved_symbol":"ZNF318","ensembl_gene_id":"ENSG00000171467","hgnc_id":"HGNC:13578","ncbi_gene_id":24149,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF318","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF319":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF319","identifiers":{"aliases":["KIAA1388","Zfp319"],"approved_symbol":"ZNF319","ensembl_gene_id":"ENSG00000166188","hgnc_id":"HGNC:13644","ncbi_gene_id":57567,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF319","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF32":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF32","identifiers":{"aliases":["KOX30","ZNF637","Zfp637"],"approved_symbol":"ZNF32","ensembl_gene_id":"ENSG00000169740","hgnc_id":"HGNC:13095","ncbi_gene_id":7580,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF32","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF32-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF32-AS3","identifiers":{"approved_symbol":"ZNF32-AS3","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF32-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF320":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF320","identifiers":{"aliases":["ZFPL","DKFZp686G16228"],"approved_symbol":"ZNF320","ensembl_gene_id":"ENSG00000182986","hgnc_id":"HGNC:13842","ncbi_gene_id":162967,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF320","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF322":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF322","identifiers":{"aliases":["bA457M11.3","bA457M11.2"],"approved_symbol":"ZNF322","ensembl_gene_id":"ENSG00000181315","hgnc_id":"HGNC:23640","ncbi_gene_id":79692,"previous_symbols":["ZNF489","ZNF388","HCG12","ZNF322A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF322","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF324":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF324","identifiers":{"aliases":["ZF5128","ZNF324A"],"approved_symbol":"ZNF324","ensembl_gene_id":"ENSG00000083812","hgnc_id":"HGNC:14096","ncbi_gene_id":25799,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF324","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF324B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF324B","identifiers":{"aliases":["FLJ45850"],"approved_symbol":"ZNF324B","ensembl_gene_id":"ENSG00000249471","hgnc_id":"HGNC:33107","ncbi_gene_id":388569,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF324B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF326":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF326","identifiers":{"aliases":["Zfp326","ZAN75","FLJ20403","ZIRD"],"approved_symbol":"ZNF326","ensembl_gene_id":"ENSG00000162664","hgnc_id":"HGNC:14104","ncbi_gene_id":284695,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF326","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF329":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF329","identifiers":{"aliases":["FLJ12586"],"approved_symbol":"ZNF329","ensembl_gene_id":"ENSG00000181894","hgnc_id":"HGNC:14209","ncbi_gene_id":79673,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF329","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF330":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF330","identifiers":{"approved_symbol":"ZNF330","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF330","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF331":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF331","identifiers":{"aliases":["RITA","ZNF463","ZNF361"],"approved_symbol":"ZNF331","ensembl_gene_id":"ENSG00000130844","hgnc_id":"HGNC:15489","ncbi_gene_id":55422,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF331","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF333":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF333","identifiers":{"aliases":["KIAA1806"],"approved_symbol":"ZNF333","ensembl_gene_id":"ENSG00000160961","hgnc_id":"HGNC:15624","ncbi_gene_id":84449,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF333","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF334":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF334","identifiers":{"aliases":["bA179N14.1"],"approved_symbol":"ZNF334","ensembl_gene_id":"ENSG00000198185","hgnc_id":"HGNC:15806","ncbi_gene_id":55713,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF334","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF335":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF335","identifiers":{"aliases":["bA465L10.2","NIF-1"],"approved_symbol":"ZNF335","ensembl_gene_id":"ENSG00000198026","hgnc_id":"HGNC:15807","ncbi_gene_id":63925,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF335","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF337":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF337","identifiers":{"aliases":["dJ694B14.1"],"approved_symbol":"ZNF337","ensembl_gene_id":"ENSG00000130684","hgnc_id":"HGNC:15809","ncbi_gene_id":26152,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF337","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF337-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF337-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF337-AS1","ensembl_gene_id":"ENSG00000213742","hgnc_id":"HGNC:40759","ncbi_gene_id":102724826,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF337-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF33A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF33A","identifiers":{"aliases":["KOX5","KOX31","KIAA0065","FLJ23404","ZZAPK"],"approved_symbol":"ZNF33A","ensembl_gene_id":"ENSG00000189180","hgnc_id":"HGNC:13096","ncbi_gene_id":7581,"previous_symbols":["ZNF33","ZNF11A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF33A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF33B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF33B","identifiers":{"aliases":["KOX31","KOX2"],"approved_symbol":"ZNF33B","ensembl_gene_id":"ENSG00000196693","hgnc_id":"HGNC:13097","ncbi_gene_id":7582,"previous_symbols":["ZNF11B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF33B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF34":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF34","identifiers":{"aliases":["KOX32"],"approved_symbol":"ZNF34","ensembl_gene_id":"ENSG00000196378","hgnc_id":"HGNC:13098","ncbi_gene_id":80778,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF34","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF341":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF341","identifiers":{"aliases":["dJ553F4.3"],"approved_symbol":"ZNF341","ensembl_gene_id":"ENSG00000131061","hgnc_id":"HGNC:15992","ncbi_gene_id":84905,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF341","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF341-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF341-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF341-AS1","ensembl_gene_id":"ENSG00000230753","hgnc_id":"HGNC:50736","ncbi_gene_id":101929746,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF341-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF343":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF343","identifiers":{"aliases":["MGC10715"],"approved_symbol":"ZNF343","ensembl_gene_id":"ENSG00000088876","hgnc_id":"HGNC:16017","ncbi_gene_id":79175,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF343","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF345":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF345","identifiers":{"aliases":["HZF10"],"approved_symbol":"ZNF345","ensembl_gene_id":"ENSG00000251247","hgnc_id":"HGNC:16367","ncbi_gene_id":25850,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF345","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF346":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF346","identifiers":{"aliases":["JAZ","Zfp346"],"approved_symbol":"ZNF346","ensembl_gene_id":"ENSG00000113761","hgnc_id":"HGNC:16403","ncbi_gene_id":23567,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF346","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF347":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF347","identifiers":{"aliases":["ZNF1111"],"approved_symbol":"ZNF347","ensembl_gene_id":"ENSG00000197937","hgnc_id":"HGNC:16447","ncbi_gene_id":84671,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF347","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF35":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF35","identifiers":{"aliases":["HF.10","HF10","Zfp105"],"approved_symbol":"ZNF35","ensembl_gene_id":"ENSG00000169981","hgnc_id":"HGNC:13099","ncbi_gene_id":7584,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF35","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF350":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF350","identifiers":{"aliases":["ZBRK1","ZFQR"],"approved_symbol":"ZNF350","ensembl_gene_id":"ENSG00000256683","hgnc_id":"HGNC:16656","ncbi_gene_id":59348,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF350","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF350-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF350-AS1","identifiers":{"aliases":["uc002pyc"],"approved_symbol":"ZNF350-AS1","ensembl_gene_id":"ENSG00000269235","hgnc_id":"HGNC:48598","ncbi_gene_id":101669766,"previous_symbols":["HCCAT3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF350-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF354A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF354A","identifiers":{"aliases":["KID-1","EZNF","HKL1","KID1"],"approved_symbol":"ZNF354A","ensembl_gene_id":"ENSG00000169131","hgnc_id":"HGNC:11628","ncbi_gene_id":6940,"previous_symbols":["TCF17"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF354A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF354B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF354B","identifiers":{"aliases":["KID2","FLJ25008"],"approved_symbol":"ZNF354B","ensembl_gene_id":"ENSG00000178338","hgnc_id":"HGNC:17197","ncbi_gene_id":117608,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF354B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF354C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF354C","identifiers":{"aliases":["KID3"],"approved_symbol":"ZNF354C","ensembl_gene_id":"ENSG00000177932","hgnc_id":"HGNC:16736","ncbi_gene_id":30832,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF354C","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF358":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF358","identifiers":{"aliases":["FLJ10390","ZFEND"],"approved_symbol":"ZNF358","ensembl_gene_id":"ENSG00000198816","hgnc_id":"HGNC:16838","ncbi_gene_id":140467,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF358","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF362":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF362","identifiers":{"aliases":["FLJ25476","lin-29","RN"],"approved_symbol":"ZNF362","ensembl_gene_id":"ENSG00000160094","hgnc_id":"HGNC:18079","ncbi_gene_id":149076,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF362","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF365":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF365","identifiers":{"aliases":["KIAA0844","UAN","Su48"],"approved_symbol":"ZNF365","ensembl_gene_id":"ENSG00000138311","hgnc_id":"HGNC:18194","ncbi_gene_id":22891,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF365","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF366":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF366","identifiers":{"aliases":["FLJ39796"],"approved_symbol":"ZNF366","ensembl_gene_id":"ENSG00000178175","hgnc_id":"HGNC:18316","ncbi_gene_id":167465,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF366","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF367":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF367","identifiers":{"aliases":["FLJ33970"],"approved_symbol":"ZNF367","ensembl_gene_id":"ENSG00000165244","hgnc_id":"HGNC:18320","ncbi_gene_id":195828,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF367","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF37A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF37A","identifiers":{"aliases":["KOX21","ZNF37"],"approved_symbol":"ZNF37A","ensembl_gene_id":"ENSG00000075407","hgnc_id":"HGNC:13102","ncbi_gene_id":7587,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF37A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF382":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF382","identifiers":{"aliases":["FLJ14686","KS1"],"approved_symbol":"ZNF382","ensembl_gene_id":"ENSG00000161298","hgnc_id":"HGNC:17409","ncbi_gene_id":84911,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF382","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF383":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF383","identifiers":{"aliases":["FLJ35863","Zfp383"],"approved_symbol":"ZNF383","ensembl_gene_id":"ENSG00000188283","hgnc_id":"HGNC:18609","ncbi_gene_id":163087,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF383","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF384":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF384","identifiers":{"aliases":["CAGH1A","CIZ","NMP4","NP"],"approved_symbol":"ZNF384","ensembl_gene_id":"ENSG00000126746","hgnc_id":"HGNC:11955","ncbi_gene_id":171017,"previous_symbols":["TNRC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF384","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF385A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF385A","identifiers":{"aliases":["DKFZp586G1122","Hzf","ZFP385"],"approved_symbol":"ZNF385A","ensembl_gene_id":"ENSG00000161642","hgnc_id":"HGNC:17521","ncbi_gene_id":25946,"previous_symbols":["ZNF385"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF385A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF385B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF385B","identifiers":{"aliases":["FLJ25270"],"approved_symbol":"ZNF385B","ensembl_gene_id":"ENSG00000144331","hgnc_id":"HGNC:26332","ncbi_gene_id":151126,"previous_symbols":["ZNF533"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF385B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF385C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF385C","identifiers":{"aliases":[],"approved_symbol":"ZNF385C","ensembl_gene_id":"ENSG00000187595","hgnc_id":"HGNC:33722","ncbi_gene_id":201181,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF385C","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF385D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF385D","identifiers":{"aliases":["FLJ22419"],"approved_symbol":"ZNF385D","ensembl_gene_id":"ENSG00000151789","hgnc_id":"HGNC:26191","ncbi_gene_id":79750,"previous_symbols":["ZNF659"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF385D","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF385D-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF385D-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF385D-AS1","ensembl_gene_id":"ENSG00000225542","hgnc_id":"HGNC:41136","ncbi_gene_id":100874216,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF385D-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF385D-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF385D-AS2","identifiers":{"aliases":[],"approved_symbol":"ZNF385D-AS2","ensembl_gene_id":"ENSG00000223351","hgnc_id":"HGNC:42420","ncbi_gene_id":100874221,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF385D-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF391":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF391","identifiers":{"aliases":["dJ153G14.3"],"approved_symbol":"ZNF391","ensembl_gene_id":"ENSG00000124613","hgnc_id":"HGNC:18779","ncbi_gene_id":346157,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF391","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF394":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF394","identifiers":{"aliases":["ZKSCAN14","FLJ12298","ZSCAN46"],"approved_symbol":"ZNF394","ensembl_gene_id":"ENSG00000160908","hgnc_id":"HGNC:18832","ncbi_gene_id":84124,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF394","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF395":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF395","identifiers":{"aliases":["PRF-1","HDBP2","PBF","DKFZp434K1210"],"approved_symbol":"ZNF395","ensembl_gene_id":"ENSG00000186918","hgnc_id":"HGNC:18737","ncbi_gene_id":55893,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF395","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF396":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF396","identifiers":{"aliases":["ZSCAN14","FLJ31213"],"approved_symbol":"ZNF396","ensembl_gene_id":"ENSG00000186496","hgnc_id":"HGNC:18824","ncbi_gene_id":252884,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF396","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF397":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF397","identifiers":{"aliases":["ZSCAN15","MGC13250"],"approved_symbol":"ZNF397","ensembl_gene_id":"ENSG00000186812","hgnc_id":"HGNC:18818","ncbi_gene_id":84307,"previous_symbols":["ZNF47"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF397","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF398":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF398","identifiers":{"aliases":["p71-ZER6","p52-ZER6","ZER6","KIAA1339","P51","P71"],"approved_symbol":"ZNF398","ensembl_gene_id":"ENSG00000197024","hgnc_id":"HGNC:18373","ncbi_gene_id":57541,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF398","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF404":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF404","identifiers":{"aliases":[],"approved_symbol":"ZNF404","ensembl_gene_id":"ENSG00000176222","hgnc_id":"HGNC:19417","ncbi_gene_id":342908,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF404","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF407":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF407","identifiers":{"aliases":["FLJ20307","FLJ13839","KIAA1703"],"approved_symbol":"ZNF407","ensembl_gene_id":"ENSG00000215421","hgnc_id":"HGNC:19904","ncbi_gene_id":55628,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF407","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF408":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF408","identifiers":{"aliases":["FLJ12827","PRDM17"],"approved_symbol":"ZNF408","ensembl_gene_id":"ENSG00000175213","hgnc_id":"HGNC:20041","ncbi_gene_id":79797,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF408","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF41":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF41","identifiers":{"aliases":["MGC8941","MRX89"],"approved_symbol":"ZNF41","ensembl_gene_id":"ENSG00000147124","hgnc_id":"HGNC:13107","ncbi_gene_id":7592,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF41","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF410":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF410","identifiers":{"aliases":["APA1","APA-1"],"approved_symbol":"ZNF410","ensembl_gene_id":"ENSG00000119725","hgnc_id":"HGNC:20144","ncbi_gene_id":57862,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF410","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF414":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF414","identifiers":{"aliases":["MGC15716","Zfp414"],"approved_symbol":"ZNF414","ensembl_gene_id":"ENSG00000133250","hgnc_id":"HGNC:20630","ncbi_gene_id":84330,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF414","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF415":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF415","identifiers":{"aliases":[],"approved_symbol":"ZNF415","ensembl_gene_id":"ENSG00000170954","hgnc_id":"HGNC:20636","ncbi_gene_id":55786,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF415","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF416":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF416","identifiers":{"aliases":["FLJ20557"],"approved_symbol":"ZNF416","ensembl_gene_id":"ENSG00000083817","hgnc_id":"HGNC:20645","ncbi_gene_id":55659,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF416","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF417":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF417","identifiers":{"aliases":["MGC34079"],"approved_symbol":"ZNF417","ensembl_gene_id":"ENSG00000173480","hgnc_id":"HGNC:20646","ncbi_gene_id":147687,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF417","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF418":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF418","identifiers":{"aliases":["KIAA1956","FLJ31551"],"approved_symbol":"ZNF418","ensembl_gene_id":"ENSG00000196724","hgnc_id":"HGNC:20647","ncbi_gene_id":147686,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF418","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF419":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF419","identifiers":{"aliases":["ZAPHIR"],"approved_symbol":"ZNF419","ensembl_gene_id":"ENSG00000105136","hgnc_id":"HGNC:20648","ncbi_gene_id":79744,"previous_symbols":["ZNF419A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF419","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF420":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF420","identifiers":{"aliases":["FLJ32191"],"approved_symbol":"ZNF420","ensembl_gene_id":"ENSG00000197050","hgnc_id":"HGNC:20649","ncbi_gene_id":147923,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF420","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF423":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF423","identifiers":{"aliases":["KIAA0760","OAZ","hOAZ","Ebfaz","Zfp104","NPHP14","JBTS19"],"approved_symbol":"ZNF423","ensembl_gene_id":"ENSG00000102935","hgnc_id":"HGNC:16762","ncbi_gene_id":23090,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF423","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF425":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF425","identifiers":{"aliases":[],"approved_symbol":"ZNF425","ensembl_gene_id":"ENSG00000204947","hgnc_id":"HGNC:20690","ncbi_gene_id":155054,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF425","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF426":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF426","identifiers":{"aliases":["MGC2663"],"approved_symbol":"ZNF426","ensembl_gene_id":"ENSG00000130818","hgnc_id":"HGNC:20725","ncbi_gene_id":79088,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF426","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF428":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF428","identifiers":{"aliases":["MGC51082","Zfp428"],"approved_symbol":"ZNF428","ensembl_gene_id":"ENSG00000131116","hgnc_id":"HGNC:20804","ncbi_gene_id":126299,"previous_symbols":["C19orf37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF428","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF429":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF429","identifiers":{"aliases":[],"approved_symbol":"ZNF429","ensembl_gene_id":"ENSG00000197013","hgnc_id":"HGNC:20817","ncbi_gene_id":353088,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF429","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF43":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF43","identifiers":{"aliases":["HTF6","KOX27"],"approved_symbol":"ZNF43","ensembl_gene_id":"ENSG00000198521","hgnc_id":"HGNC:13109","ncbi_gene_id":7594,"previous_symbols":["ZNF39L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF43","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF430":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF430","identifiers":{"aliases":["FLJ13659"],"approved_symbol":"ZNF430","ensembl_gene_id":"ENSG00000118620","hgnc_id":"HGNC:20808","ncbi_gene_id":80264,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF430","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF431":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF431","identifiers":{"aliases":["KIAA1969"],"approved_symbol":"ZNF431","ensembl_gene_id":"ENSG00000196705","hgnc_id":"HGNC:20809","ncbi_gene_id":170959,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF431","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF432":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF432","identifiers":{"aliases":["KIAA0798"],"approved_symbol":"ZNF432","ensembl_gene_id":"ENSG00000256087","hgnc_id":"HGNC:20810","ncbi_gene_id":9668,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF432","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF433":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF433","identifiers":{"aliases":["FLJ40981"],"approved_symbol":"ZNF433","ensembl_gene_id":"ENSG00000197647","hgnc_id":"HGNC:20811","ncbi_gene_id":163059,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF433","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF433-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF433-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF433-AS1","ensembl_gene_id":"ENSG00000219665","hgnc_id":"HGNC:53776","ncbi_gene_id":101928464,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF433-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF436":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF436","identifiers":{"aliases":["KIAA1710","Zfp46"],"approved_symbol":"ZNF436","ensembl_gene_id":"ENSG00000125945","hgnc_id":"HGNC:20814","ncbi_gene_id":80818,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF436","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF436-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF436-AS1","identifiers":{"aliases":["FLJ90508"],"approved_symbol":"ZNF436-AS1","ensembl_gene_id":"ENSG00000249087","hgnc_id":"HGNC:25122","ncbi_gene_id":148898,"previous_symbols":["C1orf213"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF436-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF438":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF438","identifiers":{"aliases":["bA330O11.1"],"approved_symbol":"ZNF438","ensembl_gene_id":"ENSG00000183621","hgnc_id":"HGNC:21029","ncbi_gene_id":220929,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF438","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF439":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF439","identifiers":{"aliases":["DKFZp571K0837"],"approved_symbol":"ZNF439","ensembl_gene_id":"ENSG00000171291","hgnc_id":"HGNC:20873","ncbi_gene_id":90594,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF439","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF44":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF44","identifiers":{"aliases":["KOX7","ZNF504"],"approved_symbol":"ZNF44","ensembl_gene_id":"ENSG00000197857","hgnc_id":"HGNC:13110","ncbi_gene_id":51710,"previous_symbols":["ZNF58","ZNF55"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF44","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF440":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF440","identifiers":{"aliases":["FLJ37933"],"approved_symbol":"ZNF440","ensembl_gene_id":"ENSG00000171295","hgnc_id":"HGNC:20874","ncbi_gene_id":126070,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF440","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF441":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF441","identifiers":{"aliases":["FLJ38637"],"approved_symbol":"ZNF441","ensembl_gene_id":"ENSG00000197044","hgnc_id":"HGNC:20875","ncbi_gene_id":126068,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF441","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF442":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF442","identifiers":{"aliases":["FLJ14356"],"approved_symbol":"ZNF442","ensembl_gene_id":"ENSG00000198342","hgnc_id":"HGNC:20877","ncbi_gene_id":79973,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF442","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF443":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF443","identifiers":{"aliases":["ZK1"],"approved_symbol":"ZNF443","ensembl_gene_id":"ENSG00000180855","hgnc_id":"HGNC:20878","ncbi_gene_id":10224,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF443","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF444":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF444","identifiers":{"aliases":["ZSCAN17","FLJ11137","EZF2"],"approved_symbol":"ZNF444","ensembl_gene_id":"ENSG00000167685","hgnc_id":"HGNC:16052","ncbi_gene_id":55311,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF444","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF445":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF445","identifiers":{"aliases":["ZKSCAN15","ZSCAN47"],"approved_symbol":"ZNF445","ensembl_gene_id":"ENSG00000185219","hgnc_id":"HGNC:21018","ncbi_gene_id":353274,"previous_symbols":["ZNF168"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF445","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF446":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF446","identifiers":{"aliases":["ZKSCAN20","FLJ20626","ZSCAN52"],"approved_symbol":"ZNF446","ensembl_gene_id":"ENSG00000083838","hgnc_id":"HGNC:21036","ncbi_gene_id":55663,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF446","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF449":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF449","identifiers":{"aliases":["ZSCAN19","FLJ23614"],"approved_symbol":"ZNF449","ensembl_gene_id":"ENSG00000173275","hgnc_id":"HGNC:21039","ncbi_gene_id":203523,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF449","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF45":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF45","identifiers":{"aliases":[],"approved_symbol":"ZNF45","ensembl_gene_id":"ENSG00000124459","hgnc_id":"HGNC:13111","ncbi_gene_id":7596,"previous_symbols":["ZNF13"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF45","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF451":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF451","identifiers":{"aliases":["KIAA0576","COASTER","dJ417I1.1","KIAA1702","ZATT"],"approved_symbol":"ZNF451","ensembl_gene_id":"ENSG00000112200","hgnc_id":"HGNC:21091","ncbi_gene_id":26036,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF451","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF451-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF451-AS1","identifiers":{"aliases":["BC032020"],"approved_symbol":"ZNF451-AS1","ensembl_gene_id":"ENSG00000226803","hgnc_id":"HGNC:53824","ncbi_gene_id":101927211,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF451-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF454":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF454","identifiers":{"aliases":["FLJ37444"],"approved_symbol":"ZNF454","ensembl_gene_id":"ENSG00000178187","hgnc_id":"HGNC:21200","ncbi_gene_id":285676,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF454","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF460":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF460","identifiers":{"aliases":["HZF8"],"approved_symbol":"ZNF460","ensembl_gene_id":"ENSG00000197714","hgnc_id":"HGNC:21628","ncbi_gene_id":10794,"previous_symbols":["ZNF272"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF460","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF460-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF460-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF460-AS1","ensembl_gene_id":"ENSG00000267871","hgnc_id":"HGNC:53774","ncbi_gene_id":105372476,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF460-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF461":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF461","identifiers":{"aliases":["GIOT-1","MGC33911"],"approved_symbol":"ZNF461","ensembl_gene_id":"ENSG00000197808","hgnc_id":"HGNC:21629","ncbi_gene_id":92283,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF461","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF462":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF462","identifiers":{"aliases":["DKFZP762N2316","KIAA1803","Zfp462"],"approved_symbol":"ZNF462","ensembl_gene_id":"ENSG00000148143","hgnc_id":"HGNC:21684","ncbi_gene_id":58499,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF462","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF467":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF467","identifiers":{"aliases":["EZI","Zfp467"],"approved_symbol":"ZNF467","ensembl_gene_id":"ENSG00000181444","hgnc_id":"HGNC:23154","ncbi_gene_id":168544,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF467","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF468":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF468","identifiers":{"aliases":[],"approved_symbol":"ZNF468","ensembl_gene_id":"ENSG00000204604","hgnc_id":"HGNC:33105","ncbi_gene_id":90333,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF468","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF469":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF469","identifiers":{"aliases":["KIAA1858","Zfp469"],"approved_symbol":"ZNF469","ensembl_gene_id":"ENSG00000225614","hgnc_id":"HGNC:23216","ncbi_gene_id":84627,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF469","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF470":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF470","identifiers":{"aliases":["CZF-1","FLJ26175"],"approved_symbol":"ZNF470","ensembl_gene_id":"ENSG00000197016","hgnc_id":"HGNC:22220","ncbi_gene_id":388566,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF470","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF471":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF471","identifiers":{"aliases":["KIAA1396","Z1971","Zfp78"],"approved_symbol":"ZNF471","ensembl_gene_id":"ENSG00000196263","hgnc_id":"HGNC:23226","ncbi_gene_id":57573,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF471","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF473":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF473","identifiers":{"aliases":["KIAA1141","DKFZP434N043","HZFP100"],"approved_symbol":"ZNF473","ensembl_gene_id":"ENSG00000142528","hgnc_id":"HGNC:23239","ncbi_gene_id":25888,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF473","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF48":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF48","identifiers":{"aliases":["DKFZp762K013","FLJ31751","MGC43952"],"approved_symbol":"ZNF48","ensembl_gene_id":"ENSG00000180035","hgnc_id":"HGNC:13114","ncbi_gene_id":197407,"previous_symbols":["ZNF553"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF48","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF480":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF480","identifiers":{"aliases":["MGC32104"],"approved_symbol":"ZNF480","ensembl_gene_id":"ENSG00000198464","hgnc_id":"HGNC:23305","ncbi_gene_id":147657,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF480","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF483":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF483","identifiers":{"aliases":["ZKSCAN16","KIAA1962","ZSCAN48"],"approved_symbol":"ZNF483","ensembl_gene_id":"ENSG00000173258","hgnc_id":"HGNC:23384","ncbi_gene_id":158399,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF483","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF484":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF484","identifiers":{"aliases":["BA526D8.4","FLJ33884"],"approved_symbol":"ZNF484","ensembl_gene_id":"ENSG00000127081","hgnc_id":"HGNC:23385","ncbi_gene_id":83744,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF484","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF485":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF485","identifiers":{"aliases":[],"approved_symbol":"ZNF485","ensembl_gene_id":"ENSG00000198298","hgnc_id":"HGNC:23440","ncbi_gene_id":220992,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF485","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF486":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF486","identifiers":{"aliases":["MGC2396"],"approved_symbol":"ZNF486","ensembl_gene_id":"ENSG00000256229","hgnc_id":"HGNC:20807","ncbi_gene_id":90649,"previous_symbols":["KRBO2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF486","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF487":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF487","identifiers":{"aliases":[],"approved_symbol":"ZNF487","ensembl_gene_id":"ENSG00000243660","hgnc_id":"HGNC:23488","ncbi_gene_id":642819,"previous_symbols":["KRBO1","ZNF487P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF487","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF488":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF488","identifiers":{"aliases":["FLJ32104"],"approved_symbol":"ZNF488","ensembl_gene_id":"ENSG00000265763","hgnc_id":"HGNC:23535","ncbi_gene_id":118738,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZNF488","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF490":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF490","identifiers":{"aliases":["KIAA1198"],"approved_symbol":"ZNF490","ensembl_gene_id":"ENSG00000188033","hgnc_id":"HGNC:23705","ncbi_gene_id":57474,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF490","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF491":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF491","identifiers":{"aliases":["FLJ34791"],"approved_symbol":"ZNF491","ensembl_gene_id":"ENSG00000177599","hgnc_id":"HGNC:23706","ncbi_gene_id":126069,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF491","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF492":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF492","identifiers":{"aliases":["KIAA1473"],"approved_symbol":"ZNF492","ensembl_gene_id":"ENSG00000229676","hgnc_id":"HGNC:23707","ncbi_gene_id":57615,"previous_symbols":["ZNF115"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF492","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF493":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF493","identifiers":{"aliases":["FLJ36504"],"approved_symbol":"ZNF493","ensembl_gene_id":"ENSG00000196268","hgnc_id":"HGNC:23708","ncbi_gene_id":284443,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF493","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF496":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF496","identifiers":{"aliases":["ZKSCAN17","MGC15548","ZSCAN49"],"approved_symbol":"ZNF496","ensembl_gene_id":"ENSG00000162714","hgnc_id":"HGNC:23713","ncbi_gene_id":84838,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF496","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF497":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF497","identifiers":{"aliases":["FLJ44773"],"approved_symbol":"ZNF497","ensembl_gene_id":"ENSG00000174586","hgnc_id":"HGNC:23714","ncbi_gene_id":162968,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF497","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF500":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF500","identifiers":{"aliases":["ZKSCAN18","KIAA0557","ZSCAN50"],"approved_symbol":"ZNF500","ensembl_gene_id":"ENSG00000103199","hgnc_id":"HGNC:23716","ncbi_gene_id":26048,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF500","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF501":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF501","identifiers":{"aliases":["MGC21738"],"approved_symbol":"ZNF501","ensembl_gene_id":"ENSG00000186446","hgnc_id":"HGNC:23717","ncbi_gene_id":115560,"previous_symbols":["ZNF52"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF501","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF502":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF502","identifiers":{"aliases":["FLJ14855","FLJ12515"],"approved_symbol":"ZNF502","ensembl_gene_id":"ENSG00000196653","hgnc_id":"HGNC:23718","ncbi_gene_id":91392,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF502","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF503":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF503","identifiers":{"aliases":["ZPO2","ZEPPO2","FLJ45745","MGC2555","Nlz2"],"approved_symbol":"ZNF503","ensembl_gene_id":"ENSG00000165655","hgnc_id":"HGNC:23589","ncbi_gene_id":84858,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF503","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF503-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF503-AS1","identifiers":{"aliases":["uc.286"],"approved_symbol":"ZNF503-AS1","ensembl_gene_id":"ENSG00000226051","hgnc_id":"HGNC:27370","ncbi_gene_id":253264,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF503-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF503-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF503-AS2","identifiers":{"aliases":[],"approved_symbol":"ZNF503-AS2","ensembl_gene_id":"ENSG00000237149","hgnc_id":"HGNC:23525","ncbi_gene_id":100131213,"previous_symbols":["C10orf41","NCRNA00245"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF503-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF506":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF506","identifiers":{"aliases":["DKFZp761G1812"],"approved_symbol":"ZNF506","ensembl_gene_id":"ENSG00000081665","hgnc_id":"HGNC:23780","ncbi_gene_id":440515,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF506","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF507":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF507","identifiers":{"aliases":["KIAA1084","Zfp507"],"approved_symbol":"ZNF507","ensembl_gene_id":"ENSG00000168813","hgnc_id":"HGNC:23783","ncbi_gene_id":22847,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF507","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF510":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF510","identifiers":{"aliases":["KIAA0972"],"approved_symbol":"ZNF510","ensembl_gene_id":"ENSG00000081386","hgnc_id":"HGNC:29161","ncbi_gene_id":22869,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF510","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF511":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF511","identifiers":{"aliases":["MGC30006","Zfp511"],"approved_symbol":"ZNF511","ensembl_gene_id":"ENSG00000198546","hgnc_id":"HGNC:28445","ncbi_gene_id":118472,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF511","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF512":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF512","identifiers":{"aliases":["KIAA1805"],"approved_symbol":"ZNF512","ensembl_gene_id":"ENSG00000243943","hgnc_id":"HGNC:29380","ncbi_gene_id":84450,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF512","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF512B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF512B","identifiers":{"aliases":["GM632","MGC149845","MGC149846"],"approved_symbol":"ZNF512B","ensembl_gene_id":"ENSG00000196700","hgnc_id":"HGNC:29212","ncbi_gene_id":57473,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF512B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF513":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF513","identifiers":{"aliases":["FLJ32203","RP58","Zfp513"],"approved_symbol":"ZNF513","ensembl_gene_id":"ENSG00000163795","hgnc_id":"HGNC:26498","ncbi_gene_id":130557,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF513","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF514":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF514","identifiers":{"aliases":["FLJ14457"],"approved_symbol":"ZNF514","ensembl_gene_id":"ENSG00000144026","hgnc_id":"HGNC:25894","ncbi_gene_id":84874,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF514","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF516":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF516","identifiers":{"aliases":["HsT287","KIAA0222"],"approved_symbol":"ZNF516","ensembl_gene_id":"ENSG00000101493","hgnc_id":"HGNC:28990","ncbi_gene_id":9658,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF516","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF517":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF517","identifiers":{"aliases":[],"approved_symbol":"ZNF517","ensembl_gene_id":"ENSG00000197363","hgnc_id":"HGNC:27984","ncbi_gene_id":340385,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF517","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF518A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF518A","identifiers":{"aliases":["KIAA0335"],"approved_symbol":"ZNF518A","ensembl_gene_id":"ENSG00000177853","hgnc_id":"HGNC:29009","ncbi_gene_id":9849,"previous_symbols":["ZNF518"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF518A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF518B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF518B","identifiers":{"aliases":["KIAA1729"],"approved_symbol":"ZNF518B","ensembl_gene_id":"ENSG00000178163","hgnc_id":"HGNC:29365","ncbi_gene_id":85460,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF518B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF519":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF519","identifiers":{"aliases":["HsT2362","FLJ36809"],"approved_symbol":"ZNF519","ensembl_gene_id":"ENSG00000175322","hgnc_id":"HGNC:30574","ncbi_gene_id":162655,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF519","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF521":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF521","identifiers":{"aliases":["EHZF","Evi3"],"approved_symbol":"ZNF521","ensembl_gene_id":"ENSG00000198795","hgnc_id":"HGNC:24605","ncbi_gene_id":25925,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF521","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF524":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF524","identifiers":{"aliases":["MGC23143"],"approved_symbol":"ZNF524","ensembl_gene_id":"ENSG00000171443","hgnc_id":"HGNC:28322","ncbi_gene_id":147807,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF524","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF525":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF525","identifiers":{"aliases":["KIAA1979"],"approved_symbol":"ZNF525","ensembl_gene_id":"ENSG00000203326","hgnc_id":"HGNC:29423","ncbi_gene_id":170958,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF525","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF526":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF526","identifiers":{"aliases":["KIAA1951","MGC4267"],"approved_symbol":"ZNF526","ensembl_gene_id":"ENSG00000167625","hgnc_id":"HGNC:29415","ncbi_gene_id":116115,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF526","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF527":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF527","identifiers":{"aliases":["KIAA1829"],"approved_symbol":"ZNF527","ensembl_gene_id":"ENSG00000189164","hgnc_id":"HGNC:29385","ncbi_gene_id":84503,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF527","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF528":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF528","identifiers":{"aliases":["KIAA1827"],"approved_symbol":"ZNF528","ensembl_gene_id":"ENSG00000167555","hgnc_id":"HGNC:29384","ncbi_gene_id":84436,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF528","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF528-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF528-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF528-AS1","ensembl_gene_id":"ENSG00000269834","hgnc_id":"HGNC:51305","ncbi_gene_id":102724105,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF528-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF529":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF529","identifiers":{"aliases":["KIAA1615"],"approved_symbol":"ZNF529","ensembl_gene_id":"ENSG00000186020","hgnc_id":"HGNC:29328","ncbi_gene_id":57711,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF529","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF529-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF529-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF529-AS1","ensembl_gene_id":"ENSG00000233527","hgnc_id":"HGNC:51275","ncbi_gene_id":101927599,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF529-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF530":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF530","identifiers":{"aliases":["KIAA1508"],"approved_symbol":"ZNF530","ensembl_gene_id":"ENSG00000183647","hgnc_id":"HGNC:29297","ncbi_gene_id":348327,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF530","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF532":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF532","identifiers":{"aliases":["FLJ10697"],"approved_symbol":"ZNF532","ensembl_gene_id":"ENSG00000074657","hgnc_id":"HGNC:30940","ncbi_gene_id":55205,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF532","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF534":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF534","identifiers":{"aliases":["FLJ25344"],"approved_symbol":"ZNF534","ensembl_gene_id":"ENSG00000198633","hgnc_id":"HGNC:26337","ncbi_gene_id":147658,"previous_symbols":["KRBO3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF534","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF536":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF536","identifiers":{"aliases":["KIAA0390"],"approved_symbol":"ZNF536","ensembl_gene_id":"ENSG00000198597","hgnc_id":"HGNC:29025","ncbi_gene_id":9745,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF536","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF540":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF540","identifiers":{"aliases":["DKFZp547B0714"],"approved_symbol":"ZNF540","ensembl_gene_id":"ENSG00000171817","hgnc_id":"HGNC:25331","ncbi_gene_id":163255,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF540","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF541":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF541","identifiers":{"aliases":["DKFZp434I1930"],"approved_symbol":"ZNF541","ensembl_gene_id":"ENSG00000118156","hgnc_id":"HGNC:25294","ncbi_gene_id":84215,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF541","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF543":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF543","identifiers":{"aliases":["DKFZp434H055"],"approved_symbol":"ZNF543","ensembl_gene_id":"ENSG00000178229","hgnc_id":"HGNC:25281","ncbi_gene_id":125919,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF543","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF544":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF544","identifiers":{"aliases":["AF020591"],"approved_symbol":"ZNF544","ensembl_gene_id":"ENSG00000198131","hgnc_id":"HGNC:16759","ncbi_gene_id":27300,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF544","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF546":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF546","identifiers":{"aliases":["MGC43537"],"approved_symbol":"ZNF546","ensembl_gene_id":"ENSG00000187187","hgnc_id":"HGNC:28671","ncbi_gene_id":339327,"previous_symbols":["ZNF49"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF546","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF547":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF547","identifiers":{"aliases":["FLJ31100"],"approved_symbol":"ZNF547","ensembl_gene_id":"ENSG00000152433","hgnc_id":"HGNC:26432","ncbi_gene_id":284306,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF547","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF548":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF548","identifiers":{"aliases":["FLJ32932"],"approved_symbol":"ZNF548","ensembl_gene_id":"ENSG00000188785","hgnc_id":"HGNC:26561","ncbi_gene_id":147694,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF548","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF549":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF549","identifiers":{"aliases":["FLJ34917"],"approved_symbol":"ZNF549","ensembl_gene_id":"ENSG00000121406","hgnc_id":"HGNC:26632","ncbi_gene_id":256051,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF549","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF550":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF550","identifiers":{"aliases":["MGC41917"],"approved_symbol":"ZNF550","ensembl_gene_id":"ENSG00000251369","hgnc_id":"HGNC:28643","ncbi_gene_id":162972,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF550","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF551":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF551","identifiers":{"aliases":["DKFZp686H1038"],"approved_symbol":"ZNF551","ensembl_gene_id":"ENSG00000204519","hgnc_id":"HGNC:25108","ncbi_gene_id":90233,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF551","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF552":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF552","identifiers":{"aliases":["FLJ21603"],"approved_symbol":"ZNF552","ensembl_gene_id":"ENSG00000178935","hgnc_id":"HGNC:26135","ncbi_gene_id":79818,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF552","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF554":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF554","identifiers":{"aliases":["FLJ34817"],"approved_symbol":"ZNF554","ensembl_gene_id":"ENSG00000172006","hgnc_id":"HGNC:26629","ncbi_gene_id":115196,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF554","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF555":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF555","identifiers":{"aliases":["MGC26707"],"approved_symbol":"ZNF555","ensembl_gene_id":"ENSG00000186300","hgnc_id":"HGNC:28382","ncbi_gene_id":148254,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF555","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF556":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF556","identifiers":{"aliases":["FLJ11637"],"approved_symbol":"ZNF556","ensembl_gene_id":"ENSG00000172000","hgnc_id":"HGNC:25669","ncbi_gene_id":80032,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF556","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF557":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF557","identifiers":{"aliases":["MGC4054"],"approved_symbol":"ZNF557","ensembl_gene_id":"ENSG00000130544","hgnc_id":"HGNC:28632","ncbi_gene_id":79230,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF557","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF558":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF558","identifiers":{"aliases":["FLJ30932"],"approved_symbol":"ZNF558","ensembl_gene_id":"ENSG00000167785","hgnc_id":"HGNC:26422","ncbi_gene_id":148156,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF558","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF559":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF559","identifiers":{"aliases":["MGC13105"],"approved_symbol":"ZNF559","ensembl_gene_id":"ENSG00000188321","hgnc_id":"HGNC:28197","ncbi_gene_id":84527,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF559","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF560":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF560","identifiers":{"aliases":["FLJ31986"],"approved_symbol":"ZNF560","ensembl_gene_id":"ENSG00000198028","hgnc_id":"HGNC:26484","ncbi_gene_id":147741,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZNF560","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF561":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF561","identifiers":{"aliases":["MGC45408"],"approved_symbol":"ZNF561","ensembl_gene_id":"ENSG00000171469","hgnc_id":"HGNC:28684","ncbi_gene_id":93134,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF561","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF561-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF561-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF561-AS1","ensembl_gene_id":"ENSG00000267106","hgnc_id":"HGNC:27613","ncbi_gene_id":284385,"previous_symbols":["C19orf82"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF561-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF562":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF562","identifiers":{"aliases":["FLJ20079"],"approved_symbol":"ZNF562","ensembl_gene_id":"ENSG00000171466","hgnc_id":"HGNC:25950","ncbi_gene_id":54811,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF562","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF563":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF563","identifiers":{"aliases":["FLJ34797"],"approved_symbol":"ZNF563","ensembl_gene_id":"ENSG00000188868","hgnc_id":"HGNC:30498","ncbi_gene_id":147837,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF563","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF564":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF564","identifiers":{"aliases":["MGC26914"],"approved_symbol":"ZNF564","ensembl_gene_id":"ENSG00000249709","hgnc_id":"HGNC:31106","ncbi_gene_id":163050,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF564","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF565":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF565","identifiers":{"aliases":["FLJ36991"],"approved_symbol":"ZNF565","ensembl_gene_id":"ENSG00000196357","hgnc_id":"HGNC:26726","ncbi_gene_id":147929,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF565","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF566":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF566","identifiers":{"aliases":["FLJ14779","MGC12515"],"approved_symbol":"ZNF566","ensembl_gene_id":"ENSG00000186017","hgnc_id":"HGNC:25919","ncbi_gene_id":84924,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF566","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF567":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF567","identifiers":{"aliases":["MGC45586"],"approved_symbol":"ZNF567","ensembl_gene_id":"ENSG00000189042","hgnc_id":"HGNC:28696","ncbi_gene_id":163081,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF567","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF568":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF568","identifiers":{"aliases":["PISA","DKFZp686B0797"],"approved_symbol":"ZNF568","ensembl_gene_id":"ENSG00000198453","hgnc_id":"HGNC:25392","ncbi_gene_id":374900,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF568","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF569":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF569","identifiers":{"aliases":["FLJ32053","ZAP1","Zfp74"],"approved_symbol":"ZNF569","ensembl_gene_id":"ENSG00000196437","hgnc_id":"HGNC:24737","ncbi_gene_id":148266,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF569","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF57":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF57","identifiers":{"aliases":[],"approved_symbol":"ZNF57","ensembl_gene_id":"ENSG00000171970","hgnc_id":"HGNC:13125","ncbi_gene_id":126295,"previous_symbols":["ZNF424"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF57","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF570":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF570","identifiers":{"aliases":["FLJ30791"],"approved_symbol":"ZNF570","ensembl_gene_id":"ENSG00000171827","hgnc_id":"HGNC:26416","ncbi_gene_id":148268,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF570","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF571":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF571","identifiers":{"aliases":["HSPC059"],"approved_symbol":"ZNF571","ensembl_gene_id":"ENSG00000180479","hgnc_id":"HGNC:25000","ncbi_gene_id":51276,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF571","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF571-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF571-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF571-AS1","ensembl_gene_id":"ENSG00000267470","hgnc_id":"HGNC:44324","ncbi_gene_id":100507433,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF571-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF572":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF572","identifiers":{"aliases":["FLJ38002"],"approved_symbol":"ZNF572","ensembl_gene_id":"ENSG00000180938","hgnc_id":"HGNC:26758","ncbi_gene_id":137209,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF572","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF573":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF573","identifiers":{"aliases":["FLJ30921"],"approved_symbol":"ZNF573","ensembl_gene_id":"ENSG00000189144","hgnc_id":"HGNC:26420","ncbi_gene_id":126231,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF573","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF574":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF574","identifiers":{"aliases":["FLJ22059"],"approved_symbol":"ZNF574","ensembl_gene_id":"ENSG00000105732","hgnc_id":"HGNC:26166","ncbi_gene_id":64763,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF574","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF575":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF575","identifiers":{"aliases":["FLJ32567"],"approved_symbol":"ZNF575","ensembl_gene_id":"ENSG00000176472","hgnc_id":"HGNC:27606","ncbi_gene_id":284346,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF575","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF576":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF576","identifiers":{"aliases":["MGC2508"],"approved_symbol":"ZNF576","ensembl_gene_id":"ENSG00000124444","hgnc_id":"HGNC:28357","ncbi_gene_id":79177,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF576","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF577":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF577","identifiers":{"aliases":["MGC4400"],"approved_symbol":"ZNF577","ensembl_gene_id":"ENSG00000161551","hgnc_id":"HGNC:28673","ncbi_gene_id":84765,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF577","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF578":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF578","identifiers":{"aliases":["FLJ31384"],"approved_symbol":"ZNF578","ensembl_gene_id":"ENSG00000258405","hgnc_id":"HGNC:26449","ncbi_gene_id":147660,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF578","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF579":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF579","identifiers":{"aliases":["FLJ35453"],"approved_symbol":"ZNF579","ensembl_gene_id":"ENSG00000218891","hgnc_id":"HGNC:26646","ncbi_gene_id":163033,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF579","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF580":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF580","identifiers":{"aliases":[],"approved_symbol":"ZNF580","ensembl_gene_id":"ENSG00000213015","hgnc_id":"HGNC:29473","ncbi_gene_id":51157,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF580","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF581":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF581","identifiers":{"aliases":["HSPC189","FLJ22550"],"approved_symbol":"ZNF581","ensembl_gene_id":"ENSG00000171425","hgnc_id":"HGNC:25017","ncbi_gene_id":51545,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF581","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF582":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF582","identifiers":{"aliases":["FLJ30927"],"approved_symbol":"ZNF582","ensembl_gene_id":"ENSG00000018869","hgnc_id":"HGNC:26421","ncbi_gene_id":147948,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF582","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF583":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF583","identifiers":{"aliases":["FLJ31030"],"approved_symbol":"ZNF583","ensembl_gene_id":"ENSG00000198440","hgnc_id":"HGNC:26427","ncbi_gene_id":147949,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF583","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF584":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF584","identifiers":{"aliases":["FLJ39899"],"approved_symbol":"ZNF584","ensembl_gene_id":"ENSG00000171574","hgnc_id":"HGNC:27318","ncbi_gene_id":201514,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF584","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF585A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF585A","identifiers":{"aliases":["FLJ23765","Zfp27"],"approved_symbol":"ZNF585A","ensembl_gene_id":"ENSG00000196967","hgnc_id":"HGNC:26305","ncbi_gene_id":199704,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF585A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF585B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF585B","identifiers":{"aliases":["FLJ14928","SZFP41","Zfp27"],"approved_symbol":"ZNF585B","ensembl_gene_id":"ENSG00000245680","hgnc_id":"HGNC:30948","ncbi_gene_id":92285,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF585B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF586":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF586","identifiers":{"aliases":["FLJ20070"],"approved_symbol":"ZNF586","ensembl_gene_id":"ENSG00000083828","hgnc_id":"HGNC:25949","ncbi_gene_id":54807,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF586","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF587":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF587","identifiers":{"aliases":["ZF6","FLJ14710","UBF-fl","FLJ20813"],"approved_symbol":"ZNF587","ensembl_gene_id":"ENSG00000198466","hgnc_id":"HGNC:30955","ncbi_gene_id":84914,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF587","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF587B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF587B","identifiers":{"aliases":[],"approved_symbol":"ZNF587B","ensembl_gene_id":"ENSG00000269343","hgnc_id":"HGNC:37142","ncbi_gene_id":100293516,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF587B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF589":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF589","identifiers":{"aliases":["SZF1"],"approved_symbol":"ZNF589","ensembl_gene_id":"ENSG00000164048","hgnc_id":"HGNC:16747","ncbi_gene_id":51385,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF589","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF592":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF592","identifiers":{"aliases":["KIAA0211","CAMOS"],"approved_symbol":"ZNF592","ensembl_gene_id":"ENSG00000166716","hgnc_id":"HGNC:28986","ncbi_gene_id":9640,"previous_symbols":["SCAR5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF592","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF593":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF593","identifiers":{"aliases":["ZT86"],"approved_symbol":"ZNF593","ensembl_gene_id":"ENSG00000142684","hgnc_id":"HGNC:30943","ncbi_gene_id":51042,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF593","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF594":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF594","identifiers":{"aliases":["KIAA1871"],"approved_symbol":"ZNF594","ensembl_gene_id":"ENSG00000180626","hgnc_id":"HGNC:29392","ncbi_gene_id":84622,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF594","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF595":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF595","identifiers":{"aliases":["FLJ31740"],"approved_symbol":"ZNF595","ensembl_gene_id":"ENSG00000272602","hgnc_id":"HGNC:27196","ncbi_gene_id":152687,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF595","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF596":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF596","identifiers":{"aliases":[],"approved_symbol":"ZNF596","ensembl_gene_id":"ENSG00000172748","hgnc_id":"HGNC:27268","ncbi_gene_id":169270,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF596","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF597":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF597","identifiers":{"aliases":["FLJ33071","HIT-4"],"approved_symbol":"ZNF597","ensembl_gene_id":"ENSG00000167981","hgnc_id":"HGNC:26573","ncbi_gene_id":146434,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF597","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF598":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF598","identifiers":{"aliases":["FLJ00086","HEL2"],"approved_symbol":"ZNF598","ensembl_gene_id":"ENSG00000167962","hgnc_id":"HGNC:28079","ncbi_gene_id":90850,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF598","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF599":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF599","identifiers":{"aliases":["FLJ30663"],"approved_symbol":"ZNF599","ensembl_gene_id":"ENSG00000153896","hgnc_id":"HGNC:26408","ncbi_gene_id":148103,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF599","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF600":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF600","identifiers":{"aliases":["KR-ZNF1","DKFZp686F06123"],"approved_symbol":"ZNF600","ensembl_gene_id":"ENSG00000189190","hgnc_id":"HGNC:30951","ncbi_gene_id":162966,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF600","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF605":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF605","identifiers":{"aliases":[],"approved_symbol":"ZNF605","ensembl_gene_id":"ENSG00000196458","hgnc_id":"HGNC:28068","ncbi_gene_id":100289635,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF605","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF606":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF606","identifiers":{"aliases":["FLJ14260","KIAA1852"],"approved_symbol":"ZNF606","ensembl_gene_id":"ENSG00000166704","hgnc_id":"HGNC:25879","ncbi_gene_id":80095,"previous_symbols":["ZNF328"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF606","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF607":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF607","identifiers":{"aliases":["MGC13071","FLJ14802"],"approved_symbol":"ZNF607","ensembl_gene_id":"ENSG00000198182","hgnc_id":"HGNC:28192","ncbi_gene_id":84775,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF607","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF608":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF608","identifiers":{"aliases":["KIAA1281","DKFZp434M098","NY-REN-36"],"approved_symbol":"ZNF608","ensembl_gene_id":"ENSG00000168916","hgnc_id":"HGNC:29238","ncbi_gene_id":57507,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF608","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF609":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF609","identifiers":{"aliases":["KIAA0295"],"approved_symbol":"ZNF609","ensembl_gene_id":"ENSG00000180357","hgnc_id":"HGNC:29003","ncbi_gene_id":23060,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF609","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF610":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF610","identifiers":{"aliases":["FLJ36040"],"approved_symbol":"ZNF610","ensembl_gene_id":"ENSG00000167554","hgnc_id":"HGNC:26687","ncbi_gene_id":162963,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF610","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF611":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF611","identifiers":{"aliases":["MGC5384"],"approved_symbol":"ZNF611","ensembl_gene_id":"ENSG00000213020","hgnc_id":"HGNC:28766","ncbi_gene_id":81856,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF611","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF613":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF613","identifiers":{"aliases":["FLJ13590"],"approved_symbol":"ZNF613","ensembl_gene_id":"ENSG00000176024","hgnc_id":"HGNC:25827","ncbi_gene_id":79898,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF613","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF614":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF614","identifiers":{"aliases":["FLJ21941"],"approved_symbol":"ZNF614","ensembl_gene_id":"ENSG00000142556","hgnc_id":"HGNC:24722","ncbi_gene_id":80110,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF614","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF615":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF615","identifiers":{"aliases":["FLJ33710"],"approved_symbol":"ZNF615","ensembl_gene_id":"ENSG00000197619","hgnc_id":"HGNC:24740","ncbi_gene_id":284370,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF615","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF616":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF616","identifiers":{"aliases":["MGC45556"],"approved_symbol":"ZNF616","ensembl_gene_id":"ENSG00000204611","hgnc_id":"HGNC:28062","ncbi_gene_id":90317,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF616","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF618":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF618","identifiers":{"aliases":["KIAA1952","NEDD10"],"approved_symbol":"ZNF618","ensembl_gene_id":"ENSG00000157657","hgnc_id":"HGNC:29416","ncbi_gene_id":114991,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF618","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF619":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF619","identifiers":{"aliases":["FLJ90764"],"approved_symbol":"ZNF619","ensembl_gene_id":"ENSG00000177873","hgnc_id":"HGNC:26910","ncbi_gene_id":285267,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF619","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF620":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF620","identifiers":{"aliases":["MGC50836"],"approved_symbol":"ZNF620","ensembl_gene_id":"ENSG00000177842","hgnc_id":"HGNC:28742","ncbi_gene_id":253639,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF620","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF621":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF621","identifiers":{"aliases":["FLJ45246"],"approved_symbol":"ZNF621","ensembl_gene_id":"ENSG00000172888","hgnc_id":"HGNC:24787","ncbi_gene_id":285268,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF621","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF622":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF622","identifiers":{"aliases":["MGC2485","MGC17552","ZPR9"],"approved_symbol":"ZNF622","ensembl_gene_id":"ENSG00000173545","hgnc_id":"HGNC:30958","ncbi_gene_id":90441,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF622","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF623":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF623","identifiers":{"aliases":["KIAA0628"],"approved_symbol":"ZNF623","ensembl_gene_id":"ENSG00000183309","hgnc_id":"HGNC:29084","ncbi_gene_id":9831,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF623","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF624":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF624","identifiers":{"aliases":["KIAA1349"],"approved_symbol":"ZNF624","ensembl_gene_id":"ENSG00000197566","hgnc_id":"HGNC:29254","ncbi_gene_id":57547,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF624","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF625":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF625","identifiers":{"aliases":[],"approved_symbol":"ZNF625","ensembl_gene_id":"ENSG00000257591","hgnc_id":"HGNC:30571","ncbi_gene_id":90589,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF625","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF626":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF626","identifiers":{"aliases":[],"approved_symbol":"ZNF626","ensembl_gene_id":"ENSG00000188171","hgnc_id":"HGNC:30461","ncbi_gene_id":199777,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF626","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF627":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF627","identifiers":{"aliases":["FLJ90365"],"approved_symbol":"ZNF627","ensembl_gene_id":"ENSG00000198551","hgnc_id":"HGNC:30570","ncbi_gene_id":199692,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF627","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF628":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF628","identifiers":{"aliases":["ZEC","Zfp628"],"approved_symbol":"ZNF628","ensembl_gene_id":"ENSG00000197483","hgnc_id":"HGNC:28054","ncbi_gene_id":89887,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF628","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF629":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF629","identifiers":{"aliases":["KIAA0326"],"approved_symbol":"ZNF629","ensembl_gene_id":"ENSG00000102870","hgnc_id":"HGNC:29008","ncbi_gene_id":23361,"previous_symbols":["ZNF65"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF629","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF630":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF630","identifiers":{"aliases":["BC037316","dJ54B20.2","FLJ20573","MGC138344"],"approved_symbol":"ZNF630","ensembl_gene_id":"ENSG00000221994","hgnc_id":"HGNC:28855","ncbi_gene_id":57232,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF630","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF630-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF630-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF630-AS1","ensembl_gene_id":"ENSG00000277541","hgnc_id":"HGNC:41215","ncbi_gene_id":100874120,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZNF630-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF638":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF638","identifiers":{"aliases":["NP220","MGC26130","Zfp638"],"approved_symbol":"ZNF638","ensembl_gene_id":"ENSG00000075292","hgnc_id":"HGNC:17894","ncbi_gene_id":27332,"previous_symbols":["ZFML"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF638","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF639":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF639","identifiers":{"aliases":["ANC-2H01","ZASC1"],"approved_symbol":"ZNF639","ensembl_gene_id":"ENSG00000121864","hgnc_id":"HGNC:30950","ncbi_gene_id":51193,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF639","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF641":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF641","identifiers":{"aliases":["FLJ31295"],"approved_symbol":"ZNF641","ensembl_gene_id":"ENSG00000167528","hgnc_id":"HGNC:31834","ncbi_gene_id":121274,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF641","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF644":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF644","identifiers":{"aliases":["KIAA1221","BM-005","MGC60165","MGC70410"],"approved_symbol":"ZNF644","ensembl_gene_id":"ENSG00000122482","hgnc_id":"HGNC:29222","ncbi_gene_id":84146,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF644","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF646":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF646","identifiers":{"aliases":["KIAA0296"],"approved_symbol":"ZNF646","ensembl_gene_id":"ENSG00000167395","hgnc_id":"HGNC:29004","ncbi_gene_id":9726,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF646","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF649":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF649","identifiers":{"aliases":["FLJ12644"],"approved_symbol":"ZNF649","ensembl_gene_id":"ENSG00000198093","hgnc_id":"HGNC:25741","ncbi_gene_id":65251,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF649","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF652":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF652","identifiers":{"aliases":["KIAA0924"],"approved_symbol":"ZNF652","ensembl_gene_id":"ENSG00000198740","hgnc_id":"HGNC:29147","ncbi_gene_id":22834,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF652","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF653":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF653","identifiers":{"aliases":["Zip67"],"approved_symbol":"ZNF653","ensembl_gene_id":"ENSG00000161914","hgnc_id":"HGNC:25196","ncbi_gene_id":115950,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF653","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF654":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF654","identifiers":{"aliases":["FLJ10997","FLJ21142"],"approved_symbol":"ZNF654","ensembl_gene_id":"ENSG00000175105","hgnc_id":"HGNC:25612","ncbi_gene_id":55279,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF654","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF655":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF655","identifiers":{"aliases":["VIK-1","VIK"],"approved_symbol":"ZNF655","ensembl_gene_id":"ENSG00000197343","hgnc_id":"HGNC:30899","ncbi_gene_id":79027,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF655","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF658":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF658","identifiers":{"aliases":["MGC35232","DKFZp572C163","FLJ32813"],"approved_symbol":"ZNF658","ensembl_gene_id":"ENSG00000274349","hgnc_id":"HGNC:25226","ncbi_gene_id":26149,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF658","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF66":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF66","identifiers":{"aliases":["FLJ16537"],"approved_symbol":"ZNF66","ensembl_gene_id":"ENSG00000160229","hgnc_id":"HGNC:13135","ncbi_gene_id":7617,"previous_symbols":["ZNF66P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF66","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF660":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF660","identifiers":{"aliases":["FLJ36870"],"approved_symbol":"ZNF660","ensembl_gene_id":"ENSG00000144792","hgnc_id":"HGNC:26720","ncbi_gene_id":285349,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF660","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF662":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF662","identifiers":{"aliases":["FLJ45880"],"approved_symbol":"ZNF662","ensembl_gene_id":"ENSG00000182983","hgnc_id":"HGNC:31930","ncbi_gene_id":389114,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF662","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF664":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF664","identifiers":{"aliases":["ZFOC1","DKFZp761B128"],"approved_symbol":"ZNF664","ensembl_gene_id":"ENSG00000179195","hgnc_id":"HGNC:25406","ncbi_gene_id":144348,"previous_symbols":["ZNF176"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF664","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF665":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF665","identifiers":{"aliases":["FLJ14345","ZFP160L"],"approved_symbol":"ZNF665","ensembl_gene_id":"ENSG00000197497","hgnc_id":"HGNC:25885","ncbi_gene_id":79788,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF665","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF667":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF667","identifiers":{"aliases":["FLJ14011"],"approved_symbol":"ZNF667","ensembl_gene_id":"ENSG00000198046","hgnc_id":"HGNC:28854","ncbi_gene_id":63934,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF667","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF667-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF667-AS1","identifiers":{"aliases":["MORT"],"approved_symbol":"ZNF667-AS1","ensembl_gene_id":"ENSG00000166770","hgnc_id":"HGNC:44321","ncbi_gene_id":100128252,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF667-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF668":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF668","identifiers":{"aliases":["FLJ13479"],"approved_symbol":"ZNF668","ensembl_gene_id":"ENSG00000167394","hgnc_id":"HGNC:25821","ncbi_gene_id":79759,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF668","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF669":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF669","identifiers":{"aliases":["FLJ12606"],"approved_symbol":"ZNF669","ensembl_gene_id":"ENSG00000188295","hgnc_id":"HGNC:25736","ncbi_gene_id":79862,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF669","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF670":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF670","identifiers":{"aliases":["MGC12466"],"approved_symbol":"ZNF670","ensembl_gene_id":"ENSG00000277462","hgnc_id":"HGNC:28167","ncbi_gene_id":93474,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF670","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF671":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF671","identifiers":{"aliases":["FLJ23506"],"approved_symbol":"ZNF671","ensembl_gene_id":"ENSG00000083814","hgnc_id":"HGNC:26279","ncbi_gene_id":79891,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF671","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF672":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF672","identifiers":{"aliases":["FLJ22301"],"approved_symbol":"ZNF672","ensembl_gene_id":"ENSG00000171161","hgnc_id":"HGNC:26179","ncbi_gene_id":79894,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF672","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF674":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF674","identifiers":{"aliases":["ZNF673B"],"approved_symbol":"ZNF674","ensembl_gene_id":"ENSG00000251192","hgnc_id":"HGNC:17625","ncbi_gene_id":641339,"previous_symbols":["MRX92"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF674","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF674-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF674-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF674-AS1","ensembl_gene_id":"ENSG00000230844","hgnc_id":"HGNC:44266","ncbi_gene_id":401588,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF674-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF675":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF675","identifiers":{"aliases":["TIZ","TBZF"],"approved_symbol":"ZNF675","ensembl_gene_id":"ENSG00000197372","hgnc_id":"HGNC:30768","ncbi_gene_id":171392,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF675","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF676":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF676","identifiers":{"aliases":[],"approved_symbol":"ZNF676","ensembl_gene_id":"ENSG00000196109","hgnc_id":"HGNC:20429","ncbi_gene_id":163223,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF676","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF677":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF677","identifiers":{"aliases":["MGC48625"],"approved_symbol":"ZNF677","ensembl_gene_id":"ENSG00000197928","hgnc_id":"HGNC:28730","ncbi_gene_id":342926,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF677","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF678":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF678","identifiers":{"aliases":["MGC42493"],"approved_symbol":"ZNF678","ensembl_gene_id":"ENSG00000181450","hgnc_id":"HGNC:28652","ncbi_gene_id":339500,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF678","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF680":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF680","identifiers":{"aliases":["FLJ90430"],"approved_symbol":"ZNF680","ensembl_gene_id":"ENSG00000173041","hgnc_id":"HGNC:26897","ncbi_gene_id":340252,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF680","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF681":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF681","identifiers":{"aliases":["FLJ31526"],"approved_symbol":"ZNF681","ensembl_gene_id":"ENSG00000196172","hgnc_id":"HGNC:26457","ncbi_gene_id":148213,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF681","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF682":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF682","identifiers":{"aliases":["BC39498_3"],"approved_symbol":"ZNF682","ensembl_gene_id":"ENSG00000197124","hgnc_id":"HGNC:28857","ncbi_gene_id":91120,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF682","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF683":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF683","identifiers":{"aliases":["MGC33414","Hobit"],"approved_symbol":"ZNF683","ensembl_gene_id":"ENSG00000176083","hgnc_id":"HGNC:28495","ncbi_gene_id":257101,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF683","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF684":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF684","identifiers":{"aliases":["MGC27466"],"approved_symbol":"ZNF684","ensembl_gene_id":"ENSG00000117010","hgnc_id":"HGNC:28418","ncbi_gene_id":127396,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF684","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF687":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF687","identifiers":{"aliases":["KIAA1441"],"approved_symbol":"ZNF687","ensembl_gene_id":"ENSG00000143373","hgnc_id":"HGNC:29277","ncbi_gene_id":57592,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.13169,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF687","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF687-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF687-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF687-AS1","ensembl_gene_id":"ENSG00000232671","hgnc_id":"HGNC:54048","ncbi_gene_id":100507670,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF687-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF688":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF688","identifiers":{"aliases":[],"approved_symbol":"ZNF688","ensembl_gene_id":"ENSG00000229809","hgnc_id":"HGNC:30489","ncbi_gene_id":146542,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF688","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF689":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF689","identifiers":{"aliases":["FLJ90415","TIPUH1"],"approved_symbol":"ZNF689","ensembl_gene_id":"ENSG00000156853","hgnc_id":"HGNC:25173","ncbi_gene_id":115509,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF689","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF69":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF69","identifiers":{"aliases":["Cos5"],"approved_symbol":"ZNF69","ensembl_gene_id":"ENSG00000198429","hgnc_id":"HGNC:13138","ncbi_gene_id":7620,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF69","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF691":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF691","identifiers":{"aliases":["Zfp691"],"approved_symbol":"ZNF691","ensembl_gene_id":"ENSG00000164011","hgnc_id":"HGNC:28028","ncbi_gene_id":51058,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF691","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF692":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF692","identifiers":{"aliases":["FLJ20531","Zfp692","AREBP"],"approved_symbol":"ZNF692","ensembl_gene_id":"ENSG00000171163","hgnc_id":"HGNC:26049","ncbi_gene_id":55657,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF692","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF696":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF696","identifiers":{"aliases":["FLJ14129"],"approved_symbol":"ZNF696","ensembl_gene_id":"ENSG00000185730","hgnc_id":"HGNC:25872","ncbi_gene_id":79943,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF696","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF697":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF697","identifiers":{"aliases":["MGC45731"],"approved_symbol":"ZNF697","ensembl_gene_id":"ENSG00000143067","hgnc_id":"HGNC:32034","ncbi_gene_id":90874,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF697","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF699":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF699","identifiers":{"aliases":["FLJ38144"],"approved_symbol":"ZNF699","ensembl_gene_id":"ENSG00000196110","hgnc_id":"HGNC:24750","ncbi_gene_id":374879,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF699","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF7","identifiers":{"aliases":["KOX4","HF.16"],"approved_symbol":"ZNF7","ensembl_gene_id":"ENSG00000147789","hgnc_id":"HGNC:13139","ncbi_gene_id":7553,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF7","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF70":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF70","identifiers":{"aliases":["Cos17","MGC48959"],"approved_symbol":"ZNF70","ensembl_gene_id":"ENSG00000187792","hgnc_id":"HGNC:13140","ncbi_gene_id":7621,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF70","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF700":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF700","identifiers":{"aliases":["DKFZp434I1610"],"approved_symbol":"ZNF700","ensembl_gene_id":"ENSG00000196757","hgnc_id":"HGNC:25292","ncbi_gene_id":90592,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF700","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF701":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF701","identifiers":{"aliases":["FLJ10891"],"approved_symbol":"ZNF701","ensembl_gene_id":"ENSG00000167562","hgnc_id":"HGNC:25597","ncbi_gene_id":55762,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF701","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF703":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF703","identifiers":{"aliases":["FLJ14299","ZNF503L","NLZ1","Zpo1","ZEPPO1"],"approved_symbol":"ZNF703","ensembl_gene_id":"ENSG00000183779","hgnc_id":"HGNC:25883","ncbi_gene_id":80139,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF703","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF704":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF704","identifiers":{"aliases":["FLJ16218","Gig1"],"approved_symbol":"ZNF704","ensembl_gene_id":"ENSG00000164684","hgnc_id":"HGNC:32291","ncbi_gene_id":619279,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF704","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF706":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF706","identifiers":{"aliases":["HSPC038"],"approved_symbol":"ZNF706","ensembl_gene_id":"ENSG00000120963","hgnc_id":"HGNC:24992","ncbi_gene_id":51123,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.18045,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF706","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF707":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF707","identifiers":{"aliases":[],"approved_symbol":"ZNF707","ensembl_gene_id":"ENSG00000181135","hgnc_id":"HGNC:27815","ncbi_gene_id":286075,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF707","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF708":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF708","identifiers":{"aliases":["KOX8"],"approved_symbol":"ZNF708","ensembl_gene_id":"ENSG00000182141","hgnc_id":"HGNC:12945","ncbi_gene_id":7562,"previous_symbols":["ZNF15","ZNF15L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF708","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF709":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF709","identifiers":{"aliases":["FLJ38281"],"approved_symbol":"ZNF709","ensembl_gene_id":"ENSG00000242852","hgnc_id":"HGNC:20629","ncbi_gene_id":163051,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF709","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF71":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF71","identifiers":{"aliases":["Cos26","EZFIT"],"approved_symbol":"ZNF71","ensembl_gene_id":"ENSG00000197951","hgnc_id":"HGNC:13141","ncbi_gene_id":58491,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF71","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF710":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF710","identifiers":{"aliases":["DKFZp547K1113","FLJ37393","FLJ00306"],"approved_symbol":"ZNF710","ensembl_gene_id":"ENSG00000140548","hgnc_id":"HGNC:25352","ncbi_gene_id":374655,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF710","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF710-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF710-AS1","identifiers":{"aliases":["ENST00000558334"],"approved_symbol":"ZNF710-AS1","ensembl_gene_id":"ENSG00000259291","hgnc_id":"HGNC:53141","ncbi_gene_id":109729181,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF710-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF711":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF711","identifiers":{"aliases":["CMPX1","ZNF4","ZNF5","dJ75N13.1","Zfp711","MRX97"],"approved_symbol":"ZNF711","ensembl_gene_id":"ENSG00000147180","hgnc_id":"HGNC:13128","ncbi_gene_id":7552,"previous_symbols":["ZNF6","MRX65"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF711","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF713":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF713","identifiers":{"aliases":["FLJ39963"],"approved_symbol":"ZNF713","ensembl_gene_id":"ENSG00000178665","hgnc_id":"HGNC:22043","ncbi_gene_id":349075,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF713","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF714":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF714","identifiers":{"aliases":[],"approved_symbol":"ZNF714","ensembl_gene_id":"ENSG00000160352","hgnc_id":"HGNC:27124","ncbi_gene_id":148206,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF714","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF717":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF717","identifiers":{"aliases":["X17"],"approved_symbol":"ZNF717","ensembl_gene_id":"ENSG00000227124","hgnc_id":"HGNC:29448","ncbi_gene_id":100131827,"previous_symbols":["ZNF838"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF717","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF718":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF718","identifiers":{"aliases":["FLJ90036"],"approved_symbol":"ZNF718","ensembl_gene_id":"ENSG00000250312","hgnc_id":"HGNC:26889","ncbi_gene_id":255403,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF718","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF721":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF721","identifiers":{"aliases":["KIAA1982"],"approved_symbol":"ZNF721","ensembl_gene_id":"ENSG00000182903","hgnc_id":"HGNC:29425","ncbi_gene_id":170960,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF721","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF724":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF724","identifiers":{"aliases":[],"approved_symbol":"ZNF724","ensembl_gene_id":"ENSG00000196081","hgnc_id":"HGNC:32460","ncbi_gene_id":440519,"previous_symbols":["ZNF724P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF724","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF726":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF726","identifiers":{"aliases":[],"approved_symbol":"ZNF726","ensembl_gene_id":"ENSG00000213967","hgnc_id":"HGNC:32462","ncbi_gene_id":730087,"previous_symbols":["ZNF92P3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF726","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF727":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF727","identifiers":{"aliases":[],"approved_symbol":"ZNF727","ensembl_gene_id":"ENSG00000214652","hgnc_id":"HGNC:22785","ncbi_gene_id":442319,"previous_symbols":["ZNF727P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF727","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF728":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF728","identifiers":{"aliases":[],"approved_symbol":"ZNF728","ensembl_gene_id":"ENSG00000269067","hgnc_id":"HGNC:32463","ncbi_gene_id":388523,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF728","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF730":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF730","identifiers":{"aliases":[],"approved_symbol":"ZNF730","ensembl_gene_id":"ENSG00000183850","hgnc_id":"HGNC:32470","ncbi_gene_id":100129543,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF730","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF736":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF736","identifiers":{"aliases":[],"approved_symbol":"ZNF736","ensembl_gene_id":"ENSG00000234444","hgnc_id":"HGNC:32467","ncbi_gene_id":728927,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF736","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF737":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF737","identifiers":{"aliases":["ZNF102"],"approved_symbol":"ZNF737","ensembl_gene_id":"ENSG00000237440","hgnc_id":"HGNC:32468","ncbi_gene_id":100129842,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF737","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF738":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF738","identifiers":{"aliases":[],"approved_symbol":"ZNF738","ensembl_gene_id":"ENSG00000172687","hgnc_id":"HGNC:32469","ncbi_gene_id":148203,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF738","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF74":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF74","identifiers":{"aliases":["Cos52","Zfp520","ZNF520"],"approved_symbol":"ZNF74","ensembl_gene_id":"ENSG00000185252","hgnc_id":"HGNC:13144","ncbi_gene_id":7625,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF74","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF740":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF740","identifiers":{"aliases":["Zfp740"],"approved_symbol":"ZNF740","ensembl_gene_id":"ENSG00000139651","hgnc_id":"HGNC:27465","ncbi_gene_id":283337,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF740","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF746":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF746","identifiers":{"aliases":["FLJ31413","PARIS"],"approved_symbol":"ZNF746","ensembl_gene_id":"ENSG00000181220","hgnc_id":"HGNC:21948","ncbi_gene_id":155061,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF746","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF747":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF747","identifiers":{"aliases":["MGC2474"],"approved_symbol":"ZNF747","ensembl_gene_id":"ENSG00000169955","hgnc_id":"HGNC:28350","ncbi_gene_id":65988,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF747","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF749":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF749","identifiers":{"aliases":["FLJ16360"],"approved_symbol":"ZNF749","ensembl_gene_id":"ENSG00000186230","hgnc_id":"HGNC:32783","ncbi_gene_id":388567,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF749","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF750":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF750","identifiers":{"aliases":["FLJ13841","Zfp750"],"approved_symbol":"ZNF750","ensembl_gene_id":"ENSG00000141579","hgnc_id":"HGNC:25843","ncbi_gene_id":79755,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZNF750","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF75A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF75A","identifiers":{"aliases":["FLJ31529"],"approved_symbol":"ZNF75A","ensembl_gene_id":"ENSG00000162086","hgnc_id":"HGNC:13146","ncbi_gene_id":7627,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF75A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF75D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF75D","identifiers":{"aliases":["ZKSCAN24","D8C6","ZSCAN28"],"approved_symbol":"ZNF75D","ensembl_gene_id":"ENSG00000186376","hgnc_id":"HGNC:13145","ncbi_gene_id":7626,"previous_symbols":["ZNF82","ZNF75"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF75D","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF76":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF76","identifiers":{"aliases":["Zfp523","ZNF523"],"approved_symbol":"ZNF76","ensembl_gene_id":"ENSG00000065029","hgnc_id":"HGNC:13149","ncbi_gene_id":7629,"previous_symbols":["D6S229E"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF76","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF761":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF761","identifiers":{"aliases":["KIAA2033","FLJ16231","FLJ35333"],"approved_symbol":"ZNF761","ensembl_gene_id":"ENSG00000160336","hgnc_id":"HGNC:23179","ncbi_gene_id":388561,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF761","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF763":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF763","identifiers":{"aliases":["ZNF440L"],"approved_symbol":"ZNF763","ensembl_gene_id":"ENSG00000197054","hgnc_id":"HGNC:27614","ncbi_gene_id":284390,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF763","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF764":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF764","identifiers":{"aliases":["MGC13138"],"approved_symbol":"ZNF764","ensembl_gene_id":"ENSG00000169951","hgnc_id":"HGNC:28200","ncbi_gene_id":92595,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF764","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF765":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF765","identifiers":{"aliases":[],"approved_symbol":"ZNF765","ensembl_gene_id":"ENSG00000196417","hgnc_id":"HGNC:25092","ncbi_gene_id":91661,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF765","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF766":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF766","identifiers":{"aliases":[],"approved_symbol":"ZNF766","ensembl_gene_id":"ENSG00000196214","hgnc_id":"HGNC:28063","ncbi_gene_id":90321,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF766","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF768":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF768","identifiers":{"aliases":["FLJ23436"],"approved_symbol":"ZNF768","ensembl_gene_id":"ENSG00000169957","hgnc_id":"HGNC:26273","ncbi_gene_id":79724,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF768","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF77":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF77","identifiers":{"aliases":["pT1"],"approved_symbol":"ZNF77","ensembl_gene_id":"ENSG00000175691","hgnc_id":"HGNC:13150","ncbi_gene_id":58492,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF77","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF770":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF770","identifiers":{"aliases":["FLJ20582","PRO1914"],"approved_symbol":"ZNF770","ensembl_gene_id":"ENSG00000198146","hgnc_id":"HGNC:26061","ncbi_gene_id":54989,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF770","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF771":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF771","identifiers":{"aliases":["DSC43"],"approved_symbol":"ZNF771","ensembl_gene_id":"ENSG00000179965","hgnc_id":"HGNC:29653","ncbi_gene_id":51333,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF771","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF772":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF772","identifiers":{"aliases":["DKFZp686I1569"],"approved_symbol":"ZNF772","ensembl_gene_id":"ENSG00000197128","hgnc_id":"HGNC:33106","ncbi_gene_id":400720,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF772","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF773":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF773","identifiers":{"aliases":["MGC4728"],"approved_symbol":"ZNF773","ensembl_gene_id":"ENSG00000152439","hgnc_id":"HGNC:30487","ncbi_gene_id":374928,"previous_symbols":["ZNF419B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF773","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF774":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF774","identifiers":{"aliases":["MGC75360"],"approved_symbol":"ZNF774","ensembl_gene_id":"ENSG00000196391","hgnc_id":"HGNC:33108","ncbi_gene_id":342132,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF774","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF775":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF775","identifiers":{"aliases":["MGC33584"],"approved_symbol":"ZNF775","ensembl_gene_id":"ENSG00000196456","hgnc_id":"HGNC:28501","ncbi_gene_id":285971,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF775","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF776":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF776","identifiers":{"aliases":["FLJ38288"],"approved_symbol":"ZNF776","ensembl_gene_id":"ENSG00000152443","hgnc_id":"HGNC:26765","ncbi_gene_id":284309,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF776","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF777":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF777","identifiers":{"aliases":["KIAA1285"],"approved_symbol":"ZNF777","ensembl_gene_id":"ENSG00000196453","hgnc_id":"HGNC:22213","ncbi_gene_id":27153,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF777","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF778":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF778","identifiers":{"aliases":["FLJ31875"],"approved_symbol":"ZNF778","ensembl_gene_id":"ENSG00000170100","hgnc_id":"HGNC:26479","ncbi_gene_id":197320,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF778","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF780A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF780A","identifiers":{"aliases":["ZNF780"],"approved_symbol":"ZNF780A","ensembl_gene_id":"ENSG00000197782","hgnc_id":"HGNC:27603","ncbi_gene_id":284323,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF780A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF780B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF780B","identifiers":{"aliases":[],"approved_symbol":"ZNF780B","ensembl_gene_id":"ENSG00000128000","hgnc_id":"HGNC:33109","ncbi_gene_id":163131,"previous_symbols":["ZNF779"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF780B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF781":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF781","identifiers":{"aliases":["FLJ37549"],"approved_symbol":"ZNF781","ensembl_gene_id":"ENSG00000196381","hgnc_id":"HGNC:26745","ncbi_gene_id":163115,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF781","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF782":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF782","identifiers":{"aliases":["FLJ16636"],"approved_symbol":"ZNF782","ensembl_gene_id":"ENSG00000196597","hgnc_id":"HGNC:33110","ncbi_gene_id":158431,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF782","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF783":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF783","identifiers":{"aliases":["DKFZp667J212"],"approved_symbol":"ZNF783","ensembl_gene_id":"ENSG00000204946","hgnc_id":"HGNC:27222","ncbi_gene_id":100289678,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF783","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF784":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF784","identifiers":{"aliases":["MGC75238"],"approved_symbol":"ZNF784","ensembl_gene_id":"ENSG00000179922","hgnc_id":"HGNC:33111","ncbi_gene_id":147808,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF784","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF785":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF785","identifiers":{"aliases":["FLJ32130"],"approved_symbol":"ZNF785","ensembl_gene_id":"ENSG00000197162","hgnc_id":"HGNC:26496","ncbi_gene_id":146540,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF785","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF786":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF786","identifiers":{"aliases":["DKFZp762I137"],"approved_symbol":"ZNF786","ensembl_gene_id":"ENSG00000197362","hgnc_id":"HGNC:21806","ncbi_gene_id":136051,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF786","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF787":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF787","identifiers":{"aliases":[],"approved_symbol":"ZNF787","ensembl_gene_id":"ENSG00000142409","hgnc_id":"HGNC:26998","ncbi_gene_id":126208,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.20125,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF787","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF789":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF789","identifiers":{"aliases":[],"approved_symbol":"ZNF789","ensembl_gene_id":"ENSG00000198556","hgnc_id":"HGNC:27801","ncbi_gene_id":285989,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF789","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF79":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF79","identifiers":{"aliases":["pT7"],"approved_symbol":"ZNF79","ensembl_gene_id":"ENSG00000196152","hgnc_id":"HGNC:13153","ncbi_gene_id":7633,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF79","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF790":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF790","identifiers":{"aliases":["MGC62100","FLJ20350"],"approved_symbol":"ZNF790","ensembl_gene_id":"ENSG00000197863","hgnc_id":"HGNC:33114","ncbi_gene_id":388536,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF790","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF790-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF790-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF790-AS1","ensembl_gene_id":"ENSG00000267254","hgnc_id":"HGNC:27617","ncbi_gene_id":284408,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF790-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF791":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF791","identifiers":{"aliases":["FLJ90396"],"approved_symbol":"ZNF791","ensembl_gene_id":"ENSG00000173875","hgnc_id":"HGNC:26895","ncbi_gene_id":163049,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF791","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF792":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF792","identifiers":{"aliases":["FLJ38451"],"approved_symbol":"ZNF792","ensembl_gene_id":"ENSG00000180884","hgnc_id":"HGNC:24751","ncbi_gene_id":126375,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF792","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF793":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF793","identifiers":{"aliases":[],"approved_symbol":"ZNF793","ensembl_gene_id":"ENSG00000188227","hgnc_id":"HGNC:33115","ncbi_gene_id":390927,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF793","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF793-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF793-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNF793-AS1","ensembl_gene_id":"ENSG00000266916","hgnc_id":"HGNC:51303","ncbi_gene_id":101927720,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF793-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF799":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF799","identifiers":{"aliases":["HIT-40","MGC71805"],"approved_symbol":"ZNF799","ensembl_gene_id":"ENSG00000196466","hgnc_id":"HGNC:28071","ncbi_gene_id":90576,"previous_symbols":["ZNF842"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF799","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF8","identifiers":{"aliases":["HF.18","Zfp128"],"approved_symbol":"ZNF8","ensembl_gene_id":"ENSG00000278129","hgnc_id":"HGNC:13154","ncbi_gene_id":7554,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF8","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF800":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF800","identifiers":{"aliases":[],"approved_symbol":"ZNF800","ensembl_gene_id":"ENSG00000048405","hgnc_id":"HGNC:27267","ncbi_gene_id":168850,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF800","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF804A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF804A","identifiers":{"aliases":[],"approved_symbol":"ZNF804A","ensembl_gene_id":"ENSG00000170396","hgnc_id":"HGNC:21711","ncbi_gene_id":91752,"previous_symbols":["C2orf10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF804A","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF804B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF804B","identifiers":{"aliases":["FLJ32110"],"approved_symbol":"ZNF804B","ensembl_gene_id":"ENSG00000182348","hgnc_id":"HGNC:21958","ncbi_gene_id":219578,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF804B","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF805":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF805","identifiers":{"aliases":[],"approved_symbol":"ZNF805","ensembl_gene_id":"ENSG00000204524","hgnc_id":"HGNC:23272","ncbi_gene_id":390980,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF805","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF808":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF808","identifiers":{"aliases":[],"approved_symbol":"ZNF808","ensembl_gene_id":"ENSG00000198482","hgnc_id":"HGNC:33230","ncbi_gene_id":388558,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF808","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF81":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF81","identifiers":{"aliases":["HFZ20"],"approved_symbol":"ZNF81","ensembl_gene_id":"ENSG00000197779","hgnc_id":"HGNC:13156","ncbi_gene_id":347344,"previous_symbols":["MRX45"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF81","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF813":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF813","identifiers":{"aliases":["FLJ16542"],"approved_symbol":"ZNF813","ensembl_gene_id":"ENSG00000198346","hgnc_id":"HGNC:33257","ncbi_gene_id":126017,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF813","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF814":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF814","identifiers":{"aliases":[],"approved_symbol":"ZNF814","ensembl_gene_id":"ENSG00000204514","hgnc_id":"HGNC:33258","ncbi_gene_id":730051,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF814","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF816":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF816","identifiers":{"aliases":[],"approved_symbol":"ZNF816","ensembl_gene_id":"ENSG00000180257","hgnc_id":"HGNC:26995","ncbi_gene_id":125893,"previous_symbols":["ZNF816A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF816","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF821":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF821","identifiers":{"aliases":[],"approved_symbol":"ZNF821","ensembl_gene_id":"ENSG00000102984","hgnc_id":"HGNC:28043","ncbi_gene_id":55565,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF821","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF823":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF823","identifiers":{"aliases":["HSZFP36"],"approved_symbol":"ZNF823","ensembl_gene_id":"ENSG00000197933","hgnc_id":"HGNC:30936","ncbi_gene_id":55552,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF823","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF827":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF827","identifiers":{"aliases":[],"approved_symbol":"ZNF827","ensembl_gene_id":"ENSG00000151612","hgnc_id":"HGNC:27193","ncbi_gene_id":152485,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF827","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF829":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF829","identifiers":{"aliases":["DKFZp779O175"],"approved_symbol":"ZNF829","ensembl_gene_id":"ENSG00000185869","hgnc_id":"HGNC:34032","ncbi_gene_id":374899,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF829","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF83":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF83","identifiers":{"aliases":["FLJ11015","HPF1"],"approved_symbol":"ZNF83","ensembl_gene_id":"ENSG00000167766","hgnc_id":"HGNC:13158","ncbi_gene_id":55769,"previous_symbols":["ZNF816B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF83","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF830":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF830","identifiers":{"aliases":["MGC20398","OMCG1"],"approved_symbol":"ZNF830","ensembl_gene_id":"ENSG00000198783","hgnc_id":"HGNC:28291","ncbi_gene_id":91603,"previous_symbols":["CCDC16"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF830","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF831":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF831","identifiers":{"aliases":["dJ492J12.1"],"approved_symbol":"ZNF831","ensembl_gene_id":"ENSG00000124203","hgnc_id":"HGNC:16167","ncbi_gene_id":128611,"previous_symbols":["C20orf174"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF831","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF835":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF835","identifiers":{"aliases":["BC37295_3"],"approved_symbol":"ZNF835","ensembl_gene_id":"ENSG00000127903","hgnc_id":"HGNC:34332","ncbi_gene_id":90485,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF835","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF836":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF836","identifiers":{"aliases":["FLJ16287"],"approved_symbol":"ZNF836","ensembl_gene_id":"ENSG00000196267","hgnc_id":"HGNC:34333","ncbi_gene_id":162962,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF836","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF837":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF837","identifiers":{"aliases":[],"approved_symbol":"ZNF837","ensembl_gene_id":"ENSG00000152475","hgnc_id":"HGNC:25164","ncbi_gene_id":116412,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF837","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF839":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF839","identifiers":{"aliases":[],"approved_symbol":"ZNF839","ensembl_gene_id":"ENSG00000022976","hgnc_id":"HGNC:20345","ncbi_gene_id":55778,"previous_symbols":["C14orf131"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF839","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF84":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF84","identifiers":{"aliases":["HPF2"],"approved_symbol":"ZNF84","ensembl_gene_id":"ENSG00000198040","hgnc_id":"HGNC:13159","ncbi_gene_id":7637,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF84","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF841":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF841","identifiers":{"aliases":["LOC284371"],"approved_symbol":"ZNF841","ensembl_gene_id":"ENSG00000197608","hgnc_id":"HGNC:27611","ncbi_gene_id":284371,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF841","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF843":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF843","identifiers":{"aliases":["MGC46336"],"approved_symbol":"ZNF843","ensembl_gene_id":"ENSG00000176723","hgnc_id":"HGNC:28710","ncbi_gene_id":283933,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF843","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF844":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF844","identifiers":{"aliases":["FLJ14959"],"approved_symbol":"ZNF844","ensembl_gene_id":"ENSG00000223547","hgnc_id":"HGNC:25932","ncbi_gene_id":284391,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF844","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF845":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF845","identifiers":{"aliases":[],"approved_symbol":"ZNF845","ensembl_gene_id":"ENSG00000213799","hgnc_id":"HGNC:25112","ncbi_gene_id":91664,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF845","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF846":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF846","identifiers":{"aliases":[],"approved_symbol":"ZNF846","ensembl_gene_id":"ENSG00000196605","hgnc_id":"HGNC:27260","ncbi_gene_id":162993,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF846","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF85":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF85","identifiers":{"aliases":["HPF4","HTF1"],"approved_symbol":"ZNF85","ensembl_gene_id":"ENSG00000105750","hgnc_id":"HGNC:13160","ncbi_gene_id":7639,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF85","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF850":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF850","identifiers":{"aliases":[],"approved_symbol":"ZNF850","ensembl_gene_id":"ENSG00000267041","hgnc_id":"HGNC:27994","ncbi_gene_id":342892,"previous_symbols":["ZNF850P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF850","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF852":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF852","identifiers":{"aliases":[],"approved_symbol":"ZNF852","ensembl_gene_id":"ENSG00000178917","hgnc_id":"HGNC:27713","ncbi_gene_id":285346,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF852","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF853":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF853","identifiers":{"aliases":["DKFZp434J1015"],"approved_symbol":"ZNF853","ensembl_gene_id":"ENSG00000236609","hgnc_id":"HGNC:21767","ncbi_gene_id":54753,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF853","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF860":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF860","identifiers":{"aliases":[],"approved_symbol":"ZNF860","ensembl_gene_id":"ENSG00000197385","hgnc_id":"HGNC:34513","ncbi_gene_id":344787,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF860","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF862":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF862","identifiers":{"aliases":[],"approved_symbol":"ZNF862","ensembl_gene_id":"ENSG00000106479","hgnc_id":"HGNC:34519","ncbi_gene_id":643641,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF862","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF865":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF865","identifiers":{"aliases":[],"approved_symbol":"ZNF865","ensembl_gene_id":"ENSG00000261221","hgnc_id":"HGNC:38705","ncbi_gene_id":100507290,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF865","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF875":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF875","identifiers":{"aliases":[],"approved_symbol":"ZNF875","ensembl_gene_id":"ENSG00000181666","hgnc_id":"HGNC:4928","ncbi_gene_id":284459,"previous_symbols":["HKR1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF875","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF878":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF878","identifiers":{"aliases":[],"approved_symbol":"ZNF878","ensembl_gene_id":"ENSG00000257446","hgnc_id":"HGNC:37246","ncbi_gene_id":729747,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF878","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF879":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF879","identifiers":{"aliases":["DKFZp686E2433"],"approved_symbol":"ZNF879","ensembl_gene_id":"ENSG00000234284","hgnc_id":"HGNC:37273","ncbi_gene_id":345462,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF879","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF880":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF880","identifiers":{"aliases":[],"approved_symbol":"ZNF880","ensembl_gene_id":"ENSG00000221923","hgnc_id":"HGNC:37249","ncbi_gene_id":400713,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF880","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF883":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF883","identifiers":{"aliases":[],"approved_symbol":"ZNF883","ensembl_gene_id":"ENSG00000228623","hgnc_id":"HGNC:27271","ncbi_gene_id":169834,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNF883","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF888":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF888","identifiers":{"aliases":[],"approved_symbol":"ZNF888","ensembl_gene_id":"ENSG00000213793","hgnc_id":"HGNC:38695","ncbi_gene_id":388559,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF888","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF891":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF891","identifiers":{"aliases":[],"approved_symbol":"ZNF891","ensembl_gene_id":"ENSG00000214029","hgnc_id":"HGNC:38709","ncbi_gene_id":101060200,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF891","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF90":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF90","identifiers":{"aliases":["HTF9"],"approved_symbol":"ZNF90","ensembl_gene_id":"ENSG00000213988","hgnc_id":"HGNC:13165","ncbi_gene_id":7643,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF90","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF91":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF91","identifiers":{"aliases":["HPF7","HTF10"],"approved_symbol":"ZNF91","ensembl_gene_id":"ENSG00000167232","hgnc_id":"HGNC:13166","ncbi_gene_id":7644,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF91","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF92":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF92","identifiers":{"aliases":["HPF12","TF12"],"approved_symbol":"ZNF92","ensembl_gene_id":"ENSG00000146757","hgnc_id":"HGNC:13168","ncbi_gene_id":168374,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF92","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF93":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF93","identifiers":{"aliases":["HPF34","TF34","FLJ12488"],"approved_symbol":"ZNF93","ensembl_gene_id":"ENSG00000184635","hgnc_id":"HGNC:13169","ncbi_gene_id":81931,"previous_symbols":["ZNF505"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNF93","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF98":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF98","identifiers":{"aliases":["ZNF739","F7175"],"approved_symbol":"ZNF98","ensembl_gene_id":"ENSG00000197360","hgnc_id":"HGNC:13174","ncbi_gene_id":148198,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZNF98","release_manifest":"api/v1.1/release_manifest.json"}},"ZNF99":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNF99","identifiers":{"aliases":["MGC24986"],"approved_symbol":"ZNF99","ensembl_gene_id":"ENSG00000213973","hgnc_id":"HGNC:13175","ncbi_gene_id":7652,"previous_symbols":["C19orf9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNF99","release_manifest":"api/v1.1/release_manifest.json"}},"ZNFX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNFX1","identifiers":{"aliases":["KIAA1404","FLJ11277"],"approved_symbol":"ZNFX1","ensembl_gene_id":"ENSG00000124201","hgnc_id":"HGNC:29271","ncbi_gene_id":57169,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNFX1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNHIT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNHIT1","identifiers":{"aliases":["CG1I","H_DJ0747G18.14","p18(Hamlet)"],"approved_symbol":"ZNHIT1","ensembl_gene_id":"ENSG00000106400","hgnc_id":"HGNC:21688","ncbi_gene_id":10467,"previous_symbols":["ZNFN4A1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.081627,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNHIT1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNHIT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNHIT2","identifiers":{"aliases":["FON"],"approved_symbol":"ZNHIT2","ensembl_gene_id":"ENSG00000174276","hgnc_id":"HGNC:1177","ncbi_gene_id":741,"previous_symbols":["C11orf5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNHIT2","release_manifest":"api/v1.1/release_manifest.json"}},"ZNHIT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNHIT3","identifiers":{"aliases":["Hit1"],"approved_symbol":"ZNHIT3","ensembl_gene_id":"ENSG00000273611","hgnc_id":"HGNC:12309","ncbi_gene_id":9326,"previous_symbols":["TRIP3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNHIT3","release_manifest":"api/v1.1/release_manifest.json"}},"ZNHIT6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNHIT6","identifiers":{"aliases":["FLJ20729","NY-BR-75","BCD1"],"approved_symbol":"ZNHIT6","ensembl_gene_id":"ENSG00000117174","hgnc_id":"HGNC:26089","ncbi_gene_id":54680,"previous_symbols":["C1orf181"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNHIT6","release_manifest":"api/v1.1/release_manifest.json"}},"ZNRD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNRD1","identifiers":{"approved_symbol":"ZNRD1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZNRD1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNRD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNRD2","identifiers":{"aliases":["p27"],"approved_symbol":"ZNRD2","ensembl_gene_id":"ENSG00000173465","hgnc_id":"HGNC:11328","ncbi_gene_id":10534,"previous_symbols":["SSSCA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZNRD2","release_manifest":"api/v1.1/release_manifest.json"}},"ZNRF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNRF1","identifiers":{"aliases":["nin283","FLJ14846","DKFZp434E229"],"approved_symbol":"ZNRF1","ensembl_gene_id":"ENSG00000186187","hgnc_id":"HGNC:18452","ncbi_gene_id":84937,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNRF1","release_manifest":"api/v1.1/release_manifest.json"}},"ZNRF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNRF2","identifiers":{"aliases":["RNF202"],"approved_symbol":"ZNRF2","ensembl_gene_id":"ENSG00000180233","hgnc_id":"HGNC:22316","ncbi_gene_id":223082,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNRF2","release_manifest":"api/v1.1/release_manifest.json"}},"ZNRF3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNRF3","identifiers":{"aliases":["KIAA1133","BK747E2.3","FLJ22057","RNF203"],"approved_symbol":"ZNRF3","ensembl_gene_id":"ENSG00000183579","hgnc_id":"HGNC:18126","ncbi_gene_id":84133,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZNRF3","release_manifest":"api/v1.1/release_manifest.json"}},"ZNRF3-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZNRF3-AS1","identifiers":{"aliases":[],"approved_symbol":"ZNRF3-AS1","ensembl_gene_id":"ENSG00000177993","hgnc_id":"HGNC:41927","ncbi_gene_id":100874123,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZNRF3-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZP1","identifiers":{"aliases":["ZPB1"],"approved_symbol":"ZP1","ensembl_gene_id":"ENSG00000149506","hgnc_id":"HGNC:13187","ncbi_gene_id":22917,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZP1","release_manifest":"api/v1.1/release_manifest.json"}},"ZP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZP3","identifiers":{"aliases":["ZP3-424","ZP3-372","ZPC"],"approved_symbol":"ZP3","ensembl_gene_id":"ENSG00000188372","hgnc_id":"HGNC:13189","ncbi_gene_id":7784,"previous_symbols":["ZP3A","ZP3B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZP3","release_manifest":"api/v1.1/release_manifest.json"}},"ZPBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZPBP","identifiers":{"aliases":["SP38","ZPBP1"],"approved_symbol":"ZPBP","ensembl_gene_id":"ENSG00000042813","hgnc_id":"HGNC:15662","ncbi_gene_id":11055,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ZPBP","release_manifest":"api/v1.1/release_manifest.json"}},"ZPLD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZPLD1","identifiers":{"aliases":[],"approved_symbol":"ZPLD1","ensembl_gene_id":"ENSG00000170044","hgnc_id":"HGNC:27022","ncbi_gene_id":131368,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZPLD1","release_manifest":"api/v1.1/release_manifest.json"}},"ZPR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZPR1","identifiers":{"aliases":[],"approved_symbol":"ZPR1","ensembl_gene_id":"ENSG00000109917","hgnc_id":"HGNC:13051","ncbi_gene_id":8882,"previous_symbols":["ZNF259"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZPR1","release_manifest":"api/v1.1/release_manifest.json"}},"ZRANB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZRANB1","identifiers":{"aliases":["TRABID"],"approved_symbol":"ZRANB1","ensembl_gene_id":"ENSG00000019995","hgnc_id":"HGNC:18224","ncbi_gene_id":54764,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZRANB1","release_manifest":"api/v1.1/release_manifest.json"}},"ZRANB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZRANB2","identifiers":{"aliases":["ZIS","ZIS1","ZIS2"],"approved_symbol":"ZRANB2","ensembl_gene_id":"ENSG00000132485","hgnc_id":"HGNC:13058","ncbi_gene_id":9406,"previous_symbols":["ZNF265"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZRANB2","release_manifest":"api/v1.1/release_manifest.json"}},"ZRANB2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZRANB2-AS1","identifiers":{"aliases":[],"approved_symbol":"ZRANB2-AS1","ensembl_gene_id":"ENSG00000235079","hgnc_id":"HGNC:43594","ncbi_gene_id":100132618,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/ZRANB2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZRANB3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZRANB3","identifiers":{"aliases":["DKFZP434B1727","AH2"],"approved_symbol":"ZRANB3","ensembl_gene_id":"ENSG00000121988","hgnc_id":"HGNC:25249","ncbi_gene_id":84083,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZRANB3","release_manifest":"api/v1.1/release_manifest.json"}},"ZRSR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZRSR2","identifiers":{"aliases":["U2AF1-RS2","URP","ZC3H22"],"approved_symbol":"ZRSR2","ensembl_gene_id":"ENSG00000169249","hgnc_id":"HGNC:23019","ncbi_gene_id":8233,"previous_symbols":["U2AF1L2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZRSR2","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN1","identifiers":{"aliases":["FLJ33779","ZNF915"],"approved_symbol":"ZSCAN1","ensembl_gene_id":"ENSG00000152467","hgnc_id":"HGNC:23712","ncbi_gene_id":284312,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/ZSCAN1","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN12","identifiers":{"aliases":["KIAA0426","ZNF29K1","ZFP96","dJ29K1.2"],"approved_symbol":"ZSCAN12","ensembl_gene_id":"ENSG00000158691","hgnc_id":"HGNC:13172","ncbi_gene_id":9753,"previous_symbols":["ZNF305","ZNF96"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN12","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN16","identifiers":{"aliases":["FLJ22191","dJ265C24.3"],"approved_symbol":"ZSCAN16","ensembl_gene_id":"ENSG00000196812","hgnc_id":"HGNC:20813","ncbi_gene_id":80345,"previous_symbols":["ZNF392","ZNF435"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN16","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN16-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN16-AS1","identifiers":{"aliases":[],"approved_symbol":"ZSCAN16-AS1","ensembl_gene_id":"ENSG00000269293","hgnc_id":"HGNC:48982","ncbi_gene_id":100129195,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN16-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN18","identifiers":{"aliases":["FLJ12895"],"approved_symbol":"ZSCAN18","ensembl_gene_id":"ENSG00000121413","hgnc_id":"HGNC:21037","ncbi_gene_id":65982,"previous_symbols":["ZNF447"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN18","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN2","identifiers":{"aliases":["FLJ20595","ZNF854"],"approved_symbol":"ZSCAN2","ensembl_gene_id":"ENSG00000176371","hgnc_id":"HGNC:20994","ncbi_gene_id":54993,"previous_symbols":["ZFP29"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN2","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN20","identifiers":{"aliases":["KOX29"],"approved_symbol":"ZSCAN20","ensembl_gene_id":"ENSG00000121903","hgnc_id":"HGNC:13093","ncbi_gene_id":7579,"previous_symbols":["ZNF360","ZNF31"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN20","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN21","identifiers":{"aliases":["DKFZp434L134","NY-REN-21","Zipro1"],"approved_symbol":"ZSCAN21","ensembl_gene_id":"ENSG00000166529","hgnc_id":"HGNC:13104","ncbi_gene_id":7589,"previous_symbols":["ZNF38"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN21","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN22","identifiers":{"aliases":[],"approved_symbol":"ZSCAN22","ensembl_gene_id":"ENSG00000182318","hgnc_id":"HGNC:4929","ncbi_gene_id":342945,"previous_symbols":["ZNF50","HKR2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN22","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN23","identifiers":{"aliases":["dJ29K1.3.1"],"approved_symbol":"ZSCAN23","ensembl_gene_id":"ENSG00000187987","hgnc_id":"HGNC:21193","ncbi_gene_id":222696,"previous_symbols":["ZNF453","ZNF390"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN23","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN25","identifiers":{"aliases":["FLJ32468"],"approved_symbol":"ZSCAN25","ensembl_gene_id":"ENSG00000197037","hgnc_id":"HGNC:21961","ncbi_gene_id":221785,"previous_symbols":["ZNF498"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN25","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN26","identifiers":{"aliases":["SRE-ZBP"],"approved_symbol":"ZSCAN26","ensembl_gene_id":"ENSG00000197062","hgnc_id":"HGNC:12978","ncbi_gene_id":7741,"previous_symbols":["ZNF187"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN26","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN29":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN29","identifiers":{"aliases":["FLJ35867","Zfp690"],"approved_symbol":"ZSCAN29","ensembl_gene_id":"ENSG00000140265","hgnc_id":"HGNC:26673","ncbi_gene_id":146050,"previous_symbols":["ZNF690"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZSCAN29","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN30","identifiers":{"aliases":["ZNF917"],"approved_symbol":"ZSCAN30","ensembl_gene_id":"ENSG00000186814","hgnc_id":"HGNC:33517","ncbi_gene_id":100101467,"previous_symbols":["ZNF397OS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN30","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN31":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN31","identifiers":{"aliases":[],"approved_symbol":"ZSCAN31","ensembl_gene_id":"ENSG00000235109","hgnc_id":"HGNC:14097","ncbi_gene_id":64288,"previous_symbols":["ZNF310P","ZNF323"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZSCAN31","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN32":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN32","identifiers":{"aliases":["FLJ20417"],"approved_symbol":"ZSCAN32","ensembl_gene_id":"ENSG00000140987","hgnc_id":"HGNC:20812","ncbi_gene_id":54925,"previous_symbols":["ZNF434"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN32","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN5A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN5A","identifiers":{"aliases":["MGC4161"],"approved_symbol":"ZSCAN5A","ensembl_gene_id":"ENSG00000131848","hgnc_id":"HGNC:23710","ncbi_gene_id":79149,"previous_symbols":["ZNF495","ZSCAN5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN5A","release_manifest":"api/v1.1/release_manifest.json"}},"ZSCAN9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSCAN9","identifiers":{"aliases":["PRD51"],"approved_symbol":"ZSCAN9","ensembl_gene_id":"ENSG00000137185","hgnc_id":"HGNC:12984","ncbi_gene_id":7746,"previous_symbols":["ZNF193"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSCAN9","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM1","identifiers":{"aliases":["dJ337O18.5"],"approved_symbol":"ZSWIM1","ensembl_gene_id":"ENSG00000168612","hgnc_id":"HGNC:16155","ncbi_gene_id":90204,"previous_symbols":["C20orf162"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM1","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM3","identifiers":{"aliases":["dJ337O18.7","PPP1R174"],"approved_symbol":"ZSWIM3","ensembl_gene_id":"ENSG00000132801","hgnc_id":"HGNC:16157","ncbi_gene_id":140831,"previous_symbols":["C20orf164"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM3","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM4","identifiers":{"aliases":["FLJ12221"],"approved_symbol":"ZSWIM4","ensembl_gene_id":"ENSG00000132003","hgnc_id":"HGNC:25704","ncbi_gene_id":65249,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM4","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM5","identifiers":{"aliases":["KIAA1511"],"approved_symbol":"ZSWIM5","ensembl_gene_id":"ENSG00000162415","hgnc_id":"HGNC:29299","ncbi_gene_id":57643,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM5","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM6","identifiers":{"aliases":["KIAA1577"],"approved_symbol":"ZSWIM6","ensembl_gene_id":"ENSG00000130449","hgnc_id":"HGNC:29316","ncbi_gene_id":57688,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM6","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM7","identifiers":{"aliases":["SWS1"],"approved_symbol":"ZSWIM7","ensembl_gene_id":"ENSG00000214941","hgnc_id":"HGNC:26993","ncbi_gene_id":125150,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM7","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM8","identifiers":{"aliases":["4832404P21Rik"],"approved_symbol":"ZSWIM8","ensembl_gene_id":"ENSG00000214655","hgnc_id":"HGNC:23528","ncbi_gene_id":23053,"previous_symbols":["KIAA0913"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM8","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM8-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM8-AS1","identifiers":{"aliases":[],"approved_symbol":"ZSWIM8-AS1","ensembl_gene_id":"ENSG00000272589","hgnc_id":"HGNC:45103","ncbi_gene_id":100507331,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM8-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"ZSWIM9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZSWIM9","identifiers":{"aliases":["LOC374920"],"approved_symbol":"ZSWIM9","ensembl_gene_id":"ENSG00000185453","hgnc_id":"HGNC:34495","ncbi_gene_id":374920,"previous_symbols":["C19orf68"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZSWIM9","release_manifest":"api/v1.1/release_manifest.json"}},"ZUP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZUP1","identifiers":{"aliases":["dJ412I7.3"],"approved_symbol":"ZUP1","ensembl_gene_id":"ENSG00000153975","hgnc_id":"HGNC:21224","ncbi_gene_id":221302,"previous_symbols":["C6orf113","ZUFSP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZUP1","release_manifest":"api/v1.1/release_manifest.json"}},"ZW10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZW10","identifiers":{"aliases":["KNTC1AP"],"approved_symbol":"ZW10","ensembl_gene_id":"ENSG00000086827","hgnc_id":"HGNC:13194","ncbi_gene_id":9183,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZW10","release_manifest":"api/v1.1/release_manifest.json"}},"ZWILCH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZWILCH","identifiers":{"aliases":["FLJ10036","KNTC1AP"],"approved_symbol":"ZWILCH","ensembl_gene_id":"ENSG00000174442","hgnc_id":"HGNC:25468","ncbi_gene_id":55055,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZWILCH","release_manifest":"api/v1.1/release_manifest.json"}},"ZWINT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZWINT","identifiers":{"aliases":["KNTC2AP","SIP30","Zwint1"],"approved_symbol":"ZWINT","ensembl_gene_id":"ENSG00000122952","hgnc_id":"HGNC:13195","ncbi_gene_id":11130,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZWINT","release_manifest":"api/v1.1/release_manifest.json"}},"ZXDA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZXDA","identifiers":{"aliases":["ZNF896"],"approved_symbol":"ZXDA","ensembl_gene_id":"ENSG00000198205","hgnc_id":"HGNC:13198","ncbi_gene_id":7789,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZXDA","release_manifest":"api/v1.1/release_manifest.json"}},"ZXDB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZXDB","identifiers":{"aliases":["ZNF905"],"approved_symbol":"ZXDB","ensembl_gene_id":"ENSG00000198455","hgnc_id":"HGNC:13199","ncbi_gene_id":158586,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZXDB","release_manifest":"api/v1.1/release_manifest.json"}},"ZXDC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZXDC","identifiers":{"aliases":["MGC11349","FLJ13861"],"approved_symbol":"ZXDC","ensembl_gene_id":"ENSG00000070476","hgnc_id":"HGNC:28160","ncbi_gene_id":79364,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZXDC","release_manifest":"api/v1.1/release_manifest.json"}},"ZYG11A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZYG11A","identifiers":{"aliases":["ZYG11"],"approved_symbol":"ZYG11A","ensembl_gene_id":"ENSG00000203995","hgnc_id":"HGNC:32058","ncbi_gene_id":440590,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZYG11A","release_manifest":"api/v1.1/release_manifest.json"}},"ZYG11B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZYG11B","identifiers":{"aliases":["FLJ13456"],"approved_symbol":"ZYG11B","ensembl_gene_id":"ENSG00000162378","hgnc_id":"HGNC:25820","ncbi_gene_id":79699,"previous_symbols":["ZYG11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZYG11B","release_manifest":"api/v1.1/release_manifest.json"}},"ZYX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZYX","identifiers":{"aliases":[],"approved_symbol":"ZYX","ensembl_gene_id":"ENSG00000159840","hgnc_id":"HGNC:13200","ncbi_gene_id":7791,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ZYX","release_manifest":"api/v1.1/release_manifest.json"}},"ZZEF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ZZEF1","identifiers":{"aliases":["KIAA0399","ZZZ4","FLJ10821"],"approved_symbol":"ZZEF1","ensembl_gene_id":"ENSG00000074755","hgnc_id":"HGNC:29027","ncbi_gene_id":23140,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ZZEF1","release_manifest":"api/v1.1/release_manifest.json"}}}