{"OAF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAF","identifiers":{"aliases":["MGC52117"],"approved_symbol":"OAF","ensembl_gene_id":"ENSG00000184232","hgnc_id":"HGNC:28752","ncbi_gene_id":220323,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OAF","release_manifest":"api/v1.1/release_manifest.json"}},"OARD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OARD1","identifiers":{"aliases":["MGC19570","dJ34B21.3","TARG1"],"approved_symbol":"OARD1","ensembl_gene_id":"ENSG00000124596","hgnc_id":"HGNC:21257","ncbi_gene_id":221443,"previous_symbols":["C6orf130"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OARD1","release_manifest":"api/v1.1/release_manifest.json"}},"OAS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAS1","identifiers":{"aliases":["OIASI","IFI-4"],"approved_symbol":"OAS1","ensembl_gene_id":"ENSG00000089127","hgnc_id":"HGNC:8086","ncbi_gene_id":4938,"previous_symbols":["OIAS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OAS1","release_manifest":"api/v1.1/release_manifest.json"}},"OAS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAS2","identifiers":{"aliases":[],"approved_symbol":"OAS2","ensembl_gene_id":"ENSG00000111335","hgnc_id":"HGNC:8087","ncbi_gene_id":4939,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OAS2","release_manifest":"api/v1.1/release_manifest.json"}},"OAS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAS3","identifiers":{"aliases":[],"approved_symbol":"OAS3","ensembl_gene_id":"ENSG00000111331","hgnc_id":"HGNC:8088","ncbi_gene_id":4940,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OAS3","release_manifest":"api/v1.1/release_manifest.json"}},"OASL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OASL","identifiers":{"aliases":["TRIP14","p59OASL","OASL1"],"approved_symbol":"OASL","ensembl_gene_id":"ENSG00000135114","hgnc_id":"HGNC:8090","ncbi_gene_id":8638,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OASL","release_manifest":"api/v1.1/release_manifest.json"}},"OAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAT","identifiers":{"aliases":["HOGA"],"approved_symbol":"OAT","ensembl_gene_id":"ENSG00000065154","hgnc_id":"HGNC:8091","ncbi_gene_id":4942,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OAT","release_manifest":"api/v1.1/release_manifest.json"}},"OAZ1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAZ1","identifiers":{"aliases":["AZI","MGC138338","AZ1"],"approved_symbol":"OAZ1","ensembl_gene_id":"ENSG00000104904","hgnc_id":"HGNC:8095","ncbi_gene_id":4946,"previous_symbols":["OAZ"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OAZ1","release_manifest":"api/v1.1/release_manifest.json"}},"OAZ2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAZ2","identifiers":{"aliases":[],"approved_symbol":"OAZ2","ensembl_gene_id":"ENSG00000180304","hgnc_id":"HGNC:8096","ncbi_gene_id":4947,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OAZ2","release_manifest":"api/v1.1/release_manifest.json"}},"OAZ3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OAZ3","identifiers":{"aliases":[],"approved_symbol":"OAZ3","ensembl_gene_id":"ENSG00000143450","hgnc_id":"HGNC:8097","ncbi_gene_id":51686,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OAZ3","release_manifest":"api/v1.1/release_manifest.json"}},"OBI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OBI1","identifiers":{"aliases":["FLJ13449"],"approved_symbol":"OBI1","ensembl_gene_id":"ENSG00000152193","hgnc_id":"HGNC:20308","ncbi_gene_id":79596,"previous_symbols":["C13orf7","RNF219"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OBI1","release_manifest":"api/v1.1/release_manifest.json"}},"OBI1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OBI1-AS1","identifiers":{"aliases":["uc.354"],"approved_symbol":"OBI1-AS1","ensembl_gene_id":"ENSG00000234377","hgnc_id":"HGNC:42700","ncbi_gene_id":100874222,"previous_symbols":["POU4F1-AS1","RNF219-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OBI1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OBSCN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OBSCN","identifiers":{"aliases":["KIAA1556","UNC89","KIAA1639","ARHGEF30"],"approved_symbol":"OBSCN","ensembl_gene_id":"ENSG00000154358","hgnc_id":"HGNC:15719","ncbi_gene_id":84033,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OBSCN","release_manifest":"api/v1.1/release_manifest.json"}},"OBSL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OBSL1","identifiers":{"aliases":["KIAA0657"],"approved_symbol":"OBSL1","ensembl_gene_id":"ENSG00000124006","hgnc_id":"HGNC:29092","ncbi_gene_id":23363,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OBSL1","release_manifest":"api/v1.1/release_manifest.json"}},"OCA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OCA2","identifiers":{"aliases":["BEY","BEY1","BEY2","EYCL","SLC13B1"],"approved_symbol":"OCA2","ensembl_gene_id":"ENSG00000104044","hgnc_id":"HGNC:8101","ncbi_gene_id":4948,"previous_symbols":["D15S12","P","EYCL3","EYCL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OCA2","release_manifest":"api/v1.1/release_manifest.json"}},"OCEL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OCEL1","identifiers":{"aliases":["FLJ22709"],"approved_symbol":"OCEL1","ensembl_gene_id":"ENSG00000099330","hgnc_id":"HGNC:26221","ncbi_gene_id":79629,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OCEL1","release_manifest":"api/v1.1/release_manifest.json"}},"OCIAD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OCIAD1","identifiers":{"aliases":["FLJ20455","TPA018","OCIA","Asrij"],"approved_symbol":"OCIAD1","ensembl_gene_id":"ENSG00000109180","hgnc_id":"HGNC:16074","ncbi_gene_id":54940,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OCIAD1","release_manifest":"api/v1.1/release_manifest.json"}},"OCIAD1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OCIAD1-AS1","identifiers":{"aliases":[],"approved_symbol":"OCIAD1-AS1","ensembl_gene_id":"ENSG00000248256","hgnc_id":"HGNC:40751","ncbi_gene_id":100861517,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OCIAD1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OCIAD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OCIAD2","identifiers":{"aliases":["MGC45416"],"approved_symbol":"OCIAD2","ensembl_gene_id":"ENSG00000145247","hgnc_id":"HGNC:28685","ncbi_gene_id":132299,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OCIAD2","release_manifest":"api/v1.1/release_manifest.json"}},"OCLN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OCLN","identifiers":{"aliases":["PPP1R115"],"approved_symbol":"OCLN","ensembl_gene_id":"ENSG00000197822","hgnc_id":"HGNC:8104","ncbi_gene_id":100506658,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OCLN","release_manifest":"api/v1.1/release_manifest.json"}},"OCRL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OCRL","identifiers":{"aliases":["OCRL1","Dent-2"],"approved_symbol":"OCRL","ensembl_gene_id":"ENSG00000122126","hgnc_id":"HGNC:8108","ncbi_gene_id":4952,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OCRL","release_manifest":"api/v1.1/release_manifest.json"}},"ODAPH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODAPH","identifiers":{"aliases":["FLJ23657","AI2A4"],"approved_symbol":"ODAPH","ensembl_gene_id":"ENSG00000174792","hgnc_id":"HGNC:26300","ncbi_gene_id":152816,"previous_symbols":["C4orf26"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ODAPH","release_manifest":"api/v1.1/release_manifest.json"}},"ODC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODC1","identifiers":{"aliases":["ODC"],"approved_symbol":"ODC1","ensembl_gene_id":"ENSG00000115758","hgnc_id":"HGNC:8109","ncbi_gene_id":4953,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODC1","release_manifest":"api/v1.1/release_manifest.json"}},"ODC1-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODC1-DT","identifiers":{"aliases":["lncRNA-MIF"],"approved_symbol":"ODC1-DT","ensembl_gene_id":"ENSG00000257135","hgnc_id":"HGNC:54070","ncbi_gene_id":101929715,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODC1-DT","release_manifest":"api/v1.1/release_manifest.json"}},"ODF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODF2","identifiers":{"aliases":["ODF84","CT134"],"approved_symbol":"ODF2","ensembl_gene_id":"ENSG00000136811","hgnc_id":"HGNC:8114","ncbi_gene_id":4957,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODF2","release_manifest":"api/v1.1/release_manifest.json"}},"ODF2L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODF2L","identifiers":{"aliases":["KIAA1229"],"approved_symbol":"ODF2L","ensembl_gene_id":"ENSG00000122417","hgnc_id":"HGNC:29225","ncbi_gene_id":57489,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODF2L","release_manifest":"api/v1.1/release_manifest.json"}},"ODF3B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODF3B","identifiers":{"approved_symbol":"ODF3B","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODF3B","release_manifest":"api/v1.1/release_manifest.json"}},"ODF3L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODF3L1","identifiers":{"approved_symbol":"ODF3L1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODF3L1","release_manifest":"api/v1.1/release_manifest.json"}},"ODF3L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODF3L2","identifiers":{"approved_symbol":"ODF3L2","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODF3L2","release_manifest":"api/v1.1/release_manifest.json"}},"ODF4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODF4","identifiers":{"aliases":["OPPO1","CT136"],"approved_symbol":"ODF4","ensembl_gene_id":"ENSG00000184650","hgnc_id":"HGNC:19056","ncbi_gene_id":146852,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODF4","release_manifest":"api/v1.1/release_manifest.json"}},"ODR4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ODR4","identifiers":{"aliases":["FLJ20505","odr-4","TTG1"],"approved_symbol":"ODR4","ensembl_gene_id":"ENSG00000157181","hgnc_id":"HGNC:24299","ncbi_gene_id":54953,"previous_symbols":["C1orf27"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ODR4","release_manifest":"api/v1.1/release_manifest.json"}},"OFD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OFD1","identifiers":{"aliases":["71-7A","JBTS10"],"approved_symbol":"OFD1","ensembl_gene_id":"ENSG00000046651","hgnc_id":"HGNC:2567","ncbi_gene_id":8481,"previous_symbols":["CXorf5","RP23"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OFD1","release_manifest":"api/v1.1/release_manifest.json"}},"OGA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGA","identifiers":{"aliases":["MEA5","NCOAT"],"approved_symbol":"OGA","ensembl_gene_id":"ENSG00000198408","hgnc_id":"HGNC:7056","ncbi_gene_id":10724,"previous_symbols":["MGEA5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGA","release_manifest":"api/v1.1/release_manifest.json"}},"OGDH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGDH","identifiers":{"aliases":["E1k","OGDC-E1","OGDH2","KGD1"],"approved_symbol":"OGDH","ensembl_gene_id":"ENSG00000105953","hgnc_id":"HGNC:8124","ncbi_gene_id":4967,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGDH","release_manifest":"api/v1.1/release_manifest.json"}},"OGFOD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGFOD1","identifiers":{"aliases":["KIAA1612","FLJ10826","TPA1"],"approved_symbol":"OGFOD1","ensembl_gene_id":"ENSG00000087263","hgnc_id":"HGNC:25585","ncbi_gene_id":55239,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.17497,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGFOD1","release_manifest":"api/v1.1/release_manifest.json"}},"OGFOD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGFOD2","identifiers":{"aliases":["FLJ13491","FLJ37501"],"approved_symbol":"OGFOD2","ensembl_gene_id":"ENSG00000111325","hgnc_id":"HGNC:25823","ncbi_gene_id":79676,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGFOD2","release_manifest":"api/v1.1/release_manifest.json"}},"OGFOD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGFOD3","identifiers":{"aliases":["FLJ22222"],"approved_symbol":"OGFOD3","ensembl_gene_id":"ENSG00000181396","hgnc_id":"HGNC:26174","ncbi_gene_id":79701,"previous_symbols":["C17orf101"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGFOD3","release_manifest":"api/v1.1/release_manifest.json"}},"OGFR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGFR","identifiers":{"aliases":["7-60"],"approved_symbol":"OGFR","ensembl_gene_id":"ENSG00000060491","hgnc_id":"HGNC:15768","ncbi_gene_id":11054,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGFR","release_manifest":"api/v1.1/release_manifest.json"}},"OGFRL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGFRL1","identifiers":{"aliases":["dJ331H24.1"],"approved_symbol":"OGFRL1","ensembl_gene_id":"ENSG00000119900","hgnc_id":"HGNC:21378","ncbi_gene_id":79627,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OGFRL1","release_manifest":"api/v1.1/release_manifest.json"}},"OGFRP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGFRP1","identifiers":{"aliases":[],"approved_symbol":"OGFRP1","ensembl_gene_id":"ENSG00000182057","hgnc_id":"HGNC:50511","ncbi_gene_id":388906,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OGFRP1","release_manifest":"api/v1.1/release_manifest.json"}},"OGG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGG1","identifiers":{"aliases":["HMMH","HOGG1","OGH1","MUTM"],"approved_symbol":"OGG1","ensembl_gene_id":"ENSG00000114026","hgnc_id":"HGNC:8125","ncbi_gene_id":4968,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGG1","release_manifest":"api/v1.1/release_manifest.json"}},"OGN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGN","identifiers":{"aliases":["mimecan","OIF","SLRR3A"],"approved_symbol":"OGN","ensembl_gene_id":"ENSG00000106809","hgnc_id":"HGNC:8126","ncbi_gene_id":4969,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGN","release_manifest":"api/v1.1/release_manifest.json"}},"OGT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OGT","identifiers":{"aliases":["O-GLCNAC","HRNT1","MGC22921","FLJ23071","OGT1"],"approved_symbol":"OGT","ensembl_gene_id":"ENSG00000147162","hgnc_id":"HGNC:8127","ncbi_gene_id":8473,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OGT","release_manifest":"api/v1.1/release_manifest.json"}},"OIP5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OIP5","identifiers":{"aliases":["MIS18B","hMIS18beta","CT86"],"approved_symbol":"OIP5","ensembl_gene_id":"ENSG00000104147","hgnc_id":"HGNC:20300","ncbi_gene_id":11339,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OIP5","release_manifest":"api/v1.1/release_manifest.json"}},"OIP5-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OIP5-AS1","identifiers":{"aliases":["cyrano","linc-OIP5"],"approved_symbol":"OIP5-AS1","ensembl_gene_id":"ENSG00000247556","hgnc_id":"HGNC:43563","ncbi_gene_id":729082,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OIP5-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OIT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OIT3","identifiers":{"aliases":["LZP","FLJ39116"],"approved_symbol":"OIT3","ensembl_gene_id":"ENSG00000138315","hgnc_id":"HGNC:29953","ncbi_gene_id":170392,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OIT3","release_manifest":"api/v1.1/release_manifest.json"}},"OLA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLA1","identifiers":{"aliases":["PTD004"],"approved_symbol":"OLA1","ensembl_gene_id":"ENSG00000138430","hgnc_id":"HGNC:28833","ncbi_gene_id":29789,"previous_symbols":["GTPBP9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OLA1","release_manifest":"api/v1.1/release_manifest.json"}},"OLFM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLFM1","identifiers":{"aliases":["NOE1","OlfA","AMY","NOELIN"],"approved_symbol":"OLFM1","ensembl_gene_id":"ENSG00000130558","hgnc_id":"HGNC:17187","ncbi_gene_id":10439,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OLFM1","release_manifest":"api/v1.1/release_manifest.json"}},"OLFM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLFM2","identifiers":{"aliases":["OlfC","NOE2"],"approved_symbol":"OLFM2","ensembl_gene_id":"ENSG00000105088","hgnc_id":"HGNC:17189","ncbi_gene_id":93145,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OLFM2","release_manifest":"api/v1.1/release_manifest.json"}},"OLFM4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLFM4","identifiers":{"aliases":["OlfD","GW112","GC1","pDP4"],"approved_symbol":"OLFM4","ensembl_gene_id":"ENSG00000102837","hgnc_id":"HGNC:17190","ncbi_gene_id":10562,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OLFM4","release_manifest":"api/v1.1/release_manifest.json"}},"OLFML1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLFML1","identifiers":{"aliases":["UNQ564","ONT2"],"approved_symbol":"OLFML1","ensembl_gene_id":"ENSG00000183801","hgnc_id":"HGNC:24473","ncbi_gene_id":283298,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OLFML1","release_manifest":"api/v1.1/release_manifest.json"}},"OLFML2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLFML2A","identifiers":{"aliases":["FLJ00237"],"approved_symbol":"OLFML2A","ensembl_gene_id":"ENSG00000185585","hgnc_id":"HGNC:27270","ncbi_gene_id":169611,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OLFML2A","release_manifest":"api/v1.1/release_manifest.json"}},"OLFML2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLFML2B","identifiers":{"aliases":["DKFZP586L151"],"approved_symbol":"OLFML2B","ensembl_gene_id":"ENSG00000162745","hgnc_id":"HGNC:24558","ncbi_gene_id":25903,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OLFML2B","release_manifest":"api/v1.1/release_manifest.json"}},"OLFML3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLFML3","identifiers":{"aliases":["HNOEL-iso","OLF44"],"approved_symbol":"OLFML3","ensembl_gene_id":"ENSG00000116774","hgnc_id":"HGNC:24956","ncbi_gene_id":56944,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.11391,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OLFML3","release_manifest":"api/v1.1/release_manifest.json"}},"OLMALINC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLMALINC","identifiers":{"aliases":["bA34D15.5","FLJ12974","HI-LNC80"],"approved_symbol":"OLMALINC","ensembl_gene_id":"ENSG00000235823","hgnc_id":"HGNC:28060","ncbi_gene_id":90271,"previous_symbols":["C10orf75","NCRNA00263","LINC00263"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OLMALINC","release_manifest":"api/v1.1/release_manifest.json"}},"OLR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OLR1","identifiers":{"aliases":["LOX-1","SCARE1","CLEC8A"],"approved_symbol":"OLR1","ensembl_gene_id":"ENSG00000173391","hgnc_id":"HGNC:8133","ncbi_gene_id":4973,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OLR1","release_manifest":"api/v1.1/release_manifest.json"}},"OMA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OMA1","identifiers":{"aliases":["MPRP-1","YKR087C","ZMPOMA1","FLJ33782"],"approved_symbol":"OMA1","ensembl_gene_id":"ENSG00000162600","hgnc_id":"HGNC:29661","ncbi_gene_id":115209,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OMA1","release_manifest":"api/v1.1/release_manifest.json"}},"OMD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OMD","identifiers":{"aliases":["osteoadherin","SLRR2C"],"approved_symbol":"OMD","ensembl_gene_id":"ENSG00000127083","hgnc_id":"HGNC:8134","ncbi_gene_id":4958,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OMD","release_manifest":"api/v1.1/release_manifest.json"}},"OMG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OMG","identifiers":{"aliases":["OMGP"],"approved_symbol":"OMG","ensembl_gene_id":"ENSG00000126861","hgnc_id":"HGNC:8135","ncbi_gene_id":4974,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OMG","release_manifest":"api/v1.1/release_manifest.json"}},"ONECUT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ONECUT1","identifiers":{"aliases":["HNF-6"],"approved_symbol":"ONECUT1","ensembl_gene_id":"ENSG00000169856","hgnc_id":"HGNC:8138","ncbi_gene_id":3175,"previous_symbols":["HNF6","HNF6A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ONECUT1","release_manifest":"api/v1.1/release_manifest.json"}},"ONECUT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ONECUT2","identifiers":{"aliases":["OC-2"],"approved_symbol":"ONECUT2","ensembl_gene_id":"ENSG00000119547","hgnc_id":"HGNC:8139","ncbi_gene_id":9480,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/ONECUT2","release_manifest":"api/v1.1/release_manifest.json"}},"OOEP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OOEP","identifiers":{"aliases":["Em:AC019205.2","KHDC2"],"approved_symbol":"OOEP","ensembl_gene_id":"ENSG00000203907","hgnc_id":"HGNC:21382","ncbi_gene_id":441161,"previous_symbols":["C6orf156"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OOEP","release_manifest":"api/v1.1/release_manifest.json"}},"OPA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPA1","identifiers":{"aliases":["NTG","KIAA0567","FLJ12460","NPG","MGM1"],"approved_symbol":"OPA1","ensembl_gene_id":"ENSG00000198836","hgnc_id":"HGNC:8140","ncbi_gene_id":4976,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPA1","release_manifest":"api/v1.1/release_manifest.json"}},"OPA1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPA1-AS1","identifiers":{"aliases":[],"approved_symbol":"OPA1-AS1","ensembl_gene_id":"ENSG00000224855","hgnc_id":"HGNC:40421","ncbi_gene_id":100873941,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPA1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OPA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPA3","identifiers":{"aliases":["FLJ22187","MGA3"],"approved_symbol":"OPA3","ensembl_gene_id":"ENSG00000125741","hgnc_id":"HGNC:8142","ncbi_gene_id":80207,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPA3","release_manifest":"api/v1.1/release_manifest.json"}},"OPALIN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPALIN","identifiers":{"aliases":["TMP10","HTMP10"],"approved_symbol":"OPALIN","ensembl_gene_id":"ENSG00000197430","hgnc_id":"HGNC:20707","ncbi_gene_id":93377,"previous_symbols":["TMEM10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OPALIN","release_manifest":"api/v1.1/release_manifest.json"}},"OPCML":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPCML","identifiers":{"aliases":["OPCM","OBCAM","IGLON1"],"approved_symbol":"OPCML","ensembl_gene_id":"ENSG00000183715","hgnc_id":"HGNC:8143","ncbi_gene_id":4978,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPCML","release_manifest":"api/v1.1/release_manifest.json"}},"OPHN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPHN1","identifiers":{"aliases":["OPN1","ARHGAP41"],"approved_symbol":"OPHN1","ensembl_gene_id":"ENSG00000079482","hgnc_id":"HGNC:8148","ncbi_gene_id":4983,"previous_symbols":["MRX60"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPHN1","release_manifest":"api/v1.1/release_manifest.json"}},"OPLAH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPLAH","identifiers":{"aliases":["OPLA","5-Opase"],"approved_symbol":"OPLAH","ensembl_gene_id":"ENSG00000178814","hgnc_id":"HGNC:8149","ncbi_gene_id":26873,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPLAH","release_manifest":"api/v1.1/release_manifest.json"}},"OPN1SW":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPN1SW","identifiers":{"aliases":["BOP","CBT"],"approved_symbol":"OPN1SW","ensembl_gene_id":"ENSG00000128617","hgnc_id":"HGNC:1012","ncbi_gene_id":611,"previous_symbols":["BCP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPN1SW","detailed_audit_record":"gene/OPN1SW/audit","legacy_api_record":"api/v1/genes/OPN1SW.json","release_manifest":"api/v1.1/release_manifest.json"}},"OPN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPN3","identifiers":{"aliases":["ERO","NMO-1","encephalopsin","PPP1R116"],"approved_symbol":"OPN3","ensembl_gene_id":"ENSG00000054277","hgnc_id":"HGNC:14007","ncbi_gene_id":23596,"previous_symbols":["ECPN"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OPN3","release_manifest":"api/v1.1/release_manifest.json"}},"OPN4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPN4","identifiers":{"aliases":["MOP","melanopsin"],"approved_symbol":"OPN4","ensembl_gene_id":"ENSG00000122375","hgnc_id":"HGNC:14449","ncbi_gene_id":94233,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPN4","release_manifest":"api/v1.1/release_manifest.json"}},"OPN5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPN5","identifiers":{"aliases":["neuropsin","dJ402H5.1"],"approved_symbol":"OPN5","ensembl_gene_id":"ENSG00000124818","hgnc_id":"HGNC:19992","ncbi_gene_id":221391,"previous_symbols":["TMEM13"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPN5","release_manifest":"api/v1.1/release_manifest.json"}},"OPRD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPRD1","identifiers":{"aliases":[],"approved_symbol":"OPRD1","ensembl_gene_id":"ENSG00000116329","hgnc_id":"HGNC:8153","ncbi_gene_id":4985,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OPRD1","release_manifest":"api/v1.1/release_manifest.json"}},"OPRK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPRK1","identifiers":{"aliases":["KOR","OPRK"],"approved_symbol":"OPRK1","ensembl_gene_id":"ENSG00000082556","hgnc_id":"HGNC:8154","ncbi_gene_id":4986,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/OPRK1","release_manifest":"api/v1.1/release_manifest.json"}},"OPRL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPRL1","identifiers":{"aliases":["NOCIR","ORL1","OOR","KOR-3","NOPr","PNOCR"],"approved_symbol":"OPRL1","ensembl_gene_id":"ENSG00000125510","hgnc_id":"HGNC:8155","ncbi_gene_id":4987,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPRL1","release_manifest":"api/v1.1/release_manifest.json"}},"OPRM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPRM1","identifiers":{"aliases":["MOR1","MOP"],"approved_symbol":"OPRM1","ensembl_gene_id":"ENSG00000112038","hgnc_id":"HGNC:8156","ncbi_gene_id":4988,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPRM1","release_manifest":"api/v1.1/release_manifest.json"}},"OPTC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPTC","identifiers":{"aliases":[],"approved_symbol":"OPTC","ensembl_gene_id":"ENSG00000188770","hgnc_id":"HGNC:8158","ncbi_gene_id":26254,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPTC","release_manifest":"api/v1.1/release_manifest.json"}},"OPTN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OPTN","identifiers":{"aliases":["FIP2","HYPL","FIP-2","TFIIIA-INTP","NRP","HIP7"],"approved_symbol":"OPTN","ensembl_gene_id":"ENSG00000123240","hgnc_id":"HGNC:17142","ncbi_gene_id":10133,"previous_symbols":["GLC1E"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OPTN","release_manifest":"api/v1.1/release_manifest.json"}},"OR10Q1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR10Q1","identifiers":{"aliases":[],"approved_symbol":"OR10Q1","ensembl_gene_id":"ENSG00000180475","hgnc_id":"HGNC:15134","ncbi_gene_id":219960,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OR10Q1","release_manifest":"api/v1.1/release_manifest.json"}},"OR1B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR1B1","identifiers":{"aliases":["OR9-B"],"approved_symbol":"OR1B1","ensembl_gene_id":"ENSG00000280094","hgnc_id":"HGNC:8181","ncbi_gene_id":347169,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OR1B1","release_manifest":"api/v1.1/release_manifest.json"}},"OR1F1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR1F1","identifiers":{"aliases":["Olfmf","OR16-36","OR16-37","OR16-88","OR16-89","OR16-90","OLFMF","OR3-145"],"approved_symbol":"OR1F1","ensembl_gene_id":"ENSG00000168124","hgnc_id":"HGNC:8194","ncbi_gene_id":4992,"previous_symbols":["OR1F4","OR1F6","OR1F7","OR1F8","OR1F9","OR1F5","OR1F10","OR1F13P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OR1F1","release_manifest":"api/v1.1/release_manifest.json"}},"OR1L8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR1L8","identifiers":{"aliases":[],"approved_symbol":"OR1L8","ensembl_gene_id":"ENSG00000171496","hgnc_id":"HGNC:15110","ncbi_gene_id":138881,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/OR1L8","release_manifest":"api/v1.1/release_manifest.json"}},"OR2A1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR2A1-AS1","identifiers":{"aliases":[],"approved_symbol":"OR2A1-AS1","ensembl_gene_id":"ENSG00000244479","hgnc_id":"HGNC:49168","ncbi_gene_id":101928492,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OR2A1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OR2A7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR2A7","identifiers":{"aliases":["HSDJ0798C17"],"approved_symbol":"OR2A7","ensembl_gene_id":"ENSG00000243896","hgnc_id":"HGNC:8234","ncbi_gene_id":401427,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/OR2A7","release_manifest":"api/v1.1/release_manifest.json"}},"OR2B11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR2B11","identifiers":{"aliases":[],"approved_symbol":"OR2B11","ensembl_gene_id":"ENSG00000177535","hgnc_id":"HGNC:31249","ncbi_gene_id":127623,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OR2B11","release_manifest":"api/v1.1/release_manifest.json"}},"OR2C3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR2C3","identifiers":{"aliases":["OST742"],"approved_symbol":"OR2C3","ensembl_gene_id":"ENSG00000196242","hgnc_id":"HGNC:15005","ncbi_gene_id":81472,"previous_symbols":["OR2C4","OR2C5P"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OR2C3","release_manifest":"api/v1.1/release_manifest.json"}},"OR2H2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR2H2","identifiers":{"aliases":["hs6M1-12"],"approved_symbol":"OR2H2","ensembl_gene_id":"ENSG00000204657","hgnc_id":"HGNC:8253","ncbi_gene_id":7932,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OR2H2","release_manifest":"api/v1.1/release_manifest.json"}},"OR4D9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR4D9","identifiers":{"aliases":[],"approved_symbol":"OR4D9","ensembl_gene_id":"ENSG00000172742","hgnc_id":"HGNC:15178","ncbi_gene_id":390199,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OR4D9","release_manifest":"api/v1.1/release_manifest.json"}},"OR51E1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR51E1","identifiers":{"aliases":["GPR136"],"approved_symbol":"OR51E1","ensembl_gene_id":"ENSG00000180785","hgnc_id":"HGNC:15194","ncbi_gene_id":143503,"previous_symbols":["OR51E1P","OR52A3P","GPR164"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OR51E1","release_manifest":"api/v1.1/release_manifest.json"}},"OR51E2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR51E2","identifiers":{"aliases":["PSGR"],"approved_symbol":"OR51E2","ensembl_gene_id":"ENSG00000167332","hgnc_id":"HGNC:15195","ncbi_gene_id":81285,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OR51E2","release_manifest":"api/v1.1/release_manifest.json"}},"OR52H1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR52H1","identifiers":{"aliases":[],"approved_symbol":"OR52H1","ensembl_gene_id":"ENSG00000181616","hgnc_id":"HGNC:15218","ncbi_gene_id":390067,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OR52H1","release_manifest":"api/v1.1/release_manifest.json"}},"OR6Y1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR6Y1","identifiers":{"aliases":[],"approved_symbol":"OR6Y1","ensembl_gene_id":"ENSG00000197532","hgnc_id":"HGNC:14823","ncbi_gene_id":391112,"previous_symbols":["OR6Y2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/OR6Y1","release_manifest":"api/v1.1/release_manifest.json"}},"OR7D2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR7D2","identifiers":{"aliases":["OR19-4","HTPCRH03","FLJ38149"],"approved_symbol":"OR7D2","ensembl_gene_id":"ENSG00000188000","hgnc_id":"HGNC:8378","ncbi_gene_id":162998,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OR7D2","release_manifest":"api/v1.1/release_manifest.json"}},"OR9Q1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OR9Q1","identifiers":{"aliases":[],"approved_symbol":"OR9Q1","ensembl_gene_id":"ENSG00000186509","hgnc_id":"HGNC:14724","ncbi_gene_id":219956,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OR9Q1","release_manifest":"api/v1.1/release_manifest.json"}},"ORAI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORAI1","identifiers":{"aliases":["FLJ14466","CRACM1"],"approved_symbol":"ORAI1","ensembl_gene_id":"ENSG00000276045","hgnc_id":"HGNC:25896","ncbi_gene_id":84876,"previous_symbols":["TMEM142A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORAI1","release_manifest":"api/v1.1/release_manifest.json"}},"ORAI2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORAI2","identifiers":{"aliases":["CBCIP2","FLJ12474","FLJ14733","H_NH0514P08.8"],"approved_symbol":"ORAI2","ensembl_gene_id":"ENSG00000160991","hgnc_id":"HGNC:21667","ncbi_gene_id":80228,"previous_symbols":["C7orf19","TMEM142B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORAI2","release_manifest":"api/v1.1/release_manifest.json"}},"ORAI3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORAI3","identifiers":{"aliases":["MGC13024"],"approved_symbol":"ORAI3","ensembl_gene_id":"ENSG00000175938","hgnc_id":"HGNC:28185","ncbi_gene_id":93129,"previous_symbols":["TMEM142C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORAI3","release_manifest":"api/v1.1/release_manifest.json"}},"ORC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORC1","identifiers":{"aliases":["HSORC1","PARC1"],"approved_symbol":"ORC1","ensembl_gene_id":"ENSG00000085840","hgnc_id":"HGNC:8487","ncbi_gene_id":4998,"previous_symbols":["ORC1L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORC1","release_manifest":"api/v1.1/release_manifest.json"}},"ORC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORC2","identifiers":{"aliases":[],"approved_symbol":"ORC2","ensembl_gene_id":"ENSG00000115942","hgnc_id":"HGNC:8488","ncbi_gene_id":4999,"previous_symbols":["ORC2L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORC2","release_manifest":"api/v1.1/release_manifest.json"}},"ORC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORC3","identifiers":{"aliases":["IMAGE50150","LATHEO"],"approved_symbol":"ORC3","ensembl_gene_id":"ENSG00000135336","hgnc_id":"HGNC:8489","ncbi_gene_id":23595,"previous_symbols":["ORC3L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.15049,"fdr":0.593677,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/ORC3","release_manifest":"api/v1.1/release_manifest.json"}},"ORC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORC4","identifiers":{"aliases":["HsORC4","Orc4p"],"approved_symbol":"ORC4","ensembl_gene_id":"ENSG00000115947","hgnc_id":"HGNC:8490","ncbi_gene_id":5000,"previous_symbols":["ORC4L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORC4","release_manifest":"api/v1.1/release_manifest.json"}},"ORC5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORC5","identifiers":{"aliases":["Orc5p","ORC5T","PPP1R117"],"approved_symbol":"ORC5","ensembl_gene_id":"ENSG00000164815","hgnc_id":"HGNC:8491","ncbi_gene_id":5001,"previous_symbols":["ORC5L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORC5","release_manifest":"api/v1.1/release_manifest.json"}},"ORC6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORC6","identifiers":{"aliases":[],"approved_symbol":"ORC6","ensembl_gene_id":"ENSG00000091651","hgnc_id":"HGNC:17151","ncbi_gene_id":23594,"previous_symbols":["ORC6L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORC6","release_manifest":"api/v1.1/release_manifest.json"}},"ORMDL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORMDL1","identifiers":{"aliases":[],"approved_symbol":"ORMDL1","ensembl_gene_id":"ENSG00000128699","hgnc_id":"HGNC:16036","ncbi_gene_id":94101,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORMDL1","release_manifest":"api/v1.1/release_manifest.json"}},"ORMDL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORMDL2","identifiers":{"aliases":["HSPC160","adoplin-2","MST095","MSTP095"],"approved_symbol":"ORMDL2","ensembl_gene_id":"ENSG00000123353","hgnc_id":"HGNC:16037","ncbi_gene_id":29095,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORMDL2","release_manifest":"api/v1.1/release_manifest.json"}},"ORMDL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ORMDL3","identifiers":{"aliases":[],"approved_symbol":"ORMDL3","ensembl_gene_id":"ENSG00000172057","hgnc_id":"HGNC:16038","ncbi_gene_id":94103,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ORMDL3","release_manifest":"api/v1.1/release_manifest.json"}},"OS9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OS9","identifiers":{"aliases":["OS-9","ERLEC2"],"approved_symbol":"OS9","ensembl_gene_id":"ENSG00000135506","hgnc_id":"HGNC:16994","ncbi_gene_id":10956,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OS9","release_manifest":"api/v1.1/release_manifest.json"}},"OSBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBP","identifiers":{"aliases":["OSBP1"],"approved_symbol":"OSBP","ensembl_gene_id":"ENSG00000110048","hgnc_id":"HGNC:8503","ncbi_gene_id":5007,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OSBP","release_manifest":"api/v1.1/release_manifest.json"}},"OSBP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBP2","identifiers":{"aliases":["KIAA1664","ORP-4","ORP4"],"approved_symbol":"OSBP2","ensembl_gene_id":"ENSG00000184792","hgnc_id":"HGNC:8504","ncbi_gene_id":23762,"previous_symbols":["OSBPL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBP2","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL10","identifiers":{"aliases":[],"approved_symbol":"OSBPL10","ensembl_gene_id":"ENSG00000144645","hgnc_id":"HGNC:16395","ncbi_gene_id":114884,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL10","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL10-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL10-AS1","identifiers":{"aliases":[],"approved_symbol":"OSBPL10-AS1","ensembl_gene_id":"ENSG00000232490","hgnc_id":"HGNC:40767","ncbi_gene_id":100874206,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OSBPL10-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL11","identifiers":{"aliases":["ORP-11","ORP11","FLJ13012","FLJ13164"],"approved_symbol":"OSBPL11","ensembl_gene_id":"ENSG00000144909","hgnc_id":"HGNC:16397","ncbi_gene_id":114885,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL11","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL1A","identifiers":{"aliases":["ORP-1","ORP1"],"approved_symbol":"OSBPL1A","ensembl_gene_id":"ENSG00000141447","hgnc_id":"HGNC:16398","ncbi_gene_id":114876,"previous_symbols":["OSBPL1B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL1A","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL2","identifiers":{"aliases":["KIAA0772","ORP-2","DFNA67"],"approved_symbol":"OSBPL2","ensembl_gene_id":"ENSG00000130703","hgnc_id":"HGNC:15761","ncbi_gene_id":9885,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OSBPL2","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL3","identifiers":{"aliases":["ORP-3","ORP3","KIAA0704"],"approved_symbol":"OSBPL3","ensembl_gene_id":"ENSG00000070882","hgnc_id":"HGNC:16370","ncbi_gene_id":26031,"previous_symbols":["OSBP3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL3","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL5","identifiers":{"aliases":["KIAA1534","ORP5","OBPH1"],"approved_symbol":"OSBPL5","ensembl_gene_id":"ENSG00000021762","hgnc_id":"HGNC:16392","ncbi_gene_id":114879,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL5","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL6","identifiers":{"aliases":["ORP6"],"approved_symbol":"OSBPL6","ensembl_gene_id":"ENSG00000079156","hgnc_id":"HGNC:16388","ncbi_gene_id":114880,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL6","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL7","identifiers":{"aliases":["ORP7","MGC71150"],"approved_symbol":"OSBPL7","ensembl_gene_id":"ENSG00000006025","hgnc_id":"HGNC:16387","ncbi_gene_id":114881,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OSBPL7","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL8","identifiers":{"aliases":["OSBP10","ORP8","MST120","MSTP120"],"approved_symbol":"OSBPL8","ensembl_gene_id":"ENSG00000091039","hgnc_id":"HGNC:16396","ncbi_gene_id":114882,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL8","release_manifest":"api/v1.1/release_manifest.json"}},"OSBPL9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSBPL9","identifiers":{"aliases":[],"approved_symbol":"OSBPL9","ensembl_gene_id":"ENSG00000117859","hgnc_id":"HGNC:16386","ncbi_gene_id":114883,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSBPL9","release_manifest":"api/v1.1/release_manifest.json"}},"OSCAR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSCAR","identifiers":{"aliases":[],"approved_symbol":"OSCAR","ensembl_gene_id":"ENSG00000170909","hgnc_id":"HGNC:29960","ncbi_gene_id":126014,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSCAR","release_manifest":"api/v1.1/release_manifest.json"}},"OSCP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSCP1","identifiers":{"aliases":["NOR1"],"approved_symbol":"OSCP1","ensembl_gene_id":"ENSG00000116885","hgnc_id":"HGNC:29971","ncbi_gene_id":127700,"previous_symbols":["C1orf102"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSCP1","release_manifest":"api/v1.1/release_manifest.json"}},"OSER1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSER1","identifiers":{"aliases":["dJ1183I21.1","HSPC207","Perit1","Osr1"],"approved_symbol":"OSER1","ensembl_gene_id":"ENSG00000132823","hgnc_id":"HGNC:16105","ncbi_gene_id":51526,"previous_symbols":["C20orf111"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSER1","release_manifest":"api/v1.1/release_manifest.json"}},"OSER1-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSER1-DT","identifiers":{"aliases":[],"approved_symbol":"OSER1-DT","ensembl_gene_id":"ENSG00000223891","hgnc_id":"HGNC:48585","ncbi_gene_id":100505783,"previous_symbols":["OSER1-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSER1-DT","release_manifest":"api/v1.1/release_manifest.json"}},"OSGEP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSGEP","identifiers":{"aliases":["PRSMG1","GCPL1","OSGEP1","KAE1","TCS3"],"approved_symbol":"OSGEP","ensembl_gene_id":"ENSG00000092094","hgnc_id":"HGNC:18028","ncbi_gene_id":55644,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OSGEP","release_manifest":"api/v1.1/release_manifest.json"}},"OSGEPL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSGEPL1","identifiers":{"aliases":["Qri7","OSGEPL"],"approved_symbol":"OSGEPL1","ensembl_gene_id":"ENSG00000128694","hgnc_id":"HGNC:23075","ncbi_gene_id":64172,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSGEPL1","release_manifest":"api/v1.1/release_manifest.json"}},"OSGEPL1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSGEPL1-AS1","identifiers":{"aliases":[],"approved_symbol":"OSGEPL1-AS1","ensembl_gene_id":"ENSG00000253559","hgnc_id":"HGNC:41009","ncbi_gene_id":101409258,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OSGEPL1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OSGIN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSGIN1","identifiers":{"aliases":["BDGI","OKL38"],"approved_symbol":"OSGIN1","ensembl_gene_id":"ENSG00000140961","hgnc_id":"HGNC:30093","ncbi_gene_id":29948,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSGIN1","release_manifest":"api/v1.1/release_manifest.json"}},"OSGIN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSGIN2","identifiers":{"aliases":["hT41"],"approved_symbol":"OSGIN2","ensembl_gene_id":"ENSG00000164823","hgnc_id":"HGNC:1355","ncbi_gene_id":734,"previous_symbols":["C8orf1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OSGIN2","release_manifest":"api/v1.1/release_manifest.json"}},"OSM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSM","identifiers":{"aliases":["MGC20461"],"approved_symbol":"OSM","ensembl_gene_id":"ENSG00000099985","hgnc_id":"HGNC:8506","ncbi_gene_id":5008,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSM","release_manifest":"api/v1.1/release_manifest.json"}},"OSMR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSMR","identifiers":{"aliases":["OSMRB","OSMRbeta"],"approved_symbol":"OSMR","ensembl_gene_id":"ENSG00000145623","hgnc_id":"HGNC:8507","ncbi_gene_id":9180,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSMR","release_manifest":"api/v1.1/release_manifest.json"}},"OSR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSR1","identifiers":{"aliases":[],"approved_symbol":"OSR1","ensembl_gene_id":"ENSG00000143867","hgnc_id":"HGNC:8111","ncbi_gene_id":130497,"previous_symbols":["ODD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSR1","release_manifest":"api/v1.1/release_manifest.json"}},"OSR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSR2","identifiers":{"aliases":["FLJ90037"],"approved_symbol":"OSR2","ensembl_gene_id":"ENSG00000164920","hgnc_id":"HGNC:15830","ncbi_gene_id":116039,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSR2","release_manifest":"api/v1.1/release_manifest.json"}},"OST4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OST4","identifiers":{"aliases":[],"approved_symbol":"OST4","ensembl_gene_id":"ENSG00000228474","hgnc_id":"HGNC:32483","ncbi_gene_id":100128731,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OST4","release_manifest":"api/v1.1/release_manifest.json"}},"OSTC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSTC","identifiers":{"aliases":["DC2"],"approved_symbol":"OSTC","ensembl_gene_id":"ENSG00000198856","hgnc_id":"HGNC:24448","ncbi_gene_id":58505,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSTC","release_manifest":"api/v1.1/release_manifest.json"}},"OSTF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSTF1","identifiers":{"aliases":["SH3P2","OSF","bA235O14.1"],"approved_symbol":"OSTF1","ensembl_gene_id":"ENSG00000134996","hgnc_id":"HGNC:8510","ncbi_gene_id":26578,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSTF1","release_manifest":"api/v1.1/release_manifest.json"}},"OSTM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSTM1","identifiers":{"aliases":["HSPC019","GL"],"approved_symbol":"OSTM1","ensembl_gene_id":"ENSG00000081087","hgnc_id":"HGNC:21652","ncbi_gene_id":28962,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OSTM1","release_manifest":"api/v1.1/release_manifest.json"}},"OSTN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OSTN","identifiers":{"aliases":[],"approved_symbol":"OSTN","ensembl_gene_id":"ENSG00000188729","hgnc_id":"HGNC:29961","ncbi_gene_id":344901,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OSTN","release_manifest":"api/v1.1/release_manifest.json"}},"OTC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTC","identifiers":{"aliases":["OTCase","OTCD","OTC1"],"approved_symbol":"OTC","ensembl_gene_id":"ENSG00000036473","hgnc_id":"HGNC:8512","ncbi_gene_id":5009,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OTC","release_manifest":"api/v1.1/release_manifest.json"}},"OTOA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTOA","identifiers":{"aliases":["CT108"],"approved_symbol":"OTOA","ensembl_gene_id":"ENSG00000155719","hgnc_id":"HGNC:16378","ncbi_gene_id":146183,"previous_symbols":["DFNB22"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTOA","release_manifest":"api/v1.1/release_manifest.json"}},"OTOF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTOF","identifiers":{"aliases":["FER1L2","DFNB6"],"approved_symbol":"OTOF","ensembl_gene_id":"ENSG00000115155","hgnc_id":"HGNC:8515","ncbi_gene_id":9381,"previous_symbols":["DFNB9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTOF","release_manifest":"api/v1.1/release_manifest.json"}},"OTOGL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTOGL","identifiers":{"aliases":["FLJ90579"],"approved_symbol":"OTOGL","ensembl_gene_id":"ENSG00000165899","hgnc_id":"HGNC:26901","ncbi_gene_id":283310,"previous_symbols":["C12orf64"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTOGL","release_manifest":"api/v1.1/release_manifest.json"}},"OTOP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTOP3","identifiers":{"aliases":[],"approved_symbol":"OTOP3","ensembl_gene_id":"ENSG00000182938","hgnc_id":"HGNC:19658","ncbi_gene_id":347741,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OTOP3","release_manifest":"api/v1.1/release_manifest.json"}},"OTOR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTOR","identifiers":{"aliases":["MIAL","MIAL1","FDP"],"approved_symbol":"OTOR","ensembl_gene_id":"ENSG00000125879","hgnc_id":"HGNC:8517","ncbi_gene_id":56914,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/OTOR","release_manifest":"api/v1.1/release_manifest.json"}},"OTUB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUB1","identifiers":{"aliases":["FLJ20113","FLJ40710"],"approved_symbol":"OTUB1","ensembl_gene_id":"ENSG00000167770","hgnc_id":"HGNC:23077","ncbi_gene_id":55611,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTUB1","release_manifest":"api/v1.1/release_manifest.json"}},"OTUB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUB2","identifiers":{"aliases":["FLJ21916","MGC3102"],"approved_symbol":"OTUB2","ensembl_gene_id":"ENSG00000089723","hgnc_id":"HGNC:20351","ncbi_gene_id":78990,"previous_symbols":["C14orf137"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTUB2","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD1","identifiers":{"aliases":["DUBA7"],"approved_symbol":"OTUD1","ensembl_gene_id":"ENSG00000165312","hgnc_id":"HGNC:27346","ncbi_gene_id":220213,"previous_symbols":["OTDC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTUD1","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD3","identifiers":{"aliases":["KIAA0459","DUBA4"],"approved_symbol":"OTUD3","ensembl_gene_id":"ENSG00000169914","hgnc_id":"HGNC:29038","ncbi_gene_id":23252,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTUD3","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD4","identifiers":{"aliases":["HSHIN1","KIAA1046","DUBA6"],"approved_symbol":"OTUD4","ensembl_gene_id":"ENSG00000164164","hgnc_id":"HGNC:24949","ncbi_gene_id":54726,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OTUD4","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD5","identifiers":{"aliases":["DKFZp761A052","DUBA"],"approved_symbol":"OTUD5","ensembl_gene_id":"ENSG00000068308","hgnc_id":"HGNC:25402","ncbi_gene_id":55593,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OTUD5","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD6B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD6B","identifiers":{"aliases":["CGI-77","DUBA5"],"approved_symbol":"OTUD6B","ensembl_gene_id":"ENSG00000155100","hgnc_id":"HGNC:24281","ncbi_gene_id":51633,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTUD6B","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD6B-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD6B-AS1","identifiers":{"aliases":["GS1-251I9.4"],"approved_symbol":"OTUD6B-AS1","ensembl_gene_id":"ENSG00000253738","hgnc_id":"HGNC:50466","ncbi_gene_id":100506365,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTUD6B-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD7A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD7A","identifiers":{"aliases":["CEZANNE2"],"approved_symbol":"OTUD7A","ensembl_gene_id":"ENSG00000169918","hgnc_id":"HGNC:20718","ncbi_gene_id":161725,"previous_symbols":["C15orf16","OTUD7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTUD7A","release_manifest":"api/v1.1/release_manifest.json"}},"OTUD7B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTUD7B","identifiers":{"aliases":["CEZANNE"],"approved_symbol":"OTUD7B","ensembl_gene_id":"ENSG00000264522","hgnc_id":"HGNC:16683","ncbi_gene_id":56957,"previous_symbols":["ZA20D1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OTUD7B","release_manifest":"api/v1.1/release_manifest.json"}},"OTULIN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTULIN","identifiers":{"aliases":["FLJ34884"],"approved_symbol":"OTULIN","ensembl_gene_id":"ENSG00000154124","hgnc_id":"HGNC:25118","ncbi_gene_id":90268,"previous_symbols":["FAM105B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/OTULIN","release_manifest":"api/v1.1/release_manifest.json"}},"OTULINL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OTULINL","identifiers":{"aliases":["FLJ11127","NET20"],"approved_symbol":"OTULINL","ensembl_gene_id":"ENSG00000145569","hgnc_id":"HGNC:25629","ncbi_gene_id":54491,"previous_symbols":["FAM105A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OTULINL","release_manifest":"api/v1.1/release_manifest.json"}},"OVCA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OVCA2","identifiers":{"aliases":[],"approved_symbol":"OVCA2","ensembl_gene_id":"ENSG00000262664","hgnc_id":"HGNC:24203","ncbi_gene_id":124641,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.035277,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OVCA2","release_manifest":"api/v1.1/release_manifest.json"}},"OVCH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OVCH1","identifiers":{"aliases":["OVCH"],"approved_symbol":"OVCH1","ensembl_gene_id":"ENSG00000187950","hgnc_id":"HGNC:23080","ncbi_gene_id":341350,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OVCH1","release_manifest":"api/v1.1/release_manifest.json"}},"OVCH1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OVCH1-AS1","identifiers":{"aliases":[],"approved_symbol":"OVCH1-AS1","ensembl_gene_id":"ENSG00000257599","hgnc_id":"HGNC:44484","ncbi_gene_id":101055625,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OVCH1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"OVCH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OVCH2","identifiers":{"aliases":["OVTN"],"approved_symbol":"OVCH2","ensembl_gene_id":"ENSG00000183378","hgnc_id":"HGNC:29970","ncbi_gene_id":341277,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OVCH2","release_manifest":"api/v1.1/release_manifest.json"}},"OVGP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OVGP1","identifiers":{"aliases":["CHIT5","OGP"],"approved_symbol":"OVGP1","ensembl_gene_id":"ENSG00000085465","hgnc_id":"HGNC:8524","ncbi_gene_id":5016,"previous_symbols":["MUC9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OVGP1","release_manifest":"api/v1.1/release_manifest.json"}},"OVOL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OVOL2","identifiers":{"aliases":["bA504H3.3","HOVO2","CHED"],"approved_symbol":"OVOL2","ensembl_gene_id":"ENSG00000125850","hgnc_id":"HGNC:15804","ncbi_gene_id":58495,"previous_symbols":["ZNF339","CHED1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OVOL2","release_manifest":"api/v1.1/release_manifest.json"}},"OVOL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OVOL3","identifiers":{"aliases":["HOVO3"],"approved_symbol":"OVOL3","ensembl_gene_id":"ENSG00000105261","hgnc_id":"HGNC:14186","ncbi_gene_id":728361,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/OVOL3","release_manifest":"api/v1.1/release_manifest.json"}},"OXA1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXA1L","identifiers":{"aliases":["MGC133129","OXA1","OXA1L1"],"approved_symbol":"OXA1L","ensembl_gene_id":"ENSG00000155463","hgnc_id":"HGNC:8526","ncbi_gene_id":5018,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXA1L","release_manifest":"api/v1.1/release_manifest.json"}},"OXCT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXCT1","identifiers":{"aliases":["SCOT"],"approved_symbol":"OXCT1","ensembl_gene_id":"ENSG00000083720","hgnc_id":"HGNC:8527","ncbi_gene_id":5019,"previous_symbols":["OXCT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXCT1","release_manifest":"api/v1.1/release_manifest.json"}},"OXCT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXCT2","identifiers":{"aliases":["FKSG25","FLJ00030","SCOT-T"],"approved_symbol":"OXCT2","ensembl_gene_id":"ENSG00000198754","hgnc_id":"HGNC:18606","ncbi_gene_id":64064,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OXCT2","release_manifest":"api/v1.1/release_manifest.json"}},"OXER1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXER1","identifiers":{"aliases":["GPCR","TG1019","GPR170"],"approved_symbol":"OXER1","ensembl_gene_id":"ENSG00000162881","hgnc_id":"HGNC:24884","ncbi_gene_id":165140,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXER1","release_manifest":"api/v1.1/release_manifest.json"}},"OXLD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXLD1","identifiers":{"aliases":["MGC104712"],"approved_symbol":"OXLD1","ensembl_gene_id":"ENSG00000204237","hgnc_id":"HGNC:27901","ncbi_gene_id":339229,"previous_symbols":["C17orf90"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXLD1","release_manifest":"api/v1.1/release_manifest.json"}},"OXNAD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXNAD1","identifiers":{"aliases":["MGC15763"],"approved_symbol":"OXNAD1","ensembl_gene_id":"ENSG00000154814","hgnc_id":"HGNC:25128","ncbi_gene_id":92106,"previous_symbols":["RFTN1-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXNAD1","release_manifest":"api/v1.1/release_manifest.json"}},"OXR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXR1","identifiers":{"aliases":["TLDC3"],"approved_symbol":"OXR1","ensembl_gene_id":"ENSG00000164830","hgnc_id":"HGNC:15822","ncbi_gene_id":55074,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXR1","release_manifest":"api/v1.1/release_manifest.json"}},"OXSM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXSM","identifiers":{"aliases":["KS","FLJ20604","FASN2D","CEM1"],"approved_symbol":"OXSM","ensembl_gene_id":"ENSG00000151093","hgnc_id":"HGNC:26063","ncbi_gene_id":54995,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXSM","release_manifest":"api/v1.1/release_manifest.json"}},"OXSR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXSR1","identifiers":{"aliases":["KIAA1101"],"approved_symbol":"OXSR1","ensembl_gene_id":"ENSG00000172939","hgnc_id":"HGNC:8508","ncbi_gene_id":9943,"previous_symbols":["OSR1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXSR1","release_manifest":"api/v1.1/release_manifest.json"}},"OXT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXT","identifiers":{"aliases":["OXT-NPI","OT-NPI"],"approved_symbol":"OXT","ensembl_gene_id":"ENSG00000101405","hgnc_id":"HGNC:8528","ncbi_gene_id":5020,"previous_symbols":["OT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/OXT","release_manifest":"api/v1.1/release_manifest.json"}},"OXTR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"OXTR","identifiers":{"aliases":["OTR"],"approved_symbol":"OXTR","ensembl_gene_id":"ENSG00000180914","hgnc_id":"HGNC:8529","ncbi_gene_id":5021,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/OXTR","release_manifest":"api/v1.1/release_manifest.json"}}}
