{"M1AP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"M1AP","identifiers":{"aliases":["D6Mm5e","SPATA37"],"approved_symbol":"M1AP","ensembl_gene_id":"ENSG00000159374","hgnc_id":"HGNC:25183","ncbi_gene_id":130951,"previous_symbols":["C2orf65"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/M1AP","release_manifest":"api/v1.1/release_manifest.json"}},"M6PR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"M6PR","identifiers":{"aliases":["CD-MPR","CD-M6PR"],"approved_symbol":"M6PR","ensembl_gene_id":"ENSG00000003056","hgnc_id":"HGNC:6752","ncbi_gene_id":4074,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/M6PR","release_manifest":"api/v1.1/release_manifest.json"}},"MAATS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAATS1","identifiers":{"approved_symbol":"MAATS1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MAATS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAB21L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAB21L1","identifiers":{"aliases":["CAGR1"],"approved_symbol":"MAB21L1","ensembl_gene_id":"ENSG00000180660","hgnc_id":"HGNC:6757","ncbi_gene_id":4081,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAB21L1","release_manifest":"api/v1.1/release_manifest.json"}},"MAB21L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAB21L2","identifiers":{"aliases":[],"approved_symbol":"MAB21L2","ensembl_gene_id":"ENSG00000181541","hgnc_id":"HGNC:6758","ncbi_gene_id":10586,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MAB21L2","release_manifest":"api/v1.1/release_manifest.json"}},"MAB21L3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAB21L3","identifiers":{"aliases":["FLJ38716","D5"],"approved_symbol":"MAB21L3","ensembl_gene_id":"ENSG00000173212","hgnc_id":"HGNC:26787","ncbi_gene_id":126868,"previous_symbols":["C1orf161"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MAB21L3","release_manifest":"api/v1.1/release_manifest.json"}},"MACC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MACC1","identifiers":{"aliases":["7A5","SH3BP4L"],"approved_symbol":"MACC1","ensembl_gene_id":"ENSG00000183742","hgnc_id":"HGNC:30215","ncbi_gene_id":346389,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MACC1","release_manifest":"api/v1.1/release_manifest.json"}},"MACF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MACF1","identifiers":{"aliases":["KIAA0465","ACF7","ABP620","KIAA1251","MACF","FLJ45612","FLJ46776","Lnc-PMIF"],"approved_symbol":"MACF1","ensembl_gene_id":"ENSG00000127603","hgnc_id":"HGNC:13664","ncbi_gene_id":23499,"previous_symbols":["KIAA0754"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MACF1","release_manifest":"api/v1.1/release_manifest.json"}},"MACO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MACO1","identifiers":{"aliases":["FLJ10747"],"approved_symbol":"MACO1","ensembl_gene_id":"ENSG00000204178","hgnc_id":"HGNC:25572","ncbi_gene_id":55219,"previous_symbols":["TMEM57"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MACO1","release_manifest":"api/v1.1/release_manifest.json"}},"MACORIS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MACORIS","identifiers":{"aliases":[],"approved_symbol":"MACORIS","ensembl_gene_id":"ENSG00000237797","hgnc_id":"HGNC:53963","ncbi_gene_id":101929951,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MACORIS","release_manifest":"api/v1.1/release_manifest.json"}},"MACROD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MACROD1","identifiers":{"aliases":["LRP16"],"approved_symbol":"MACROD1","ensembl_gene_id":"ENSG00000133315","hgnc_id":"HGNC:29598","ncbi_gene_id":28992,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MACROD1","release_manifest":"api/v1.1/release_manifest.json"}},"MACROD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MACROD2","identifiers":{"aliases":["dJ631M13.5"],"approved_symbol":"MACROD2","ensembl_gene_id":"ENSG00000172264","hgnc_id":"HGNC:16126","ncbi_gene_id":140733,"previous_symbols":["C20orf133"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MACROD2","release_manifest":"api/v1.1/release_manifest.json"}},"MACROD2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MACROD2-AS1","identifiers":{"aliases":["BA318C17.1"],"approved_symbol":"MACROD2-AS1","ensembl_gene_id":"ENSG00000235914","hgnc_id":"HGNC:37193","ncbi_gene_id":100379174,"previous_symbols":["NCRNA00186"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MACROD2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAD1L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAD1L1","identifiers":{"aliases":["HsMAD1","TXBP181","MAD1","PIG9","TP53I9"],"approved_symbol":"MAD1L1","ensembl_gene_id":"ENSG00000002822","hgnc_id":"HGNC:6762","ncbi_gene_id":8379,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAD1L1","release_manifest":"api/v1.1/release_manifest.json"}},"MAD2L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAD2L1","identifiers":{"aliases":["MAD2","HSMAD2"],"approved_symbol":"MAD2L1","ensembl_gene_id":"ENSG00000164109","hgnc_id":"HGNC:6763","ncbi_gene_id":4085,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAD2L1","release_manifest":"api/v1.1/release_manifest.json"}},"MAD2L1BP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAD2L1BP","identifiers":{"aliases":["CMT2","KIAA0110","dJ261G23.1","p31comet"],"approved_symbol":"MAD2L1BP","ensembl_gene_id":"ENSG00000124688","hgnc_id":"HGNC:21059","ncbi_gene_id":9587,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAD2L1BP","release_manifest":"api/v1.1/release_manifest.json"}},"MAD2L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAD2L2","identifiers":{"aliases":["MAD2B","REV7","POLZ2","FANCV"],"approved_symbol":"MAD2L2","ensembl_gene_id":"ENSG00000116670","hgnc_id":"HGNC:6764","ncbi_gene_id":10459,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAD2L2","release_manifest":"api/v1.1/release_manifest.json"}},"MADCAM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MADCAM1","identifiers":{"aliases":["MACAM1"],"approved_symbol":"MADCAM1","ensembl_gene_id":"ENSG00000099866","hgnc_id":"HGNC:6765","ncbi_gene_id":8174,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MADCAM1","release_manifest":"api/v1.1/release_manifest.json"}},"MADD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MADD","identifiers":{"aliases":["DENN","KIAA0358","RAB3GEP","IG20"],"approved_symbol":"MADD","ensembl_gene_id":"ENSG00000110514","hgnc_id":"HGNC:6766","ncbi_gene_id":8567,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MADD","release_manifest":"api/v1.1/release_manifest.json"}},"MAEA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAEA","identifiers":{"aliases":["EMP","GID9","p44EMLP","HLC-10"],"approved_symbol":"MAEA","ensembl_gene_id":"ENSG00000090316","hgnc_id":"HGNC:13731","ncbi_gene_id":10296,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAEA","release_manifest":"api/v1.1/release_manifest.json"}},"MAEL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAEL","identifiers":{"aliases":["FLJ14904","CT128","SPATA35"],"approved_symbol":"MAEL","ensembl_gene_id":"ENSG00000143194","hgnc_id":"HGNC:25929","ncbi_gene_id":84944,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MAEL","release_manifest":"api/v1.1/release_manifest.json"}},"MAF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAF","identifiers":{"aliases":["c-MAF"],"approved_symbol":"MAF","ensembl_gene_id":"ENSG00000178573","hgnc_id":"HGNC:6776","ncbi_gene_id":4094,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAF","release_manifest":"api/v1.1/release_manifest.json"}},"MAF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAF1","identifiers":{"aliases":["DKFZp586G1123"],"approved_symbol":"MAF1","ensembl_gene_id":"ENSG00000179632","hgnc_id":"HGNC:24966","ncbi_gene_id":84232,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAF1","release_manifest":"api/v1.1/release_manifest.json"}},"MAFA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFA","identifiers":{"aliases":["RIPE3b1","hMafA"],"approved_symbol":"MAFA","ensembl_gene_id":"ENSG00000182759","hgnc_id":"HGNC:23145","ncbi_gene_id":389692,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAFA","release_manifest":"api/v1.1/release_manifest.json"}},"MAFA-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFA-AS1","identifiers":{"aliases":["RP11-909N17.2","RP11-909N17.3","TCONS_00014882"],"approved_symbol":"MAFA-AS1","ensembl_gene_id":"ENSG00000254338","hgnc_id":"HGNC:51203","ncbi_gene_id":104326051,"previous_symbols":["LINC02990"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MAFA-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAFB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFB","identifiers":{"aliases":[],"approved_symbol":"MAFB","ensembl_gene_id":"ENSG00000204103","hgnc_id":"HGNC:6408","ncbi_gene_id":9935,"previous_symbols":["KRML"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAFB","release_manifest":"api/v1.1/release_manifest.json"}},"MAFF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFF","identifiers":{"aliases":["hMafF"],"approved_symbol":"MAFF","ensembl_gene_id":"ENSG00000185022","hgnc_id":"HGNC:6780","ncbi_gene_id":23764,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAFF","release_manifest":"api/v1.1/release_manifest.json"}},"MAFG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFG","identifiers":{"aliases":["MGC13090","MGC20149"],"approved_symbol":"MAFG","ensembl_gene_id":"ENSG00000197063","hgnc_id":"HGNC:6781","ncbi_gene_id":4097,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAFG","release_manifest":"api/v1.1/release_manifest.json"}},"MAFIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFIP","identifiers":{"aliases":["FLJ35473","FLJ00219","FLJ39633","MIP","pp5644","TEKT4P4"],"approved_symbol":"MAFIP","ensembl_gene_id":"ENSG00000274847","hgnc_id":"HGNC:31102","ncbi_gene_id":727764,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAFIP","release_manifest":"api/v1.1/release_manifest.json"}},"MAFK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFK","identifiers":{"aliases":["P18","NFE2U"],"approved_symbol":"MAFK","ensembl_gene_id":"ENSG00000198517","hgnc_id":"HGNC:6782","ncbi_gene_id":7975,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAFK","release_manifest":"api/v1.1/release_manifest.json"}},"MAFTRR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAFTRR","identifiers":{"aliases":["linc-MAF-4"],"approved_symbol":"MAFTRR","ensembl_gene_id":"ENSG00000261390","hgnc_id":"HGNC:51525","ncbi_gene_id":102467146,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAFTRR","release_manifest":"api/v1.1/release_manifest.json"}},"MAG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAG","identifiers":{"aliases":["SIGLEC4A","SIGLEC-4A","S-MAG","SIGLEC4"],"approved_symbol":"MAG","ensembl_gene_id":"ENSG00000105695","hgnc_id":"HGNC:6783","ncbi_gene_id":4099,"previous_symbols":["GMA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MAG","release_manifest":"api/v1.1/release_manifest.json"}},"MAGEC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGEC3","identifiers":{"aliases":["HCA2","MAGE-C3","CT7.2"],"approved_symbol":"MAGEC3","ensembl_gene_id":"ENSG00000165509","hgnc_id":"HGNC:23798","ncbi_gene_id":139081,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MAGEC3","release_manifest":"api/v1.1/release_manifest.json"}},"MAGED1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGED1","identifiers":{"aliases":["NRAGE","DLXIN-1"],"approved_symbol":"MAGED1","ensembl_gene_id":"ENSG00000179222","hgnc_id":"HGNC:6813","ncbi_gene_id":9500,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGED1","release_manifest":"api/v1.1/release_manifest.json"}},"MAGED2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGED2","identifiers":{"aliases":["JCL-1","BCG1","11B6","MAGE-D2","HCA10","MAGED","MGC8386"],"approved_symbol":"MAGED2","ensembl_gene_id":"ENSG00000102316","hgnc_id":"HGNC:16353","ncbi_gene_id":10916,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGED2","release_manifest":"api/v1.1/release_manifest.json"}},"MAGED4B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGED4B","identifiers":{"aliases":[],"approved_symbol":"MAGED4B","ensembl_gene_id":"ENSG00000187243","hgnc_id":"HGNC:22880","ncbi_gene_id":81557,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MAGED4B","release_manifest":"api/v1.1/release_manifest.json"}},"MAGEE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGEE1","identifiers":{"aliases":["KIAA1587","DAMAGE"],"approved_symbol":"MAGEE1","ensembl_gene_id":"ENSG00000198934","hgnc_id":"HGNC:24934","ncbi_gene_id":57692,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGEE1","release_manifest":"api/v1.1/release_manifest.json"}},"MAGEE2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGEE2","identifiers":{"aliases":["HCA3"],"approved_symbol":"MAGEE2","ensembl_gene_id":"ENSG00000186675","hgnc_id":"HGNC:24935","ncbi_gene_id":139599,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MAGEE2","release_manifest":"api/v1.1/release_manifest.json"}},"MAGEF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGEF1","identifiers":{"aliases":[],"approved_symbol":"MAGEF1","ensembl_gene_id":"ENSG00000177383","hgnc_id":"HGNC:29639","ncbi_gene_id":64110,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAGEF1","release_manifest":"api/v1.1/release_manifest.json"}},"MAGEH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGEH1","identifiers":{"aliases":["APR1"],"approved_symbol":"MAGEH1","ensembl_gene_id":"ENSG00000187601","hgnc_id":"HGNC:24092","ncbi_gene_id":28986,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGEH1","release_manifest":"api/v1.1/release_manifest.json"}},"MAGEL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGEL2","identifiers":{"aliases":["nM15"],"approved_symbol":"MAGEL2","ensembl_gene_id":"ENSG00000254585","hgnc_id":"HGNC:6814","ncbi_gene_id":54551,"previous_symbols":["NDNL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGEL2","release_manifest":"api/v1.1/release_manifest.json"}},"MAGI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGI1","identifiers":{"aliases":["BAP1","MAGI-1","TNRC19","AIP3","WWP3"],"approved_symbol":"MAGI1","ensembl_gene_id":"ENSG00000151276","hgnc_id":"HGNC:946","ncbi_gene_id":9223,"previous_symbols":["BAIAP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGI1","release_manifest":"api/v1.1/release_manifest.json"}},"MAGI1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGI1-AS1","identifiers":{"aliases":[],"approved_symbol":"MAGI1-AS1","ensembl_gene_id":"ENSG00000240175","hgnc_id":"HGNC:40091","ncbi_gene_id":100873983,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGI1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAGI1-IT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGI1-IT1","identifiers":{"aliases":[],"approved_symbol":"MAGI1-IT1","ensembl_gene_id":"ENSG00000272610","hgnc_id":"HGNC:42436","ncbi_gene_id":151877,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MAGI1-IT1","release_manifest":"api/v1.1/release_manifest.json"}},"MAGI2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGI2","identifiers":{"aliases":["AIP1","ARIP1","KIAA0705","ACVRIP1","MAGI-2"],"approved_symbol":"MAGI2","ensembl_gene_id":"ENSG00000187391","hgnc_id":"HGNC:18957","ncbi_gene_id":9863,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGI2","release_manifest":"api/v1.1/release_manifest.json"}},"MAGI2-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGI2-AS3","identifiers":{"aliases":["ENST00000414797"],"approved_symbol":"MAGI2-AS3","ensembl_gene_id":"ENSG00000234456","hgnc_id":"HGNC:40862","ncbi_gene_id":100505881,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGI2-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"MAGI3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGI3","identifiers":{"aliases":["MAGI-3"],"approved_symbol":"MAGI3","ensembl_gene_id":"ENSG00000081026","hgnc_id":"HGNC:29647","ncbi_gene_id":260425,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGI3","release_manifest":"api/v1.1/release_manifest.json"}},"MAGIX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGIX","identifiers":{"aliases":["PDZX","JM10","FLJ21687"],"approved_symbol":"MAGIX","ensembl_gene_id":"ENSG00000269313","hgnc_id":"HGNC:30006","ncbi_gene_id":79917,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGIX","release_manifest":"api/v1.1/release_manifest.json"}},"MAGOH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGOH","identifiers":{"aliases":["MAGOHA","MAGOH1"],"approved_symbol":"MAGOH","ensembl_gene_id":"ENSG00000162385","hgnc_id":"HGNC:6815","ncbi_gene_id":4116,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGOH","release_manifest":"api/v1.1/release_manifest.json"}},"MAGOHB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGOHB","identifiers":{"aliases":["FLJ10292","MGN2"],"approved_symbol":"MAGOHB","ensembl_gene_id":"ENSG00000111196","hgnc_id":"HGNC:25504","ncbi_gene_id":55110,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGOHB","release_manifest":"api/v1.1/release_manifest.json"}},"MAGT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAGT1","identifiers":{"aliases":["DKFZp564K142","IAP","OST3B","MRX95","SLC58A1"],"approved_symbol":"MAGT1","ensembl_gene_id":"ENSG00000102158","hgnc_id":"HGNC:28880","ncbi_gene_id":84061,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAGT1","release_manifest":"api/v1.1/release_manifest.json"}},"MAIP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAIP1","identifiers":{"aliases":["DKFZp666A212","FLJ22555"],"approved_symbol":"MAIP1","ensembl_gene_id":"ENSG00000162972","hgnc_id":"HGNC:26198","ncbi_gene_id":79568,"previous_symbols":["C2orf47"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAIP1","release_manifest":"api/v1.1/release_manifest.json"}},"MAJIN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAJIN","identifiers":{"aliases":[],"approved_symbol":"MAJIN","ensembl_gene_id":"ENSG00000168070","hgnc_id":"HGNC:27441","ncbi_gene_id":283129,"previous_symbols":["C11orf85"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAJIN","release_manifest":"api/v1.1/release_manifest.json"}},"MAK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAK","identifiers":{"aliases":["dJ417M14.2","RP62"],"approved_symbol":"MAK","ensembl_gene_id":"ENSG00000111837","hgnc_id":"HGNC:6816","ncbi_gene_id":4117,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAK","release_manifest":"api/v1.1/release_manifest.json"}},"MAK16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAK16","identifiers":{"aliases":["MAK16L"],"approved_symbol":"MAK16","ensembl_gene_id":"ENSG00000198042","hgnc_id":"HGNC:13703","ncbi_gene_id":84549,"previous_symbols":["RBM13"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAK16","release_manifest":"api/v1.1/release_manifest.json"}},"MAL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAL","identifiers":{"aliases":["MVP17","VIP17"],"approved_symbol":"MAL","ensembl_gene_id":"ENSG00000172005","hgnc_id":"HGNC:6817","ncbi_gene_id":4118,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAL","detailed_audit_record":"gene/MAL/audit","legacy_api_record":"api/v1/genes/MAL.json","release_manifest":"api/v1.1/release_manifest.json"}},"MAL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAL2","identifiers":{"aliases":[],"approved_symbol":"MAL2","ensembl_gene_id":"ENSG00000147676","hgnc_id":"HGNC:13634","ncbi_gene_id":114569,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MAL2","release_manifest":"api/v1.1/release_manifest.json"}},"MAL2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAL2-AS1","identifiers":{"aliases":[],"approved_symbol":"MAL2-AS1","ensembl_gene_id":"ENSG00000253972","hgnc_id":"HGNC:53626","ncbi_gene_id":105375726,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAL2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MALAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MALAT1","identifiers":{"aliases":["miPEP-52","PRO1073","MALAT-1","NCRNA00047","HCN","NEAT2","LINC00047","mascRNA"],"approved_symbol":"MALAT1","ensembl_gene_id":"ENSG00000251562","hgnc_id":"HGNC:29665","ncbi_gene_id":378938,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MALAT1","release_manifest":"api/v1.1/release_manifest.json"}},"MALINC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MALINC1","identifiers":{"aliases":["MA-linc1"],"approved_symbol":"MALINC1","ensembl_gene_id":"ENSG00000245146","hgnc_id":"HGNC:49009","ncbi_gene_id":100505636,"previous_symbols":["LINC01024"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MALINC1","release_manifest":"api/v1.1/release_manifest.json"}},"MALL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MALL","identifiers":{"aliases":["BENE"],"approved_symbol":"MALL","ensembl_gene_id":"ENSG00000144063","hgnc_id":"HGNC:6818","ncbi_gene_id":7851,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MALL","release_manifest":"api/v1.1/release_manifest.json"}},"MALRD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MALRD1","identifiers":{"aliases":["bA265G8.2","Diet1"],"approved_symbol":"MALRD1","ensembl_gene_id":"ENSG00000204740","hgnc_id":"HGNC:24331","ncbi_gene_id":340895,"previous_symbols":["C10orf112"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MALRD1","release_manifest":"api/v1.1/release_manifest.json"}},"MALSU1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MALSU1","identifiers":{"aliases":["mtRsfA"],"approved_symbol":"MALSU1","ensembl_gene_id":"ENSG00000156928","hgnc_id":"HGNC:21721","ncbi_gene_id":115416,"previous_symbols":["C7orf30"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.019354,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MALSU1","release_manifest":"api/v1.1/release_manifest.json"}},"MALT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MALT1","identifiers":{"aliases":["PCASP1"],"approved_symbol":"MALT1","ensembl_gene_id":"ENSG00000172175","hgnc_id":"HGNC:6819","ncbi_gene_id":10892,"previous_symbols":["MLT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MALT1","release_manifest":"api/v1.1/release_manifest.json"}},"MAMDC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAMDC2","identifiers":{"aliases":["MGC21981"],"approved_symbol":"MAMDC2","ensembl_gene_id":"ENSG00000165072","hgnc_id":"HGNC:23673","ncbi_gene_id":256691,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAMDC2","release_manifest":"api/v1.1/release_manifest.json"}},"MAMDC2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAMDC2-AS1","identifiers":{"aliases":[],"approved_symbol":"MAMDC2-AS1","ensembl_gene_id":"ENSG00000204706","hgnc_id":"HGNC:48719","ncbi_gene_id":100507244,"previous_symbols":["SMC5-DT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAMDC2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAMDC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAMDC4","identifiers":{"aliases":["AEGP","DKFZp434M1411","EDTB"],"approved_symbol":"MAMDC4","ensembl_gene_id":"ENSG00000177943","hgnc_id":"HGNC:24083","ncbi_gene_id":158056,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAMDC4","release_manifest":"api/v1.1/release_manifest.json"}},"MAML1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAML1","identifiers":{"aliases":["KIAA0200","Mam-1"],"approved_symbol":"MAML1","ensembl_gene_id":"ENSG00000161021","hgnc_id":"HGNC:13632","ncbi_gene_id":9794,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAML1","release_manifest":"api/v1.1/release_manifest.json"}},"MAML2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAML2","identifiers":{"aliases":["KIAA1819","MAM3"],"approved_symbol":"MAML2","ensembl_gene_id":"ENSG00000184384","hgnc_id":"HGNC:16259","ncbi_gene_id":84441,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAML2","release_manifest":"api/v1.1/release_manifest.json"}},"MAML3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAML3","identifiers":{"aliases":["KIAA1816","MAM2","CAGH3","GDN"],"approved_symbol":"MAML3","ensembl_gene_id":"ENSG00000196782","hgnc_id":"HGNC:16272","ncbi_gene_id":55534,"previous_symbols":["TNRC3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAML3","release_manifest":"api/v1.1/release_manifest.json"}},"MAMLD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAMLD1","identifiers":{"aliases":["CG1","F18"],"approved_symbol":"MAMLD1","ensembl_gene_id":"ENSG00000013619","hgnc_id":"HGNC:2568","ncbi_gene_id":10046,"previous_symbols":["CXorf6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAMLD1","release_manifest":"api/v1.1/release_manifest.json"}},"MAMSTR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAMSTR","identifiers":{"aliases":["MASTR","FLJ36070"],"approved_symbol":"MAMSTR","ensembl_gene_id":"ENSG00000176909","hgnc_id":"HGNC:26689","ncbi_gene_id":284358,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAMSTR","release_manifest":"api/v1.1/release_manifest.json"}},"MAN1A1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN1A1","identifiers":{"aliases":[],"approved_symbol":"MAN1A1","ensembl_gene_id":"ENSG00000111885","hgnc_id":"HGNC:6821","ncbi_gene_id":4121,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN1A1","release_manifest":"api/v1.1/release_manifest.json"}},"MAN1A2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN1A2","identifiers":{"aliases":["MAN1B"],"approved_symbol":"MAN1A2","ensembl_gene_id":"ENSG00000198162","hgnc_id":"HGNC:6822","ncbi_gene_id":10905,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN1A2","release_manifest":"api/v1.1/release_manifest.json"}},"MAN1B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN1B1","identifiers":{"aliases":["MANA-ER","MRT15","ERManI","ERMan1"],"approved_symbol":"MAN1B1","ensembl_gene_id":"ENSG00000177239","hgnc_id":"HGNC:6823","ncbi_gene_id":11253,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN1B1","release_manifest":"api/v1.1/release_manifest.json"}},"MAN1B1-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN1B1-DT","identifiers":{"aliases":[],"approved_symbol":"MAN1B1-DT","ensembl_gene_id":"ENSG00000268996","hgnc_id":"HGNC:48715","ncbi_gene_id":100289341,"previous_symbols":["MAN1B1-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MAN1B1-DT","release_manifest":"api/v1.1/release_manifest.json"}},"MAN1C1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN1C1","identifiers":{"aliases":["HMIC"],"approved_symbol":"MAN1C1","ensembl_gene_id":"ENSG00000117643","hgnc_id":"HGNC:19080","ncbi_gene_id":57134,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN1C1","release_manifest":"api/v1.1/release_manifest.json"}},"MAN2A1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN2A1","identifiers":{"aliases":["GOLIM7","MANII"],"approved_symbol":"MAN2A1","ensembl_gene_id":"ENSG00000112893","hgnc_id":"HGNC:6824","ncbi_gene_id":4124,"previous_symbols":["MANA2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN2A1","release_manifest":"api/v1.1/release_manifest.json"}},"MAN2A2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN2A2","identifiers":{"aliases":["MANA2X","HsT19662","alpha-MIIx"],"approved_symbol":"MAN2A2","ensembl_gene_id":"ENSG00000196547","hgnc_id":"HGNC:6825","ncbi_gene_id":4122,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN2A2","release_manifest":"api/v1.1/release_manifest.json"}},"MAN2B1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN2B1","identifiers":{"aliases":["LAMAN"],"approved_symbol":"MAN2B1","ensembl_gene_id":"ENSG00000104774","hgnc_id":"HGNC:6826","ncbi_gene_id":4125,"previous_symbols":["MANB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN2B1","release_manifest":"api/v1.1/release_manifest.json"}},"MAN2B2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN2B2","identifiers":{"aliases":["KIAA0935","EpMAN"],"approved_symbol":"MAN2B2","ensembl_gene_id":"ENSG00000013288","hgnc_id":"HGNC:29623","ncbi_gene_id":23324,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAN2B2","release_manifest":"api/v1.1/release_manifest.json"}},"MAN2C1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAN2C1","identifiers":{"aliases":[],"approved_symbol":"MAN2C1","ensembl_gene_id":"ENSG00000140400","hgnc_id":"HGNC:6827","ncbi_gene_id":4123,"previous_symbols":["MANA1","MANA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAN2C1","release_manifest":"api/v1.1/release_manifest.json"}},"MANBA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANBA","identifiers":{"aliases":[],"approved_symbol":"MANBA","ensembl_gene_id":"ENSG00000109323","hgnc_id":"HGNC:6831","ncbi_gene_id":4126,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MANBA","release_manifest":"api/v1.1/release_manifest.json"}},"MANBAL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANBAL","identifiers":{"aliases":["dJ1141E15.2"],"approved_symbol":"MANBAL","ensembl_gene_id":"ENSG00000101363","hgnc_id":"HGNC:15799","ncbi_gene_id":63905,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MANBAL","release_manifest":"api/v1.1/release_manifest.json"}},"MANEA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANEA","identifiers":{"aliases":["FLJ12838","mandaselin"],"approved_symbol":"MANEA","ensembl_gene_id":"ENSG00000172469","hgnc_id":"HGNC:21072","ncbi_gene_id":79694,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MANEA","release_manifest":"api/v1.1/release_manifest.json"}},"MANEA-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANEA-DT","identifiers":{"aliases":[],"approved_symbol":"MANEA-DT","ensembl_gene_id":"ENSG00000261366","hgnc_id":"HGNC:43732","ncbi_gene_id":101927288,"previous_symbols":["MANEA-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MANEA-DT","release_manifest":"api/v1.1/release_manifest.json"}},"MANEAL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANEAL","identifiers":{"aliases":["FLJ31434"],"approved_symbol":"MANEAL","ensembl_gene_id":"ENSG00000185090","hgnc_id":"HGNC:26452","ncbi_gene_id":149175,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MANEAL","release_manifest":"api/v1.1/release_manifest.json"}},"MANF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANF","identifiers":{"aliases":["ARP"],"approved_symbol":"MANF","ensembl_gene_id":"ENSG00000145050","hgnc_id":"HGNC:15461","ncbi_gene_id":7873,"previous_symbols":["ARMET"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.047073,"fdr":0.984022,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MANF","release_manifest":"api/v1.1/release_manifest.json"}},"MANSC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANSC1","identifiers":{"aliases":["FLJ10298","LOH12CR3"],"approved_symbol":"MANSC1","ensembl_gene_id":"ENSG00000111261","hgnc_id":"HGNC:25505","ncbi_gene_id":54682,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MANSC1","release_manifest":"api/v1.1/release_manifest.json"}},"MANSC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MANSC4","identifiers":{"aliases":[],"approved_symbol":"MANSC4","ensembl_gene_id":"ENSG00000205693","hgnc_id":"HGNC:40023","ncbi_gene_id":100287284,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MANSC4","release_manifest":"api/v1.1/release_manifest.json"}},"MAOA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAOA","identifiers":{"aliases":[],"approved_symbol":"MAOA","ensembl_gene_id":"ENSG00000189221","hgnc_id":"HGNC:6833","ncbi_gene_id":4128,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAOA","release_manifest":"api/v1.1/release_manifest.json"}},"MAOB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAOB","identifiers":{"aliases":[],"approved_symbol":"MAOB","ensembl_gene_id":"ENSG00000069535","hgnc_id":"HGNC:6834","ncbi_gene_id":4129,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAOB","release_manifest":"api/v1.1/release_manifest.json"}},"MAP10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP10","identifiers":{"aliases":["MTR120"],"approved_symbol":"MAP10","ensembl_gene_id":"ENSG00000212916","hgnc_id":"HGNC:29265","ncbi_gene_id":54627,"previous_symbols":["KIAA1383"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP10","release_manifest":"api/v1.1/release_manifest.json"}},"MAP11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP11","identifiers":{"approved_symbol":"MAP11","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MAP11","release_manifest":"api/v1.1/release_manifest.json"}},"MAP1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP1A","identifiers":{"aliases":[],"approved_symbol":"MAP1A","ensembl_gene_id":"ENSG00000166963","hgnc_id":"HGNC:6835","ncbi_gene_id":4130,"previous_symbols":["MAP1L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP1A","release_manifest":"api/v1.1/release_manifest.json"}},"MAP1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP1B","identifiers":{"aliases":["MAP5","PPP1R102"],"approved_symbol":"MAP1B","ensembl_gene_id":"ENSG00000131711","hgnc_id":"HGNC:6836","ncbi_gene_id":4131,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP1B","release_manifest":"api/v1.1/release_manifest.json"}},"MAP1LC3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP1LC3A","identifiers":{"aliases":["MAP1BLC3","MAP1ALC3","LC3","LC3A","ATG8E"],"approved_symbol":"MAP1LC3A","ensembl_gene_id":"ENSG00000101460","hgnc_id":"HGNC:6838","ncbi_gene_id":84557,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP1LC3A","release_manifest":"api/v1.1/release_manifest.json"}},"MAP1LC3B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP1LC3B","identifiers":{"aliases":["ATG8F"],"approved_symbol":"MAP1LC3B","ensembl_gene_id":"ENSG00000140941","hgnc_id":"HGNC:13352","ncbi_gene_id":81631,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP1LC3B","release_manifest":"api/v1.1/release_manifest.json"}},"MAP1LC3B2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP1LC3B2","identifiers":{"aliases":["ATG8G"],"approved_symbol":"MAP1LC3B2","ensembl_gene_id":"ENSG00000258102","hgnc_id":"HGNC:34390","ncbi_gene_id":643246,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP1LC3B2","release_manifest":"api/v1.1/release_manifest.json"}},"MAP1LC3C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP1LC3C","identifiers":{"aliases":["ATG8J"],"approved_symbol":"MAP1LC3C","ensembl_gene_id":"ENSG00000197769","hgnc_id":"HGNC:13353","ncbi_gene_id":440738,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP1LC3C","release_manifest":"api/v1.1/release_manifest.json"}},"MAP1S":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP1S","identifiers":{"aliases":["FLJ10669","MAP8"],"approved_symbol":"MAP1S","ensembl_gene_id":"ENSG00000130479","hgnc_id":"HGNC:15715","ncbi_gene_id":55201,"previous_symbols":["C19orf5","VCY2IP1","BPY2IP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP1S","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2","identifiers":{"aliases":["MAP2A","MAP2B","MAP2C"],"approved_symbol":"MAP2","ensembl_gene_id":"ENSG00000078018","hgnc_id":"HGNC:6839","ncbi_gene_id":4133,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2K1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2K1","identifiers":{"aliases":["MEK1","MAPKK1","MKK1"],"approved_symbol":"MAP2K1","ensembl_gene_id":"ENSG00000169032","hgnc_id":"HGNC:6840","ncbi_gene_id":5604,"previous_symbols":["PRKMK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2K1","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2K2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2K2","identifiers":{"aliases":["MEK2","MKK2"],"approved_symbol":"MAP2K2","ensembl_gene_id":"ENSG00000126934","hgnc_id":"HGNC:6842","ncbi_gene_id":5605,"previous_symbols":["PRKMK2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2K2","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2K3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2K3","identifiers":{"aliases":["MEK3","MKK3","MAPKK3","SAPKK2"],"approved_symbol":"MAP2K3","ensembl_gene_id":"ENSG00000034152","hgnc_id":"HGNC:6843","ncbi_gene_id":5606,"previous_symbols":["PRKMK3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2K3","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2K4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2K4","identifiers":{"aliases":["MEK4","JNKK1","PRKMK4","MKK4","MAPKK4","SAPKK1","SKK1","JNKK","SEK1"],"approved_symbol":"MAP2K4","ensembl_gene_id":"ENSG00000065559","hgnc_id":"HGNC:6844","ncbi_gene_id":6416,"previous_symbols":["SERK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2K4","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2K5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2K5","identifiers":{"aliases":["MEK5","MAPKK5","HsT17454"],"approved_symbol":"MAP2K5","ensembl_gene_id":"ENSG00000137764","hgnc_id":"HGNC:6845","ncbi_gene_id":5607,"previous_symbols":["PRKMK5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2K5","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2K6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2K6","identifiers":{"aliases":["MEK6","MKK6","SAPKK3","MAPKK6","CRCMSL"],"approved_symbol":"MAP2K6","ensembl_gene_id":"ENSG00000108984","hgnc_id":"HGNC:6846","ncbi_gene_id":5608,"previous_symbols":["PRKMK6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2K6","release_manifest":"api/v1.1/release_manifest.json"}},"MAP2K7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP2K7","identifiers":{"aliases":["MKK7","Jnkk2","SAPKK4"],"approved_symbol":"MAP2K7","ensembl_gene_id":"ENSG00000076984","hgnc_id":"HGNC:6847","ncbi_gene_id":5609,"previous_symbols":["PRKMK7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP2K7","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K1","identifiers":{"aliases":["MEKK","MAPKKK1"],"approved_symbol":"MAP3K1","ensembl_gene_id":"ENSG00000095015","hgnc_id":"HGNC:6848","ncbi_gene_id":4214,"previous_symbols":["MEKK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K1","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K10","identifiers":{"aliases":["MST","MEKK10"],"approved_symbol":"MAP3K10","ensembl_gene_id":"ENSG00000130758","hgnc_id":"HGNC:6849","ncbi_gene_id":4294,"previous_symbols":["MLK2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K10","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K11","identifiers":{"aliases":["SPRK","MEKK11"],"approved_symbol":"MAP3K11","ensembl_gene_id":"ENSG00000173327","hgnc_id":"HGNC:6850","ncbi_gene_id":4296,"previous_symbols":["MLK3","PTK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K11","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K12","identifiers":{"aliases":["MUK","DLK","ZPKP1","MEKK12"],"approved_symbol":"MAP3K12","ensembl_gene_id":"ENSG00000139625","hgnc_id":"HGNC:6851","ncbi_gene_id":7786,"previous_symbols":["ZPK"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP3K12","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K13","identifiers":{"aliases":["LZK","MEKK13"],"approved_symbol":"MAP3K13","ensembl_gene_id":"ENSG00000073803","hgnc_id":"HGNC:6852","ncbi_gene_id":9175,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP3K13","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K14","identifiers":{"aliases":["NIK","HSNIK","FTDCR1B","HS"],"approved_symbol":"MAP3K14","ensembl_gene_id":"ENSG00000006062","hgnc_id":"HGNC:6853","ncbi_gene_id":9020,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K14","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K14-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K14-AS1","identifiers":{"aliases":[],"approved_symbol":"MAP3K14-AS1","ensembl_gene_id":"ENSG00000267278","hgnc_id":"HGNC:44359","ncbi_gene_id":100133991,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K14-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K15","identifiers":{"aliases":["bA723P2.3","FLJ16518","ASK3"],"approved_symbol":"MAP3K15","ensembl_gene_id":"ENSG00000180815","hgnc_id":"HGNC:31689","ncbi_gene_id":389840,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K15","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K19","identifiers":{"aliases":["FLJ23074","RCK"],"approved_symbol":"MAP3K19","ensembl_gene_id":"ENSG00000176601","hgnc_id":"HGNC:26249","ncbi_gene_id":80122,"previous_symbols":["YSK4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K19","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K2","identifiers":{"aliases":["MEKK2B"],"approved_symbol":"MAP3K2","ensembl_gene_id":"ENSG00000169967","hgnc_id":"HGNC:6854","ncbi_gene_id":10746,"previous_symbols":["MEKK2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K2","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K2-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K2-DT","identifiers":{"aliases":["ENST00000433673"],"approved_symbol":"MAP3K2-DT","ensembl_gene_id":"ENSG00000236682","hgnc_id":"HGNC:54088","ncbi_gene_id":100506922,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K2-DT","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K20","identifiers":{"aliases":["MLTKalpha","MLTKbeta","ZAK","MLTK","MLK7","MRK"],"approved_symbol":"MAP3K20","ensembl_gene_id":"ENSG00000091436","hgnc_id":"HGNC:17797","ncbi_gene_id":51776,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K20","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K20-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K20-AS1","identifiers":{"aliases":[],"approved_symbol":"MAP3K20-AS1","ensembl_gene_id":"ENSG00000238133","hgnc_id":"HGNC:27935","ncbi_gene_id":339751,"previous_symbols":["MLK7-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K20-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K21","identifiers":{"aliases":["KIAA1804","MLK4"],"approved_symbol":"MAP3K21","ensembl_gene_id":"ENSG00000143674","hgnc_id":"HGNC:29798","ncbi_gene_id":84451,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP3K21","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K3","identifiers":{"aliases":["MAPKKK3"],"approved_symbol":"MAP3K3","ensembl_gene_id":"ENSG00000198909","hgnc_id":"HGNC:6855","ncbi_gene_id":4215,"previous_symbols":["MEKK3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP3K3","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K4","identifiers":{"aliases":["MTK1","MAPKKK4","KIAA0213"],"approved_symbol":"MAP3K4","ensembl_gene_id":"ENSG00000085511","hgnc_id":"HGNC:6856","ncbi_gene_id":4216,"previous_symbols":["MEKK4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K4","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K5","identifiers":{"aliases":["MAPKKK5","ASK1"],"approved_symbol":"MAP3K5","ensembl_gene_id":"ENSG00000197442","hgnc_id":"HGNC:6857","ncbi_gene_id":4217,"previous_symbols":["MEKK5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP3K5","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K6","identifiers":{"aliases":["MAPKKK6","ASK2","MEKK6"],"approved_symbol":"MAP3K6","ensembl_gene_id":"ENSG00000142733","hgnc_id":"HGNC:6858","ncbi_gene_id":9064,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K6","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K7","identifiers":{"aliases":["MEKK7"],"approved_symbol":"MAP3K7","ensembl_gene_id":"ENSG00000135341","hgnc_id":"HGNC:6859","ncbi_gene_id":6885,"previous_symbols":["TAK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K7","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K7CL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K7CL","identifiers":{"aliases":["TAKL","TAK1L","TAKL-1","TAKL-2","TAKL-4"],"approved_symbol":"MAP3K7CL","ensembl_gene_id":"ENSG00000156265","hgnc_id":"HGNC:16457","ncbi_gene_id":56911,"previous_symbols":["C21orf7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K7CL","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K8","identifiers":{"aliases":["Tpl-2","EST","c-COT","MEKK8"],"approved_symbol":"MAP3K8","ensembl_gene_id":"ENSG00000107968","hgnc_id":"HGNC:6860","ncbi_gene_id":1326,"previous_symbols":["COT","ESTF"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K8","release_manifest":"api/v1.1/release_manifest.json"}},"MAP3K9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP3K9","identifiers":{"aliases":["PRKE1","MEKK9"],"approved_symbol":"MAP3K9","ensembl_gene_id":"ENSG00000006432","hgnc_id":"HGNC:6861","ncbi_gene_id":4293,"previous_symbols":["MLK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP3K9","release_manifest":"api/v1.1/release_manifest.json"}},"MAP4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP4","identifiers":{"aliases":[],"approved_symbol":"MAP4","ensembl_gene_id":"ENSG00000047849","hgnc_id":"HGNC:6862","ncbi_gene_id":4134,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP4","release_manifest":"api/v1.1/release_manifest.json"}},"MAP4K1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP4K1","identifiers":{"aliases":["HPK1"],"approved_symbol":"MAP4K1","ensembl_gene_id":"ENSG00000104814","hgnc_id":"HGNC:6863","ncbi_gene_id":11184,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP4K1","release_manifest":"api/v1.1/release_manifest.json"}},"MAP4K2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP4K2","identifiers":{"aliases":["GCK","BL44"],"approved_symbol":"MAP4K2","ensembl_gene_id":"ENSG00000168067","hgnc_id":"HGNC:6864","ncbi_gene_id":5871,"previous_symbols":["RAB8IP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP4K2","release_manifest":"api/v1.1/release_manifest.json"}},"MAP4K3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP4K3","identifiers":{"aliases":["GLK","MAPKKKK3"],"approved_symbol":"MAP4K3","ensembl_gene_id":"ENSG00000011566","hgnc_id":"HGNC:6865","ncbi_gene_id":8491,"previous_symbols":["RAB8IPL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP4K3","release_manifest":"api/v1.1/release_manifest.json"}},"MAP4K3-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP4K3-DT","identifiers":{"aliases":[],"approved_symbol":"MAP4K3-DT","ensembl_gene_id":"ENSG00000231312","hgnc_id":"HGNC:54056","ncbi_gene_id":728730,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP4K3-DT","release_manifest":"api/v1.1/release_manifest.json"}},"MAP4K4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP4K4","identifiers":{"aliases":["HGK","NIK","FLH21957"],"approved_symbol":"MAP4K4","ensembl_gene_id":"ENSG00000071054","hgnc_id":"HGNC:6866","ncbi_gene_id":9448,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP4K4","release_manifest":"api/v1.1/release_manifest.json"}},"MAP4K5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP4K5","identifiers":{"aliases":["KHS1","GCKR","KHS"],"approved_symbol":"MAP4K5","ensembl_gene_id":"ENSG00000012983","hgnc_id":"HGNC:6867","ncbi_gene_id":11183,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP4K5","release_manifest":"api/v1.1/release_manifest.json"}},"MAP6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP6","identifiers":{"aliases":["KIAA1878","STOP","FLJ41346","MAP6-N"],"approved_symbol":"MAP6","ensembl_gene_id":"ENSG00000171533","hgnc_id":"HGNC:6868","ncbi_gene_id":4135,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP6","release_manifest":"api/v1.1/release_manifest.json"}},"MAP6D1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP6D1","identifiers":{"aliases":["FLJ12748","SL21"],"approved_symbol":"MAP6D1","ensembl_gene_id":"ENSG00000180834","hgnc_id":"HGNC:25753","ncbi_gene_id":79929,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP6D1","release_manifest":"api/v1.1/release_manifest.json"}},"MAP7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP7","identifiers":{"aliases":["E-MAP-115"],"approved_symbol":"MAP7","ensembl_gene_id":"ENSG00000135525","hgnc_id":"HGNC:6869","ncbi_gene_id":9053,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP7","release_manifest":"api/v1.1/release_manifest.json"}},"MAP7D1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP7D1","identifiers":{"aliases":["FLJ10350","FLJ39022"],"approved_symbol":"MAP7D1","ensembl_gene_id":"ENSG00000116871","hgnc_id":"HGNC:25514","ncbi_gene_id":55700,"previous_symbols":["PARCC1","RPRC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAP7D1","release_manifest":"api/v1.1/release_manifest.json"}},"MAP7D2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP7D2","identifiers":{"aliases":["FLJ14503"],"approved_symbol":"MAP7D2","ensembl_gene_id":"ENSG00000184368","hgnc_id":"HGNC:25899","ncbi_gene_id":256714,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP7D2","release_manifest":"api/v1.1/release_manifest.json"}},"MAP7D3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP7D3","identifiers":{"aliases":["FLJ12649"],"approved_symbol":"MAP7D3","ensembl_gene_id":"ENSG00000129680","hgnc_id":"HGNC:25742","ncbi_gene_id":79649,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP7D3","release_manifest":"api/v1.1/release_manifest.json"}},"MAP9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAP9","identifiers":{"aliases":["ASAP","FLJ21159"],"approved_symbol":"MAP9","ensembl_gene_id":"ENSG00000164114","hgnc_id":"HGNC:26118","ncbi_gene_id":79884,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAP9","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK1","identifiers":{"aliases":["ERK","ERK2","p41mapk","MAPK2"],"approved_symbol":"MAPK1","ensembl_gene_id":"ENSG00000100030","hgnc_id":"HGNC:6871","ncbi_gene_id":5594,"previous_symbols":["PRKM2","PRKM1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK1","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK10","identifiers":{"aliases":["JNK3","p493F12","p54bSAPK"],"approved_symbol":"MAPK10","ensembl_gene_id":"ENSG00000109339","hgnc_id":"HGNC:6872","ncbi_gene_id":5602,"previous_symbols":["PRKM10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK10","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK11","identifiers":{"aliases":["p38-2","p38Beta","SAPK2"],"approved_symbol":"MAPK11","ensembl_gene_id":"ENSG00000185386","hgnc_id":"HGNC:6873","ncbi_gene_id":5600,"previous_symbols":["PRKM11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAPK11","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK12","identifiers":{"aliases":["ERK6","PRKM12","p38gamma","SAPK-3"],"approved_symbol":"MAPK12","ensembl_gene_id":"ENSG00000188130","hgnc_id":"HGNC:6874","ncbi_gene_id":6300,"previous_symbols":["SAPK3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK12","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK13","identifiers":{"aliases":["SAPK4","p38delta"],"approved_symbol":"MAPK13","ensembl_gene_id":"ENSG00000156711","hgnc_id":"HGNC:6875","ncbi_gene_id":5603,"previous_symbols":["PRKM13"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK13","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK14","identifiers":{"aliases":["p38alpha","PRKM14","p38","Mxi2","PRKM15"],"approved_symbol":"MAPK14","ensembl_gene_id":"ENSG00000112062","hgnc_id":"HGNC:6876","ncbi_gene_id":1432,"previous_symbols":["CSPB1","CSBP1","CSBP2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK14","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK15","identifiers":{"aliases":["ERK8","ERK7"],"approved_symbol":"MAPK15","ensembl_gene_id":"ENSG00000181085","hgnc_id":"HGNC:24667","ncbi_gene_id":225689,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MAPK15","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK1IP1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK1IP1L","identifiers":{"aliases":[],"approved_symbol":"MAPK1IP1L","ensembl_gene_id":"ENSG00000168175","hgnc_id":"HGNC:19840","ncbi_gene_id":93487,"previous_symbols":["C14orf32"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK1IP1L","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK3","identifiers":{"aliases":["ERK1","p44mapk","p44erk1","ERK-1"],"approved_symbol":"MAPK3","ensembl_gene_id":"ENSG00000102882","hgnc_id":"HGNC:6877","ncbi_gene_id":5595,"previous_symbols":["PRKM3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK3","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK4","identifiers":{"aliases":["Erk3-related","Erk4"],"approved_symbol":"MAPK4","ensembl_gene_id":"ENSG00000141639","hgnc_id":"HGNC:6878","ncbi_gene_id":5596,"previous_symbols":["PRKM4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK4","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK6","identifiers":{"aliases":["ERK3","p97MAPK","HsT17250"],"approved_symbol":"MAPK6","ensembl_gene_id":"ENSG00000069956","hgnc_id":"HGNC:6879","ncbi_gene_id":5597,"previous_symbols":["PRKM6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK6","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK6-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK6-DT","identifiers":{"aliases":["lncMAPK6"],"approved_symbol":"MAPK6-DT","ensembl_gene_id":"ENSG00000259438","hgnc_id":"HGNC:53900","ncbi_gene_id":112543478,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK6-DT","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK7","identifiers":{"aliases":["BMK1","ERK5"],"approved_symbol":"MAPK7","ensembl_gene_id":"ENSG00000166484","hgnc_id":"HGNC:6880","ncbi_gene_id":5598,"previous_symbols":["PRKM7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK7","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK8","identifiers":{"aliases":["JNK","JNK1","SAPK1"],"approved_symbol":"MAPK8","ensembl_gene_id":"ENSG00000107643","hgnc_id":"HGNC:6881","ncbi_gene_id":5599,"previous_symbols":["PRKM8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK8","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK8IP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK8IP1","identifiers":{"aliases":["IB1","JIP-1","JIP1"],"approved_symbol":"MAPK8IP1","ensembl_gene_id":"ENSG00000121653","hgnc_id":"HGNC:6882","ncbi_gene_id":9479,"previous_symbols":["PRKM8IP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK8IP1","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK8IP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK8IP2","identifiers":{"aliases":["IB2","JIP2"],"approved_symbol":"MAPK8IP2","ensembl_gene_id":"ENSG00000008735","hgnc_id":"HGNC:6883","ncbi_gene_id":23542,"previous_symbols":["PRKM8IPL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK8IP2","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK8IP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK8IP3","identifiers":{"aliases":["KIAA1066","JSAP1","JIP3","syd"],"approved_symbol":"MAPK8IP3","ensembl_gene_id":"ENSG00000138834","hgnc_id":"HGNC:6884","ncbi_gene_id":23162,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK8IP3","release_manifest":"api/v1.1/release_manifest.json"}},"MAPK9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPK9","identifiers":{"aliases":["JNK2","p54a","SAPK"],"approved_symbol":"MAPK9","ensembl_gene_id":"ENSG00000050748","hgnc_id":"HGNC:6886","ncbi_gene_id":5601,"previous_symbols":["PRKM9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPK9","release_manifest":"api/v1.1/release_manifest.json"}},"MAPKAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPKAP1","identifiers":{"aliases":["MGC2745","SIN1","MIP1"],"approved_symbol":"MAPKAP1","ensembl_gene_id":"ENSG00000119487","hgnc_id":"HGNC:18752","ncbi_gene_id":79109,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPKAP1","release_manifest":"api/v1.1/release_manifest.json"}},"MAPKAPK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPKAPK2","identifiers":{"aliases":["MK2"],"approved_symbol":"MAPKAPK2","ensembl_gene_id":"ENSG00000162889","hgnc_id":"HGNC:6887","ncbi_gene_id":9261,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPKAPK2","release_manifest":"api/v1.1/release_manifest.json"}},"MAPKAPK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPKAPK3","identifiers":{"aliases":["3pK","MAPKAP3","3PK","MK-3","MK3"],"approved_symbol":"MAPKAPK3","ensembl_gene_id":"ENSG00000114738","hgnc_id":"HGNC:6888","ncbi_gene_id":7867,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPKAPK3","release_manifest":"api/v1.1/release_manifest.json"}},"MAPKAPK5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPKAPK5","identifiers":{"aliases":["PRAK","MK5"],"approved_symbol":"MAPKAPK5","ensembl_gene_id":"ENSG00000089022","hgnc_id":"HGNC:6889","ncbi_gene_id":8550,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPKAPK5","release_manifest":"api/v1.1/release_manifest.json"}},"MAPKAPK5-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPKAPK5-AS1","identifiers":{"aliases":["FLJ39616","MAAS","lncRNA-cCSC1"],"approved_symbol":"MAPKAPK5-AS1","ensembl_gene_id":"ENSG00000234608","hgnc_id":"HGNC:24091","ncbi_gene_id":51275,"previous_symbols":["C12orf47"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPKAPK5-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MAPKBP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPKBP1","identifiers":{"aliases":["KIAA0596","NPHP20"],"approved_symbol":"MAPKBP1","ensembl_gene_id":"ENSG00000137802","hgnc_id":"HGNC:29536","ncbi_gene_id":23005,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPKBP1","release_manifest":"api/v1.1/release_manifest.json"}},"MAPRE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPRE1","identifiers":{"aliases":["EB1"],"approved_symbol":"MAPRE1","ensembl_gene_id":"ENSG00000101367","hgnc_id":"HGNC:6890","ncbi_gene_id":22919,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPRE1","release_manifest":"api/v1.1/release_manifest.json"}},"MAPRE2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPRE2","identifiers":{"aliases":["RP1","EB1","EB2"],"approved_symbol":"MAPRE2","ensembl_gene_id":"ENSG00000166974","hgnc_id":"HGNC:6891","ncbi_gene_id":10982,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPRE2","release_manifest":"api/v1.1/release_manifest.json"}},"MAPRE3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPRE3","identifiers":{"aliases":["RP3","EB3"],"approved_symbol":"MAPRE3","ensembl_gene_id":"ENSG00000084764","hgnc_id":"HGNC:6892","ncbi_gene_id":22924,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPRE3","release_manifest":"api/v1.1/release_manifest.json"}},"MAPT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPT","identifiers":{"aliases":["MTBT1","tau","PPND","FTDP-17","TAU","MSTD","MTBT2","FLJ31424","MGC138549","PPP1R103","tau-40","Tau-PHF6"],"approved_symbol":"MAPT","ensembl_gene_id":"ENSG00000186868","hgnc_id":"HGNC:6893","ncbi_gene_id":4137,"previous_symbols":["DDPAC","MAPTL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAPT","release_manifest":"api/v1.1/release_manifest.json"}},"MAPT-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAPT-AS1","identifiers":{"aliases":["MAPT-AS"],"approved_symbol":"MAPT-AS1","ensembl_gene_id":"ENSG00000264589","hgnc_id":"HGNC:43738","ncbi_gene_id":100128977,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MAPT-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MARC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARC1","identifiers":{"approved_symbol":"MARC1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARC1","release_manifest":"api/v1.1/release_manifest.json"}},"MARC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARC2","identifiers":{"approved_symbol":"MARC2","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARC2","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH1","identifiers":{"approved_symbol":"MARCH1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MARCH1","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH10","identifiers":{"approved_symbol":"MARCH10","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MARCH10","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH2","identifiers":{"approved_symbol":"MARCH2","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCH2","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH3","identifiers":{"approved_symbol":"MARCH3","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCH3","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH5","identifiers":{"approved_symbol":"MARCH5","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MARCH5","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH6","identifiers":{"approved_symbol":"MARCH6","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MARCH6","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH7","identifiers":{"approved_symbol":"MARCH7","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCH7","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH8","identifiers":{"approved_symbol":"MARCH8","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCH8","release_manifest":"api/v1.1/release_manifest.json"}},"MARCH9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCH9","identifiers":{"approved_symbol":"MARCH9","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCH9","release_manifest":"api/v1.1/release_manifest.json"}},"MARCKS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCKS","identifiers":{"aliases":["PKCSL","80K-L"],"approved_symbol":"MARCKS","ensembl_gene_id":"ENSG00000277443","hgnc_id":"HGNC:6759","ncbi_gene_id":4082,"previous_symbols":["MACS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCKS","release_manifest":"api/v1.1/release_manifest.json"}},"MARCKSL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCKSL1","identifiers":{"aliases":["F52","MacMARCKS","MLP1"],"approved_symbol":"MARCKSL1","ensembl_gene_id":"ENSG00000175130","hgnc_id":"HGNC:7142","ncbi_gene_id":65108,"previous_symbols":["MLP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCKSL1","release_manifest":"api/v1.1/release_manifest.json"}},"MARCO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARCO","identifiers":{"aliases":["SCARA2","SR-A6"],"approved_symbol":"MARCO","ensembl_gene_id":"ENSG00000019169","hgnc_id":"HGNC:6895","ncbi_gene_id":8685,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARCO","release_manifest":"api/v1.1/release_manifest.json"}},"MARF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARF1","identifiers":{"aliases":["LKAP","PPP1R34","LMKB"],"approved_symbol":"MARF1","ensembl_gene_id":"ENSG00000166783","hgnc_id":"HGNC:29562","ncbi_gene_id":9665,"previous_symbols":["KIAA0430"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MARF1","release_manifest":"api/v1.1/release_manifest.json"}},"MARK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARK1","identifiers":{"aliases":["MARK","PAR-1C"],"approved_symbol":"MARK1","ensembl_gene_id":"ENSG00000116141","hgnc_id":"HGNC:6896","ncbi_gene_id":4139,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARK1","release_manifest":"api/v1.1/release_manifest.json"}},"MARK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARK2","identifiers":{"aliases":["PAR-1","Par1b","PAR-1B"],"approved_symbol":"MARK2","ensembl_gene_id":"ENSG00000072518","hgnc_id":"HGNC:3332","ncbi_gene_id":2011,"previous_symbols":["EMK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARK2","release_manifest":"api/v1.1/release_manifest.json"}},"MARK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARK3","identifiers":{"aliases":["CTAK1","KP78","PAR-1A"],"approved_symbol":"MARK3","ensembl_gene_id":"ENSG00000075413","hgnc_id":"HGNC:6897","ncbi_gene_id":4140,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARK3","release_manifest":"api/v1.1/release_manifest.json"}},"MARK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARK4","identifiers":{"aliases":["Nbla00650","FLJ90097","KIAA1860","PAR-1D"],"approved_symbol":"MARK4","ensembl_gene_id":"ENSG00000007047","hgnc_id":"HGNC:13538","ncbi_gene_id":57787,"previous_symbols":["MARKL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARK4","release_manifest":"api/v1.1/release_manifest.json"}},"MARS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARS","identifiers":{"approved_symbol":"MARS","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MARS","release_manifest":"api/v1.1/release_manifest.json"}},"MARS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARS2","identifiers":{"aliases":["mtMetRS","SPAX3"],"approved_symbol":"MARS2","ensembl_gene_id":"ENSG00000247626","hgnc_id":"HGNC:25133","ncbi_gene_id":92935,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARS2","release_manifest":"api/v1.1/release_manifest.json"}},"MARVELD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARVELD1","identifiers":{"aliases":["MGC4415","GB14","FLJ23440","FLJ22343","bA548K23.8"],"approved_symbol":"MARVELD1","ensembl_gene_id":"ENSG00000155254","hgnc_id":"HGNC:28674","ncbi_gene_id":83742,"previous_symbols":["MRVLDC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARVELD1","release_manifest":"api/v1.1/release_manifest.json"}},"MARVELD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARVELD2","identifiers":{"aliases":["FLJ30532","TRIC"],"approved_symbol":"MARVELD2","ensembl_gene_id":"ENSG00000152939","hgnc_id":"HGNC:26401","ncbi_gene_id":153562,"previous_symbols":["MRVLDC2","DFNB49"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MARVELD2","release_manifest":"api/v1.1/release_manifest.json"}},"MARVELD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MARVELD3","identifiers":{"aliases":[],"approved_symbol":"MARVELD3","ensembl_gene_id":"ENSG00000140832","hgnc_id":"HGNC:30525","ncbi_gene_id":91862,"previous_symbols":["MRVLDC3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MARVELD3","release_manifest":"api/v1.1/release_manifest.json"}},"MASP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MASP1","identifiers":{"aliases":["MASP","Map44","MASP-3","MAP-1"],"approved_symbol":"MASP1","ensembl_gene_id":"ENSG00000127241","hgnc_id":"HGNC:6901","ncbi_gene_id":5648,"previous_symbols":["CRARF","PRSS5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MASP1","release_manifest":"api/v1.1/release_manifest.json"}},"MASP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MASP2","identifiers":{"aliases":["Map19","sMAP","MAP-2"],"approved_symbol":"MASP2","ensembl_gene_id":"ENSG00000009724","hgnc_id":"HGNC:6902","ncbi_gene_id":10747,"previous_symbols":["MASP1P1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MASP2","release_manifest":"api/v1.1/release_manifest.json"}},"MAST1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAST1","identifiers":{"aliases":["SAST","KIAA0973"],"approved_symbol":"MAST1","ensembl_gene_id":"ENSG00000105613","hgnc_id":"HGNC:19034","ncbi_gene_id":22983,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAST1","release_manifest":"api/v1.1/release_manifest.json"}},"MAST2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAST2","identifiers":{"aliases":["MAST205","KIAA0807"],"approved_symbol":"MAST2","ensembl_gene_id":"ENSG00000086015","hgnc_id":"HGNC:19035","ncbi_gene_id":23139,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAST2","release_manifest":"api/v1.1/release_manifest.json"}},"MAST3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAST3","identifiers":{"aliases":["KIAA0561"],"approved_symbol":"MAST3","ensembl_gene_id":"ENSG00000099308","hgnc_id":"HGNC:19036","ncbi_gene_id":23031,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAST3","release_manifest":"api/v1.1/release_manifest.json"}},"MAST4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAST4","identifiers":{"aliases":["KIAA0303"],"approved_symbol":"MAST4","ensembl_gene_id":"ENSG00000069020","hgnc_id":"HGNC:19037","ncbi_gene_id":375449,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAST4","release_manifest":"api/v1.1/release_manifest.json"}},"MAST4-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAST4-AS1","identifiers":{"aliases":[],"approved_symbol":"MAST4-AS1","ensembl_gene_id":"ENSG00000229666","hgnc_id":"HGNC:40865","ncbi_gene_id":101928794,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MAST4-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MASTL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MASTL","identifiers":{"aliases":["FLJ14813","THC2","Gwl"],"approved_symbol":"MASTL","ensembl_gene_id":"ENSG00000120539","hgnc_id":"HGNC:19042","ncbi_gene_id":84930,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MASTL","release_manifest":"api/v1.1/release_manifest.json"}},"MAT2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAT2A","identifiers":{"aliases":["SAMS2","MATA2","MATII","MAT-II"],"approved_symbol":"MAT2A","ensembl_gene_id":"ENSG00000168906","hgnc_id":"HGNC:6904","ncbi_gene_id":4144,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MAT2A","release_manifest":"api/v1.1/release_manifest.json"}},"MAT2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAT2B","identifiers":{"aliases":["MATIIbeta","SDR23E1"],"approved_symbol":"MAT2B","ensembl_gene_id":"ENSG00000038274","hgnc_id":"HGNC:6905","ncbi_gene_id":27430,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAT2B","release_manifest":"api/v1.1/release_manifest.json"}},"MATK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MATK","identifiers":{"aliases":["HYLTK","CTK","HYL","Lsk","CHK","HHYLTK","DKFZp434N1212","MGC1708","MGC2101"],"approved_symbol":"MATK","ensembl_gene_id":"ENSG00000007264","hgnc_id":"HGNC:6906","ncbi_gene_id":4145,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MATK","release_manifest":"api/v1.1/release_manifest.json"}},"MATN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MATN1","identifiers":{"aliases":[],"approved_symbol":"MATN1","ensembl_gene_id":"ENSG00000162510","hgnc_id":"HGNC:6907","ncbi_gene_id":4146,"previous_symbols":["CRTM","CMP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MATN1","release_manifest":"api/v1.1/release_manifest.json"}},"MATN1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MATN1-AS1","identifiers":{"aliases":[],"approved_symbol":"MATN1-AS1","ensembl_gene_id":"ENSG00000186056","hgnc_id":"HGNC:40364","ncbi_gene_id":100129196,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MATN1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MATN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MATN2","identifiers":{"aliases":[],"approved_symbol":"MATN2","ensembl_gene_id":"ENSG00000132561","hgnc_id":"HGNC:6908","ncbi_gene_id":4147,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MATN2","release_manifest":"api/v1.1/release_manifest.json"}},"MATN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MATN3","identifiers":{"aliases":["EDM5","HOA"],"approved_symbol":"MATN3","ensembl_gene_id":"ENSG00000132031","hgnc_id":"HGNC:6909","ncbi_gene_id":4148,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MATN3","release_manifest":"api/v1.1/release_manifest.json"}},"MATN4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MATN4","identifiers":{"aliases":[],"approved_symbol":"MATN4","ensembl_gene_id":"ENSG00000124159","hgnc_id":"HGNC:6910","ncbi_gene_id":8785,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MATN4","release_manifest":"api/v1.1/release_manifest.json"}},"MATR3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MATR3","identifiers":{"aliases":["KIAA0723","MGC9105","VCPDM"],"approved_symbol":"MATR3","ensembl_gene_id":"ENSG00000015479","hgnc_id":"HGNC:6912","ncbi_gene_id":9782,"previous_symbols":["MPD2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/MATR3","release_manifest":"api/v1.1/release_manifest.json"}},"MAU2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAU2","identifiers":{"aliases":["MGC75361","mau-2","MAU2L","SCC4"],"approved_symbol":"MAU2","ensembl_gene_id":"ENSG00000129933","hgnc_id":"HGNC:29140","ncbi_gene_id":23383,"previous_symbols":["KIAA0892"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAU2","release_manifest":"api/v1.1/release_manifest.json"}},"MAVS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAVS","identifiers":{"aliases":["VISA","KIAA1271","IPS-1","Cardif"],"approved_symbol":"MAVS","ensembl_gene_id":"ENSG00000088888","hgnc_id":"HGNC:29233","ncbi_gene_id":57506,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAVS","release_manifest":"api/v1.1/release_manifest.json"}},"MAX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAX","identifiers":{"aliases":["bHLHd4","bHLHd5","bHLHd6","bHLHd7","bHLHd8"],"approved_symbol":"MAX","ensembl_gene_id":"ENSG00000125952","hgnc_id":"HGNC:6913","ncbi_gene_id":4149,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAX","release_manifest":"api/v1.1/release_manifest.json"}},"MAZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MAZ","identifiers":{"aliases":["ZF87","Pur-1","Zif87","ZNF801"],"approved_symbol":"MAZ","ensembl_gene_id":"ENSG00000103495","hgnc_id":"HGNC:6914","ncbi_gene_id":4150,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MAZ","release_manifest":"api/v1.1/release_manifest.json"}},"MB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MB","identifiers":{"aliases":["PVALB"],"approved_symbol":"MB","ensembl_gene_id":"ENSG00000198125","hgnc_id":"HGNC:6915","ncbi_gene_id":4151,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MB","release_manifest":"api/v1.1/release_manifest.json"}},"MB21D2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MB21D2","identifiers":{"aliases":["D2A"],"approved_symbol":"MB21D2","ensembl_gene_id":"ENSG00000180611","hgnc_id":"HGNC:30438","ncbi_gene_id":151963,"previous_symbols":["C3orf59"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MB21D2","release_manifest":"api/v1.1/release_manifest.json"}},"MBD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBD1","identifiers":{"aliases":["PCM1","CXXC3"],"approved_symbol":"MBD1","ensembl_gene_id":"ENSG00000141644","hgnc_id":"HGNC:6916","ncbi_gene_id":4152,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBD1","release_manifest":"api/v1.1/release_manifest.json"}},"MBD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBD2","identifiers":{"aliases":[],"approved_symbol":"MBD2","ensembl_gene_id":"ENSG00000134046","hgnc_id":"HGNC:6917","ncbi_gene_id":8932,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBD2","release_manifest":"api/v1.1/release_manifest.json"}},"MBD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBD3","identifiers":{"aliases":[],"approved_symbol":"MBD3","ensembl_gene_id":"ENSG00000071655","hgnc_id":"HGNC:6918","ncbi_gene_id":53615,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.012908,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MBD3","release_manifest":"api/v1.1/release_manifest.json"}},"MBD3L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBD3L1","identifiers":{"aliases":[],"approved_symbol":"MBD3L1","ensembl_gene_id":"ENSG00000170948","hgnc_id":"HGNC:15774","ncbi_gene_id":85509,"previous_symbols":["MBD3L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MBD3L1","release_manifest":"api/v1.1/release_manifest.json"}},"MBD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBD4","identifiers":{"aliases":["MED1"],"approved_symbol":"MBD4","ensembl_gene_id":"ENSG00000129071","hgnc_id":"HGNC:6919","ncbi_gene_id":8930,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBD4","release_manifest":"api/v1.1/release_manifest.json"}},"MBD5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBD5","identifiers":{"aliases":["FLJ11113","KIAA1461"],"approved_symbol":"MBD5","ensembl_gene_id":"ENSG00000204406","hgnc_id":"HGNC:20444","ncbi_gene_id":55777,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBD5","release_manifest":"api/v1.1/release_manifest.json"}},"MBD6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBD6","identifiers":{"aliases":["KIAA1887"],"approved_symbol":"MBD6","ensembl_gene_id":"ENSG00000166987","hgnc_id":"HGNC:20445","ncbi_gene_id":114785,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBD6","release_manifest":"api/v1.1/release_manifest.json"}},"MBIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBIP","identifiers":{"aliases":[],"approved_symbol":"MBIP","ensembl_gene_id":"ENSG00000151332","hgnc_id":"HGNC:20427","ncbi_gene_id":51562,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBIP","release_manifest":"api/v1.1/release_manifest.json"}},"MBLAC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBLAC1","identifiers":{"aliases":["MGC49416"],"approved_symbol":"MBLAC1","ensembl_gene_id":"ENSG00000214309","hgnc_id":"HGNC:22180","ncbi_gene_id":255374,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBLAC1","release_manifest":"api/v1.1/release_manifest.json"}},"MBLAC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBLAC2","identifiers":{"aliases":["DKFZp686P15118","MGC46734"],"approved_symbol":"MBLAC2","ensembl_gene_id":"ENSG00000176055","hgnc_id":"HGNC:33711","ncbi_gene_id":153364,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBLAC2","release_manifest":"api/v1.1/release_manifest.json"}},"MBNL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBNL1","identifiers":{"aliases":["KIAA0428","EXP42","EXP40","EXP35","EXP"],"approved_symbol":"MBNL1","ensembl_gene_id":"ENSG00000152601","hgnc_id":"HGNC:6923","ncbi_gene_id":4154,"previous_symbols":["MBNL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.55229,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBNL1","release_manifest":"api/v1.1/release_manifest.json"}},"MBNL1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBNL1-AS1","identifiers":{"aliases":["LOC401093"],"approved_symbol":"MBNL1-AS1","ensembl_gene_id":"ENSG00000229619","hgnc_id":"HGNC:44584","ncbi_gene_id":401093,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBNL1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MBNL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBNL2","identifiers":{"aliases":["MBLL","MBLL39"],"approved_symbol":"MBNL2","ensembl_gene_id":"ENSG00000139793","hgnc_id":"HGNC:16746","ncbi_gene_id":10150,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBNL2","release_manifest":"api/v1.1/release_manifest.json"}},"MBNL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBNL3","identifiers":{"aliases":["CHCR","FLJ11316","MBLX39","MBXL"],"approved_symbol":"MBNL3","ensembl_gene_id":"ENSG00000076770","hgnc_id":"HGNC:20564","ncbi_gene_id":55796,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBNL3","release_manifest":"api/v1.1/release_manifest.json"}},"MBOAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBOAT1","identifiers":{"aliases":["MGC44669","dJ434O11.1","LPEAT1","LPLAT14"],"approved_symbol":"MBOAT1","ensembl_gene_id":"ENSG00000172197","hgnc_id":"HGNC:21579","ncbi_gene_id":154141,"previous_symbols":["OACT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBOAT1","release_manifest":"api/v1.1/release_manifest.json"}},"MBOAT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBOAT2","identifiers":{"aliases":["FLJ14415","FLJ90298","LPLAT13"],"approved_symbol":"MBOAT2","ensembl_gene_id":"ENSG00000143797","hgnc_id":"HGNC:25193","ncbi_gene_id":129642,"previous_symbols":["OACT2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBOAT2","release_manifest":"api/v1.1/release_manifest.json"}},"MBOAT4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBOAT4","identifiers":{"aliases":["FKSG89","GOAT"],"approved_symbol":"MBOAT4","ensembl_gene_id":"ENSG00000177669","hgnc_id":"HGNC:32311","ncbi_gene_id":619373,"previous_symbols":["OACT4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MBOAT4","release_manifest":"api/v1.1/release_manifest.json"}},"MBOAT7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBOAT7","identifiers":{"aliases":["BB1","hMBOA-7","LPLAT","LPIAT1","LPLAT11"],"approved_symbol":"MBOAT7","ensembl_gene_id":"ENSG00000125505","hgnc_id":"HGNC:15505","ncbi_gene_id":79143,"previous_symbols":["LENG4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBOAT7","release_manifest":"api/v1.1/release_manifest.json"}},"MBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBP","identifiers":{"aliases":[],"approved_symbol":"MBP","ensembl_gene_id":"ENSG00000197971","hgnc_id":"HGNC:6925","ncbi_gene_id":4155,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MBP","release_manifest":"api/v1.1/release_manifest.json"}},"MBTD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBTD1","identifiers":{"aliases":["SA49P01","FLJ20055"],"approved_symbol":"MBTD1","ensembl_gene_id":"ENSG00000011258","hgnc_id":"HGNC:19866","ncbi_gene_id":54799,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBTD1","release_manifest":"api/v1.1/release_manifest.json"}},"MBTPS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBTPS1","identifiers":{"aliases":["S1P","KIAA0091","SKI-1","PCSK8"],"approved_symbol":"MBTPS1","ensembl_gene_id":"ENSG00000140943","hgnc_id":"HGNC:15456","ncbi_gene_id":8720,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBTPS1","release_manifest":"api/v1.1/release_manifest.json"}},"MBTPS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MBTPS2","identifiers":{"aliases":["S2P"],"approved_symbol":"MBTPS2","ensembl_gene_id":"ENSG00000012174","hgnc_id":"HGNC:15455","ncbi_gene_id":51360,"previous_symbols":["KFSD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MBTPS2","release_manifest":"api/v1.1/release_manifest.json"}},"MC1R":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MC1R","identifiers":{"aliases":["MSH-R"],"approved_symbol":"MC1R","ensembl_gene_id":"ENSG00000258839","hgnc_id":"HGNC:6929","ncbi_gene_id":4157,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MC1R","release_manifest":"api/v1.1/release_manifest.json"}},"MCAM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCAM","identifiers":{"aliases":["MUC18","CD146","MelCAM","METCAM","HEMCAM"],"approved_symbol":"MCAM","ensembl_gene_id":"ENSG00000076706","hgnc_id":"HGNC:6934","ncbi_gene_id":4162,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCAM","release_manifest":"api/v1.1/release_manifest.json"}},"MCAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCAT","identifiers":{"aliases":["MT","MCT","fabD","FASN2C","NET62","MCT1"],"approved_symbol":"MCAT","ensembl_gene_id":"ENSG00000100294","hgnc_id":"HGNC:29622","ncbi_gene_id":27349,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCAT","release_manifest":"api/v1.1/release_manifest.json"}},"MCC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCC","identifiers":{"aliases":[],"approved_symbol":"MCC","ensembl_gene_id":"ENSG00000171444","hgnc_id":"HGNC:6935","ncbi_gene_id":4163,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCC","release_manifest":"api/v1.1/release_manifest.json"}},"MCCC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCCC1","identifiers":{"aliases":["MCCA","MCCCα"],"approved_symbol":"MCCC1","ensembl_gene_id":"ENSG00000078070","hgnc_id":"HGNC:6936","ncbi_gene_id":56922,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCCC1","release_manifest":"api/v1.1/release_manifest.json"}},"MCCC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCCC2","identifiers":{"aliases":["MCCB","MCCCβ"],"approved_symbol":"MCCC2","ensembl_gene_id":"ENSG00000131844","hgnc_id":"HGNC:6937","ncbi_gene_id":64087,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCCC2","release_manifest":"api/v1.1/release_manifest.json"}},"MCEE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCEE","identifiers":{"aliases":["GLOD2","MCE","MMCE"],"approved_symbol":"MCEE","ensembl_gene_id":"ENSG00000124370","hgnc_id":"HGNC:16732","ncbi_gene_id":84693,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCEE","release_manifest":"api/v1.1/release_manifest.json"}},"MCEMP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCEMP1","identifiers":{"aliases":["MGC132456"],"approved_symbol":"MCEMP1","ensembl_gene_id":"ENSG00000183019","hgnc_id":"HGNC:27291","ncbi_gene_id":199675,"previous_symbols":["C19orf59"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MCEMP1","release_manifest":"api/v1.1/release_manifest.json"}},"MCF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCF2","identifiers":{"aliases":["DBL","ARHGEF21"],"approved_symbol":"MCF2","ensembl_gene_id":"ENSG00000101977","hgnc_id":"HGNC:6940","ncbi_gene_id":4168,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCF2","release_manifest":"api/v1.1/release_manifest.json"}},"MCF2L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCF2L","identifiers":{"aliases":["KIAA0362","DBS","OST","ARHGEF14"],"approved_symbol":"MCF2L","ensembl_gene_id":"ENSG00000126217","hgnc_id":"HGNC:14576","ncbi_gene_id":23263,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCF2L","release_manifest":"api/v1.1/release_manifest.json"}},"MCF2L-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCF2L-AS1","identifiers":{"aliases":[],"approved_symbol":"MCF2L-AS1","ensembl_gene_id":"ENSG00000235280","hgnc_id":"HGNC:39825","ncbi_gene_id":100289410,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MCF2L-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MCF2L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCF2L2","identifiers":{"aliases":["KIAA0861","ARHGEF22"],"approved_symbol":"MCF2L2","ensembl_gene_id":"ENSG00000053524","hgnc_id":"HGNC:30319","ncbi_gene_id":23101,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCF2L2","release_manifest":"api/v1.1/release_manifest.json"}},"MCFD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCFD2","identifiers":{"aliases":["F5F8D","LMAN1IP","SDNSF"],"approved_symbol":"MCFD2","ensembl_gene_id":"ENSG00000180398","hgnc_id":"HGNC:18451","ncbi_gene_id":90411,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCFD2","release_manifest":"api/v1.1/release_manifest.json"}},"MCHR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCHR1","identifiers":{"aliases":["SLC1","MCH1R"],"approved_symbol":"MCHR1","ensembl_gene_id":"ENSG00000128285","hgnc_id":"HGNC:4479","ncbi_gene_id":2847,"previous_symbols":["GPR24"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MCHR1","release_manifest":"api/v1.1/release_manifest.json"}},"MCHR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCHR2","identifiers":{"aliases":["SLT","MCH2","MCH2R"],"approved_symbol":"MCHR2","ensembl_gene_id":"ENSG00000152034","hgnc_id":"HGNC:20867","ncbi_gene_id":84539,"previous_symbols":["GPR145"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MCHR2","release_manifest":"api/v1.1/release_manifest.json"}},"MCHR2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCHR2-AS1","identifiers":{"aliases":[],"approved_symbol":"MCHR2-AS1","ensembl_gene_id":"ENSG00000229315","hgnc_id":"HGNC:48980","ncbi_gene_id":728012,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MCHR2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MCL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCL1","identifiers":{"aliases":["BCL2L3","Mcl-1"],"approved_symbol":"MCL1","ensembl_gene_id":"ENSG00000143384","hgnc_id":"HGNC:6943","ncbi_gene_id":4170,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MCL1","release_manifest":"api/v1.1/release_manifest.json"}},"MCM10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM10","identifiers":{"aliases":["PRO2249","CNA43","DNA43"],"approved_symbol":"MCM10","ensembl_gene_id":"ENSG00000065328","hgnc_id":"HGNC:18043","ncbi_gene_id":55388,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MCM10","release_manifest":"api/v1.1/release_manifest.json"}},"MCM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM2","identifiers":{"aliases":["D3S3194","KIAA0030","BM28","cdc19","DFNA70"],"approved_symbol":"MCM2","ensembl_gene_id":"ENSG00000073111","hgnc_id":"HGNC:6944","ncbi_gene_id":4171,"previous_symbols":["CCNL1","CDCL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM2","release_manifest":"api/v1.1/release_manifest.json"}},"MCM3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM3","identifiers":{"aliases":[],"approved_symbol":"MCM3","ensembl_gene_id":"ENSG00000112118","hgnc_id":"HGNC:6945","ncbi_gene_id":4172,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM3","release_manifest":"api/v1.1/release_manifest.json"}},"MCM3AP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM3AP","identifiers":{"aliases":["Map80","KIAA0572","GANP","SAC3"],"approved_symbol":"MCM3AP","ensembl_gene_id":"ENSG00000160294","hgnc_id":"HGNC:6946","ncbi_gene_id":8888,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM3AP","release_manifest":"api/v1.1/release_manifest.json"}},"MCM3AP-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM3AP-AS1","identifiers":{"aliases":["FLJ10508","NCRNA00031"],"approved_symbol":"MCM3AP-AS1","ensembl_gene_id":"ENSG00000215424","hgnc_id":"HGNC:16417","ncbi_gene_id":114044,"previous_symbols":["C21orf85","MCM3APAS","MCM3AP-AS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM3AP-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MCM4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM4","identifiers":{"aliases":["CDC54","hCdc21","P1-Cdc21","MGC33310"],"approved_symbol":"MCM4","ensembl_gene_id":"ENSG00000104738","hgnc_id":"HGNC:6947","ncbi_gene_id":4173,"previous_symbols":["CDC21"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM4","release_manifest":"api/v1.1/release_manifest.json"}},"MCM5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM5","identifiers":{"aliases":[],"approved_symbol":"MCM5","ensembl_gene_id":"ENSG00000100297","hgnc_id":"HGNC:6948","ncbi_gene_id":4174,"previous_symbols":["CDC46"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM5","release_manifest":"api/v1.1/release_manifest.json"}},"MCM6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM6","identifiers":{"aliases":["Mis5"],"approved_symbol":"MCM6","ensembl_gene_id":"ENSG00000076003","hgnc_id":"HGNC:6949","ncbi_gene_id":4175,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM6","release_manifest":"api/v1.1/release_manifest.json"}},"MCM7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM7","identifiers":{"aliases":["CDC47","PPP1R104"],"approved_symbol":"MCM7","ensembl_gene_id":"ENSG00000166508","hgnc_id":"HGNC:6950","ncbi_gene_id":4176,"previous_symbols":["MCM2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM7","release_manifest":"api/v1.1/release_manifest.json"}},"MCM8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM8","identifiers":{"aliases":["MGC4816","MGC12866","MGC119522","MGC119523","dJ967N21.5","REC"],"approved_symbol":"MCM8","ensembl_gene_id":"ENSG00000125885","hgnc_id":"HGNC:16147","ncbi_gene_id":84515,"previous_symbols":["C20orf154"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM8","release_manifest":"api/v1.1/release_manifest.json"}},"MCM9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCM9","identifiers":{"aliases":["MGC35304","dJ329L24.3","FLJ20170"],"approved_symbol":"MCM9","ensembl_gene_id":"ENSG00000111877","hgnc_id":"HGNC:21484","ncbi_gene_id":254394,"previous_symbols":["MCMDC1","C6orf61"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCM9","release_manifest":"api/v1.1/release_manifest.json"}},"MCMBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCMBP","identifiers":{"aliases":["FLJ13081","MCM-BP"],"approved_symbol":"MCMBP","ensembl_gene_id":"ENSG00000197771","hgnc_id":"HGNC:25782","ncbi_gene_id":79892,"previous_symbols":["C10orf119"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MCMBP","release_manifest":"api/v1.1/release_manifest.json"}},"MCMDC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCMDC2","identifiers":{"aliases":["FLJ25692"],"approved_symbol":"MCMDC2","ensembl_gene_id":"ENSG00000178460","hgnc_id":"HGNC:26368","ncbi_gene_id":157777,"previous_symbols":["C8orf45"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCMDC2","release_manifest":"api/v1.1/release_manifest.json"}},"MCOLN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCOLN1","identifiers":{"aliases":["TRPML1","ML4","MLIV","MST080","MSTP080","TRPM-L1"],"approved_symbol":"MCOLN1","ensembl_gene_id":"ENSG00000090674","hgnc_id":"HGNC:13356","ncbi_gene_id":57192,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCOLN1","release_manifest":"api/v1.1/release_manifest.json"}},"MCOLN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCOLN2","identifiers":{"aliases":["TRPML2","FLJ36691","TRP-ML2"],"approved_symbol":"MCOLN2","ensembl_gene_id":"ENSG00000153898","hgnc_id":"HGNC:13357","ncbi_gene_id":255231,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCOLN2","release_manifest":"api/v1.1/release_manifest.json"}},"MCOLN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCOLN3","identifiers":{"aliases":["TRPML3","FLJ11006","TRP-ML3"],"approved_symbol":"MCOLN3","ensembl_gene_id":"ENSG00000055732","hgnc_id":"HGNC:13358","ncbi_gene_id":55283,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCOLN3","release_manifest":"api/v1.1/release_manifest.json"}},"MCPH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCPH1","identifiers":{"aliases":["FLJ12847","BRIT1"],"approved_symbol":"MCPH1","ensembl_gene_id":"ENSG00000147316","hgnc_id":"HGNC:6954","ncbi_gene_id":79648,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCPH1","release_manifest":"api/v1.1/release_manifest.json"}},"MCPH1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCPH1-AS1","identifiers":{"aliases":[],"approved_symbol":"MCPH1-AS1","ensembl_gene_id":"ENSG00000249898","hgnc_id":"HGNC:51655","ncbi_gene_id":100507530,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MCPH1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MCRIP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCRIP1","identifiers":{"aliases":["GRAN2","MCRIP"],"approved_symbol":"MCRIP1","ensembl_gene_id":"ENSG00000225663","hgnc_id":"HGNC:28007","ncbi_gene_id":348262,"previous_symbols":["FAM195B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCRIP1","release_manifest":"api/v1.1/release_manifest.json"}},"MCRIP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCRIP2","identifiers":{"aliases":["MGC15416"],"approved_symbol":"MCRIP2","ensembl_gene_id":"ENSG00000172366","hgnc_id":"HGNC:14142","ncbi_gene_id":84331,"previous_symbols":["C16orf14","FAM195A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCRIP2","release_manifest":"api/v1.1/release_manifest.json"}},"MCRS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCRS1","identifiers":{"aliases":["ICP22BP","MSP58","P78","MCRS2","INO80Q"],"approved_symbol":"MCRS1","ensembl_gene_id":"ENSG00000187778","hgnc_id":"HGNC:6960","ncbi_gene_id":10445,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCRS1","release_manifest":"api/v1.1/release_manifest.json"}},"MCTP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCTP1","identifiers":{"aliases":["FLJ22344"],"approved_symbol":"MCTP1","ensembl_gene_id":"ENSG00000175471","hgnc_id":"HGNC:26183","ncbi_gene_id":79772,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCTP1","release_manifest":"api/v1.1/release_manifest.json"}},"MCTP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCTP2","identifiers":{"aliases":["FLJ11175","FLJ33303"],"approved_symbol":"MCTP2","ensembl_gene_id":"ENSG00000140563","hgnc_id":"HGNC:25636","ncbi_gene_id":55784,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCTP2","release_manifest":"api/v1.1/release_manifest.json"}},"MCTS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCTS1","identifiers":{"aliases":["MCT-1"],"approved_symbol":"MCTS1","ensembl_gene_id":"ENSG00000232119","hgnc_id":"HGNC:23357","ncbi_gene_id":28985,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MCTS1","release_manifest":"api/v1.1/release_manifest.json"}},"MCU":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCU","identifiers":{"aliases":["FLJ46135"],"approved_symbol":"MCU","ensembl_gene_id":"ENSG00000156026","hgnc_id":"HGNC:23526","ncbi_gene_id":90550,"previous_symbols":["C10orf42","CCDC109A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCU","release_manifest":"api/v1.1/release_manifest.json"}},"MCUB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCUB","identifiers":{"aliases":["FLJ20647"],"approved_symbol":"MCUB","ensembl_gene_id":"ENSG00000005059","hgnc_id":"HGNC:26076","ncbi_gene_id":55013,"previous_symbols":["CCDC109B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MCUB","release_manifest":"api/v1.1/release_manifest.json"}},"MCUR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MCUR1","identifiers":{"aliases":["FLJ20958"],"approved_symbol":"MCUR1","ensembl_gene_id":"ENSG00000050393","hgnc_id":"HGNC:21097","ncbi_gene_id":63933,"previous_symbols":["C6orf79","CCDC90A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MCUR1","release_manifest":"api/v1.1/release_manifest.json"}},"MDC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDC1","identifiers":{"aliases":["NFBD1","KIAA0170","Em:AB023051.5"],"approved_symbol":"MDC1","ensembl_gene_id":"ENSG00000137337","hgnc_id":"HGNC:21163","ncbi_gene_id":9656,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDC1","release_manifest":"api/v1.1/release_manifest.json"}},"MDC1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDC1-AS1","identifiers":{"aliases":["MDC1-AS"],"approved_symbol":"MDC1-AS1","ensembl_gene_id":"ENSG00000224328","hgnc_id":"HGNC:39764","ncbi_gene_id":106478956,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDC1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MDFI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDFI","identifiers":{"aliases":["I-mfa"],"approved_symbol":"MDFI","ensembl_gene_id":"ENSG00000112559","hgnc_id":"HGNC:6967","ncbi_gene_id":4188,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDFI","release_manifest":"api/v1.1/release_manifest.json"}},"MDFIC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDFIC","identifiers":{"aliases":["HIC","MDFIC1"],"approved_symbol":"MDFIC","ensembl_gene_id":"ENSG00000135272","hgnc_id":"HGNC:28870","ncbi_gene_id":29969,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDFIC","release_manifest":"api/v1.1/release_manifest.json"}},"MDGA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDGA1","identifiers":{"aliases":["GPIM","MAMDC3"],"approved_symbol":"MDGA1","ensembl_gene_id":"ENSG00000112139","hgnc_id":"HGNC:19267","ncbi_gene_id":266727,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDGA1","release_manifest":"api/v1.1/release_manifest.json"}},"MDGA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDGA2","identifiers":{"aliases":[],"approved_symbol":"MDGA2","ensembl_gene_id":"ENSG00000139915","hgnc_id":"HGNC:19835","ncbi_gene_id":161357,"previous_symbols":["MAMDC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDGA2","release_manifest":"api/v1.1/release_manifest.json"}},"MDH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDH1","identifiers":{"aliases":[],"approved_symbol":"MDH1","ensembl_gene_id":"ENSG00000014641","hgnc_id":"HGNC:6970","ncbi_gene_id":4190,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDH1","release_manifest":"api/v1.1/release_manifest.json"}},"MDH1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDH1B","identifiers":{"aliases":["FLJ25341","RP11-95H11"],"approved_symbol":"MDH1B","ensembl_gene_id":"ENSG00000138400","hgnc_id":"HGNC:17836","ncbi_gene_id":130752,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MDH1B","release_manifest":"api/v1.1/release_manifest.json"}},"MDH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDH2","identifiers":{"aliases":[],"approved_symbol":"MDH2","ensembl_gene_id":"ENSG00000146701","hgnc_id":"HGNC:6971","ncbi_gene_id":4191,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDH2","release_manifest":"api/v1.1/release_manifest.json"}},"MDK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDK","identifiers":{"aliases":["MK","FLJ27379"],"approved_symbol":"MDK","ensembl_gene_id":"ENSG00000110492","hgnc_id":"HGNC:6972","ncbi_gene_id":4192,"previous_symbols":["NEGF2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDK","release_manifest":"api/v1.1/release_manifest.json"}},"MDM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDM1","identifiers":{"approved_symbol":"MDM1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDM1","release_manifest":"api/v1.1/release_manifest.json"}},"MDM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDM2","identifiers":{"aliases":["HDM2","MGC5370"],"approved_symbol":"MDM2","ensembl_gene_id":"ENSG00000135679","hgnc_id":"HGNC:6973","ncbi_gene_id":4193,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDM2","release_manifest":"api/v1.1/release_manifest.json"}},"MDM4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDM4","identifiers":{"aliases":["MDMX","HDMX"],"approved_symbol":"MDM4","ensembl_gene_id":"ENSG00000198625","hgnc_id":"HGNC:6974","ncbi_gene_id":4194,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDM4","release_manifest":"api/v1.1/release_manifest.json"}},"MDN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDN1","identifiers":{"aliases":["KIAA0301","Rea1"],"approved_symbol":"MDN1","ensembl_gene_id":"ENSG00000112159","hgnc_id":"HGNC:18302","ncbi_gene_id":23195,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDN1","release_manifest":"api/v1.1/release_manifest.json"}},"MDP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDP1","identifiers":{"aliases":["MGC5987","FN6Pase"],"approved_symbol":"MDP1","ensembl_gene_id":"ENSG00000213920","hgnc_id":"HGNC:28781","ncbi_gene_id":145553,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MDP1","release_manifest":"api/v1.1/release_manifest.json"}},"MDS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MDS2","identifiers":{"aliases":[],"approved_symbol":"MDS2","ensembl_gene_id":"ENSG00000197880","hgnc_id":"HGNC:29633","ncbi_gene_id":259283,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MDS2","release_manifest":"api/v1.1/release_manifest.json"}},"ME1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ME1","identifiers":{"aliases":[],"approved_symbol":"ME1","ensembl_gene_id":"ENSG00000065833","hgnc_id":"HGNC:6983","ncbi_gene_id":4199,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ME1","release_manifest":"api/v1.1/release_manifest.json"}},"ME2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ME2","identifiers":{"aliases":[],"approved_symbol":"ME2","ensembl_gene_id":"ENSG00000082212","hgnc_id":"HGNC:6984","ncbi_gene_id":4200,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ME2","release_manifest":"api/v1.1/release_manifest.json"}},"ME3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"ME3","identifiers":{"aliases":[],"approved_symbol":"ME3","ensembl_gene_id":"ENSG00000151376","hgnc_id":"HGNC:6985","ncbi_gene_id":10873,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/ME3","release_manifest":"api/v1.1/release_manifest.json"}},"MEA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEA1","identifiers":{"aliases":[],"approved_symbol":"MEA1","ensembl_gene_id":"ENSG00000124733","hgnc_id":"HGNC:6986","ncbi_gene_id":4201,"previous_symbols":["MEA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEA1","release_manifest":"api/v1.1/release_manifest.json"}},"MEAF6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEAF6","identifiers":{"aliases":["NY-SAR-91","FLJ11730","Eaf6","CENP-28"],"approved_symbol":"MEAF6","ensembl_gene_id":"ENSG00000163875","hgnc_id":"HGNC:25674","ncbi_gene_id":64769,"previous_symbols":["C1orf149"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MEAF6","release_manifest":"api/v1.1/release_manifest.json"}},"MEAK7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEAK7","identifiers":{"aliases":["mEAK-7"],"approved_symbol":"MEAK7","ensembl_gene_id":"ENSG00000140950","hgnc_id":"HGNC:29325","ncbi_gene_id":57707,"previous_symbols":["KIAA1609","TLDC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEAK7","release_manifest":"api/v1.1/release_manifest.json"}},"MECOM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MECOM","identifiers":{"aliases":["MDS1-EVI1","PRDM3","KMT8E"],"approved_symbol":"MECOM","ensembl_gene_id":"ENSG00000085276","hgnc_id":"HGNC:3498","ncbi_gene_id":2122,"previous_symbols":["MDS1","EVI1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MECOM","release_manifest":"api/v1.1/release_manifest.json"}},"MECP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MECP2","identifiers":{"aliases":[],"approved_symbol":"MECP2","ensembl_gene_id":"ENSG00000169057","hgnc_id":"HGNC:6990","ncbi_gene_id":4204,"previous_symbols":["RTT","MRX16","MRX79"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MECP2","release_manifest":"api/v1.1/release_manifest.json"}},"MECR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MECR","identifiers":{"aliases":["CGI-63","NRBF1","FASN2B","ETR1"],"approved_symbol":"MECR","ensembl_gene_id":"ENSG00000116353","hgnc_id":"HGNC:19691","ncbi_gene_id":51102,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MECR","release_manifest":"api/v1.1/release_manifest.json"}},"MED1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED1","identifiers":{"aliases":["PBP","TRAP220","RB18A","DRIP230","CRSP200","CRSP1"],"approved_symbol":"MED1","ensembl_gene_id":"ENSG00000125686","hgnc_id":"HGNC:9234","ncbi_gene_id":5469,"previous_symbols":["TRIP2","PPARGBP","PPARBP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED1","release_manifest":"api/v1.1/release_manifest.json"}},"MED10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED10","identifiers":{"aliases":["TRG20","L6","MGC5309","NUT2"],"approved_symbol":"MED10","ensembl_gene_id":"ENSG00000133398","hgnc_id":"HGNC:28760","ncbi_gene_id":84246,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED10","release_manifest":"api/v1.1/release_manifest.json"}},"MED11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED11","identifiers":{"aliases":["HSPC296","MGC88387"],"approved_symbol":"MED11","ensembl_gene_id":"ENSG00000161920","hgnc_id":"HGNC:32687","ncbi_gene_id":400569,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED11","release_manifest":"api/v1.1/release_manifest.json"}},"MED12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED12","identifiers":{"aliases":["CAGH45","HOPA","OPA1","TRAP230","KIAA0192","OKS","ARC240","Kto"],"approved_symbol":"MED12","ensembl_gene_id":"ENSG00000184634","hgnc_id":"HGNC:11957","ncbi_gene_id":9968,"previous_symbols":["TNRC11","FGS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED12","release_manifest":"api/v1.1/release_manifest.json"}},"MED12L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED12L","identifiers":{"aliases":["KIAA1635","TNRC11L","TRALPUSH","TRALP"],"approved_symbol":"MED12L","ensembl_gene_id":"ENSG00000144893","hgnc_id":"HGNC:16050","ncbi_gene_id":116931,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED12L","release_manifest":"api/v1.1/release_manifest.json"}},"MED13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED13","identifiers":{"aliases":["KIAA0593","TRAP240"],"approved_symbol":"MED13","ensembl_gene_id":"ENSG00000108510","hgnc_id":"HGNC:22474","ncbi_gene_id":9969,"previous_symbols":["THRAP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED13","release_manifest":"api/v1.1/release_manifest.json"}},"MED13L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED13L","identifiers":{"aliases":["KIAA1025","TRAP240L"],"approved_symbol":"MED13L","ensembl_gene_id":"ENSG00000123066","hgnc_id":"HGNC:22962","ncbi_gene_id":23389,"previous_symbols":["THRAP2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MED13L","release_manifest":"api/v1.1/release_manifest.json"}},"MED14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED14","identifiers":{"aliases":["EXLM1","CRSP150","TRAP170","RGR1","CSRP"],"approved_symbol":"MED14","ensembl_gene_id":"ENSG00000180182","hgnc_id":"HGNC:2370","ncbi_gene_id":9282,"previous_symbols":["CXorf4","CRSP2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED14","release_manifest":"api/v1.1/release_manifest.json"}},"MED14OS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED14OS","identifiers":{"aliases":[],"approved_symbol":"MED14OS","ensembl_gene_id":"ENSG00000234636","hgnc_id":"HGNC:40162","ncbi_gene_id":100873985,"previous_symbols":["MED14-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED14OS","release_manifest":"api/v1.1/release_manifest.json"}},"MED15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED15","identifiers":{"aliases":["TIG-1","CAG7A","Arc105"],"approved_symbol":"MED15","ensembl_gene_id":"ENSG00000099917","hgnc_id":"HGNC:14248","ncbi_gene_id":51586,"previous_symbols":["TNRC7","PCQAP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED15","release_manifest":"api/v1.1/release_manifest.json"}},"MED16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED16","identifiers":{"aliases":["DRIP92","TRAP95"],"approved_symbol":"MED16","ensembl_gene_id":"ENSG00000175221","hgnc_id":"HGNC:17556","ncbi_gene_id":10025,"previous_symbols":["THRAP5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.28292,"fdr":0.874686,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED16","release_manifest":"api/v1.1/release_manifest.json"}},"MED17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED17","identifiers":{"aliases":["CRSP77","TRAP80","DRIP80","SRB4"],"approved_symbol":"MED17","ensembl_gene_id":"ENSG00000042429","hgnc_id":"HGNC:2375","ncbi_gene_id":9440,"previous_symbols":["CRSP6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED17","release_manifest":"api/v1.1/release_manifest.json"}},"MED18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED18","identifiers":{"aliases":["FLJ20045","p28b","SRB5"],"approved_symbol":"MED18","ensembl_gene_id":"ENSG00000130772","hgnc_id":"HGNC:25944","ncbi_gene_id":54797,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED18","release_manifest":"api/v1.1/release_manifest.json"}},"MED19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED19","identifiers":{"aliases":["LCMR1"],"approved_symbol":"MED19","ensembl_gene_id":"ENSG00000156603","hgnc_id":"HGNC:29600","ncbi_gene_id":219541,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED19","release_manifest":"api/v1.1/release_manifest.json"}},"MED20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED20","identifiers":{"aliases":["DKFZp586D2223","PRO0213","SRB2"],"approved_symbol":"MED20","ensembl_gene_id":"ENSG00000124641","hgnc_id":"HGNC:16840","ncbi_gene_id":9477,"previous_symbols":["TRFP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED20","release_manifest":"api/v1.1/release_manifest.json"}},"MED21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED21","identifiers":{"aliases":["SRB7"],"approved_symbol":"MED21","ensembl_gene_id":"ENSG00000152944","hgnc_id":"HGNC:11473","ncbi_gene_id":9412,"previous_symbols":["SURB7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED21","release_manifest":"api/v1.1/release_manifest.json"}},"MED22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED22","identifiers":{"aliases":["Med24","SRB6"],"approved_symbol":"MED22","ensembl_gene_id":"ENSG00000148297","hgnc_id":"HGNC:11477","ncbi_gene_id":6837,"previous_symbols":["SURF5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED22","release_manifest":"api/v1.1/release_manifest.json"}},"MED23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED23","identifiers":{"aliases":["CRSP130","DRIP130","Sur2"],"approved_symbol":"MED23","ensembl_gene_id":"ENSG00000112282","hgnc_id":"HGNC:2372","ncbi_gene_id":9439,"previous_symbols":["CRSP3","MRT18"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED23","release_manifest":"api/v1.1/release_manifest.json"}},"MED24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED24","identifiers":{"aliases":["TRAP100","KIAA0130","DRIP100","CRSP100","MED5"],"approved_symbol":"MED24","ensembl_gene_id":"ENSG00000008838","hgnc_id":"HGNC:22963","ncbi_gene_id":9862,"previous_symbols":["THRAP4","CRSP4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED24","release_manifest":"api/v1.1/release_manifest.json"}},"MED25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED25","identifiers":{"aliases":["ARC92","ACID1","TCBAP0758","DKFZp434K0512"],"approved_symbol":"MED25","ensembl_gene_id":"ENSG00000104973","hgnc_id":"HGNC:28845","ncbi_gene_id":81857,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED25","release_manifest":"api/v1.1/release_manifest.json"}},"MED26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED26","identifiers":{"aliases":["CRSP70"],"approved_symbol":"MED26","ensembl_gene_id":"ENSG00000105085","hgnc_id":"HGNC:2376","ncbi_gene_id":9441,"previous_symbols":["CRSP7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED26","release_manifest":"api/v1.1/release_manifest.json"}},"MED27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED27","identifiers":{"aliases":["TRAP37","CRSP34","MED3"],"approved_symbol":"MED27","ensembl_gene_id":"ENSG00000160563","hgnc_id":"HGNC:2377","ncbi_gene_id":9442,"previous_symbols":["CRSP8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED27","release_manifest":"api/v1.1/release_manifest.json"}},"MED28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED28","identifiers":{"aliases":["EG1","DKFZP434N185","magicin"],"approved_symbol":"MED28","ensembl_gene_id":"ENSG00000118579","hgnc_id":"HGNC:24628","ncbi_gene_id":80306,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED28","release_manifest":"api/v1.1/release_manifest.json"}},"MED29":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED29","identifiers":{"aliases":["DKFZp434H247","MED2"],"approved_symbol":"MED29","ensembl_gene_id":"ENSG00000063322","hgnc_id":"HGNC:23074","ncbi_gene_id":55588,"previous_symbols":["IXL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED29","release_manifest":"api/v1.1/release_manifest.json"}},"MED30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED30","identifiers":{"aliases":["TRAP25"],"approved_symbol":"MED30","ensembl_gene_id":"ENSG00000164758","hgnc_id":"HGNC:23032","ncbi_gene_id":90390,"previous_symbols":["THRAP6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED30","release_manifest":"api/v1.1/release_manifest.json"}},"MED31":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED31","identifiers":{"aliases":["CGI-125","Soh1"],"approved_symbol":"MED31","ensembl_gene_id":"ENSG00000108590","hgnc_id":"HGNC:24260","ncbi_gene_id":51003,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED31","release_manifest":"api/v1.1/release_manifest.json"}},"MED4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED4","identifiers":{"aliases":["HSPC126","DRIP36","TRAP36"],"approved_symbol":"MED4","ensembl_gene_id":"ENSG00000136146","hgnc_id":"HGNC:17903","ncbi_gene_id":29079,"previous_symbols":["VDRIP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED4","release_manifest":"api/v1.1/release_manifest.json"}},"MED6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED6","identifiers":{"aliases":["NY-REN-28"],"approved_symbol":"MED6","ensembl_gene_id":"ENSG00000133997","hgnc_id":"HGNC:19970","ncbi_gene_id":10001,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED6","release_manifest":"api/v1.1/release_manifest.json"}},"MED7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED7","identifiers":{"aliases":["CRSP33"],"approved_symbol":"MED7","ensembl_gene_id":"ENSG00000155868","hgnc_id":"HGNC:2378","ncbi_gene_id":9443,"previous_symbols":["CRSP9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED7","release_manifest":"api/v1.1/release_manifest.json"}},"MED8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED8","identifiers":{"aliases":["MGC17544","MGC19641","ARC32"],"approved_symbol":"MED8","ensembl_gene_id":"ENSG00000159479","hgnc_id":"HGNC:19971","ncbi_gene_id":112950,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED8","release_manifest":"api/v1.1/release_manifest.json"}},"MED9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MED9","identifiers":{"aliases":["FLJ10193","MED25"],"approved_symbol":"MED9","ensembl_gene_id":"ENSG00000141026","hgnc_id":"HGNC:25487","ncbi_gene_id":55090,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MED9","release_manifest":"api/v1.1/release_manifest.json"}},"MEDAG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEDAG","identifiers":{"aliases":["FLJ14834","AWMS3","MEDA-4"],"approved_symbol":"MEDAG","ensembl_gene_id":"ENSG00000102802","hgnc_id":"HGNC:25926","ncbi_gene_id":84935,"previous_symbols":["C13orf33"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEDAG","release_manifest":"api/v1.1/release_manifest.json"}},"MEF2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEF2A","identifiers":{"aliases":["RSRFC4","RSRFC9"],"approved_symbol":"MEF2A","ensembl_gene_id":"ENSG00000068305","hgnc_id":"HGNC:6993","ncbi_gene_id":4205,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.24002,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEF2A","release_manifest":"api/v1.1/release_manifest.json"}},"MEF2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEF2B","identifiers":{"aliases":["RSRFR2"],"approved_symbol":"MEF2B","ensembl_gene_id":"ENSG00000213999","hgnc_id":"HGNC:6995","ncbi_gene_id":100271849,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEF2B","release_manifest":"api/v1.1/release_manifest.json"}},"MEF2C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEF2C","identifiers":{"aliases":[],"approved_symbol":"MEF2C","ensembl_gene_id":"ENSG00000081189","hgnc_id":"HGNC:6996","ncbi_gene_id":4208,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEF2C","release_manifest":"api/v1.1/release_manifest.json"}},"MEF2C-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEF2C-AS1","identifiers":{"aliases":[],"approved_symbol":"MEF2C-AS1","ensembl_gene_id":"ENSG00000248309","hgnc_id":"HGNC:48908","ncbi_gene_id":101929423,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MEF2C-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MEF2C-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEF2C-AS2","identifiers":{"aliases":["CTC-467M3.1"],"approved_symbol":"MEF2C-AS2","ensembl_gene_id":"ENSG00000245864","hgnc_id":"HGNC:53115","ncbi_gene_id":109729137,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEF2C-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"MEF2D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEF2D","identifiers":{"aliases":[],"approved_symbol":"MEF2D","ensembl_gene_id":"ENSG00000116604","hgnc_id":"HGNC:6997","ncbi_gene_id":4209,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEF2D","release_manifest":"api/v1.1/release_manifest.json"}},"MEFV":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEFV","identifiers":{"aliases":["FMF","TRIM20"],"approved_symbol":"MEFV","ensembl_gene_id":"ENSG00000103313","hgnc_id":"HGNC:6998","ncbi_gene_id":4210,"previous_symbols":["MEF"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEFV","release_manifest":"api/v1.1/release_manifest.json"}},"MEG3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEG3","identifiers":{"aliases":["Lnc-DLK1-35","GTL2","NCRNA00023","LINC00023","onco-lncRNA-83"],"approved_symbol":"MEG3","ensembl_gene_id":"ENSG00000214548","hgnc_id":"HGNC:14575","ncbi_gene_id":55384,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEG3","release_manifest":"api/v1.1/release_manifest.json"}},"MEG8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEG8","identifiers":{"aliases":["NCRNA00024","Irm","Rian","Bsr","LINC00024","AL132709.8","lnc-MGC"],"approved_symbol":"MEG8","ensembl_gene_id":"ENSG00000225746","hgnc_id":"HGNC:14574","ncbi_gene_id":79104,"previous_symbols":["SNHG23","SNHG24"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEG8","release_manifest":"api/v1.1/release_manifest.json"}},"MEG9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEG9","identifiers":{"aliases":["LINC00584"],"approved_symbol":"MEG9","ensembl_gene_id":"ENSG00000223403","hgnc_id":"HGNC:43874","ncbi_gene_id":100507257,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEG9","release_manifest":"api/v1.1/release_manifest.json"}},"MEGF10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEGF10","identifiers":{"aliases":["KIAA1780","SR-F3"],"approved_symbol":"MEGF10","ensembl_gene_id":"ENSG00000145794","hgnc_id":"HGNC:29634","ncbi_gene_id":84466,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEGF10","release_manifest":"api/v1.1/release_manifest.json"}},"MEGF11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEGF11","identifiers":{"aliases":["KIAA1781","DKFZp434L121"],"approved_symbol":"MEGF11","ensembl_gene_id":"ENSG00000157890","hgnc_id":"HGNC:29635","ncbi_gene_id":84465,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEGF11","release_manifest":"api/v1.1/release_manifest.json"}},"MEGF6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEGF6","identifiers":{"aliases":[],"approved_symbol":"MEGF6","ensembl_gene_id":"ENSG00000162591","hgnc_id":"HGNC:3232","ncbi_gene_id":1953,"previous_symbols":["EGFL3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MEGF6","release_manifest":"api/v1.1/release_manifest.json"}},"MEGF8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEGF8","identifiers":{"aliases":["SBP1","FLJ22365"],"approved_symbol":"MEGF8","ensembl_gene_id":"ENSG00000105429","hgnc_id":"HGNC:3233","ncbi_gene_id":1954,"previous_symbols":["EGFL4","C19orf49"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEGF8","release_manifest":"api/v1.1/release_manifest.json"}},"MEGF9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEGF9","identifiers":{"aliases":[],"approved_symbol":"MEGF9","ensembl_gene_id":"ENSG00000106780","hgnc_id":"HGNC:3234","ncbi_gene_id":1955,"previous_symbols":["EGFL5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEGF9","release_manifest":"api/v1.1/release_manifest.json"}},"MEI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEI1","identifiers":{"aliases":["MGC40042","SPATA38"],"approved_symbol":"MEI1","ensembl_gene_id":"ENSG00000167077","hgnc_id":"HGNC:28613","ncbi_gene_id":150365,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEI1","release_manifest":"api/v1.1/release_manifest.json"}},"MEI4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEI4","identifiers":{"aliases":[],"approved_symbol":"MEI4","ensembl_gene_id":"ENSG00000269964","hgnc_id":"HGNC:43638","ncbi_gene_id":101928601,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MEI4","release_manifest":"api/v1.1/release_manifest.json"}},"MEIG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIG1","identifiers":{"aliases":["bA2K17.3","SPATA39"],"approved_symbol":"MEIG1","ensembl_gene_id":"ENSG00000197889","hgnc_id":"HGNC:23429","ncbi_gene_id":644890,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MEIG1","release_manifest":"api/v1.1/release_manifest.json"}},"MEIKIN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIKIN","identifiers":{"aliases":["SPO13"],"approved_symbol":"MEIKIN","ensembl_gene_id":"ENSG00000239642","hgnc_id":"HGNC:51253","ncbi_gene_id":728637,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEIKIN","release_manifest":"api/v1.1/release_manifest.json"}},"MEIOB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIOB","identifiers":{"aliases":["MGC35212"],"approved_symbol":"MEIOB","ensembl_gene_id":"ENSG00000162039","hgnc_id":"HGNC:28569","ncbi_gene_id":254528,"previous_symbols":["C16orf73"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MEIOB","release_manifest":"api/v1.1/release_manifest.json"}},"MEIOC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIOC","identifiers":{"aliases":["FLJ35848"],"approved_symbol":"MEIOC","ensembl_gene_id":"ENSG00000180336","hgnc_id":"HGNC:26670","ncbi_gene_id":284071,"previous_symbols":["C17orf104"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEIOC","release_manifest":"api/v1.1/release_manifest.json"}},"MEIS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIS1","identifiers":{"aliases":[],"approved_symbol":"MEIS1","ensembl_gene_id":"ENSG00000143995","hgnc_id":"HGNC:7000","ncbi_gene_id":4211,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEIS1","release_manifest":"api/v1.1/release_manifest.json"}},"MEIS1-AS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIS1-AS2","identifiers":{"aliases":[],"approved_symbol":"MEIS1-AS2","ensembl_gene_id":"ENSG00000230749","hgnc_id":"HGNC:40370","ncbi_gene_id":100873998,"previous_symbols":["MEIS1-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MEIS1-AS2","release_manifest":"api/v1.1/release_manifest.json"}},"MEIS1-AS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIS1-AS3","identifiers":{"aliases":[],"approved_symbol":"MEIS1-AS3","ensembl_gene_id":"ENSG00000226819","hgnc_id":"HGNC:40369","ncbi_gene_id":730198,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MEIS1-AS3","release_manifest":"api/v1.1/release_manifest.json"}},"MEIS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIS2","identifiers":{"aliases":["MRG1","HsT18361"],"approved_symbol":"MEIS2","ensembl_gene_id":"ENSG00000134138","hgnc_id":"HGNC:7001","ncbi_gene_id":4212,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEIS2","release_manifest":"api/v1.1/release_manifest.json"}},"MEIS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEIS3","identifiers":{"aliases":["MRG2","DKFZp547H236"],"approved_symbol":"MEIS3","ensembl_gene_id":"ENSG00000105419","hgnc_id":"HGNC:29537","ncbi_gene_id":56917,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEIS3","release_manifest":"api/v1.1/release_manifest.json"}},"MELK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MELK","identifiers":{"aliases":["KIAA0175"],"approved_symbol":"MELK","ensembl_gene_id":"ENSG00000165304","hgnc_id":"HGNC:16870","ncbi_gene_id":9833,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MELK","release_manifest":"api/v1.1/release_manifest.json"}},"MELTF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MELTF","identifiers":{"aliases":["CD228","FLJ38863","MAP97","MGC4856","MTF1","MTf"],"approved_symbol":"MELTF","ensembl_gene_id":"ENSG00000163975","hgnc_id":"HGNC:7037","ncbi_gene_id":4241,"previous_symbols":["MFI2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MELTF","release_manifest":"api/v1.1/release_manifest.json"}},"MELTF-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MELTF-AS1","identifiers":{"aliases":["AC068302.3","PLANE"],"approved_symbol":"MELTF-AS1","ensembl_gene_id":"ENSG00000228109","hgnc_id":"HGNC:40373","ncbi_gene_id":100507057,"previous_symbols":["MFI2-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MELTF-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MEMO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEMO1","identifiers":{"aliases":["CGI-27","MEMO"],"approved_symbol":"MEMO1","ensembl_gene_id":"ENSG00000162959","hgnc_id":"HGNC:14014","ncbi_gene_id":51072,"previous_symbols":["C2orf4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEMO1","release_manifest":"api/v1.1/release_manifest.json"}},"MEN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEN1","identifiers":{"aliases":[],"approved_symbol":"MEN1","ensembl_gene_id":"ENSG00000133895","hgnc_id":"HGNC:7010","ncbi_gene_id":4221,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEN1","release_manifest":"api/v1.1/release_manifest.json"}},"MEOX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEOX1","identifiers":{"aliases":["MOX1"],"approved_symbol":"MEOX1","ensembl_gene_id":"ENSG00000005102","hgnc_id":"HGNC:7013","ncbi_gene_id":4222,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEOX1","release_manifest":"api/v1.1/release_manifest.json"}},"MEOX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEOX2","identifiers":{"aliases":["MOX2"],"approved_symbol":"MEOX2","ensembl_gene_id":"ENSG00000106511","hgnc_id":"HGNC:7014","ncbi_gene_id":4223,"previous_symbols":["GAX"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEOX2","release_manifest":"api/v1.1/release_manifest.json"}},"MEP1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEP1B","identifiers":{"aliases":[],"approved_symbol":"MEP1B","ensembl_gene_id":"ENSG00000141434","hgnc_id":"HGNC:7020","ncbi_gene_id":4225,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MEP1B","release_manifest":"api/v1.1/release_manifest.json"}},"MEPCE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEPCE","identifiers":{"aliases":["FLJ20257"],"approved_symbol":"MEPCE","ensembl_gene_id":"ENSG00000146834","hgnc_id":"HGNC:20247","ncbi_gene_id":56257,"previous_symbols":["BCDIN3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEPCE","release_manifest":"api/v1.1/release_manifest.json"}},"MERTK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MERTK","identifiers":{"aliases":["mer","RP38","c-Eyk","Tyro12"],"approved_symbol":"MERTK","ensembl_gene_id":"ENSG00000153208","hgnc_id":"HGNC:7027","ncbi_gene_id":10461,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MERTK","release_manifest":"api/v1.1/release_manifest.json"}},"MESD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MESD","identifiers":{"aliases":["KIAA0081","BOCA"],"approved_symbol":"MESD","ensembl_gene_id":"ENSG00000117899","hgnc_id":"HGNC:13520","ncbi_gene_id":23184,"previous_symbols":["MESDC2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MESD","release_manifest":"api/v1.1/release_manifest.json"}},"MESP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MESP1","identifiers":{"aliases":["MGC10676","bHLHc5"],"approved_symbol":"MESP1","ensembl_gene_id":"ENSG00000166823","hgnc_id":"HGNC:29658","ncbi_gene_id":55897,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MESP1","release_manifest":"api/v1.1/release_manifest.json"}},"MESP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MESP2","identifiers":{"aliases":["SCDO2","bHLHc6"],"approved_symbol":"MESP2","ensembl_gene_id":"ENSG00000188095","hgnc_id":"HGNC:29659","ncbi_gene_id":145873,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MESP2","release_manifest":"api/v1.1/release_manifest.json"}},"MEST":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEST","identifiers":{"aliases":["PEG1"],"approved_symbol":"MEST","ensembl_gene_id":"ENSG00000106484","hgnc_id":"HGNC:7028","ncbi_gene_id":4232,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEST","detailed_audit_record":"gene/MEST/audit","legacy_api_record":"api/v1/genes/MEST.json","release_manifest":"api/v1.1/release_manifest.json"}},"MET":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MET","identifiers":{"aliases":["HGFR","RCCP2","DFNB97"],"approved_symbol":"MET","ensembl_gene_id":"ENSG00000105976","hgnc_id":"HGNC:7029","ncbi_gene_id":4233,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MET","release_manifest":"api/v1.1/release_manifest.json"}},"METAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METAP1","identifiers":{"aliases":["KIAA0094","MetAP1A","MAP1A"],"approved_symbol":"METAP1","ensembl_gene_id":"ENSG00000164024","hgnc_id":"HGNC:15789","ncbi_gene_id":23173,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METAP1","release_manifest":"api/v1.1/release_manifest.json"}},"METAP1D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METAP1D","identifiers":{"aliases":["MAP1D","Metap1l"],"approved_symbol":"METAP1D","ensembl_gene_id":"ENSG00000172878","hgnc_id":"HGNC:32583","ncbi_gene_id":254042,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/METAP1D","release_manifest":"api/v1.1/release_manifest.json"}},"METAP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METAP2","identifiers":{"aliases":["MNPEP","p67","MAP2"],"approved_symbol":"METAP2","ensembl_gene_id":"ENSG00000111142","hgnc_id":"HGNC:16672","ncbi_gene_id":10988,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METAP2","release_manifest":"api/v1.1/release_manifest.json"}},"METRN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METRN","identifiers":{"aliases":["MGC2601"],"approved_symbol":"METRN","ensembl_gene_id":"ENSG00000103260","hgnc_id":"HGNC:14151","ncbi_gene_id":79006,"previous_symbols":["C16orf23"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METRN","release_manifest":"api/v1.1/release_manifest.json"}},"METRNL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METRNL","identifiers":{"aliases":[],"approved_symbol":"METRNL","ensembl_gene_id":"ENSG00000176845","hgnc_id":"HGNC:27584","ncbi_gene_id":284207,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METRNL","release_manifest":"api/v1.1/release_manifest.json"}},"METTL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL1","identifiers":{"aliases":["TRM8","TRMT8"],"approved_symbol":"METTL1","ensembl_gene_id":"ENSG00000037897","hgnc_id":"HGNC:7030","ncbi_gene_id":4234,"previous_symbols":["C12orf1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL1","release_manifest":"api/v1.1/release_manifest.json"}},"METTL14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL14","identifiers":{"aliases":["KIAA1627"],"approved_symbol":"METTL14","ensembl_gene_id":"ENSG00000145388","hgnc_id":"HGNC:29330","ncbi_gene_id":57721,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL14","release_manifest":"api/v1.1/release_manifest.json"}},"METTL15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL15","identifiers":{"aliases":["FLJ33979"],"approved_symbol":"METTL15","ensembl_gene_id":"ENSG00000169519","hgnc_id":"HGNC:26606","ncbi_gene_id":196074,"previous_symbols":["METT5D1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL15","release_manifest":"api/v1.1/release_manifest.json"}},"METTL16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL16","identifiers":{"aliases":["MGC3329"],"approved_symbol":"METTL16","ensembl_gene_id":"ENSG00000127804","hgnc_id":"HGNC:28484","ncbi_gene_id":79066,"previous_symbols":["METT10D"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL16","release_manifest":"api/v1.1/release_manifest.json"}},"METTL17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL17","identifiers":{"aliases":["FLJ20859"],"approved_symbol":"METTL17","ensembl_gene_id":"ENSG00000165792","hgnc_id":"HGNC:19280","ncbi_gene_id":64745,"previous_symbols":["METT11D1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL17","release_manifest":"api/v1.1/release_manifest.json"}},"METTL18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL18","identifiers":{"aliases":["MGC9084","AsTP2","HPM1"],"approved_symbol":"METTL18","ensembl_gene_id":"ENSG00000171806","hgnc_id":"HGNC:28793","ncbi_gene_id":92342,"previous_symbols":["C1orf156"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL18","release_manifest":"api/v1.1/release_manifest.json"}},"METTL21A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL21A","identifiers":{"aliases":["LOC151194","HCA557b","HSPA-KMT"],"approved_symbol":"METTL21A","ensembl_gene_id":"ENSG00000144401","hgnc_id":"HGNC:30476","ncbi_gene_id":151194,"previous_symbols":["FAM119A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL21A","release_manifest":"api/v1.1/release_manifest.json"}},"METTL22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL22","identifiers":{"aliases":["FLJ12433","MGC2654"],"approved_symbol":"METTL22","ensembl_gene_id":"ENSG00000067365","hgnc_id":"HGNC:28368","ncbi_gene_id":79091,"previous_symbols":["C16orf68"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL22","release_manifest":"api/v1.1/release_manifest.json"}},"METTL23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL23","identifiers":{"aliases":["LOC124512"],"approved_symbol":"METTL23","ensembl_gene_id":"ENSG00000181038","hgnc_id":"HGNC:26988","ncbi_gene_id":124512,"previous_symbols":["C17orf95"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.069453,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL23","release_manifest":"api/v1.1/release_manifest.json"}},"METTL24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL24","identifiers":{"aliases":["dJ71D21.2"],"approved_symbol":"METTL24","ensembl_gene_id":"ENSG00000053328","hgnc_id":"HGNC:21566","ncbi_gene_id":728464,"previous_symbols":["C6orf186"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL24","release_manifest":"api/v1.1/release_manifest.json"}},"METTL25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL25","identifiers":{"aliases":["FLJ22789"],"approved_symbol":"METTL25","ensembl_gene_id":"ENSG00000127720","hgnc_id":"HGNC:26228","ncbi_gene_id":84190,"previous_symbols":["C12orf26"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL25","release_manifest":"api/v1.1/release_manifest.json"}},"METTL26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL26","identifiers":{"aliases":["MGC13114"],"approved_symbol":"METTL26","ensembl_gene_id":"ENSG00000130731","hgnc_id":"HGNC:14141","ncbi_gene_id":84326,"previous_symbols":["C16orf13"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL26","release_manifest":"api/v1.1/release_manifest.json"}},"METTL27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL27","identifiers":{"aliases":[],"approved_symbol":"METTL27","ensembl_gene_id":"ENSG00000165171","hgnc_id":"HGNC:19068","ncbi_gene_id":155368,"previous_symbols":["WBSCR27"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL27","release_manifest":"api/v1.1/release_manifest.json"}},"METTL2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL2A","identifiers":{"aliases":["FLJ12760","METTL2"],"approved_symbol":"METTL2A","ensembl_gene_id":"ENSG00000087995","hgnc_id":"HGNC:25755","ncbi_gene_id":339175,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL2A","release_manifest":"api/v1.1/release_manifest.json"}},"METTL2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL2B","identifiers":{"aliases":["METL","FLJ11350"],"approved_symbol":"METTL2B","ensembl_gene_id":"ENSG00000165055","hgnc_id":"HGNC:18272","ncbi_gene_id":55798,"previous_symbols":["METTL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL2B","release_manifest":"api/v1.1/release_manifest.json"}},"METTL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL3","identifiers":{"aliases":["Spo8","M6A","MT-A70"],"approved_symbol":"METTL3","ensembl_gene_id":"ENSG00000165819","hgnc_id":"HGNC:17563","ncbi_gene_id":56339,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL3","release_manifest":"api/v1.1/release_manifest.json"}},"METTL4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL4","identifiers":{"aliases":["FLJ23017","HsT661"],"approved_symbol":"METTL4","ensembl_gene_id":"ENSG00000101574","hgnc_id":"HGNC:24726","ncbi_gene_id":64863,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL4","release_manifest":"api/v1.1/release_manifest.json"}},"METTL5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL5","identifiers":{"aliases":["HSPC133"],"approved_symbol":"METTL5","ensembl_gene_id":"ENSG00000138382","hgnc_id":"HGNC:25006","ncbi_gene_id":29081,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL5","release_manifest":"api/v1.1/release_manifest.json"}},"METTL6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL6","identifiers":{"aliases":["MGC24132"],"approved_symbol":"METTL6","ensembl_gene_id":"ENSG00000206562","hgnc_id":"HGNC:28343","ncbi_gene_id":131965,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL6","release_manifest":"api/v1.1/release_manifest.json"}},"METTL7A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL7A","identifiers":{"approved_symbol":"METTL7A","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/METTL7A","release_manifest":"api/v1.1/release_manifest.json"}},"METTL7B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL7B","identifiers":{"approved_symbol":"METTL7B","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/METTL7B","release_manifest":"api/v1.1/release_manifest.json"}},"METTL8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL8","identifiers":{"aliases":["FLJ13984","TIP"],"approved_symbol":"METTL8","ensembl_gene_id":"ENSG00000123600","hgnc_id":"HGNC:25856","ncbi_gene_id":79828,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL8","release_manifest":"api/v1.1/release_manifest.json"}},"METTL9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"METTL9","identifiers":{"aliases":["DREV1"],"approved_symbol":"METTL9","ensembl_gene_id":"ENSG00000197006","hgnc_id":"HGNC:24586","ncbi_gene_id":51108,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/METTL9","release_manifest":"api/v1.1/release_manifest.json"}},"MEX3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEX3A","identifiers":{"aliases":["RNF162"],"approved_symbol":"MEX3A","ensembl_gene_id":"ENSG00000254726","hgnc_id":"HGNC:33482","ncbi_gene_id":92312,"previous_symbols":["RKHD4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEX3A","release_manifest":"api/v1.1/release_manifest.json"}},"MEX3B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEX3B","identifiers":{"aliases":["DKFZp434J0617","RNF195"],"approved_symbol":"MEX3B","ensembl_gene_id":"ENSG00000183496","hgnc_id":"HGNC:25297","ncbi_gene_id":84206,"previous_symbols":["RKHD3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEX3B","release_manifest":"api/v1.1/release_manifest.json"}},"MEX3C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEX3C","identifiers":{"aliases":["FLJ38871","RNF194"],"approved_symbol":"MEX3C","ensembl_gene_id":"ENSG00000176624","hgnc_id":"HGNC:28040","ncbi_gene_id":51320,"previous_symbols":["RKHD2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEX3C","release_manifest":"api/v1.1/release_manifest.json"}},"MEX3D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MEX3D","identifiers":{"aliases":["Tino","KIAA2031","OK/SW-cl.4","RNF193"],"approved_symbol":"MEX3D","ensembl_gene_id":"ENSG00000181588","hgnc_id":"HGNC:16734","ncbi_gene_id":399664,"previous_symbols":["RKHD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MEX3D","release_manifest":"api/v1.1/release_manifest.json"}},"MFAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFAP1","identifiers":{"aliases":["AMP"],"approved_symbol":"MFAP1","ensembl_gene_id":"ENSG00000140259","hgnc_id":"HGNC:7032","ncbi_gene_id":4236,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFAP1","release_manifest":"api/v1.1/release_manifest.json"}},"MFAP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFAP2","identifiers":{"aliases":["MAGP","MAGP-1"],"approved_symbol":"MFAP2","ensembl_gene_id":"ENSG00000117122","hgnc_id":"HGNC:7033","ncbi_gene_id":4237,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFAP2","release_manifest":"api/v1.1/release_manifest.json"}},"MFAP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFAP3","identifiers":{"aliases":[],"approved_symbol":"MFAP3","ensembl_gene_id":"ENSG00000037749","hgnc_id":"HGNC:7034","ncbi_gene_id":4238,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFAP3","release_manifest":"api/v1.1/release_manifest.json"}},"MFAP3L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFAP3L","identifiers":{"aliases":["KIAA0626","NYD-sp9"],"approved_symbol":"MFAP3L","ensembl_gene_id":"ENSG00000198948","hgnc_id":"HGNC:29083","ncbi_gene_id":9848,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFAP3L","release_manifest":"api/v1.1/release_manifest.json"}},"MFAP4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFAP4","identifiers":{"aliases":[],"approved_symbol":"MFAP4","ensembl_gene_id":"ENSG00000166482","hgnc_id":"HGNC:7035","ncbi_gene_id":4239,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFAP4","release_manifest":"api/v1.1/release_manifest.json"}},"MFAP5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFAP5","identifiers":{"aliases":["MAGP2","MP25"],"approved_symbol":"MFAP5","ensembl_gene_id":"ENSG00000197614","hgnc_id":"HGNC:29673","ncbi_gene_id":8076,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFAP5","release_manifest":"api/v1.1/release_manifest.json"}},"MFF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFF","identifiers":{"aliases":["GL004"],"approved_symbol":"MFF","ensembl_gene_id":"ENSG00000168958","hgnc_id":"HGNC:24858","ncbi_gene_id":56947,"previous_symbols":["C2orf33"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFF","release_manifest":"api/v1.1/release_manifest.json"}},"MFGE8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFGE8","identifiers":{"aliases":["SED1","EDIL1","BA46","OAcGD3S","HsT19888","MFG-E8","hP47"],"approved_symbol":"MFGE8","ensembl_gene_id":"ENSG00000140545","hgnc_id":"HGNC:7036","ncbi_gene_id":4240,"previous_symbols":["SPAG10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFGE8","release_manifest":"api/v1.1/release_manifest.json"}},"MFHAS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFHAS1","identifiers":{"aliases":["MASL1","LRRC65"],"approved_symbol":"MFHAS1","ensembl_gene_id":"ENSG00000147324","hgnc_id":"HGNC:16982","ncbi_gene_id":9258,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFHAS1","release_manifest":"api/v1.1/release_manifest.json"}},"MFN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFN1","identifiers":{"aliases":["FLJ20693"],"approved_symbol":"MFN1","ensembl_gene_id":"ENSG00000171109","hgnc_id":"HGNC:18262","ncbi_gene_id":55669,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFN1","release_manifest":"api/v1.1/release_manifest.json"}},"MFN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFN2","identifiers":{"aliases":["CPRP1","KIAA0214","MARF","CMT2A2"],"approved_symbol":"MFN2","ensembl_gene_id":"ENSG00000116688","hgnc_id":"HGNC:16877","ncbi_gene_id":9927,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFN2","release_manifest":"api/v1.1/release_manifest.json"}},"MFNG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFNG","identifiers":{"aliases":[],"approved_symbol":"MFNG","ensembl_gene_id":"ENSG00000100060","hgnc_id":"HGNC:7038","ncbi_gene_id":4242,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFNG","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD1","identifiers":{"aliases":["Minerva","SLC72A1","FLJ14153","UG0581B09"],"approved_symbol":"MFSD1","ensembl_gene_id":"ENSG00000118855","hgnc_id":"HGNC:25874","ncbi_gene_id":64747,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD1","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD10","identifiers":{"approved_symbol":"MFSD10","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD10","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD11","identifiers":{"aliases":["FLJ22196","FLJ20226"],"approved_symbol":"MFSD11","ensembl_gene_id":"ENSG00000092931","hgnc_id":"HGNC:25458","ncbi_gene_id":79157,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD11","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD12","identifiers":{"aliases":["MGC20700","PP3501","SLC59B1"],"approved_symbol":"MFSD12","ensembl_gene_id":"ENSG00000161091","hgnc_id":"HGNC:28299","ncbi_gene_id":126321,"previous_symbols":["C19orf28"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MFSD12","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD13A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD13A","identifiers":{"approved_symbol":"MFSD13A","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD13A","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD14A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD14A","identifiers":{"approved_symbol":"MFSD14A","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD14A","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD14B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD14B","identifiers":{"approved_symbol":"MFSD14B","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MFSD14B","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD2A","identifiers":{"aliases":["FLJ14490","SLC59A1"],"approved_symbol":"MFSD2A","ensembl_gene_id":"ENSG00000168389","hgnc_id":"HGNC:25897","ncbi_gene_id":84879,"previous_symbols":["MFSD2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD2A","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD2B","identifiers":{"aliases":["SLC59A2"],"approved_symbol":"MFSD2B","ensembl_gene_id":"ENSG00000205639","hgnc_id":"HGNC:37207","ncbi_gene_id":388931,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MFSD2B","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD3","identifiers":{"approved_symbol":"MFSD3","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MFSD3","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD4A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD4A","identifiers":{"approved_symbol":"MFSD4A","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD4A","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD4B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD4B","identifiers":{"approved_symbol":"MFSD4B","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD4B","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD5","identifiers":{"approved_symbol":"MFSD5","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD5","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD6","identifiers":{"aliases":["SLC73A1","FLJ20160"],"approved_symbol":"MFSD6","ensembl_gene_id":"ENSG00000151690","hgnc_id":"HGNC:24711","ncbi_gene_id":54842,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD6","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD8","identifiers":{"aliases":["SLC74A1","MGC33302"],"approved_symbol":"MFSD8","ensembl_gene_id":"ENSG00000164073","hgnc_id":"HGNC:28486","ncbi_gene_id":256471,"previous_symbols":["CLN7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD8","release_manifest":"api/v1.1/release_manifest.json"}},"MFSD9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MFSD9","identifiers":{"approved_symbol":"MFSD9","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MFSD9","release_manifest":"api/v1.1/release_manifest.json"}},"MGA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGA","identifiers":{"aliases":["KIAA0518","MAD5","MXD5","FLJ12634"],"approved_symbol":"MGA","ensembl_gene_id":"ENSG00000174197","hgnc_id":"HGNC:14010","ncbi_gene_id":23269,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGA","release_manifest":"api/v1.1/release_manifest.json"}},"MGAM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAM","identifiers":{"aliases":["MGA"],"approved_symbol":"MGAM","ensembl_gene_id":"ENSG00000257335","hgnc_id":"HGNC:7043","ncbi_gene_id":8972,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAM","release_manifest":"api/v1.1/release_manifest.json"}},"MGARP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGARP","identifiers":{"aliases":["OSAP","CESP-1","HUMMR"],"approved_symbol":"MGARP","ensembl_gene_id":"ENSG00000137463","hgnc_id":"HGNC:29969","ncbi_gene_id":84709,"previous_symbols":["C4orf49"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGARP","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT1","identifiers":{"aliases":["GNT-1","GLCNAC-TI","GnTI"],"approved_symbol":"MGAT1","ensembl_gene_id":"ENSG00000131446","hgnc_id":"HGNC:7044","ncbi_gene_id":4245,"previous_symbols":["MGAT","GLYT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT1","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT2","identifiers":{"aliases":["GNT-II"],"approved_symbol":"MGAT2","ensembl_gene_id":"ENSG00000168282","hgnc_id":"HGNC:7045","ncbi_gene_id":4247,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT2","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT3","identifiers":{"aliases":["GNT-III"],"approved_symbol":"MGAT3","ensembl_gene_id":"ENSG00000128268","hgnc_id":"HGNC:7046","ncbi_gene_id":4248,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT3","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT4A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT4A","identifiers":{"aliases":["GnT-Iva","GnT-4a"],"approved_symbol":"MGAT4A","ensembl_gene_id":"ENSG00000071073","hgnc_id":"HGNC:7047","ncbi_gene_id":11320,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT4A","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT4B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT4B","identifiers":{"aliases":["GnT-Ivb"],"approved_symbol":"MGAT4B","ensembl_gene_id":"ENSG00000161013","hgnc_id":"HGNC:7048","ncbi_gene_id":11282,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT4B","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT4C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT4C","identifiers":{"aliases":["HGNT-IV-H"],"approved_symbol":"MGAT4C","ensembl_gene_id":"ENSG00000182050","hgnc_id":"HGNC:30871","ncbi_gene_id":25834,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT4C","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT4D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT4D","identifiers":{"aliases":["GnT1IP"],"approved_symbol":"MGAT4D","ensembl_gene_id":"ENSG00000205301","hgnc_id":"HGNC:43619","ncbi_gene_id":152586,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MGAT4D","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT5","identifiers":{"aliases":["GNT-V","MGAT5A"],"approved_symbol":"MGAT5","ensembl_gene_id":"ENSG00000152127","hgnc_id":"HGNC:7049","ncbi_gene_id":4249,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT5","release_manifest":"api/v1.1/release_manifest.json"}},"MGAT5B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGAT5B","identifiers":{"aliases":["GnT-IX","FLJ25132","GnT-VB"],"approved_symbol":"MGAT5B","ensembl_gene_id":"ENSG00000167889","hgnc_id":"HGNC:24140","ncbi_gene_id":146664,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGAT5B","release_manifest":"api/v1.1/release_manifest.json"}},"MGLL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGLL","identifiers":{"aliases":["HU-K5","MGL","MAGL"],"approved_symbol":"MGLL","ensembl_gene_id":"ENSG00000074416","hgnc_id":"HGNC:17038","ncbi_gene_id":11343,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MGLL","release_manifest":"api/v1.1/release_manifest.json"}},"MGME1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGME1","identifiers":{"aliases":["bA504H3.4","DDK1"],"approved_symbol":"MGME1","ensembl_gene_id":"ENSG00000125871","hgnc_id":"HGNC:16205","ncbi_gene_id":92667,"previous_symbols":["C20orf72"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGME1","release_manifest":"api/v1.1/release_manifest.json"}},"MGMT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGMT","identifiers":{"aliases":[],"approved_symbol":"MGMT","ensembl_gene_id":"ENSG00000170430","hgnc_id":"HGNC:7059","ncbi_gene_id":4255,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGMT","release_manifest":"api/v1.1/release_manifest.json"}},"MGP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGP","identifiers":{"aliases":[],"approved_symbol":"MGP","ensembl_gene_id":"ENSG00000111341","hgnc_id":"HGNC:7060","ncbi_gene_id":4256,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGP","release_manifest":"api/v1.1/release_manifest.json"}},"MGRN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGRN1","identifiers":{"aliases":["KIAA0544","RNF156"],"approved_symbol":"MGRN1","ensembl_gene_id":"ENSG00000102858","hgnc_id":"HGNC:20254","ncbi_gene_id":23295,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGRN1","release_manifest":"api/v1.1/release_manifest.json"}},"MGST1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGST1","identifiers":{"aliases":["MGST-I","PMAN"],"approved_symbol":"MGST1","ensembl_gene_id":"ENSG00000008394","hgnc_id":"HGNC:7061","ncbi_gene_id":4257,"previous_symbols":["GST12"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGST1","release_manifest":"api/v1.1/release_manifest.json"}},"MGST2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGST2","identifiers":{"aliases":["MGST-II"],"approved_symbol":"MGST2","ensembl_gene_id":"ENSG00000085871","hgnc_id":"HGNC:7063","ncbi_gene_id":4258,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGST2","release_manifest":"api/v1.1/release_manifest.json"}},"MGST3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MGST3","identifiers":{"aliases":["GST-III"],"approved_symbol":"MGST3","ensembl_gene_id":"ENSG00000143198","hgnc_id":"HGNC:7064","ncbi_gene_id":4259,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MGST3","release_manifest":"api/v1.1/release_manifest.json"}},"MHENCR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MHENCR","identifiers":{"aliases":[],"approved_symbol":"MHENCR","ensembl_gene_id":"ENSG00000232442","hgnc_id":"HGNC:53110","ncbi_gene_id":100505771,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MHENCR","release_manifest":"api/v1.1/release_manifest.json"}},"MIA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIA","identifiers":{"aliases":["CD-RAP","MIA1"],"approved_symbol":"MIA","ensembl_gene_id":"ENSG00000261857","hgnc_id":"HGNC:7076","ncbi_gene_id":8190,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIA","release_manifest":"api/v1.1/release_manifest.json"}},"MIA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIA2","identifiers":{"aliases":["FLJ22404","TALI","MEA6","cTAGE-5A","cTAGE-5B","cTAGE-5C","cTAGE-5D","MGEA11"],"approved_symbol":"MIA2","ensembl_gene_id":"ENSG00000150527","hgnc_id":"HGNC:18432","ncbi_gene_id":4253,"previous_symbols":["CTAGE5","MGEA","MGEA6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIA2","release_manifest":"api/v1.1/release_manifest.json"}},"MIA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIA3","identifiers":{"aliases":["UNQ6077","FLJ39207","KIAA0268","TANGO","TANGO1"],"approved_symbol":"MIA3","ensembl_gene_id":"ENSG00000154305","hgnc_id":"HGNC:24008","ncbi_gene_id":375056,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIA3","release_manifest":"api/v1.1/release_manifest.json"}},"MIAT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIAT","identifiers":{"aliases":["FLJ25967","Rncr2","gomafu","NCRNA00066","LINC00066","lncRNA-MIAT"],"approved_symbol":"MIAT","ensembl_gene_id":"ENSG00000225783","hgnc_id":"HGNC:33425","ncbi_gene_id":440823,"previous_symbols":["C22orf35"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIAT","release_manifest":"api/v1.1/release_manifest.json"}},"MIATNB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIATNB","identifiers":{"aliases":[],"approved_symbol":"MIATNB","ensembl_gene_id":"ENSG00000244625","hgnc_id":"HGNC:50731","ncbi_gene_id":102724827,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIATNB","release_manifest":"api/v1.1/release_manifest.json"}},"MIB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIB1","identifiers":{"aliases":["DIP-1","MIB","KIAA1323","ZZANK2","ZZZ6"],"approved_symbol":"MIB1","ensembl_gene_id":"ENSG00000101752","hgnc_id":"HGNC:21086","ncbi_gene_id":57534,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIB1","release_manifest":"api/v1.1/release_manifest.json"}},"MIB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIB2","identifiers":{"aliases":["skeletrophin","ZZZ5","FLJ39787"],"approved_symbol":"MIB2","ensembl_gene_id":"ENSG00000197530","hgnc_id":"HGNC:30577","ncbi_gene_id":142678,"previous_symbols":["ZZANK1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIB2","release_manifest":"api/v1.1/release_manifest.json"}},"MICA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICA","identifiers":{"aliases":["PERB11.1"],"approved_symbol":"MICA","ensembl_gene_id":"ENSG00000204520","hgnc_id":"HGNC:7090","ncbi_gene_id":100507436,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICA","release_manifest":"api/v1.1/release_manifest.json"}},"MICAL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICAL1","identifiers":{"aliases":["MICAL","FLJ11937","DKFZp434B1517","FLJ21739"],"approved_symbol":"MICAL1","ensembl_gene_id":"ENSG00000135596","hgnc_id":"HGNC:20619","ncbi_gene_id":64780,"previous_symbols":["NICAL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICAL1","release_manifest":"api/v1.1/release_manifest.json"}},"MICAL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICAL2","identifiers":{"aliases":["KIAA0750","FLJ14966"],"approved_symbol":"MICAL2","ensembl_gene_id":"ENSG00000133816","hgnc_id":"HGNC:24693","ncbi_gene_id":9645,"previous_symbols":["MICALCL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICAL2","release_manifest":"api/v1.1/release_manifest.json"}},"MICAL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICAL3","identifiers":{"aliases":["KIAA0819"],"approved_symbol":"MICAL3","ensembl_gene_id":"ENSG00000243156","hgnc_id":"HGNC:24694","ncbi_gene_id":57553,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICAL3","release_manifest":"api/v1.1/release_manifest.json"}},"MICALL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICALL1","identifiers":{"aliases":["MIRAB13","KIAA1668","MICAL-L1"],"approved_symbol":"MICALL1","ensembl_gene_id":"ENSG00000100139","hgnc_id":"HGNC:29804","ncbi_gene_id":85377,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICALL1","release_manifest":"api/v1.1/release_manifest.json"}},"MICALL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICALL2","identifiers":{"aliases":["MGC46023","FLJ23471","MICAL-L2","JRAB"],"approved_symbol":"MICALL2","ensembl_gene_id":"ENSG00000164877","hgnc_id":"HGNC:29672","ncbi_gene_id":79778,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICALL2","release_manifest":"api/v1.1/release_manifest.json"}},"MICB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICB","identifiers":{"aliases":["PERB11.2"],"approved_symbol":"MICB","ensembl_gene_id":"ENSG00000204516","hgnc_id":"HGNC:7091","ncbi_gene_id":4277,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MICB","release_manifest":"api/v1.1/release_manifest.json"}},"MICOS10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICOS10","identifiers":{"aliases":["RP5-1056L3.2","FLJ36999","MIO10","Mic10"],"approved_symbol":"MICOS10","ensembl_gene_id":"ENSG00000173436","hgnc_id":"HGNC:32068","ncbi_gene_id":440574,"previous_symbols":["C1orf151","MINOS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICOS10","release_manifest":"api/v1.1/release_manifest.json"}},"MICOS13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICOS13","identifiers":{"aliases":["QIL1","P117","MIC13","MIC12"],"approved_symbol":"MICOS13","ensembl_gene_id":"ENSG00000174917","hgnc_id":"HGNC:33702","ncbi_gene_id":125988,"previous_symbols":["C19orf70"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MICOS13","release_manifest":"api/v1.1/release_manifest.json"}},"MICU1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICU1","identifiers":{"aliases":["CALC","EFHA3","FLJ12684"],"approved_symbol":"MICU1","ensembl_gene_id":"ENSG00000107745","hgnc_id":"HGNC:1530","ncbi_gene_id":10367,"previous_symbols":["CBARA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICU1","release_manifest":"api/v1.1/release_manifest.json"}},"MICU2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICU2","identifiers":{"aliases":[],"approved_symbol":"MICU2","ensembl_gene_id":"ENSG00000165487","hgnc_id":"HGNC:31830","ncbi_gene_id":221154,"previous_symbols":["EFHA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICU2","release_manifest":"api/v1.1/release_manifest.json"}},"MICU3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MICU3","identifiers":{"aliases":["DKFZp313A0139"],"approved_symbol":"MICU3","ensembl_gene_id":"ENSG00000155970","hgnc_id":"HGNC:27820","ncbi_gene_id":286097,"previous_symbols":["EFHA2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MICU3","release_manifest":"api/v1.1/release_manifest.json"}},"MID1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MID1","identifiers":{"aliases":["OS","FXY","TRIM18","RNF59"],"approved_symbol":"MID1","ensembl_gene_id":"ENSG00000101871","hgnc_id":"HGNC:7095","ncbi_gene_id":4281,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MID1","release_manifest":"api/v1.1/release_manifest.json"}},"MID1IP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MID1IP1","identifiers":{"aliases":["STRAIT11499","FLJ10386","MIG12","THRSPL","G12-like"],"approved_symbol":"MID1IP1","ensembl_gene_id":"ENSG00000165175","hgnc_id":"HGNC:20715","ncbi_gene_id":58526,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MID1IP1","release_manifest":"api/v1.1/release_manifest.json"}},"MID2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MID2","identifiers":{"aliases":["FXY2","TRIM1","RNF60","MRX101"],"approved_symbol":"MID2","ensembl_gene_id":"ENSG00000080561","hgnc_id":"HGNC:7096","ncbi_gene_id":11043,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MID2","release_manifest":"api/v1.1/release_manifest.json"}},"MIDN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIDN","identifiers":{"aliases":["Stx"],"approved_symbol":"MIDN","ensembl_gene_id":"ENSG00000167470","hgnc_id":"HGNC:16298","ncbi_gene_id":90007,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIDN","release_manifest":"api/v1.1/release_manifest.json"}},"MIEF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIEF1","identifiers":{"aliases":["FLJ20232","MiD51","L0R8F8","D3A"],"approved_symbol":"MIEF1","ensembl_gene_id":"ENSG00000100335","hgnc_id":"HGNC:25979","ncbi_gene_id":54471,"previous_symbols":["SMCR7L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIEF1","release_manifest":"api/v1.1/release_manifest.json"}},"MIEF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIEF2","identifiers":{"aliases":["MGC23130","MiD49","D3B"],"approved_symbol":"MIEF2","ensembl_gene_id":"ENSG00000177427","hgnc_id":"HGNC:17920","ncbi_gene_id":125170,"previous_symbols":["SMCR7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIEF2","release_manifest":"api/v1.1/release_manifest.json"}},"MIEN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIEN1","identifiers":{"aliases":["MGC14832","ORB3","XTP4","C35","Rdx12"],"approved_symbol":"MIEN1","ensembl_gene_id":"ENSG00000141741","hgnc_id":"HGNC:28230","ncbi_gene_id":84299,"previous_symbols":["C17orf37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIEN1","release_manifest":"api/v1.1/release_manifest.json"}},"MIER1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIER1","identifiers":{"aliases":["hMI-ER1","MI-ER1","KIAA1610"],"approved_symbol":"MIER1","ensembl_gene_id":"ENSG00000198160","hgnc_id":"HGNC:29657","ncbi_gene_id":57708,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIER1","release_manifest":"api/v1.1/release_manifest.json"}},"MIER2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIER2","identifiers":{"aliases":[],"approved_symbol":"MIER2","ensembl_gene_id":"ENSG00000105556","hgnc_id":"HGNC:29210","ncbi_gene_id":54531,"previous_symbols":["KIAA1193"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIER2","release_manifest":"api/v1.1/release_manifest.json"}},"MIER3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIER3","identifiers":{"aliases":["FLJ35954","DKFZp686L09111","DKFZp781I1119"],"approved_symbol":"MIER3","ensembl_gene_id":"ENSG00000155545","hgnc_id":"HGNC:26678","ncbi_gene_id":166968,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIER3","release_manifest":"api/v1.1/release_manifest.json"}},"MIF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIF","identifiers":{"aliases":["GIF"],"approved_symbol":"MIF","ensembl_gene_id":"ENSG00000240972","hgnc_id":"HGNC:7097","ncbi_gene_id":4282,"previous_symbols":["GLIF"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MIF","release_manifest":"api/v1.1/release_manifest.json"}},"MIF-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIF-AS1","identifiers":{"aliases":["LOC284889","MIF-AS"],"approved_symbol":"MIF-AS1","ensembl_gene_id":"ENSG00000218537","hgnc_id":"HGNC:27669","ncbi_gene_id":284889,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIF-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MIF4GD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIF4GD","identifiers":{"aliases":["AD023","MGC45027","SLIP1"],"approved_symbol":"MIF4GD","ensembl_gene_id":"ENSG00000125457","hgnc_id":"HGNC:24030","ncbi_gene_id":57409,"previous_symbols":["MIFD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIF4GD","release_manifest":"api/v1.1/release_manifest.json"}},"MIGA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIGA1","identifiers":{"aliases":["FLJ35093"],"approved_symbol":"MIGA1","ensembl_gene_id":"ENSG00000180488","hgnc_id":"HGNC:24741","ncbi_gene_id":374986,"previous_symbols":["FAM73A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIGA1","release_manifest":"api/v1.1/release_manifest.json"}},"MIGA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIGA2","identifiers":{"aliases":["FLJ14596","FLJ00199"],"approved_symbol":"MIGA2","ensembl_gene_id":"ENSG00000148343","hgnc_id":"HGNC:23621","ncbi_gene_id":84895,"previous_symbols":["C9orf54","FAM73B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIGA2","release_manifest":"api/v1.1/release_manifest.json"}},"MIIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIIP","identifiers":{"aliases":["FLJ12438","IIp45"],"approved_symbol":"MIIP","ensembl_gene_id":"ENSG00000116691","hgnc_id":"HGNC:25715","ncbi_gene_id":60672,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIIP","release_manifest":"api/v1.1/release_manifest.json"}},"MILR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MILR1","identifiers":{"aliases":["Allergin-1","MCA-32"],"approved_symbol":"MILR1","ensembl_gene_id":"ENSG00000271605","hgnc_id":"HGNC:27570","ncbi_gene_id":284021,"previous_symbols":["C17orf60"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MILR1","release_manifest":"api/v1.1/release_manifest.json"}},"MINAR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINAR1","identifiers":{"aliases":["UBTOR"],"approved_symbol":"MINAR1","ensembl_gene_id":"ENSG00000169330","hgnc_id":"HGNC:29172","ncbi_gene_id":23251,"previous_symbols":["KIAA1024"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINAR1","release_manifest":"api/v1.1/release_manifest.json"}},"MINCR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINCR","identifiers":{"aliases":["TCONS_00015189"],"approved_symbol":"MINCR","ensembl_gene_id":"ENSG00000253716","hgnc_id":"HGNC:51653","ncbi_gene_id":100507316,"previous_symbols":["LINC01604"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINCR","release_manifest":"api/v1.1/release_manifest.json"}},"MINDY1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINDY1","identifiers":{"aliases":["FLJ11280","MINDY-1"],"approved_symbol":"MINDY1","ensembl_gene_id":"ENSG00000143409","hgnc_id":"HGNC:25648","ncbi_gene_id":55793,"previous_symbols":["FAM63A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINDY1","release_manifest":"api/v1.1/release_manifest.json"}},"MINDY2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINDY2","identifiers":{"aliases":["KIAA1164"],"approved_symbol":"MINDY2","ensembl_gene_id":"ENSG00000128923","hgnc_id":"HGNC:26954","ncbi_gene_id":54629,"previous_symbols":["FAM63B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINDY2","release_manifest":"api/v1.1/release_manifest.json"}},"MINDY3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINDY3","identifiers":{"aliases":["FLJ13397","CARP","my042","DERP5"],"approved_symbol":"MINDY3","ensembl_gene_id":"ENSG00000148481","hgnc_id":"HGNC:23578","ncbi_gene_id":80013,"previous_symbols":["C10orf97","FAM188A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINDY3","release_manifest":"api/v1.1/release_manifest.json"}},"MINDY4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINDY4","identifiers":{"aliases":["FLJ22374"],"approved_symbol":"MINDY4","ensembl_gene_id":"ENSG00000106125","hgnc_id":"HGNC:21916","ncbi_gene_id":84182,"previous_symbols":["C7orf67","FAM188B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINDY4","release_manifest":"api/v1.1/release_manifest.json"}},"MINK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINK1","identifiers":{"aliases":["B55","MINK","ZC3","MAP4K6","YSK2"],"approved_symbol":"MINK1","ensembl_gene_id":"ENSG00000141503","hgnc_id":"HGNC:17565","ncbi_gene_id":50488,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINK1","release_manifest":"api/v1.1/release_manifest.json"}},"MINPP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MINPP1","identifiers":{"aliases":["MIPP"],"approved_symbol":"MINPP1","ensembl_gene_id":"ENSG00000107789","hgnc_id":"HGNC:7102","ncbi_gene_id":9562,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MINPP1","release_manifest":"api/v1.1/release_manifest.json"}},"MIOS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIOS","identifiers":{"aliases":["FLJ20323","MIO","Sea4","Yulink"],"approved_symbol":"MIOS","ensembl_gene_id":"ENSG00000164654","hgnc_id":"HGNC:21905","ncbi_gene_id":54468,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.113,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIOS","release_manifest":"api/v1.1/release_manifest.json"}},"MIPEP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIPEP","identifiers":{"aliases":["MIP"],"approved_symbol":"MIPEP","ensembl_gene_id":"ENSG00000027001","hgnc_id":"HGNC:7104","ncbi_gene_id":4285,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIPEP","release_manifest":"api/v1.1/release_manifest.json"}},"MIPOL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIPOL1","identifiers":{"aliases":["CCDC193"],"approved_symbol":"MIPOL1","ensembl_gene_id":"ENSG00000151338","hgnc_id":"HGNC:21460","ncbi_gene_id":145282,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIPOL1","release_manifest":"api/v1.1/release_manifest.json"}},"MIR1-1HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR1-1HG","identifiers":{"aliases":["dJ353C17.1","MIR133A2HG"],"approved_symbol":"MIR1-1HG","ensembl_gene_id":"ENSG00000174407","hgnc_id":"HGNC:16159","ncbi_gene_id":128826,"previous_symbols":["C20orf166"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MIR1-1HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR100HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR100HG","identifiers":{"aliases":["AGD1","lncRNA-N2","linc-NeD125"],"approved_symbol":"MIR100HG","ensembl_gene_id":"ENSG00000255248","hgnc_id":"HGNC:39522","ncbi_gene_id":399959,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR100HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR133A1HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR133A1HG","identifiers":{"aliases":["MIR1-2HG"],"approved_symbol":"MIR133A1HG","ensembl_gene_id":"ENSG00000265142","hgnc_id":"HGNC:49594","ncbi_gene_id":102723167,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR133A1HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR155HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR155HG","identifiers":{"aliases":["BIC","BIC-155","miPEP155","NCRNA00172","LncRNA-SERB"],"approved_symbol":"MIR155HG","ensembl_gene_id":"ENSG00000234883","hgnc_id":"HGNC:35460","ncbi_gene_id":114614,"previous_symbols":["MIRHG2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR155HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR17HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR17HG","identifiers":{"aliases":["FLJ14178","MIRH1","MIHG1","NCRNA00048","miR-17-92","LINC00048"],"approved_symbol":"MIR17HG","ensembl_gene_id":"ENSG00000215417","hgnc_id":"HGNC:23564","ncbi_gene_id":407975,"previous_symbols":["C13orf25","MIRHG1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR17HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR181A1HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR181A1HG","identifiers":{"aliases":[],"approved_symbol":"MIR181A1HG","ensembl_gene_id":"ENSG00000229989","hgnc_id":"HGNC:48659","ncbi_gene_id":100131234,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR181A1HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR181A2HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR181A2HG","identifiers":{"aliases":[],"approved_symbol":"MIR181A2HG","ensembl_gene_id":"ENSG00000224020","hgnc_id":"HGNC:37188","ncbi_gene_id":100379345,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR181A2HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR1915HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR1915HG","identifiers":{"aliases":["bA418C1.3"],"approved_symbol":"MIR1915HG","ensembl_gene_id":"ENSG00000204682","hgnc_id":"HGNC:31448","ncbi_gene_id":399726,"previous_symbols":["C10orf114","CASC10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR1915HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR193BHG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR193BHG","identifiers":{"aliases":["lincNORS","HypERlnc"],"approved_symbol":"MIR193BHG","ensembl_gene_id":"ENSG00000262454","hgnc_id":"HGNC:51945","ncbi_gene_id":100129781,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR193BHG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR2052HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR2052HG","identifiers":{"aliases":[],"approved_symbol":"MIR2052HG","ensembl_gene_id":"ENSG00000254349","hgnc_id":"HGNC:51555","ncbi_gene_id":441355,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR2052HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR210HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR210HG","identifiers":{"aliases":[],"approved_symbol":"MIR210HG","ensembl_gene_id":"ENSG00000247095","hgnc_id":"HGNC:39524","ncbi_gene_id":100506211,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR210HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR222HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR222HG","identifiers":{"aliases":["Lnc-Ang362"],"approved_symbol":"MIR222HG","ensembl_gene_id":"ENSG00000270069","hgnc_id":"HGNC:49555","ncbi_gene_id":104457406,"previous_symbols":["LINC02595"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR222HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR22HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR22HG","identifiers":{"aliases":["MGC14376","DKFZp686O06159"],"approved_symbol":"MIR22HG","ensembl_gene_id":"ENSG00000186594","hgnc_id":"HGNC:28219","ncbi_gene_id":84981,"previous_symbols":["C17orf91"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR22HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR29B2CHG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR29B2CHG","identifiers":{"aliases":["FLJ35650"],"approved_symbol":"MIR29B2CHG","ensembl_gene_id":"ENSG00000203709","hgnc_id":"HGNC:32018","ncbi_gene_id":100128537,"previous_symbols":["C1orf132"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR29B2CHG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR302CHG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR302CHG","identifiers":{"aliases":[],"approved_symbol":"MIR302CHG","ensembl_gene_id":"ENSG00000249532","hgnc_id":"HGNC:41070","ncbi_gene_id":109864269,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MIR302CHG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR3142HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR3142HG","identifiers":{"aliases":[],"approved_symbol":"MIR3142HG","ensembl_gene_id":"ENSG00000253522","hgnc_id":"HGNC:51944","ncbi_gene_id":107075116,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR3142HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR31HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR31HG","identifiers":{"aliases":["LOC554202","hsa-lnc-31","LncHIFCAR"],"approved_symbol":"MIR31HG","ensembl_gene_id":"ENSG00000171889","hgnc_id":"HGNC:37187","ncbi_gene_id":554202,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MIR31HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR34AHG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR34AHG","identifiers":{"aliases":["lnc34a"],"approved_symbol":"MIR34AHG","ensembl_gene_id":"ENSG00000228526","hgnc_id":"HGNC:51913","ncbi_gene_id":106614088,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR34AHG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR3681HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR3681HG","identifiers":{"aliases":[],"approved_symbol":"MIR3681HG","ensembl_gene_id":"ENSG00000224184","hgnc_id":"HGNC:52001","ncbi_gene_id":100506457,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR3681HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR3936HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR3936HG","identifiers":{"aliases":["LOC553103","SLC22A5-AS1"],"approved_symbol":"MIR3936HG","ensembl_gene_id":"ENSG00000233006","hgnc_id":"HGNC:40538","ncbi_gene_id":553103,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR3936HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR3945HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR3945HG","identifiers":{"aliases":[],"approved_symbol":"MIR3945HG","ensembl_gene_id":"ENSG00000251230","hgnc_id":"HGNC:52002","ncbi_gene_id":731424,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR3945HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR4300HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR4300HG","identifiers":{"aliases":[],"approved_symbol":"MIR4300HG","ensembl_gene_id":"ENSG00000245832","hgnc_id":"HGNC:52003","ncbi_gene_id":101928989,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR4300HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR4422HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR4422HG","identifiers":{"aliases":["RP11-101C11.1"],"approved_symbol":"MIR4422HG","ensembl_gene_id":"ENSG00000231090","hgnc_id":"HGNC:53113","ncbi_gene_id":109729135,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MIR4422HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR4435-2HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR4435-2HG","identifiers":{"aliases":["LINC00978","AGD2","AK001796","lncRNA-AWPPH","MORRBID"],"approved_symbol":"MIR4435-2HG","ensembl_gene_id":"ENSG00000172965","hgnc_id":"HGNC:35163","ncbi_gene_id":541471,"previous_symbols":["MIR4435-1HG"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR4435-2HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR4453HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR4453HG","identifiers":{"aliases":["DKFZP434I0714"],"approved_symbol":"MIR4453HG","ensembl_gene_id":"ENSG00000268471","hgnc_id":"HGNC:25288","ncbi_gene_id":54553,"previous_symbols":["LINC02486"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR4453HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR4458HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR4458HG","identifiers":{"aliases":[],"approved_symbol":"MIR4458HG","ensembl_gene_id":"ENSG00000247516","hgnc_id":"HGNC:49008","ncbi_gene_id":100505738,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR4458HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR4713HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR4713HG","identifiers":{"aliases":["RP11-108K3.1"],"approved_symbol":"MIR4713HG","ensembl_gene_id":"ENSG00000259240","hgnc_id":"HGNC:53124","ncbi_gene_id":109729174,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR4713HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR497HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR497HG","identifiers":{"aliases":["MIR195HG"],"approved_symbol":"MIR497HG","ensembl_gene_id":"ENSG00000267532","hgnc_id":"HGNC:39523","ncbi_gene_id":100506755,"previous_symbols":["ALOX12-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR497HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR503HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR503HG","identifiers":{"aliases":["MGC16121","H19X"],"approved_symbol":"MIR503HG","ensembl_gene_id":"ENSG00000223749","hgnc_id":"HGNC:28258","ncbi_gene_id":84848,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR503HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR548A1HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR548A1HG","identifiers":{"aliases":[],"approved_symbol":"MIR548A1HG","ensembl_gene_id":"ENSG00000283408","hgnc_id":"HGNC:53539","ncbi_gene_id":105374956,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MIR548A1HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR646HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR646HG","identifiers":{"aliases":[],"approved_symbol":"MIR646HG","ensembl_gene_id":"ENSG00000228340","hgnc_id":"HGNC:27659","ncbi_gene_id":284757,"previous_symbols":["C20orf197","LINC02910"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR646HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR762HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR762HG","identifiers":{"aliases":[],"approved_symbol":"MIR762HG","ensembl_gene_id":"ENSG00000260083","hgnc_id":"HGNC:51386","ncbi_gene_id":101928736,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MIR762HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR9-3HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR9-3HG","identifiers":{"aliases":["BS-DRL1","lnc-FANCI-2"],"approved_symbol":"MIR9-3HG","ensembl_gene_id":"ENSG00000255571","hgnc_id":"HGNC:27388","ncbi_gene_id":254559,"previous_symbols":["LINC00925"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR9-3HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR924HG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR924HG","identifiers":{"aliases":[],"approved_symbol":"MIR924HG","ensembl_gene_id":"ENSG00000267374","hgnc_id":"HGNC:44332","ncbi_gene_id":647946,"previous_symbols":["LINC00669"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR924HG","release_manifest":"api/v1.1/release_manifest.json"}},"MIR99AHG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIR99AHG","identifiers":{"aliases":["MONC","DILA1"],"approved_symbol":"MIR99AHG","ensembl_gene_id":"ENSG00000215386","hgnc_id":"HGNC:1274","ncbi_gene_id":388815,"previous_symbols":["C21orf35","FLJ38295","C21orf34","LINC00478"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIR99AHG","release_manifest":"api/v1.1/release_manifest.json"}},"MIRLET7BHG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIRLET7BHG","identifiers":{"aliases":["linc-Ppara"],"approved_symbol":"MIRLET7BHG","ensembl_gene_id":"ENSG00000197182","hgnc_id":"HGNC:37189","ncbi_gene_id":400931,"previous_symbols":["PRR34-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIRLET7BHG","release_manifest":"api/v1.1/release_manifest.json"}},"MIS12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIS12","identifiers":{"aliases":["MGC2488","hMIS12","KNTC2AP","MTW1"],"approved_symbol":"MIS12","ensembl_gene_id":"ENSG00000167842","hgnc_id":"HGNC:24967","ncbi_gene_id":79003,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIS12","release_manifest":"api/v1.1/release_manifest.json"}},"MIS18A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIS18A","identifiers":{"aliases":["B28","FASP1","hMis18alpha"],"approved_symbol":"MIS18A","ensembl_gene_id":"ENSG00000159055","hgnc_id":"HGNC:1286","ncbi_gene_id":54069,"previous_symbols":["C21orf46","C21orf45"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIS18A","release_manifest":"api/v1.1/release_manifest.json"}},"MIS18BP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIS18BP1","identifiers":{"aliases":["M18BP1","FLJ11186","KIAA1903","KNL2"],"approved_symbol":"MIS18BP1","ensembl_gene_id":"ENSG00000129534","hgnc_id":"HGNC:20190","ncbi_gene_id":55320,"previous_symbols":["C14orf106"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MIS18BP1","release_manifest":"api/v1.1/release_manifest.json"}},"MISP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MISP","identifiers":{"aliases":["DKFZp686H18209","Caprice","MISP1"],"approved_symbol":"MISP","ensembl_gene_id":"ENSG00000099812","hgnc_id":"HGNC:27000","ncbi_gene_id":126353,"previous_symbols":["C19orf21"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MISP","release_manifest":"api/v1.1/release_manifest.json"}},"MISP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MISP3","identifiers":{"aliases":[],"approved_symbol":"MISP3","ensembl_gene_id":"ENSG00000141854","hgnc_id":"HGNC:26963","ncbi_gene_id":113230,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MISP3","release_manifest":"api/v1.1/release_manifest.json"}},"MITD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MITD1","identifiers":{"aliases":["LOC129531"],"approved_symbol":"MITD1","ensembl_gene_id":"ENSG00000158411","hgnc_id":"HGNC:25207","ncbi_gene_id":129531,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MITD1","release_manifest":"api/v1.1/release_manifest.json"}},"MITF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MITF","identifiers":{"aliases":["MI","bHLHe32"],"approved_symbol":"MITF","ensembl_gene_id":"ENSG00000187098","hgnc_id":"HGNC:7105","ncbi_gene_id":4286,"previous_symbols":["WS2A","WS2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MITF","release_manifest":"api/v1.1/release_manifest.json"}},"MIXL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MIXL1","identifiers":{"aliases":["MILD1","MIXL"],"approved_symbol":"MIXL1","ensembl_gene_id":"ENSG00000185155","hgnc_id":"HGNC:13363","ncbi_gene_id":83881,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MIXL1","release_manifest":"api/v1.1/release_manifest.json"}},"MKI67":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKI67","identifiers":{"aliases":["MIB-1","PPP1R105","Ki-67"],"approved_symbol":"MKI67","ensembl_gene_id":"ENSG00000148773","hgnc_id":"HGNC:7107","ncbi_gene_id":4288,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKI67","release_manifest":"api/v1.1/release_manifest.json"}},"MKKS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKKS","identifiers":{"aliases":[],"approved_symbol":"MKKS","ensembl_gene_id":"ENSG00000125863","hgnc_id":"HGNC:7108","ncbi_gene_id":8195,"previous_symbols":["BBS6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKKS","release_manifest":"api/v1.1/release_manifest.json"}},"MKLN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKLN1","identifiers":{"aliases":["TWA2"],"approved_symbol":"MKLN1","ensembl_gene_id":"ENSG00000128585","hgnc_id":"HGNC:7109","ncbi_gene_id":4289,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKLN1","release_manifest":"api/v1.1/release_manifest.json"}},"MKLN1-AS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKLN1-AS","identifiers":{"aliases":[],"approved_symbol":"MKLN1-AS","ensembl_gene_id":"ENSG00000236753","hgnc_id":"HGNC:40374","ncbi_gene_id":100506881,"previous_symbols":["MKLN1-AS2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKLN1-AS","release_manifest":"api/v1.1/release_manifest.json"}},"MKNK1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKNK1","identifiers":{"aliases":["MNK1"],"approved_symbol":"MKNK1","ensembl_gene_id":"ENSG00000079277","hgnc_id":"HGNC:7110","ncbi_gene_id":8569,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKNK1","release_manifest":"api/v1.1/release_manifest.json"}},"MKNK1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKNK1-AS1","identifiers":{"aliases":[],"approved_symbol":"MKNK1-AS1","ensembl_gene_id":"ENSG00000269956","hgnc_id":"HGNC:44129","ncbi_gene_id":100507423,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MKNK1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MKNK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKNK2","identifiers":{"aliases":["MNK2"],"approved_symbol":"MKNK2","ensembl_gene_id":"ENSG00000099875","hgnc_id":"HGNC:7111","ncbi_gene_id":2872,"previous_symbols":["GPRK7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKNK2","release_manifest":"api/v1.1/release_manifest.json"}},"MKRN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKRN1","identifiers":{"aliases":["RNF61"],"approved_symbol":"MKRN1","ensembl_gene_id":"ENSG00000133606","hgnc_id":"HGNC:7112","ncbi_gene_id":23608,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKRN1","release_manifest":"api/v1.1/release_manifest.json"}},"MKRN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKRN2","identifiers":{"aliases":["RNF62","HSPC070"],"approved_symbol":"MKRN2","ensembl_gene_id":"ENSG00000075975","hgnc_id":"HGNC:7113","ncbi_gene_id":23609,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKRN2","release_manifest":"api/v1.1/release_manifest.json"}},"MKRN2OS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKRN2OS","identifiers":{"aliases":[],"approved_symbol":"MKRN2OS","ensembl_gene_id":"ENSG00000225526","hgnc_id":"HGNC:40375","ncbi_gene_id":100129480,"previous_symbols":["MKRN2-AS1","C3orf83"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MKRN2OS","release_manifest":"api/v1.1/release_manifest.json"}},"MKRN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKRN3","identifiers":{"aliases":["RNF63","ZFP127","MGC88288"],"approved_symbol":"MKRN3","ensembl_gene_id":"ENSG00000179455","hgnc_id":"HGNC:7114","ncbi_gene_id":7681,"previous_symbols":["ZNF127","D15S9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKRN3","release_manifest":"api/v1.1/release_manifest.json"}},"MKS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKS1","identifiers":{"aliases":["FLJ20345","POC12","BBS13"],"approved_symbol":"MKS1","ensembl_gene_id":"ENSG00000011143","hgnc_id":"HGNC:7121","ncbi_gene_id":54903,"previous_symbols":["MKS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKS1","release_manifest":"api/v1.1/release_manifest.json"}},"MKX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MKX","identifiers":{"aliases":["MGC39616"],"approved_symbol":"MKX","ensembl_gene_id":"ENSG00000150051","hgnc_id":"HGNC:23729","ncbi_gene_id":283078,"previous_symbols":["C10orf48","IRXL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MKX","release_manifest":"api/v1.1/release_manifest.json"}},"MLANA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLANA","identifiers":{"aliases":["MART1","MART-1"],"approved_symbol":"MLANA","ensembl_gene_id":"ENSG00000120215","hgnc_id":"HGNC:7124","ncbi_gene_id":2315,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLANA","release_manifest":"api/v1.1/release_manifest.json"}},"MLC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLC1","identifiers":{"aliases":["MLC","KIAA0027","LVM","VL"],"approved_symbol":"MLC1","ensembl_gene_id":"ENSG00000100427","hgnc_id":"HGNC:17082","ncbi_gene_id":23209,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MLC1","release_manifest":"api/v1.1/release_manifest.json"}},"MLEC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLEC","identifiers":{"aliases":[],"approved_symbol":"MLEC","ensembl_gene_id":"ENSG00000110917","hgnc_id":"HGNC:28973","ncbi_gene_id":9761,"previous_symbols":["KIAA0152"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MLEC","release_manifest":"api/v1.1/release_manifest.json"}},"MLF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLF1","identifiers":{"aliases":[],"approved_symbol":"MLF1","ensembl_gene_id":"ENSG00000178053","hgnc_id":"HGNC:7125","ncbi_gene_id":4291,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLF1","release_manifest":"api/v1.1/release_manifest.json"}},"MLF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLF2","identifiers":{"aliases":["NTN4"],"approved_symbol":"MLF2","ensembl_gene_id":"ENSG00000089693","hgnc_id":"HGNC:7126","ncbi_gene_id":8079,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLF2","release_manifest":"api/v1.1/release_manifest.json"}},"MLH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLH1","identifiers":{"aliases":["HNPCC","FCC2","HNPCC2","MLH-1"],"approved_symbol":"MLH1","ensembl_gene_id":"ENSG00000076242","hgnc_id":"HGNC:7127","ncbi_gene_id":4292,"previous_symbols":["COCA2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLH1","release_manifest":"api/v1.1/release_manifest.json"}},"MLH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLH3","identifiers":{"aliases":[],"approved_symbol":"MLH3","ensembl_gene_id":"ENSG00000119684","hgnc_id":"HGNC:7128","ncbi_gene_id":27030,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLH3","release_manifest":"api/v1.1/release_manifest.json"}},"MLIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLIP","identifiers":{"aliases":["MGC18257","CIP"],"approved_symbol":"MLIP","ensembl_gene_id":"ENSG00000146147","hgnc_id":"HGNC:21355","ncbi_gene_id":90523,"previous_symbols":["C6orf142"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLIP","release_manifest":"api/v1.1/release_manifest.json"}},"MLIP-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLIP-AS1","identifiers":{"aliases":[],"approved_symbol":"MLIP-AS1","ensembl_gene_id":"ENSG00000235050","hgnc_id":"HGNC:40963","ncbi_gene_id":100873951,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MLIP-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MLKL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLKL","identifiers":{"aliases":["FLJ34389"],"approved_symbol":"MLKL","ensembl_gene_id":"ENSG00000168404","hgnc_id":"HGNC:26617","ncbi_gene_id":197259,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MLKL","release_manifest":"api/v1.1/release_manifest.json"}},"MLLT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLLT1","identifiers":{"aliases":["ENL","LTG19","YEATS1"],"approved_symbol":"MLLT1","ensembl_gene_id":"ENSG00000130382","hgnc_id":"HGNC:7134","ncbi_gene_id":4298,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLLT1","release_manifest":"api/v1.1/release_manifest.json"}},"MLLT10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLLT10","identifiers":{"aliases":["AF10"],"approved_symbol":"MLLT10","ensembl_gene_id":"ENSG00000078403","hgnc_id":"HGNC:16063","ncbi_gene_id":8028,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLLT10","release_manifest":"api/v1.1/release_manifest.json"}},"MLLT11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLLT11","identifiers":{"aliases":["AF1Q"],"approved_symbol":"MLLT11","ensembl_gene_id":"ENSG00000213190","hgnc_id":"HGNC:16997","ncbi_gene_id":10962,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MLLT11","release_manifest":"api/v1.1/release_manifest.json"}},"MLLT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLLT3","identifiers":{"aliases":["AF-9","AF9","YEATS3"],"approved_symbol":"MLLT3","ensembl_gene_id":"ENSG00000171843","hgnc_id":"HGNC:7136","ncbi_gene_id":4300,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLLT3","release_manifest":"api/v1.1/release_manifest.json"}},"MLLT6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLLT6","identifiers":{"aliases":["AF17","FLJ23480"],"approved_symbol":"MLLT6","ensembl_gene_id":"ENSG00000275023","hgnc_id":"HGNC:7138","ncbi_gene_id":4302,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLLT6","release_manifest":"api/v1.1/release_manifest.json"}},"MLNR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLNR","identifiers":{"aliases":[],"approved_symbol":"MLNR","ensembl_gene_id":"ENSG00000102539","hgnc_id":"HGNC:4495","ncbi_gene_id":2862,"previous_symbols":["GPR38"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MLNR","release_manifest":"api/v1.1/release_manifest.json"}},"MLPH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLPH","identifiers":{"aliases":["l1Rk3","l(1)-3Rk","Slac-2a","ln","exophilin-3","SLAC2-A"],"approved_symbol":"MLPH","ensembl_gene_id":"ENSG00000115648","hgnc_id":"HGNC:29643","ncbi_gene_id":79083,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLPH","release_manifest":"api/v1.1/release_manifest.json"}},"MLST8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLST8","identifiers":{"aliases":["Lst8","Pop3","GBL","GbetaL"],"approved_symbol":"MLST8","ensembl_gene_id":"ENSG00000167965","hgnc_id":"HGNC:24825","ncbi_gene_id":64223,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MLST8","release_manifest":"api/v1.1/release_manifest.json"}},"MLX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLX","identifiers":{"aliases":["MAD7","MXD7","bHLHd13"],"approved_symbol":"MLX","ensembl_gene_id":"ENSG00000108788","hgnc_id":"HGNC:11645","ncbi_gene_id":6945,"previous_symbols":["TCFL4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MLX","release_manifest":"api/v1.1/release_manifest.json"}},"MLXIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLXIP","identifiers":{"aliases":["MONDOA","KIAA0867","MIR","bHLHe36"],"approved_symbol":"MLXIP","ensembl_gene_id":"ENSG00000175727","hgnc_id":"HGNC:17055","ncbi_gene_id":22877,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLXIP","release_manifest":"api/v1.1/release_manifest.json"}},"MLXIPL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLXIPL","identifiers":{"aliases":["WS-bHLH","MIO","CHREBP","MONDOB","bHLHd14"],"approved_symbol":"MLXIPL","ensembl_gene_id":"ENSG00000009950","hgnc_id":"HGNC:12744","ncbi_gene_id":51085,"previous_symbols":["WBSCR14"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLXIPL","detailed_audit_record":"gene/MLXIPL/audit","legacy_api_record":"api/v1/genes/MLXIPL.json","release_manifest":"api/v1.1/release_manifest.json"}},"MLYCD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MLYCD","identifiers":{"aliases":["MCD","hMCD"],"approved_symbol":"MLYCD","ensembl_gene_id":"ENSG00000103150","hgnc_id":"HGNC:7150","ncbi_gene_id":23417,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MLYCD","release_manifest":"api/v1.1/release_manifest.json"}},"MMAA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMAA","identifiers":{"aliases":["cblA"],"approved_symbol":"MMAA","ensembl_gene_id":"ENSG00000151611","hgnc_id":"HGNC:18871","ncbi_gene_id":166785,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MMAA","release_manifest":"api/v1.1/release_manifest.json"}},"MMAB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMAB","identifiers":{"aliases":["cblB","CFAP23"],"approved_symbol":"MMAB","ensembl_gene_id":"ENSG00000139428","hgnc_id":"HGNC:19331","ncbi_gene_id":326625,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMAB","release_manifest":"api/v1.1/release_manifest.json"}},"MMACHC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMACHC","identifiers":{"aliases":["DKFZP564I122","cblC"],"approved_symbol":"MMACHC","ensembl_gene_id":"ENSG00000132763","hgnc_id":"HGNC:24525","ncbi_gene_id":25974,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMACHC","release_manifest":"api/v1.1/release_manifest.json"}},"MMADHC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMADHC","identifiers":{"aliases":["CL25022","cblD"],"approved_symbol":"MMADHC","ensembl_gene_id":"ENSG00000168288","hgnc_id":"HGNC:25221","ncbi_gene_id":27249,"previous_symbols":["C2orf25"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMADHC","release_manifest":"api/v1.1/release_manifest.json"}},"MMD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMD","identifiers":{"aliases":["MMA","PAQR11"],"approved_symbol":"MMD","ensembl_gene_id":"ENSG00000108960","hgnc_id":"HGNC:7153","ncbi_gene_id":23531,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMD","release_manifest":"api/v1.1/release_manifest.json"}},"MMD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMD2","identifiers":{"aliases":["PAQR10"],"approved_symbol":"MMD2","ensembl_gene_id":"ENSG00000136297","hgnc_id":"HGNC:30133","ncbi_gene_id":221938,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MMD2","release_manifest":"api/v1.1/release_manifest.json"}},"MME":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MME","identifiers":{"aliases":["CALLA","CD10","NEP"],"approved_symbol":"MME","ensembl_gene_id":"ENSG00000196549","hgnc_id":"HGNC:7154","ncbi_gene_id":4311,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MME","release_manifest":"api/v1.1/release_manifest.json"}},"MME-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MME-AS1","identifiers":{"aliases":[],"approved_symbol":"MME-AS1","ensembl_gene_id":"ENSG00000240666","hgnc_id":"HGNC:40376","ncbi_gene_id":100873918,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MME-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MMEL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMEL1","identifiers":{"aliases":["SEP","NL1","NL2","NEPII"],"approved_symbol":"MMEL1","ensembl_gene_id":"ENSG00000142606","hgnc_id":"HGNC:14668","ncbi_gene_id":79258,"previous_symbols":["MMEL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMEL1","release_manifest":"api/v1.1/release_manifest.json"}},"MMGT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMGT1","identifiers":{"aliases":["EMC5"],"approved_symbol":"MMGT1","ensembl_gene_id":"ENSG00000169446","hgnc_id":"HGNC:28100","ncbi_gene_id":93380,"previous_symbols":["TMEM32"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMGT1","release_manifest":"api/v1.1/release_manifest.json"}},"MMP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP1","identifiers":{"aliases":[],"approved_symbol":"MMP1","ensembl_gene_id":"ENSG00000196611","hgnc_id":"HGNC:7155","ncbi_gene_id":4312,"previous_symbols":["CLG"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP1","release_manifest":"api/v1.1/release_manifest.json"}},"MMP11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP11","identifiers":{"aliases":[],"approved_symbol":"MMP11","ensembl_gene_id":"ENSG00000099953","hgnc_id":"HGNC:7157","ncbi_gene_id":4320,"previous_symbols":["STMY3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP11","release_manifest":"api/v1.1/release_manifest.json"}},"MMP12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP12","identifiers":{"aliases":["HME"],"approved_symbol":"MMP12","ensembl_gene_id":"ENSG00000262406","hgnc_id":"HGNC:7158","ncbi_gene_id":4321,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP12","release_manifest":"api/v1.1/release_manifest.json"}},"MMP14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP14","identifiers":{"aliases":["MT1-MMP"],"approved_symbol":"MMP14","ensembl_gene_id":"ENSG00000157227","hgnc_id":"HGNC:7160","ncbi_gene_id":4323,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP14","release_manifest":"api/v1.1/release_manifest.json"}},"MMP15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP15","identifiers":{"aliases":["MT2-MMP","MTMMP2","SMCP-2"],"approved_symbol":"MMP15","ensembl_gene_id":"ENSG00000102996","hgnc_id":"HGNC:7161","ncbi_gene_id":4324,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP15","release_manifest":"api/v1.1/release_manifest.json"}},"MMP16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP16","identifiers":{"aliases":["MT3-MMP","DKFZp761D112"],"approved_symbol":"MMP16","ensembl_gene_id":"ENSG00000156103","hgnc_id":"HGNC:7162","ncbi_gene_id":4325,"previous_symbols":["C8orf57"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP16","release_manifest":"api/v1.1/release_manifest.json"}},"MMP17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP17","identifiers":{"aliases":["MT4-MMP"],"approved_symbol":"MMP17","ensembl_gene_id":"ENSG00000198598","hgnc_id":"HGNC:7163","ncbi_gene_id":4326,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP17","release_manifest":"api/v1.1/release_manifest.json"}},"MMP19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP19","identifiers":{"aliases":["RASI-1"],"approved_symbol":"MMP19","ensembl_gene_id":"ENSG00000123342","hgnc_id":"HGNC:7165","ncbi_gene_id":4327,"previous_symbols":["MMP18"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP19","release_manifest":"api/v1.1/release_manifest.json"}},"MMP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP2","identifiers":{"aliases":["MMP-2","TBE-1"],"approved_symbol":"MMP2","ensembl_gene_id":"ENSG00000087245","hgnc_id":"HGNC:7166","ncbi_gene_id":4313,"previous_symbols":["CLG4","CLG4A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP2","release_manifest":"api/v1.1/release_manifest.json"}},"MMP2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP2-AS1","identifiers":{"aliases":["ENST00000569037"],"approved_symbol":"MMP2-AS1","ensembl_gene_id":"ENSG00000260135","hgnc_id":"HGNC:53142","ncbi_gene_id":107984884,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MMP20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP20","identifiers":{"aliases":[],"approved_symbol":"MMP20","ensembl_gene_id":"ENSG00000137674","hgnc_id":"HGNC:7167","ncbi_gene_id":9313,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MMP20","release_manifest":"api/v1.1/release_manifest.json"}},"MMP21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP21","identifiers":{"aliases":[],"approved_symbol":"MMP21","ensembl_gene_id":"ENSG00000154485","hgnc_id":"HGNC:14357","ncbi_gene_id":118856,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP21","release_manifest":"api/v1.1/release_manifest.json"}},"MMP23B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP23B","identifiers":{"aliases":["MIFR","MIFR-1"],"approved_symbol":"MMP23B","ensembl_gene_id":"ENSG00000189409","hgnc_id":"HGNC:7171","ncbi_gene_id":8510,"previous_symbols":["MMP22"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP23B","release_manifest":"api/v1.1/release_manifest.json"}},"MMP24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP24","identifiers":{"aliases":["MT5-MMP"],"approved_symbol":"MMP24","ensembl_gene_id":"ENSG00000125966","hgnc_id":"HGNC:7172","ncbi_gene_id":10893,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP24","release_manifest":"api/v1.1/release_manifest.json"}},"MMP24OS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP24OS","identifiers":{"aliases":[],"approved_symbol":"MMP24OS","ensembl_gene_id":"ENSG00000126005","hgnc_id":"HGNC:44421","ncbi_gene_id":101410538,"previous_symbols":["MMP24-AS1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP24OS","release_manifest":"api/v1.1/release_manifest.json"}},"MMP25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP25","identifiers":{"aliases":["MT6-MMP"],"approved_symbol":"MMP25","ensembl_gene_id":"ENSG00000008516","hgnc_id":"HGNC:14246","ncbi_gene_id":64386,"previous_symbols":["MMPL1","MMP20"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP25","release_manifest":"api/v1.1/release_manifest.json"}},"MMP25-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP25-AS1","identifiers":{"aliases":[],"approved_symbol":"MMP25-AS1","ensembl_gene_id":"ENSG00000261971","hgnc_id":"HGNC:51372","ncbi_gene_id":100507419,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MMP25-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MMP26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP26","identifiers":{"aliases":["endometase","MGC126590","MGC126592"],"approved_symbol":"MMP26","ensembl_gene_id":"ENSG00000167346","hgnc_id":"HGNC:14249","ncbi_gene_id":56547,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP26","release_manifest":"api/v1.1/release_manifest.json"}},"MMP27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP27","identifiers":{"aliases":[],"approved_symbol":"MMP27","ensembl_gene_id":"ENSG00000137675","hgnc_id":"HGNC:14250","ncbi_gene_id":64066,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP27","detailed_audit_record":"gene/MMP27/audit","legacy_api_record":"api/v1/genes/MMP27.json","release_manifest":"api/v1.1/release_manifest.json"}},"MMP28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP28","identifiers":{"aliases":["MMP-25","MM28","EPILYSIN","MMP-28"],"approved_symbol":"MMP28","ensembl_gene_id":"ENSG00000271447","hgnc_id":"HGNC:14366","ncbi_gene_id":79148,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP28","release_manifest":"api/v1.1/release_manifest.json"}},"MMP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP3","identifiers":{"aliases":[],"approved_symbol":"MMP3","ensembl_gene_id":"ENSG00000149968","hgnc_id":"HGNC:7173","ncbi_gene_id":4314,"previous_symbols":["STMY1","STMY"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP3","release_manifest":"api/v1.1/release_manifest.json"}},"MMP7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP7","identifiers":{"aliases":["PUMP-1"],"approved_symbol":"MMP7","ensembl_gene_id":"ENSG00000137673","hgnc_id":"HGNC:7174","ncbi_gene_id":4316,"previous_symbols":["MPSL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMP7","release_manifest":"api/v1.1/release_manifest.json"}},"MMP8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP8","identifiers":{"aliases":[],"approved_symbol":"MMP8","ensembl_gene_id":"ENSG00000118113","hgnc_id":"HGNC:7175","ncbi_gene_id":4317,"previous_symbols":["CLG1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MMP8","release_manifest":"api/v1.1/release_manifest.json"}},"MMP9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMP9","identifiers":{"aliases":[],"approved_symbol":"MMP9","ensembl_gene_id":"ENSG00000100985","hgnc_id":"HGNC:7176","ncbi_gene_id":4318,"previous_symbols":["CLG4B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MMP9","release_manifest":"api/v1.1/release_manifest.json"}},"MMRN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMRN1","identifiers":{"aliases":["ECM","EMILIN4","GPIa*"],"approved_symbol":"MMRN1","ensembl_gene_id":"ENSG00000138722","hgnc_id":"HGNC:7178","ncbi_gene_id":22915,"previous_symbols":["MMRN"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMRN1","release_manifest":"api/v1.1/release_manifest.json"}},"MMRN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMRN2","identifiers":{"aliases":["EndoGlyx-1","FLJ13465"],"approved_symbol":"MMRN2","ensembl_gene_id":"ENSG00000173269","hgnc_id":"HGNC:19888","ncbi_gene_id":79812,"previous_symbols":["EMILIN3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMRN2","release_manifest":"api/v1.1/release_manifest.json"}},"MMS19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMS19","identifiers":{"aliases":["MET18","hMMS19","CIAO4"],"approved_symbol":"MMS19","ensembl_gene_id":"ENSG00000155229","hgnc_id":"HGNC:13824","ncbi_gene_id":64210,"previous_symbols":["MMS19L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMS19","release_manifest":"api/v1.1/release_manifest.json"}},"MMS22L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMS22L","identifiers":{"aliases":["dJ39B17.2"],"approved_symbol":"MMS22L","ensembl_gene_id":"ENSG00000146263","hgnc_id":"HGNC:21475","ncbi_gene_id":253714,"previous_symbols":["C6orf167"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMS22L","release_manifest":"api/v1.1/release_manifest.json"}},"MMUT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MMUT","identifiers":{"aliases":["MCM"],"approved_symbol":"MMUT","ensembl_gene_id":"ENSG00000146085","hgnc_id":"HGNC:7526","ncbi_gene_id":4594,"previous_symbols":["MUT"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MMUT","release_manifest":"api/v1.1/release_manifest.json"}},"MN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MN1","identifiers":{"aliases":["MGCR1-PEN","MGCR1"],"approved_symbol":"MN1","ensembl_gene_id":"ENSG00000169184","hgnc_id":"HGNC:7180","ncbi_gene_id":4330,"previous_symbols":["MGCR"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MN1","release_manifest":"api/v1.1/release_manifest.json"}},"MNAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MNAT1","identifiers":{"aliases":["MAT1","RNF66"],"approved_symbol":"MNAT1","ensembl_gene_id":"ENSG00000020426","hgnc_id":"HGNC:7181","ncbi_gene_id":4331,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MNAT1","release_manifest":"api/v1.1/release_manifest.json"}},"MND1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MND1","identifiers":{"aliases":["GAJ"],"approved_symbol":"MND1","ensembl_gene_id":"ENSG00000121211","hgnc_id":"HGNC:24839","ncbi_gene_id":84057,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MND1","release_manifest":"api/v1.1/release_manifest.json"}},"MNDA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MNDA","identifiers":{"aliases":["PYHIN3"],"approved_symbol":"MNDA","ensembl_gene_id":"ENSG00000163563","hgnc_id":"HGNC:7183","ncbi_gene_id":4332,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MNDA","release_manifest":"api/v1.1/release_manifest.json"}},"MNS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MNS1","identifiers":{"aliases":["CFAP127","FLJ11222","SPATA40"],"approved_symbol":"MNS1","ensembl_gene_id":"ENSG00000138587","hgnc_id":"HGNC:29636","ncbi_gene_id":55329,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MNS1","release_manifest":"api/v1.1/release_manifest.json"}},"MNT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MNT","identifiers":{"aliases":["ROX","MXD6","MAD6","bHLHd3","lncRNA-HAL"],"approved_symbol":"MNT","ensembl_gene_id":"ENSG00000070444","hgnc_id":"HGNC:7188","ncbi_gene_id":4335,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MNT","release_manifest":"api/v1.1/release_manifest.json"}},"MOAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOAP1","identifiers":{"aliases":["MAP-1","PNMA4"],"approved_symbol":"MOAP1","ensembl_gene_id":"ENSG00000165943","hgnc_id":"HGNC:16658","ncbi_gene_id":64112,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOAP1","release_manifest":"api/v1.1/release_manifest.json"}},"MOB1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOB1A","identifiers":{"aliases":["FLJ10788","MOB1","FLJ11595","Mob4B","Mats1"],"approved_symbol":"MOB1A","ensembl_gene_id":"ENSG00000114978","hgnc_id":"HGNC:16015","ncbi_gene_id":55233,"previous_symbols":["C2orf6","MOBK1B","MOBKL1B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOB1A","release_manifest":"api/v1.1/release_manifest.json"}},"MOB1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOB1B","identifiers":{"aliases":["MOB4A"],"approved_symbol":"MOB1B","ensembl_gene_id":"ENSG00000173542","hgnc_id":"HGNC:29801","ncbi_gene_id":92597,"previous_symbols":["MOBKL1A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOB1B","release_manifest":"api/v1.1/release_manifest.json"}},"MOB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOB2","identifiers":{"aliases":["HCCA2"],"approved_symbol":"MOB2","ensembl_gene_id":"ENSG00000182208","hgnc_id":"HGNC:24904","ncbi_gene_id":81532,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOB2","release_manifest":"api/v1.1/release_manifest.json"}},"MOB3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOB3A","identifiers":{"aliases":["MOB1C","MOB-LAK","moblak"],"approved_symbol":"MOB3A","ensembl_gene_id":"ENSG00000172081","hgnc_id":"HGNC:29802","ncbi_gene_id":126308,"previous_symbols":["MOBKL2A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOB3A","release_manifest":"api/v1.1/release_manifest.json"}},"MOB3B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOB3B","identifiers":{"aliases":["MOB1D","FLJ13204"],"approved_symbol":"MOB3B","ensembl_gene_id":"ENSG00000120162","hgnc_id":"HGNC:23825","ncbi_gene_id":79817,"previous_symbols":["MOBKL2B","C9orf35"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOB3B","release_manifest":"api/v1.1/release_manifest.json"}},"MOB3C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOB3C","identifiers":{"aliases":["MOB1E"],"approved_symbol":"MOB3C","ensembl_gene_id":"ENSG00000142961","hgnc_id":"HGNC:29800","ncbi_gene_id":148932,"previous_symbols":["MOBKL2C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOB3C","release_manifest":"api/v1.1/release_manifest.json"}},"MOB4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOB4","identifiers":{"aliases":["MOB3","DKFZP564M112","CGI-95","2C4D","PHOCN"],"approved_symbol":"MOB4","ensembl_gene_id":"ENSG00000115540","hgnc_id":"HGNC:17261","ncbi_gene_id":25843,"previous_symbols":["PREI3","MOBKL3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOB4","release_manifest":"api/v1.1/release_manifest.json"}},"MOBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOBP","identifiers":{"aliases":[],"approved_symbol":"MOBP","ensembl_gene_id":"ENSG00000168314","hgnc_id":"HGNC:7189","ncbi_gene_id":4336,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MOBP","release_manifest":"api/v1.1/release_manifest.json"}},"MOCOS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOCOS","identifiers":{"aliases":["HMCS","FLJ20733","MOS","MCS"],"approved_symbol":"MOCOS","ensembl_gene_id":"ENSG00000075643","hgnc_id":"HGNC:18234","ncbi_gene_id":55034,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOCOS","release_manifest":"api/v1.1/release_manifest.json"}},"MOCS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOCS1","identifiers":{"aliases":["MOCOD","MOCS1A","MOCS1B"],"approved_symbol":"MOCS1","ensembl_gene_id":"ENSG00000124615","hgnc_id":"HGNC:7190","ncbi_gene_id":4337,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOCS1","release_manifest":"api/v1.1/release_manifest.json"}},"MOCS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOCS2","identifiers":{"aliases":["MOCO1","MOCS2A","MOCS2B"],"approved_symbol":"MOCS2","ensembl_gene_id":"ENSG00000164172","hgnc_id":"HGNC:7193","ncbi_gene_id":4338,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOCS2","release_manifest":"api/v1.1/release_manifest.json"}},"MOCS3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOCS3","identifiers":{"aliases":["UBA4","dJ914P20.3"],"approved_symbol":"MOCS3","ensembl_gene_id":"ENSG00000124217","hgnc_id":"HGNC:15765","ncbi_gene_id":27304,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOCS3","release_manifest":"api/v1.1/release_manifest.json"}},"MOGAT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOGAT1","identifiers":{"aliases":["DGAT2L","MGAT1"],"approved_symbol":"MOGAT1","ensembl_gene_id":"ENSG00000124003","hgnc_id":"HGNC:18210","ncbi_gene_id":116255,"previous_symbols":["DGAT2L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOGAT1","release_manifest":"api/v1.1/release_manifest.json"}},"MOGAT3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOGAT3","identifiers":{"aliases":["DC7","MGAT3","DGAT2L2"],"approved_symbol":"MOGAT3","ensembl_gene_id":"ENSG00000106384","hgnc_id":"HGNC:23249","ncbi_gene_id":346606,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MOGAT3","release_manifest":"api/v1.1/release_manifest.json"}},"MOGS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOGS","identifiers":{"aliases":["GCS1","CWH41","DER7"],"approved_symbol":"MOGS","ensembl_gene_id":"ENSG00000115275","hgnc_id":"HGNC:24862","ncbi_gene_id":7841,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOGS","release_manifest":"api/v1.1/release_manifest.json"}},"MOK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOK","identifiers":{"aliases":["RAGE1","STK30"],"approved_symbol":"MOK","ensembl_gene_id":"ENSG00000080823","hgnc_id":"HGNC:9833","ncbi_gene_id":5891,"previous_symbols":["RAGE"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOK","release_manifest":"api/v1.1/release_manifest.json"}},"MON1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MON1A","identifiers":{"aliases":["MGC13272","SAND1"],"approved_symbol":"MON1A","ensembl_gene_id":"ENSG00000164077","hgnc_id":"HGNC:28207","ncbi_gene_id":84315,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":94},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.10707,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"muscle_assay","current_display_label":"Muscle-context assay","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":5,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-02","label":"Independent muscle-context perturbation is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-03 DMD-relevant functional validation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":8.05698,"depmap_median_gene_effect":-0.1110817355734859,"moderate_dependency_flag":false,"observed_counteralignment":0.0465108672448511},"summary":"Priority B · multisource follow-up; observed DMD-prior counteralignment 0.0465; observed cells 94; integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MON1A","detailed_audit_record":"gene/MON1A/audit","legacy_api_record":"api/v1/genes/MON1A.json","release_manifest":"api/v1.1/release_manifest.json"}},"MON1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MON1B","identifiers":{"aliases":["SAND2","HSRG1","KIAA0872"],"approved_symbol":"MON1B","ensembl_gene_id":"ENSG00000103111","hgnc_id":"HGNC:25020","ncbi_gene_id":22879,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MON1B","release_manifest":"api/v1.1/release_manifest.json"}},"MON2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MON2","identifiers":{"aliases":["KIAA1040"],"approved_symbol":"MON2","ensembl_gene_id":"ENSG00000061987","hgnc_id":"HGNC:29177","ncbi_gene_id":23041,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MON2","release_manifest":"api/v1.1/release_manifest.json"}},"MORC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORC2","identifiers":{"aliases":["ZCW3","KIAA0852","AC004542.C22.1"],"approved_symbol":"MORC2","ensembl_gene_id":"ENSG00000133422","hgnc_id":"HGNC:23573","ncbi_gene_id":22880,"previous_symbols":["ZCWCC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORC2","release_manifest":"api/v1.1/release_manifest.json"}},"MORC2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORC2-AS1","identifiers":{"aliases":["FLJ35801"],"approved_symbol":"MORC2-AS1","ensembl_gene_id":"ENSG00000235989","hgnc_id":"HGNC:26662","ncbi_gene_id":150291,"previous_symbols":["C22orf27","NCRNA00325"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MORC2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MORC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORC3","identifiers":{"aliases":["ZCW5","NXP2","KIAA0136"],"approved_symbol":"MORC3","ensembl_gene_id":"ENSG00000159256","hgnc_id":"HGNC:23572","ncbi_gene_id":23515,"previous_symbols":["ZCWCC3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORC3","release_manifest":"api/v1.1/release_manifest.json"}},"MORC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORC4","identifiers":{"aliases":["ZCW4","FLJ11565"],"approved_symbol":"MORC4","ensembl_gene_id":"ENSG00000133131","hgnc_id":"HGNC:23485","ncbi_gene_id":79710,"previous_symbols":["ZCWCC2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORC4","release_manifest":"api/v1.1/release_manifest.json"}},"MORF4L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORF4L1","identifiers":{"aliases":["MRG15","MORFRG15","HsT17725","Eaf3","MEAF3"],"approved_symbol":"MORF4L1","ensembl_gene_id":"ENSG00000185787","hgnc_id":"HGNC:16989","ncbi_gene_id":10933,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORF4L1","release_manifest":"api/v1.1/release_manifest.json"}},"MORF4L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORF4L2","identifiers":{"aliases":["KIAA0026","MRGX"],"approved_symbol":"MORF4L2","ensembl_gene_id":"ENSG00000123562","hgnc_id":"HGNC:16849","ncbi_gene_id":9643,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORF4L2","release_manifest":"api/v1.1/release_manifest.json"}},"MORF4L2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORF4L2-AS1","identifiers":{"aliases":[],"approved_symbol":"MORF4L2-AS1","ensembl_gene_id":"ENSG00000231154","hgnc_id":"HGNC:27991","ncbi_gene_id":340544,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MORF4L2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MORN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORN1","identifiers":{"aliases":["FLJ13941"],"approved_symbol":"MORN1","ensembl_gene_id":"ENSG00000116151","hgnc_id":"HGNC:25852","ncbi_gene_id":79906,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORN1","release_manifest":"api/v1.1/release_manifest.json"}},"MORN2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORN2","identifiers":{"aliases":["MOPT"],"approved_symbol":"MORN2","ensembl_gene_id":"ENSG00000188010","hgnc_id":"HGNC:30166","ncbi_gene_id":729967,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORN2","release_manifest":"api/v1.1/release_manifest.json"}},"MORN3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORN3","identifiers":{"aliases":[],"approved_symbol":"MORN3","ensembl_gene_id":"ENSG00000139714","hgnc_id":"HGNC:29807","ncbi_gene_id":283385,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MORN3","release_manifest":"api/v1.1/release_manifest.json"}},"MORN4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORN4","identifiers":{"aliases":["bA548K23.4","FLJ25925","rtp"],"approved_symbol":"MORN4","ensembl_gene_id":"ENSG00000171160","hgnc_id":"HGNC:24001","ncbi_gene_id":118812,"previous_symbols":["C10orf83"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MORN4","release_manifest":"api/v1.1/release_manifest.json"}},"MORN5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MORN5","identifiers":{"aliases":["FLJ46909"],"approved_symbol":"MORN5","ensembl_gene_id":"ENSG00000185681","hgnc_id":"HGNC:17841","ncbi_gene_id":254956,"previous_symbols":["C9orf113","C9orf18"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MORN5","release_manifest":"api/v1.1/release_manifest.json"}},"MOSMO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOSMO","identifiers":{"aliases":["ATTHOG","BC030336"],"approved_symbol":"MOSMO","ensembl_gene_id":"ENSG00000185716","hgnc_id":"HGNC:27087","ncbi_gene_id":730094,"previous_symbols":["C16orf52"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MOSMO","release_manifest":"api/v1.1/release_manifest.json"}},"MOSPD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOSPD1","identifiers":{"aliases":["dJ473B4"],"approved_symbol":"MOSPD1","ensembl_gene_id":"ENSG00000101928","hgnc_id":"HGNC:25235","ncbi_gene_id":56180,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOSPD1","release_manifest":"api/v1.1/release_manifest.json"}},"MOSPD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOSPD2","identifiers":{"aliases":["MGC26706"],"approved_symbol":"MOSPD2","ensembl_gene_id":"ENSG00000130150","hgnc_id":"HGNC:28381","ncbi_gene_id":158747,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOSPD2","release_manifest":"api/v1.1/release_manifest.json"}},"MOSPD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOSPD3","identifiers":{"aliases":["CDS3","NET30"],"approved_symbol":"MOSPD3","ensembl_gene_id":"ENSG00000106330","hgnc_id":"HGNC:25078","ncbi_gene_id":64598,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOSPD3","release_manifest":"api/v1.1/release_manifest.json"}},"MOV10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOV10","identifiers":{"aliases":["gb110","MGC2948","fSAP113"],"approved_symbol":"MOV10","ensembl_gene_id":"ENSG00000155363","hgnc_id":"HGNC:7200","ncbi_gene_id":4343,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MOV10","release_manifest":"api/v1.1/release_manifest.json"}},"MOV10L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOV10L1","identifiers":{"aliases":["DJ402G11.8","DKFZp434B0717","CHAMP"],"approved_symbol":"MOV10L1","ensembl_gene_id":"ENSG00000073146","hgnc_id":"HGNC:7201","ncbi_gene_id":54456,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOV10L1","release_manifest":"api/v1.1/release_manifest.json"}},"MOXD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MOXD1","identifiers":{"aliases":["DKFZP564G202","MOX","dJ248E1.1"],"approved_symbol":"MOXD1","ensembl_gene_id":"ENSG00000079931","hgnc_id":"HGNC:21063","ncbi_gene_id":26002,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MOXD1","release_manifest":"api/v1.1/release_manifest.json"}},"MPC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPC1","identifiers":{"aliases":["dJ68L15.3","CGI-129","SLC54A1"],"approved_symbol":"MPC1","ensembl_gene_id":"ENSG00000060762","hgnc_id":"HGNC:21606","ncbi_gene_id":51660,"previous_symbols":["BRP44L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPC1","release_manifest":"api/v1.1/release_manifest.json"}},"MPC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPC2","identifiers":{"aliases":["DKFZP564B167","SLC54A2"],"approved_symbol":"MPC2","ensembl_gene_id":"ENSG00000143158","hgnc_id":"HGNC:24515","ncbi_gene_id":25874,"previous_symbols":["BRP44"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPC2","release_manifest":"api/v1.1/release_manifest.json"}},"MPDU1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPDU1","identifiers":{"aliases":["SL15","Lec35","PQLC5","CDGIf","SLC66A5"],"approved_symbol":"MPDU1","ensembl_gene_id":"ENSG00000129255","hgnc_id":"HGNC:7207","ncbi_gene_id":9526,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPDU1","release_manifest":"api/v1.1/release_manifest.json"}},"MPDZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPDZ","identifiers":{"aliases":["MUPP1"],"approved_symbol":"MPDZ","ensembl_gene_id":"ENSG00000107186","hgnc_id":"HGNC:7208","ncbi_gene_id":8777,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPDZ","release_manifest":"api/v1.1/release_manifest.json"}},"MPEG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPEG1","identifiers":{"aliases":["P2","MPS-1","MPG1"],"approved_symbol":"MPEG1","ensembl_gene_id":"ENSG00000197629","hgnc_id":"HGNC:29619","ncbi_gene_id":219972,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPEG1","release_manifest":"api/v1.1/release_manifest.json"}},"MPG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPG","identifiers":{"aliases":["MDG"],"approved_symbol":"MPG","ensembl_gene_id":"ENSG00000103152","hgnc_id":"HGNC:7211","ncbi_gene_id":4350,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.09514,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPG","release_manifest":"api/v1.1/release_manifest.json"}},"MPHOSPH10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPHOSPH10","identifiers":{"aliases":["MPP10","MPP10P","CT90","PPP1R106"],"approved_symbol":"MPHOSPH10","ensembl_gene_id":"ENSG00000124383","hgnc_id":"HGNC:7213","ncbi_gene_id":10199,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPHOSPH10","release_manifest":"api/v1.1/release_manifest.json"}},"MPHOSPH6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPHOSPH6","identifiers":{"aliases":["MPP6"],"approved_symbol":"MPHOSPH6","ensembl_gene_id":"ENSG00000135698","hgnc_id":"HGNC:7214","ncbi_gene_id":10200,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"assessed","support_status":"supported","observed_cells":83},"internal_model_support":{"assessment_status":"assessed","support_status":"supported_with_limits","target_specific_predictive_support":"not_supported","ood_status":"not_assessed","context":"same_processed_hepg2_dataset"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.37153,"fdr":0.77869,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_action":"computational_replication","current_display_label":"Computational replication","current_numeric_rank":null,"formal_deprioritization":false,"historical_rank":13,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-07","label":"Independent computational replication is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-03 DMD-relevant functional validation"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"sign_varied_across_variants","variant_count":9,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{"skeletal_muscle_median_tpm":4.94586,"depmap_median_gene_effect":-0.2173296428535816,"moderate_dependency_flag":false,"observed_counteralignment":0.0156264944854757},"summary":"Priority C · context/calibration; observed DMD-prior counteralignment 0.0156; observed cells 83; integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MPHOSPH6","detailed_audit_record":"gene/MPHOSPH6/audit","legacy_api_record":"api/v1/genes/MPHOSPH6.json","release_manifest":"api/v1.1/release_manifest.json"}},"MPHOSPH8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPHOSPH8","identifiers":{"aliases":["mpp8","HSMPP8"],"approved_symbol":"MPHOSPH8","ensembl_gene_id":"ENSG00000196199","hgnc_id":"HGNC:29810","ncbi_gene_id":54737,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPHOSPH8","release_manifest":"api/v1.1/release_manifest.json"}},"MPHOSPH9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPHOSPH9","identifiers":{"aliases":["MPP9"],"approved_symbol":"MPHOSPH9","ensembl_gene_id":"ENSG00000051825","hgnc_id":"HGNC:7215","ncbi_gene_id":10198,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPHOSPH9","release_manifest":"api/v1.1/release_manifest.json"}},"MPI":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPI","identifiers":{"aliases":[],"approved_symbol":"MPI","ensembl_gene_id":"ENSG00000178802","hgnc_id":"HGNC:7216","ncbi_gene_id":4351,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPI","release_manifest":"api/v1.1/release_manifest.json"}},"MPIG6B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPIG6B","identifiers":{"aliases":["G6b","NG31","G6b-B"],"approved_symbol":"MPIG6B","ensembl_gene_id":"ENSG00000204420","hgnc_id":"HGNC:13937","ncbi_gene_id":80739,"previous_symbols":["C6orf25"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPIG6B","release_manifest":"api/v1.1/release_manifest.json"}},"MPL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPL","identifiers":{"aliases":["CD110","TPOR","THPOR"],"approved_symbol":"MPL","ensembl_gene_id":"ENSG00000117400","hgnc_id":"HGNC:7217","ncbi_gene_id":4352,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPL","release_manifest":"api/v1.1/release_manifest.json"}},"MPLKIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPLKIP","identifiers":{"aliases":["ORF20","TTDN1"],"approved_symbol":"MPLKIP","ensembl_gene_id":"ENSG00000168303","hgnc_id":"HGNC:16002","ncbi_gene_id":136647,"previous_symbols":["C7orf11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPLKIP","release_manifest":"api/v1.1/release_manifest.json"}},"MPND":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPND","identifiers":{"aliases":["FLJ14981"],"approved_symbol":"MPND","ensembl_gene_id":"ENSG00000008382","hgnc_id":"HGNC:25934","ncbi_gene_id":84954,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MPND","release_manifest":"api/v1.1/release_manifest.json"}},"MPO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPO","identifiers":{"aliases":[],"approved_symbol":"MPO","ensembl_gene_id":"ENSG00000005381","hgnc_id":"HGNC:7218","ncbi_gene_id":4353,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MPO","release_manifest":"api/v1.1/release_manifest.json"}},"MPP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPP1","identifiers":{"aliases":["PEMP"],"approved_symbol":"MPP1","ensembl_gene_id":"ENSG00000130830","hgnc_id":"HGNC:7219","ncbi_gene_id":4354,"previous_symbols":["DXS552E"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPP1","release_manifest":"api/v1.1/release_manifest.json"}},"MPP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPP2","identifiers":{"aliases":["DKFZp761D0712"],"approved_symbol":"MPP2","ensembl_gene_id":"ENSG00000108852","hgnc_id":"HGNC:7220","ncbi_gene_id":4355,"previous_symbols":["DLG2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPP2","release_manifest":"api/v1.1/release_manifest.json"}},"MPP3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPP3","identifiers":{"aliases":[],"approved_symbol":"MPP3","ensembl_gene_id":"ENSG00000161647","hgnc_id":"HGNC:7221","ncbi_gene_id":4356,"previous_symbols":["DLG3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MPP3","release_manifest":"api/v1.1/release_manifest.json"}},"MPP4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPP4","identifiers":{"aliases":[],"approved_symbol":"MPP4","ensembl_gene_id":"ENSG00000082126","hgnc_id":"HGNC:13680","ncbi_gene_id":58538,"previous_symbols":["DLG6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPP4","release_manifest":"api/v1.1/release_manifest.json"}},"MPP5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPP5","identifiers":{"approved_symbol":"MPP5","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPP5","release_manifest":"api/v1.1/release_manifest.json"}},"MPP6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPP6","identifiers":{"approved_symbol":"MPP6","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MPP6","release_manifest":"api/v1.1/release_manifest.json"}},"MPP7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPP7","identifiers":{"aliases":["FLJ32798"],"approved_symbol":"MPP7","ensembl_gene_id":"ENSG00000150054","hgnc_id":"HGNC:26542","ncbi_gene_id":143098,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPP7","release_manifest":"api/v1.1/release_manifest.json"}},"MPPE1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPPE1","identifiers":{"aliases":["PGAP5","Cdc1"],"approved_symbol":"MPPE1","ensembl_gene_id":"ENSG00000154889","hgnc_id":"HGNC:15988","ncbi_gene_id":65258,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPPE1","release_manifest":"api/v1.1/release_manifest.json"}},"MPPED1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPPED1","identifiers":{"aliases":["239AB","FAM1A"],"approved_symbol":"MPPED1","ensembl_gene_id":"ENSG00000186732","hgnc_id":"HGNC:1306","ncbi_gene_id":758,"previous_symbols":["C22orf1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MPPED1","release_manifest":"api/v1.1/release_manifest.json"}},"MPPED2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPPED2","identifiers":{"aliases":["239FB","D11S302E","Hs.46638","FAM1B","dJ873F21.1","dJ1024C24.1"],"approved_symbol":"MPPED2","ensembl_gene_id":"ENSG00000066382","hgnc_id":"HGNC:1180","ncbi_gene_id":744,"previous_symbols":["C11orf8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPPED2","release_manifest":"api/v1.1/release_manifest.json"}},"MPRIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPRIP","identifiers":{"aliases":["RHOIP3","M-RIP","p116Rip"],"approved_symbol":"MPRIP","ensembl_gene_id":"ENSG00000133030","hgnc_id":"HGNC:30321","ncbi_gene_id":23164,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MPRIP","release_manifest":"api/v1.1/release_manifest.json"}},"MPRIP-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPRIP-AS1","identifiers":{"aliases":[],"approved_symbol":"MPRIP-AS1","ensembl_gene_id":"ENSG00000225442","hgnc_id":"HGNC:41263","ncbi_gene_id":100874529,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPRIP-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MPST":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPST","identifiers":{"aliases":["MST","TST2","TUM1"],"approved_symbol":"MPST","ensembl_gene_id":"ENSG00000128309","hgnc_id":"HGNC:7223","ncbi_gene_id":4357,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPST","release_manifest":"api/v1.1/release_manifest.json"}},"MPV17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPV17","identifiers":{"aliases":["SYM1"],"approved_symbol":"MPV17","ensembl_gene_id":"ENSG00000115204","hgnc_id":"HGNC:7224","ncbi_gene_id":4358,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPV17","release_manifest":"api/v1.1/release_manifest.json"}},"MPV17L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPV17L","identifiers":{"aliases":["FLJ39599","M-LPH","M-LPH1","M-LPH2","MPV17L1"],"approved_symbol":"MPV17L","ensembl_gene_id":"ENSG00000156968","hgnc_id":"HGNC:26827","ncbi_gene_id":255027,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MPV17L","release_manifest":"api/v1.1/release_manifest.json"}},"MPV17L2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPV17L2","identifiers":{"aliases":["FKSG24","MGC12972"],"approved_symbol":"MPV17L2","ensembl_gene_id":"ENSG00000254858","hgnc_id":"HGNC:28177","ncbi_gene_id":84769,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPV17L2","release_manifest":"api/v1.1/release_manifest.json"}},"MPZ":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPZ","identifiers":{"aliases":["HMSNIB","CMT2I","CMT2J","P0"],"approved_symbol":"MPZ","ensembl_gene_id":"ENSG00000158887","hgnc_id":"HGNC:7225","ncbi_gene_id":4359,"previous_symbols":["CMT1","CMT1B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPZ","release_manifest":"api/v1.1/release_manifest.json"}},"MPZL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPZL1","identifiers":{"aliases":["PZR","FLJ21047"],"approved_symbol":"MPZL1","ensembl_gene_id":"ENSG00000197965","hgnc_id":"HGNC:7226","ncbi_gene_id":9019,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPZL1","release_manifest":"api/v1.1/release_manifest.json"}},"MPZL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPZL2","identifiers":{"aliases":["EVA"],"approved_symbol":"MPZL2","ensembl_gene_id":"ENSG00000149573","hgnc_id":"HGNC:3496","ncbi_gene_id":10205,"previous_symbols":["EVA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPZL2","release_manifest":"api/v1.1/release_manifest.json"}},"MPZL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MPZL3","identifiers":{"aliases":[],"approved_symbol":"MPZL3","ensembl_gene_id":"ENSG00000160588","hgnc_id":"HGNC:27279","ncbi_gene_id":196264,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MPZL3","release_manifest":"api/v1.1/release_manifest.json"}},"MR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MR1","identifiers":{"aliases":[],"approved_symbol":"MR1","ensembl_gene_id":"ENSG00000153029","hgnc_id":"HGNC:4975","ncbi_gene_id":3140,"previous_symbols":["HLALS"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MR1","release_manifest":"api/v1.1/release_manifest.json"}},"MRAP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRAP","identifiers":{"aliases":["B27","FALP","MRAP1"],"approved_symbol":"MRAP","ensembl_gene_id":"ENSG00000170262","hgnc_id":"HGNC:1304","ncbi_gene_id":56246,"previous_symbols":["C21orf61"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRAP","release_manifest":"api/v1.1/release_manifest.json"}},"MRAP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRAP2","identifiers":{"aliases":["bA51G5.2"],"approved_symbol":"MRAP2","ensembl_gene_id":"ENSG00000135324","hgnc_id":"HGNC:21232","ncbi_gene_id":112609,"previous_symbols":["C6orf117"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRAP2","release_manifest":"api/v1.1/release_manifest.json"}},"MRAS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRAS","identifiers":{"aliases":["M-RAs","R-RAS3","RRAS3"],"approved_symbol":"MRAS","ensembl_gene_id":"ENSG00000158186","hgnc_id":"HGNC:7227","ncbi_gene_id":22808,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRAS","release_manifest":"api/v1.1/release_manifest.json"}},"MRC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRC1","identifiers":{"aliases":["CLEC13D","CD206","bA541I19.1","CLEC13DL"],"approved_symbol":"MRC1","ensembl_gene_id":"ENSG00000260314","hgnc_id":"HGNC:7228","ncbi_gene_id":4360,"previous_symbols":["MRC1L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRC1","release_manifest":"api/v1.1/release_manifest.json"}},"MRC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRC2","identifiers":{"aliases":["KIAA0709","ENDO180","CLEC13E","CD280"],"approved_symbol":"MRC2","ensembl_gene_id":"ENSG00000011028","hgnc_id":"HGNC:16875","ncbi_gene_id":9902,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRC2","release_manifest":"api/v1.1/release_manifest.json"}},"MRE11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRE11","identifiers":{"aliases":["ATLD"],"approved_symbol":"MRE11","ensembl_gene_id":"ENSG00000020922","hgnc_id":"HGNC:7230","ncbi_gene_id":4361,"previous_symbols":["MRE11A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRE11","release_manifest":"api/v1.1/release_manifest.json"}},"MREG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MREG","identifiers":{"aliases":["FLJ10116","DSU","WDT2"],"approved_symbol":"MREG","ensembl_gene_id":"ENSG00000118242","hgnc_id":"HGNC:25478","ncbi_gene_id":55686,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MREG","release_manifest":"api/v1.1/release_manifest.json"}},"MRFAP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRFAP1","identifiers":{"aliases":["PAM14","PGR1"],"approved_symbol":"MRFAP1","ensembl_gene_id":"ENSG00000179010","hgnc_id":"HGNC:24549","ncbi_gene_id":93621,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRFAP1","release_manifest":"api/v1.1/release_manifest.json"}},"MRFAP1L1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRFAP1L1","identifiers":{"aliases":["MGC9651"],"approved_symbol":"MRFAP1L1","ensembl_gene_id":"ENSG00000178988","hgnc_id":"HGNC:28796","ncbi_gene_id":114932,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRFAP1L1","release_manifest":"api/v1.1/release_manifest.json"}},"MRGBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRGBP","identifiers":{"aliases":["FLJ10914","MRG15BP","Eaf7"],"approved_symbol":"MRGBP","ensembl_gene_id":"ENSG00000101189","hgnc_id":"HGNC:15866","ncbi_gene_id":55257,"previous_symbols":["C20orf20"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRGBP","release_manifest":"api/v1.1/release_manifest.json"}},"MRGPRE":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRGPRE","identifiers":{"aliases":["mrgE"],"approved_symbol":"MRGPRE","ensembl_gene_id":"ENSG00000184350","hgnc_id":"HGNC:30694","ncbi_gene_id":116534,"previous_symbols":["GPR167"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MRGPRE","release_manifest":"api/v1.1/release_manifest.json"}},"MRGPRF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRGPRF","identifiers":{"aliases":["MGC21621","mrgF"],"approved_symbol":"MRGPRF","ensembl_gene_id":"ENSG00000172935","hgnc_id":"HGNC:24828","ncbi_gene_id":116535,"previous_symbols":["GPR168","GPR140"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRGPRF","release_manifest":"api/v1.1/release_manifest.json"}},"MRI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRI1","identifiers":{"aliases":["MGC3207","Ypr118w","mtnA","MRDI"],"approved_symbol":"MRI1","ensembl_gene_id":"ENSG00000037757","hgnc_id":"HGNC:28469","ncbi_gene_id":84245,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRI1","release_manifest":"api/v1.1/release_manifest.json"}},"MRLN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRLN","identifiers":{"aliases":["M1","MUSER1","MLN","Linc-RAM"],"approved_symbol":"MRLN","ensembl_gene_id":"ENSG00000227877","hgnc_id":"HGNC:48649","ncbi_gene_id":100507027,"previous_symbols":["LINC00948"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRLN","release_manifest":"api/v1.1/release_manifest.json"}},"MRM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRM1","identifiers":{"aliases":["FLJ22578"],"approved_symbol":"MRM1","ensembl_gene_id":"ENSG00000278619","hgnc_id":"HGNC:26202","ncbi_gene_id":79922,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRM1","release_manifest":"api/v1.1/release_manifest.json"}},"MRM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRM2","identifiers":{"aliases":["FJH1","RRMJ2"],"approved_symbol":"MRM2","ensembl_gene_id":"ENSG00000122687","hgnc_id":"HGNC:16352","ncbi_gene_id":29960,"previous_symbols":["FTSJ2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRM2","release_manifest":"api/v1.1/release_manifest.json"}},"MRM3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRM3","identifiers":{"aliases":["FLJ10581","HC90","RMTL1"],"approved_symbol":"MRM3","ensembl_gene_id":"ENSG00000171861","hgnc_id":"HGNC:18485","ncbi_gene_id":55178,"previous_symbols":["RNMTL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRM3","release_manifest":"api/v1.1/release_manifest.json"}},"MRNIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRNIP","identifiers":{"aliases":["MGC65027","MGC78537","DKFZp686L2452","LOC51149"],"approved_symbol":"MRNIP","ensembl_gene_id":"ENSG00000161010","hgnc_id":"HGNC:30817","ncbi_gene_id":51149,"previous_symbols":["C5orf45"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRNIP","release_manifest":"api/v1.1/release_manifest.json"}},"MRO":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRO","identifiers":{"aliases":["B29","FLJ30140"],"approved_symbol":"MRO","ensembl_gene_id":"ENSG00000134042","hgnc_id":"HGNC:24121","ncbi_gene_id":83876,"previous_symbols":["C18orf3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRO","release_manifest":"api/v1.1/release_manifest.json"}},"MROH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MROH1","identifiers":{"aliases":["KIAA1833"],"approved_symbol":"MROH1","ensembl_gene_id":"ENSG00000179832","hgnc_id":"HGNC:26958","ncbi_gene_id":727957,"previous_symbols":["HEATR7A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MROH1","release_manifest":"api/v1.1/release_manifest.json"}},"MROH2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MROH2B","identifiers":{"aliases":["DKFZp781F0822","FLJ40243","SPIF"],"approved_symbol":"MROH2B","ensembl_gene_id":"ENSG00000171495","hgnc_id":"HGNC:26857","ncbi_gene_id":133558,"previous_symbols":["HEATR7B2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MROH2B","release_manifest":"api/v1.1/release_manifest.json"}},"MROH6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MROH6","identifiers":{"aliases":[],"approved_symbol":"MROH6","ensembl_gene_id":"ENSG00000204839","hgnc_id":"HGNC:27814","ncbi_gene_id":642475,"previous_symbols":["C8orf73"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MROH6","release_manifest":"api/v1.1/release_manifest.json"}},"MROH7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MROH7","identifiers":{"aliases":["FLJ46354"],"approved_symbol":"MROH7","ensembl_gene_id":"ENSG00000184313","hgnc_id":"HGNC:24802","ncbi_gene_id":374977,"previous_symbols":["C1orf175","HEATR8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MROH7","release_manifest":"api/v1.1/release_manifest.json"}},"MROH8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MROH8","identifiers":{"aliases":["dJ621N11.4","dJ621N11.3"],"approved_symbol":"MROH8","ensembl_gene_id":"ENSG00000101353","hgnc_id":"HGNC:16125","ncbi_gene_id":140699,"previous_symbols":["C20orf131","C20orf132"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MROH8","release_manifest":"api/v1.1/release_manifest.json"}},"MROH9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MROH9","identifiers":{"aliases":["FLJ23550","ARMC11"],"approved_symbol":"MROH9","ensembl_gene_id":"ENSG00000117501","hgnc_id":"HGNC:26287","ncbi_gene_id":80133,"previous_symbols":["C1orf129"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MROH9","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL1","identifiers":{"aliases":["BM022","uL1m"],"approved_symbol":"MRPL1","ensembl_gene_id":"ENSG00000169288","hgnc_id":"HGNC:14275","ncbi_gene_id":65008,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.07412,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL1","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL10","identifiers":{"aliases":["RPML8","MRP-L8","L10MT","MRP-L10","MRPL8","MGC17973","uL10m"],"approved_symbol":"MRPL10","ensembl_gene_id":"ENSG00000159111","hgnc_id":"HGNC:14055","ncbi_gene_id":124995,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL10","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL11","identifiers":{"aliases":["uL11m"],"approved_symbol":"MRPL11","ensembl_gene_id":"ENSG00000174547","hgnc_id":"HGNC:14042","ncbi_gene_id":65003,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL11","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL12","identifiers":{"aliases":["MRPL7/L12","MRPL7","bL12m"],"approved_symbol":"MRPL12","ensembl_gene_id":"ENSG00000262814","hgnc_id":"HGNC:10378","ncbi_gene_id":6182,"previous_symbols":["RPML12"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL12","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL13","identifiers":{"aliases":["L13","RPL13","L13mt","RPML13","L13A","uL13m"],"approved_symbol":"MRPL13","ensembl_gene_id":"ENSG00000172172","hgnc_id":"HGNC:14278","ncbi_gene_id":28998,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.017205,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL13","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL14","identifiers":{"aliases":["RPML32","MRP-L32","uL14m"],"approved_symbol":"MRPL14","ensembl_gene_id":"ENSG00000180992","hgnc_id":"HGNC:14279","ncbi_gene_id":64928,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.1219,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL14","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL15","identifiers":{"aliases":["RPML7","MRP-L7","HSPC145","L15mt","MRP-L15","uL15m"],"approved_symbol":"MRPL15","ensembl_gene_id":"ENSG00000137547","hgnc_id":"HGNC:14054","ncbi_gene_id":29088,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.22176,"fdr":0.924982,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL15","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL16","identifiers":{"aliases":["FLJ20484","PNAS-111","uL16m"],"approved_symbol":"MRPL16","ensembl_gene_id":"ENSG00000166902","hgnc_id":"HGNC:14476","ncbi_gene_id":54948,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL16","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL17","identifiers":{"aliases":["RPML26","MRP-L26","bL17m"],"approved_symbol":"MRPL17","ensembl_gene_id":"ENSG00000158042","hgnc_id":"HGNC:14053","ncbi_gene_id":63875,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.024216,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL17","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL18":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL18","identifiers":{"aliases":["HSPC071","uL18m"],"approved_symbol":"MRPL18","ensembl_gene_id":"ENSG00000112110","hgnc_id":"HGNC:14477","ncbi_gene_id":29074,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL18","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL19","identifiers":{"aliases":["MRP-L15","RPML15","KIAA0104","RLX1","bL19m"],"approved_symbol":"MRPL19","ensembl_gene_id":"ENSG00000115364","hgnc_id":"HGNC:14052","ncbi_gene_id":9801,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.044262,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL19","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL2","identifiers":{"aliases":["MRP-L14","RPML14","CGI-22","uL2m"],"approved_symbol":"MRPL2","ensembl_gene_id":"ENSG00000112651","hgnc_id":"HGNC:14056","ncbi_gene_id":51069,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL2","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL20","identifiers":{"aliases":["FLJ10024","bL20m"],"approved_symbol":"MRPL20","ensembl_gene_id":"ENSG00000242485","hgnc_id":"HGNC:14478","ncbi_gene_id":55052,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.058076,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL20","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL20-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL20-AS1","identifiers":{"aliases":[],"approved_symbol":"MRPL20-AS1","ensembl_gene_id":"ENSG00000224870","hgnc_id":"HGNC:27125","ncbi_gene_id":148413,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MRPL20-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL21","identifiers":{"aliases":["bL21m"],"approved_symbol":"MRPL21","ensembl_gene_id":"ENSG00000197345","hgnc_id":"HGNC:14479","ncbi_gene_id":219927,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL21","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL22","identifiers":{"aliases":["MRP-L25","RPML25","HSPC158","uL22m"],"approved_symbol":"MRPL22","ensembl_gene_id":"ENSG00000082515","hgnc_id":"HGNC:14480","ncbi_gene_id":29093,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL22","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL23","identifiers":{"aliases":["L23MRP","uL23m"],"approved_symbol":"MRPL23","ensembl_gene_id":"ENSG00000214026","hgnc_id":"HGNC:10322","ncbi_gene_id":6150,"previous_symbols":["RPL23L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.066781,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL23","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL24","identifiers":{"aliases":["MRP-L18","uL24m"],"approved_symbol":"MRPL24","ensembl_gene_id":"ENSG00000143314","hgnc_id":"HGNC:14037","ncbi_gene_id":79590,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.012976,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL24","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL27","identifiers":{"aliases":["bL27m"],"approved_symbol":"MRPL27","ensembl_gene_id":"ENSG00000108826","hgnc_id":"HGNC:14483","ncbi_gene_id":51264,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL27","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL28","identifiers":{"aliases":["p15","bL28m"],"approved_symbol":"MRPL28","ensembl_gene_id":"ENSG00000086504","hgnc_id":"HGNC:14484","ncbi_gene_id":10573,"previous_symbols":["MAAT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL28","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL3","identifiers":{"aliases":["MRL3","uL3m"],"approved_symbol":"MRPL3","ensembl_gene_id":"ENSG00000114686","hgnc_id":"HGNC:10379","ncbi_gene_id":11222,"previous_symbols":["RPML3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.029415,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL3","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL30","identifiers":{"aliases":["MRP-L28","RPML28","uL30m"],"approved_symbol":"MRPL30","ensembl_gene_id":"ENSG00000185414","hgnc_id":"HGNC:14036","ncbi_gene_id":51263,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL30","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL32":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL32","identifiers":{"aliases":["HSPC283","L32mt","MRP-L32","bMRP-59b","bL32m"],"approved_symbol":"MRPL32","ensembl_gene_id":"ENSG00000106591","hgnc_id":"HGNC:14035","ncbi_gene_id":64983,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL32","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL33":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL33","identifiers":{"aliases":["RPL33L","bL33m"],"approved_symbol":"MRPL33","ensembl_gene_id":"ENSG00000243147","hgnc_id":"HGNC:14487","ncbi_gene_id":9553,"previous_symbols":["C2orf1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL33","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL34":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL34","identifiers":{"aliases":["L34mt","MGC2633","MGC24974","bL34m"],"approved_symbol":"MRPL34","ensembl_gene_id":"ENSG00000130312","hgnc_id":"HGNC:14488","ncbi_gene_id":64981,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL34","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL35":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL35","identifiers":{"aliases":["bL35m"],"approved_symbol":"MRPL35","ensembl_gene_id":"ENSG00000132313","hgnc_id":"HGNC:14489","ncbi_gene_id":51318,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL35","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL36":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL36","identifiers":{"aliases":["RPMJ","L36mt","PRPL36","MRP-L36","bL36m"],"approved_symbol":"MRPL36","ensembl_gene_id":"ENSG00000171421","hgnc_id":"HGNC:14490","ncbi_gene_id":64979,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL36","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL37":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL37","identifiers":{"aliases":["RPML2","MRP-L2","mL37"],"approved_symbol":"MRPL37","ensembl_gene_id":"ENSG00000116221","hgnc_id":"HGNC:14034","ncbi_gene_id":51253,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.052393,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL37","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL38":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL38","identifiers":{"aliases":["RPML3","MRP-L3","HSPC262","MGC4810","mL38"],"approved_symbol":"MRPL38","ensembl_gene_id":"ENSG00000204316","hgnc_id":"HGNC:14033","ncbi_gene_id":64978,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL38","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL39":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL39","identifiers":{"aliases":["RPML5","MRP-L5","MGC104174","PRED66","PRED22","C21orf92","L39mt","MSTP003","MGC3400","FLJ20451","mL39"],"approved_symbol":"MRPL39","ensembl_gene_id":"ENSG00000154719","hgnc_id":"HGNC:14027","ncbi_gene_id":54148,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL39","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL4","identifiers":{"aliases":["CGI-28","uL4m"],"approved_symbol":"MRPL4","ensembl_gene_id":"ENSG00000105364","hgnc_id":"HGNC:14276","ncbi_gene_id":51073,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL4","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL40":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL40","identifiers":{"aliases":["MRP-L22","mL40"],"approved_symbol":"MRPL40","ensembl_gene_id":"ENSG00000185608","hgnc_id":"HGNC:14491","ncbi_gene_id":64976,"previous_symbols":["NLVCF"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL40","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL41":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL41","identifiers":{"aliases":["MRP-L27","RPML27","BMRP","PIG3","MRPL27","mL41"],"approved_symbol":"MRPL41","ensembl_gene_id":"ENSG00000182154","hgnc_id":"HGNC:14492","ncbi_gene_id":64975,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL41","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL42":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL42","identifiers":{"aliases":["MRPS32","MRP-L31","RPML31","PTD007","HSPC204","MRPL31","mL42"],"approved_symbol":"MRPL42","ensembl_gene_id":"ENSG00000198015","hgnc_id":"HGNC:14493","ncbi_gene_id":28977,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL42","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL43":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL43","identifiers":{"aliases":["bMRP36a","mL43"],"approved_symbol":"MRPL43","ensembl_gene_id":"ENSG00000055950","hgnc_id":"HGNC:14517","ncbi_gene_id":84545,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL43","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL44":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL44","identifiers":{"aliases":["FLJ12701","FLJ13990","mL44"],"approved_symbol":"MRPL44","ensembl_gene_id":"ENSG00000135900","hgnc_id":"HGNC:16650","ncbi_gene_id":65080,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.039828,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL44","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL45":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL45","identifiers":{"aliases":["MGC11321","Mba1","mL45"],"approved_symbol":"MRPL45","ensembl_gene_id":"ENSG00000278845","hgnc_id":"HGNC:16651","ncbi_gene_id":84311,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL45","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL46":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL46","identifiers":{"aliases":["LIECG2","P2ECSL","mL46"],"approved_symbol":"MRPL46","ensembl_gene_id":"ENSG00000259494","hgnc_id":"HGNC:1192","ncbi_gene_id":26589,"previous_symbols":["C15orf4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.041669,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL46","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL47":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL47","identifiers":{"aliases":["CGI-204","NCM1","uL29m"],"approved_symbol":"MRPL47","ensembl_gene_id":"ENSG00000136522","hgnc_id":"HGNC:16652","ncbi_gene_id":57129,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL47","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL48":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL48","identifiers":{"aliases":["CGI-118","mL48"],"approved_symbol":"MRPL48","ensembl_gene_id":"ENSG00000175581","hgnc_id":"HGNC:16653","ncbi_gene_id":51642,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL48","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL49":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL49","identifiers":{"aliases":["NOF","NOF1","L49mt","mL49"],"approved_symbol":"MRPL49","ensembl_gene_id":"ENSG00000149792","hgnc_id":"HGNC:1176","ncbi_gene_id":740,"previous_symbols":["C11orf4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL49","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL50":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL50","identifiers":{"aliases":["FLJ20493","MRP-L50","mL50"],"approved_symbol":"MRPL50","ensembl_gene_id":"ENSG00000136897","hgnc_id":"HGNC:16654","ncbi_gene_id":54534,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.048318,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL50","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL51":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL51","identifiers":{"aliases":["CDA09","HSPC241","bMRP64","mL51"],"approved_symbol":"MRPL51","ensembl_gene_id":"ENSG00000111639","hgnc_id":"HGNC:14044","ncbi_gene_id":51258,"previous_symbols":["MRP64"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.23061,"fdr":0.803801,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL51","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL52":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL52","identifiers":{"aliases":["mL52"],"approved_symbol":"MRPL52","ensembl_gene_id":"ENSG00000172590","hgnc_id":"HGNC:16655","ncbi_gene_id":122704,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL52","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL53":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL53","identifiers":{"aliases":["mL53"],"approved_symbol":"MRPL53","ensembl_gene_id":"ENSG00000204822","hgnc_id":"HGNC:16684","ncbi_gene_id":116540,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPL53","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL54":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL54","identifiers":{"aliases":["mL54"],"approved_symbol":"MRPL54","ensembl_gene_id":"ENSG00000183617","hgnc_id":"HGNC:16685","ncbi_gene_id":116541,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.0059426,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL54","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL55":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL55","identifiers":{"aliases":["bL31m"],"approved_symbol":"MRPL55","ensembl_gene_id":"ENSG00000162910","hgnc_id":"HGNC:16686","ncbi_gene_id":128308,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL55","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL57":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL57","identifiers":{"aliases":["mL63"],"approved_symbol":"MRPL57","ensembl_gene_id":"ENSG00000173141","hgnc_id":"HGNC:14514","ncbi_gene_id":78988,"previous_symbols":["MRP63"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL57","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL58":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL58","identifiers":{"aliases":["DS-1","mL62"],"approved_symbol":"MRPL58","ensembl_gene_id":"ENSG00000167862","hgnc_id":"HGNC:5359","ncbi_gene_id":3396,"previous_symbols":["ICT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL58","release_manifest":"api/v1.1/release_manifest.json"}},"MRPL9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPL9","identifiers":{"aliases":["bL9m"],"approved_symbol":"MRPL9","ensembl_gene_id":"ENSG00000143436","hgnc_id":"HGNC:14277","ncbi_gene_id":65005,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.0055976,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPL9","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS10","identifiers":{"aliases":["FLJ10567","uS10m"],"approved_symbol":"MRPS10","ensembl_gene_id":"ENSG00000048544","hgnc_id":"HGNC:14502","ncbi_gene_id":55173,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS10","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS11","identifiers":{"aliases":["FLJ23406","HCC-2","FLJ22512","uS11m"],"approved_symbol":"MRPS11","ensembl_gene_id":"ENSG00000181991","hgnc_id":"HGNC:14050","ncbi_gene_id":64963,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS11","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS12","identifiers":{"aliases":["RPS12","RPSM12","uS12m"],"approved_symbol":"MRPS12","ensembl_gene_id":"ENSG00000128626","hgnc_id":"HGNC:10380","ncbi_gene_id":6183,"previous_symbols":["RPMS12"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS12","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS14","identifiers":{"aliases":["HSMRPS14","uS14m"],"approved_symbol":"MRPS14","ensembl_gene_id":"ENSG00000120333","hgnc_id":"HGNC:14049","ncbi_gene_id":63931,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPS14","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS15","identifiers":{"aliases":["FLJ11564","uS15m"],"approved_symbol":"MRPS15","ensembl_gene_id":"ENSG00000116898","hgnc_id":"HGNC:14504","ncbi_gene_id":64960,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS15","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS16","identifiers":{"aliases":["CGI-132","bS16m"],"approved_symbol":"MRPS16","ensembl_gene_id":"ENSG00000182180","hgnc_id":"HGNC:14048","ncbi_gene_id":51021,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS16","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS17":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS17","identifiers":{"aliases":["HSPC011","RPMS17","MRP-S17","uS17m"],"approved_symbol":"MRPS17","ensembl_gene_id":"ENSG00000239789","hgnc_id":"HGNC:14047","ncbi_gene_id":51373,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.04551,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS17","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS18A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS18A","identifiers":{"aliases":["FLJ10548","MRPS18-3","mL66"],"approved_symbol":"MRPS18A","ensembl_gene_id":"ENSG00000096080","hgnc_id":"HGNC:14515","ncbi_gene_id":55168,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS18A","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS18B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS18B","identifiers":{"aliases":["MRPS18-2","PTD017","C6orf14","HSPC183","mS40"],"approved_symbol":"MRPS18B","ensembl_gene_id":"ENSG00000204568","hgnc_id":"HGNC:14516","ncbi_gene_id":28973,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS18B","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS18C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS18C","identifiers":{"aliases":["MRPS18-1","CGI-134","FLJ11146","FLJ22967","bS18m"],"approved_symbol":"MRPS18C","ensembl_gene_id":"ENSG00000163319","hgnc_id":"HGNC:16633","ncbi_gene_id":51023,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.017587,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS18C","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS2","identifiers":{"aliases":["CGI-91","uS2m"],"approved_symbol":"MRPS2","ensembl_gene_id":"ENSG00000122140","hgnc_id":"HGNC:14495","ncbi_gene_id":51116,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.045943,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS2","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS21":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS21","identifiers":{"aliases":["bS21m"],"approved_symbol":"MRPS21","ensembl_gene_id":"ENSG00000266472","hgnc_id":"HGNC:14046","ncbi_gene_id":54460,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS21","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS22":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS22","identifiers":{"aliases":["MRP-S22","GK002","C3orf5","GIBT","mS22"],"approved_symbol":"MRPS22","ensembl_gene_id":"ENSG00000175110","hgnc_id":"HGNC:14508","ncbi_gene_id":56945,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS22","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS23":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS23","identifiers":{"aliases":["MRP-S23","CGI-138","HSPC329","mS23"],"approved_symbol":"MRPS23","ensembl_gene_id":"ENSG00000181610","hgnc_id":"HGNC:14509","ncbi_gene_id":51649,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS23","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS24":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS24","identifiers":{"aliases":["MRP-S24","HSPC335"],"approved_symbol":"MRPS24","ensembl_gene_id":"ENSG00000062582","hgnc_id":"HGNC:14510","ncbi_gene_id":64951,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.031296,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS24","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS25":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS25","identifiers":{"aliases":["MRP-S25","FLJ00023","DKFZp313H0817","RPMS25","mS25"],"approved_symbol":"MRPS25","ensembl_gene_id":"ENSG00000131368","hgnc_id":"HGNC:14511","ncbi_gene_id":64432,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPS25","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS26":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS26","identifiers":{"aliases":["MRP-S13","MRP-S26","RPMS13","dJ534B8.3","mS26"],"approved_symbol":"MRPS26","ensembl_gene_id":"ENSG00000125901","hgnc_id":"HGNC:14045","ncbi_gene_id":64949,"previous_symbols":["C20orf193"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.0206,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS26","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS27":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS27","identifiers":{"aliases":["KIAA0264","mS27"],"approved_symbol":"MRPS27","ensembl_gene_id":"ENSG00000113048","hgnc_id":"HGNC:14512","ncbi_gene_id":23107,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPS27","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS28":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS28","identifiers":{"aliases":["MRP-S28","HSPC007","MRPS35"],"approved_symbol":"MRPS28","ensembl_gene_id":"ENSG00000147586","hgnc_id":"HGNC:14513","ncbi_gene_id":28957,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.076346,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPS28","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS30":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS30","identifiers":{"aliases":["PAP","mL65"],"approved_symbol":"MRPS30","ensembl_gene_id":"ENSG00000112996","hgnc_id":"HGNC:8769","ncbi_gene_id":10884,"previous_symbols":["PDCD9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.013491,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS30","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS30-DT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS30-DT","identifiers":{"aliases":["BRCAT54","BRCAT107"],"approved_symbol":"MRPS30-DT","ensembl_gene_id":"ENSG00000251141","hgnc_id":"HGNC:53420","ncbi_gene_id":100506674,"previous_symbols":["LINC02224"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS30-DT","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS31":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS31","identifiers":{"aliases":["IMOGN38","mS31"],"approved_symbol":"MRPS31","ensembl_gene_id":"ENSG00000102738","hgnc_id":"HGNC:16632","ncbi_gene_id":10240,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS31","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS33":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS33","identifiers":{"aliases":["CGI-139","mS33"],"approved_symbol":"MRPS33","ensembl_gene_id":"ENSG00000090263","hgnc_id":"HGNC:16634","ncbi_gene_id":51650,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.09748,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS33","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS34":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS34","identifiers":{"aliases":["MRP-S12","MGC2616","mS34"],"approved_symbol":"MRPS34","ensembl_gene_id":"ENSG00000074071","hgnc_id":"HGNC:16618","ncbi_gene_id":65993,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS34","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS35":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS35","identifiers":{"aliases":["MRPS28","MDS023","mS35"],"approved_symbol":"MRPS35","ensembl_gene_id":"ENSG00000061794","hgnc_id":"HGNC:16635","ncbi_gene_id":60488,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.049606,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MRPS35","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS36":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS36","identifiers":{"approved_symbol":"MRPS36","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS36","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS5","identifiers":{"aliases":["MRP-S5","S5mt","uS5m"],"approved_symbol":"MRPS5","ensembl_gene_id":"ENSG00000144029","hgnc_id":"HGNC:14498","ncbi_gene_id":64969,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS5","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS6","identifiers":{"aliases":["MRP-S6","RPMS6","bS6m"],"approved_symbol":"MRPS6","ensembl_gene_id":"ENSG00000243927","hgnc_id":"HGNC:14051","ncbi_gene_id":64968,"previous_symbols":["C21orf101"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS6","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS7","identifiers":{"aliases":["MRP-S","RP-S7","RPMS7","uS7m"],"approved_symbol":"MRPS7","ensembl_gene_id":"ENSG00000125445","hgnc_id":"HGNC:14499","ncbi_gene_id":51081,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.040908,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS7","release_manifest":"api/v1.1/release_manifest.json"}},"MRPS9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRPS9","identifiers":{"aliases":["RPMS9","MRP-S9","S9mt","uS9m"],"approved_symbol":"MRPS9","ensembl_gene_id":"ENSG00000135972","hgnc_id":"HGNC:14501","ncbi_gene_id":64965,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.061025,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRPS9","release_manifest":"api/v1.1/release_manifest.json"}},"MRRF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRRF","identifiers":{"aliases":["RRF"],"approved_symbol":"MRRF","ensembl_gene_id":"ENSG00000148187","hgnc_id":"HGNC:7234","ncbi_gene_id":92399,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRRF","release_manifest":"api/v1.1/release_manifest.json"}},"MRS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRS2","identifiers":{"aliases":[],"approved_symbol":"MRS2","ensembl_gene_id":"ENSG00000124532","hgnc_id":"HGNC:13785","ncbi_gene_id":57380,"previous_symbols":["MRS2L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRS2","release_manifest":"api/v1.1/release_manifest.json"}},"MRTFA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRTFA","identifiers":{"aliases":["KIAA1438","MAL","MRTF-A","BSAC","MKL"],"approved_symbol":"MRTFA","ensembl_gene_id":"ENSG00000196588","hgnc_id":"HGNC:14334","ncbi_gene_id":57591,"previous_symbols":["MKL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRTFA","release_manifest":"api/v1.1/release_manifest.json"}},"MRTFA-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRTFA-AS1","identifiers":{"aliases":[],"approved_symbol":"MRTFA-AS1","ensembl_gene_id":"ENSG00000232564","hgnc_id":"HGNC:40681","ncbi_gene_id":101927257,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MRTFA-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MRTFB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRTFB","identifiers":{"aliases":["MRTF-B","FLJ31823"],"approved_symbol":"MRTFB","ensembl_gene_id":"ENSG00000186260","hgnc_id":"HGNC:29819","ncbi_gene_id":57496,"previous_symbols":["MKL2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRTFB","release_manifest":"api/v1.1/release_manifest.json"}},"MRTO4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRTO4","identifiers":{"aliases":["dJ657E11.4","MRT4"],"approved_symbol":"MRTO4","ensembl_gene_id":"ENSG00000053372","hgnc_id":"HGNC:18477","ncbi_gene_id":51154,"previous_symbols":["C1orf33"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRTO4","release_manifest":"api/v1.1/release_manifest.json"}},"MRVI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MRVI1","identifiers":{"approved_symbol":"MRVI1","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MRVI1","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A1","identifiers":{"aliases":["B1","Bp35","FMC7"],"approved_symbol":"MS4A1","ensembl_gene_id":"ENSG00000156738","hgnc_id":"HGNC:7315","ncbi_gene_id":931,"previous_symbols":["CD20"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MS4A1","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A14","identifiers":{"aliases":["NYD-SP21","FLJ32856","DKFZp434H092"],"approved_symbol":"MS4A14","ensembl_gene_id":"ENSG00000166928","hgnc_id":"HGNC:30706","ncbi_gene_id":84689,"previous_symbols":["MS4A16"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MS4A14","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A4A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A4A","identifiers":{"aliases":["CD20L1","MS4A7"],"approved_symbol":"MS4A4A","ensembl_gene_id":"ENSG00000110079","hgnc_id":"HGNC:13371","ncbi_gene_id":51338,"previous_symbols":["MS4A4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MS4A4A","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A4E":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A4E","identifiers":{"aliases":[],"approved_symbol":"MS4A4E","ensembl_gene_id":"ENSG00000214787","hgnc_id":"HGNC:14284","ncbi_gene_id":643680,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MS4A4E","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A5","identifiers":{"aliases":["CD20L2"],"approved_symbol":"MS4A5","ensembl_gene_id":"ENSG00000166930","hgnc_id":"HGNC:13374","ncbi_gene_id":64232,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MS4A5","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A6A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A6A","identifiers":{"aliases":["CD20L3"],"approved_symbol":"MS4A6A","ensembl_gene_id":"ENSG00000110077","hgnc_id":"HGNC:13375","ncbi_gene_id":64231,"previous_symbols":["MS4A6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MS4A6A","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A6E":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A6E","identifiers":{"aliases":[],"approved_symbol":"MS4A6E","ensembl_gene_id":"ENSG00000166926","hgnc_id":"HGNC:14285","ncbi_gene_id":245802,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MS4A6E","release_manifest":"api/v1.1/release_manifest.json"}},"MS4A7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MS4A7","identifiers":{"aliases":["CD20L4","CFFM4","MS4A8"],"approved_symbol":"MS4A7","ensembl_gene_id":"ENSG00000166927","hgnc_id":"HGNC:13378","ncbi_gene_id":58475,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MS4A7","detailed_audit_record":"gene/MS4A7/audit","legacy_api_record":"api/v1/genes/MS4A7.json","release_manifest":"api/v1.1/release_manifest.json"}},"MSANTD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSANTD1","identifiers":{"aliases":["LOC345222"],"approved_symbol":"MSANTD1","ensembl_gene_id":"ENSG00000188981","hgnc_id":"HGNC:33741","ncbi_gene_id":345222,"previous_symbols":["C4orf44"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSANTD1","release_manifest":"api/v1.1/release_manifest.json"}},"MSANTD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSANTD2","identifiers":{"aliases":["FLJ23342"],"approved_symbol":"MSANTD2","ensembl_gene_id":"ENSG00000120458","hgnc_id":"HGNC:26266","ncbi_gene_id":79684,"previous_symbols":["C11orf61"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSANTD2","release_manifest":"api/v1.1/release_manifest.json"}},"MSANTD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSANTD3","identifiers":{"aliases":["MGC17337"],"approved_symbol":"MSANTD3","ensembl_gene_id":"ENSG00000066697","hgnc_id":"HGNC:23370","ncbi_gene_id":91283,"previous_symbols":["C9orf30"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSANTD3","release_manifest":"api/v1.1/release_manifest.json"}},"MSANTD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSANTD4","identifiers":{"aliases":[],"approved_symbol":"MSANTD4","ensembl_gene_id":"ENSG00000170903","hgnc_id":"HGNC:29383","ncbi_gene_id":84437,"previous_symbols":["KIAA1826"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSANTD4","release_manifest":"api/v1.1/release_manifest.json"}},"MSC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSC","identifiers":{"aliases":["ABF-1","bHLHa22"],"approved_symbol":"MSC","ensembl_gene_id":"ENSG00000178860","hgnc_id":"HGNC:7321","ncbi_gene_id":9242,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSC","release_manifest":"api/v1.1/release_manifest.json"}},"MSC-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSC-AS1","identifiers":{"aliases":["MAT1"],"approved_symbol":"MSC-AS1","ensembl_gene_id":"ENSG00000235531","hgnc_id":"HGNC:48724","ncbi_gene_id":100132891,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MSC-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MSGN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSGN1","identifiers":{"aliases":["pMesogenin1"],"approved_symbol":"MSGN1","ensembl_gene_id":"ENSG00000151379","hgnc_id":"HGNC:14907","ncbi_gene_id":343930,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MSGN1","release_manifest":"api/v1.1/release_manifest.json"}},"MSH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSH2","identifiers":{"aliases":["HNPCC","HNPCC1","MSH-2"],"approved_symbol":"MSH2","ensembl_gene_id":"ENSG00000095002","hgnc_id":"HGNC:7325","ncbi_gene_id":4436,"previous_symbols":["COCA1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSH2","release_manifest":"api/v1.1/release_manifest.json"}},"MSH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSH3","identifiers":{"aliases":["DUP","MRP1"],"approved_symbol":"MSH3","ensembl_gene_id":"ENSG00000113318","hgnc_id":"HGNC:7326","ncbi_gene_id":4437,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSH3","release_manifest":"api/v1.1/release_manifest.json"}},"MSH4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSH4","identifiers":{"aliases":[],"approved_symbol":"MSH4","ensembl_gene_id":"ENSG00000057468","hgnc_id":"HGNC:7327","ncbi_gene_id":4438,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MSH4","release_manifest":"api/v1.1/release_manifest.json"}},"MSH5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSH5","identifiers":{"aliases":["G7"],"approved_symbol":"MSH5","ensembl_gene_id":"ENSG00000204410","hgnc_id":"HGNC:7328","ncbi_gene_id":4439,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSH5","release_manifest":"api/v1.1/release_manifest.json"}},"MSH6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSH6","identifiers":{"aliases":["MSH-6"],"approved_symbol":"MSH6","ensembl_gene_id":"ENSG00000116062","hgnc_id":"HGNC:7329","ncbi_gene_id":2956,"previous_symbols":["GTBP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSH6","release_manifest":"api/v1.1/release_manifest.json"}},"MSI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSI1","identifiers":{"aliases":[],"approved_symbol":"MSI1","ensembl_gene_id":"ENSG00000135097","hgnc_id":"HGNC:7330","ncbi_gene_id":4440,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSI1","release_manifest":"api/v1.1/release_manifest.json"}},"MSI2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSI2","identifiers":{"aliases":[],"approved_symbol":"MSI2","ensembl_gene_id":"ENSG00000153944","hgnc_id":"HGNC:18585","ncbi_gene_id":124540,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSI2","release_manifest":"api/v1.1/release_manifest.json"}},"MSL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSL1","identifiers":{"aliases":["hMSL1","MSL-1","DKFZp686P24239"],"approved_symbol":"MSL1","ensembl_gene_id":"ENSG00000188895","hgnc_id":"HGNC:27905","ncbi_gene_id":339287,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSL1","release_manifest":"api/v1.1/release_manifest.json"}},"MSL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSL2","identifiers":{"aliases":["FLJ10546","KIAA1585","msl-2"],"approved_symbol":"MSL2","ensembl_gene_id":"ENSG00000174579","hgnc_id":"HGNC:25544","ncbi_gene_id":55167,"previous_symbols":["RNF184","MSL2L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSL2","release_manifest":"api/v1.1/release_manifest.json"}},"MSL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSL3","identifiers":{"aliases":[],"approved_symbol":"MSL3","ensembl_gene_id":"ENSG00000005302","hgnc_id":"HGNC:7370","ncbi_gene_id":10943,"previous_symbols":["MSL3L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MSL3","release_manifest":"api/v1.1/release_manifest.json"}},"MSLNL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSLNL","identifiers":{"aliases":["MPFL"],"approved_symbol":"MSLNL","ensembl_gene_id":"ENSG00000162006","hgnc_id":"HGNC:14170","ncbi_gene_id":401827,"previous_symbols":["C16orf37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MSLNL","release_manifest":"api/v1.1/release_manifest.json"}},"MSMO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSMO1","identifiers":{"aliases":["DESP4","ERG25"],"approved_symbol":"MSMO1","ensembl_gene_id":"ENSG00000052802","hgnc_id":"HGNC:10545","ncbi_gene_id":6307,"previous_symbols":["SC4MOL"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSMO1","release_manifest":"api/v1.1/release_manifest.json"}},"MSN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSN","identifiers":{"aliases":[],"approved_symbol":"MSN","ensembl_gene_id":"ENSG00000147065","hgnc_id":"HGNC:7373","ncbi_gene_id":4478,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSN","release_manifest":"api/v1.1/release_manifest.json"}},"MSR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSR1","identifiers":{"aliases":["SCARA1","CD204","SR-AI","SR-AII","SR-AIII","SR-A"],"approved_symbol":"MSR1","ensembl_gene_id":"ENSG00000038945","hgnc_id":"HGNC:7376","ncbi_gene_id":4481,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSR1","detailed_audit_record":"gene/MSR1/audit","legacy_api_record":"api/v1/genes/MSR1.json","release_manifest":"api/v1.1/release_manifest.json"}},"MSRA":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSRA","identifiers":{"aliases":[],"approved_symbol":"MSRA","ensembl_gene_id":"ENSG00000175806","hgnc_id":"HGNC:7377","ncbi_gene_id":4482,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSRA","release_manifest":"api/v1.1/release_manifest.json"}},"MSRB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSRB1","identifiers":{"aliases":["SelR","SepR","SelX","SELENOX","SELENOR"],"approved_symbol":"MSRB1","ensembl_gene_id":"ENSG00000198736","hgnc_id":"HGNC:14133","ncbi_gene_id":51734,"previous_symbols":["SEPX1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":-0.02736,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MSRB1","release_manifest":"api/v1.1/release_manifest.json"}},"MSRB2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSRB2","identifiers":{"aliases":["PILB","CGI-131","CBS1","CBS-1"],"approved_symbol":"MSRB2","ensembl_gene_id":"ENSG00000148450","hgnc_id":"HGNC:17061","ncbi_gene_id":22921,"previous_symbols":["MSRB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSRB2","release_manifest":"api/v1.1/release_manifest.json"}},"MSRB3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSRB3","identifiers":{"aliases":["FLJ36866","DKFZp686C1178"],"approved_symbol":"MSRB3","ensembl_gene_id":"ENSG00000174099","hgnc_id":"HGNC:27375","ncbi_gene_id":253827,"previous_symbols":["DFNB74"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSRB3","release_manifest":"api/v1.1/release_manifest.json"}},"MSS51":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSS51","identifiers":{"aliases":["FLJ39565"],"approved_symbol":"MSS51","ensembl_gene_id":"ENSG00000166343","hgnc_id":"HGNC:21000","ncbi_gene_id":118490,"previous_symbols":["ZMYND17"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSS51","release_manifest":"api/v1.1/release_manifest.json"}},"MST1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MST1","identifiers":{"aliases":["MSP","NF15S2"],"approved_symbol":"MST1","ensembl_gene_id":"ENSG00000173531","hgnc_id":"HGNC:7380","ncbi_gene_id":4485,"previous_symbols":["D3F15S2","HGFL","DNF15S2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MST1","release_manifest":"api/v1.1/release_manifest.json"}},"MST1R":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MST1R","identifiers":{"aliases":["CDw136","CD136"],"approved_symbol":"MST1R","ensembl_gene_id":"ENSG00000164078","hgnc_id":"HGNC:7381","ncbi_gene_id":4486,"previous_symbols":["RON","PTK8","SEA"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MST1R","release_manifest":"api/v1.1/release_manifest.json"}},"MSTN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSTN","identifiers":{"aliases":[],"approved_symbol":"MSTN","ensembl_gene_id":"ENSG00000138379","hgnc_id":"HGNC:4223","ncbi_gene_id":2660,"previous_symbols":["GDF8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MSTN","release_manifest":"api/v1.1/release_manifest.json"}},"MSTO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSTO1","identifiers":{"aliases":["FLJ10504","LST005","MST","misato"],"approved_symbol":"MSTO1","ensembl_gene_id":"ENSG00000125459","hgnc_id":"HGNC:29678","ncbi_gene_id":55154,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSTO1","release_manifest":"api/v1.1/release_manifest.json"}},"MSX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSX1","identifiers":{"aliases":["HYD1","OFC5"],"approved_symbol":"MSX1","ensembl_gene_id":"ENSG00000163132","hgnc_id":"HGNC:7391","ncbi_gene_id":4487,"previous_symbols":["HOX7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSX1","release_manifest":"api/v1.1/release_manifest.json"}},"MSX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MSX2","identifiers":{"aliases":["CRS2","FPP","HOX8","MSH","PFM"],"approved_symbol":"MSX2","ensembl_gene_id":"ENSG00000120149","hgnc_id":"HGNC:7392","ncbi_gene_id":4488,"previous_symbols":["PFM1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MSX2","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ATP6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ATP6","identifiers":{"aliases":["ATP6","ATPase-6","Su6m"],"approved_symbol":"MT-ATP6","ensembl_gene_id":"ENSG00000198899","hgnc_id":"HGNC:7414","ncbi_gene_id":4508,"previous_symbols":["MTATP6","RP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-ATP6","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ATP8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ATP8","identifiers":{"aliases":["ATP8","A6L","URFA6L"],"approved_symbol":"MT-ATP8","ensembl_gene_id":"ENSG00000228253","hgnc_id":"HGNC:7415","ncbi_gene_id":4509,"previous_symbols":["MTATP8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-ATP8","release_manifest":"api/v1.1/release_manifest.json"}},"MT-CO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-CO1","identifiers":{"aliases":["COX1","COI"],"approved_symbol":"MT-CO1","ensembl_gene_id":"ENSG00000198804","hgnc_id":"HGNC:7419","ncbi_gene_id":4512,"previous_symbols":["MTCO1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-CO1","release_manifest":"api/v1.1/release_manifest.json"}},"MT-CO2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-CO2","identifiers":{"aliases":["COX2","CO2"],"approved_symbol":"MT-CO2","ensembl_gene_id":"ENSG00000198712","hgnc_id":"HGNC:7421","ncbi_gene_id":4513,"previous_symbols":["MTCO2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-CO2","release_manifest":"api/v1.1/release_manifest.json"}},"MT-CO3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-CO3","identifiers":{"aliases":["COX3","COIII","CO3"],"approved_symbol":"MT-CO3","ensembl_gene_id":"ENSG00000198938","hgnc_id":"HGNC:7422","ncbi_gene_id":4514,"previous_symbols":["MTCO3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-CO3","release_manifest":"api/v1.1/release_manifest.json"}},"MT-CYB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-CYB","identifiers":{"aliases":["COB","CYTB","UQCR3"],"approved_symbol":"MT-CYB","ensembl_gene_id":"ENSG00000198727","hgnc_id":"HGNC:7427","ncbi_gene_id":4519,"previous_symbols":["MTCYB"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-CYB","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ND1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ND1","identifiers":{"aliases":["ND1","NAD1"],"approved_symbol":"MT-ND1","ensembl_gene_id":"ENSG00000198888","hgnc_id":"HGNC:7455","ncbi_gene_id":4535,"previous_symbols":["MTND1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-ND1","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ND2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ND2","identifiers":{"aliases":["ND2","NAD2"],"approved_symbol":"MT-ND2","ensembl_gene_id":"ENSG00000198763","hgnc_id":"HGNC:7456","ncbi_gene_id":4536,"previous_symbols":["MTND2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MT-ND2","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ND3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ND3","identifiers":{"aliases":["ND3","NAD3"],"approved_symbol":"MT-ND3","ensembl_gene_id":"ENSG00000198840","hgnc_id":"HGNC:7458","ncbi_gene_id":4537,"previous_symbols":["MTND3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-ND3","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ND4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ND4","identifiers":{"aliases":["ND4","NAD4"],"approved_symbol":"MT-ND4","ensembl_gene_id":"ENSG00000198886","hgnc_id":"HGNC:7459","ncbi_gene_id":4538,"previous_symbols":["MTND4","LHON"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT-ND4","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ND4L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ND4L","identifiers":{"aliases":["ND4L","NAD4L"],"approved_symbol":"MT-ND4L","ensembl_gene_id":"ENSG00000212907","hgnc_id":"HGNC:7460","ncbi_gene_id":4539,"previous_symbols":["MTND4L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MT-ND4L","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ND5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ND5","identifiers":{"aliases":["ND5","NAD5"],"approved_symbol":"MT-ND5","ensembl_gene_id":"ENSG00000198786","hgnc_id":"HGNC:7461","ncbi_gene_id":4540,"previous_symbols":["MTND5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MT-ND5","release_manifest":"api/v1.1/release_manifest.json"}},"MT-ND6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT-ND6","identifiers":{"aliases":["NAD6","ND6"],"approved_symbol":"MT-ND6","ensembl_gene_id":"ENSG00000198695","hgnc_id":"HGNC:7462","ncbi_gene_id":4541,"previous_symbols":["MTND6"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MT-ND6","release_manifest":"api/v1.1/release_manifest.json"}},"MT1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT1A","identifiers":{"aliases":[],"approved_symbol":"MT1A","ensembl_gene_id":"ENSG00000205362","hgnc_id":"HGNC:7393","ncbi_gene_id":4489,"previous_symbols":["MT1","MT1S"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MT1A","release_manifest":"api/v1.1/release_manifest.json"}},"MT1E":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT1E","identifiers":{"aliases":["MTD"],"approved_symbol":"MT1E","ensembl_gene_id":"ENSG00000169715","hgnc_id":"HGNC:7397","ncbi_gene_id":4493,"previous_symbols":["MT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MT1E","release_manifest":"api/v1.1/release_manifest.json"}},"MT1F":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT1F","identifiers":{"aliases":[],"approved_symbol":"MT1F","ensembl_gene_id":"ENSG00000198417","hgnc_id":"HGNC:7398","ncbi_gene_id":4494,"previous_symbols":["MT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT1F","release_manifest":"api/v1.1/release_manifest.json"}},"MT1G":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT1G","identifiers":{"aliases":["MT1K"],"approved_symbol":"MT1G","ensembl_gene_id":"ENSG00000125144","hgnc_id":"HGNC:7399","ncbi_gene_id":4495,"previous_symbols":["MT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT1G","release_manifest":"api/v1.1/release_manifest.json"}},"MT1M":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT1M","identifiers":{"aliases":[],"approved_symbol":"MT1M","ensembl_gene_id":"ENSG00000205364","hgnc_id":"HGNC:14296","ncbi_gene_id":4499,"previous_symbols":["MT1","MT1K"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT1M","release_manifest":"api/v1.1/release_manifest.json"}},"MT1X":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT1X","identifiers":{"aliases":["MT-1l"],"approved_symbol":"MT1X","ensembl_gene_id":"ENSG00000187193","hgnc_id":"HGNC:7405","ncbi_gene_id":4501,"previous_symbols":["MT1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MT1X","release_manifest":"api/v1.1/release_manifest.json"}},"MT2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MT2A","identifiers":{"aliases":[],"approved_symbol":"MT2A","ensembl_gene_id":"ENSG00000125148","hgnc_id":"HGNC:7406","ncbi_gene_id":4502,"previous_symbols":["MT2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MT2A","release_manifest":"api/v1.1/release_manifest.json"}},"MTA1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTA1","identifiers":{"aliases":[],"approved_symbol":"MTA1","ensembl_gene_id":"ENSG00000182979","hgnc_id":"HGNC:7410","ncbi_gene_id":9112,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTA1","release_manifest":"api/v1.1/release_manifest.json"}},"MTA2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTA2","identifiers":{"aliases":["MTA1-L1"],"approved_symbol":"MTA2","ensembl_gene_id":"ENSG00000149480","hgnc_id":"HGNC:7411","ncbi_gene_id":9219,"previous_symbols":["MTA1L1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTA2","release_manifest":"api/v1.1/release_manifest.json"}},"MTA3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTA3","identifiers":{"aliases":["KIAA1266"],"approved_symbol":"MTA3","ensembl_gene_id":"ENSG00000057935","hgnc_id":"HGNC:23784","ncbi_gene_id":57504,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTA3","release_manifest":"api/v1.1/release_manifest.json"}},"MTAP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTAP","identifiers":{"aliases":["MSAP","c86fus"],"approved_symbol":"MTAP","ensembl_gene_id":"ENSG00000099810","hgnc_id":"HGNC:7413","ncbi_gene_id":4507,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTAP","release_manifest":"api/v1.1/release_manifest.json"}},"MTBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTBP","identifiers":{"aliases":[],"approved_symbol":"MTBP","ensembl_gene_id":"ENSG00000172167","hgnc_id":"HGNC:7417","ncbi_gene_id":27085,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTBP","release_manifest":"api/v1.1/release_manifest.json"}},"MTCH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTCH1","identifiers":{"aliases":["CGI-64","PSAP","SLC25A49"],"approved_symbol":"MTCH1","ensembl_gene_id":"ENSG00000137409","hgnc_id":"HGNC:17586","ncbi_gene_id":23787,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTCH1","release_manifest":"api/v1.1/release_manifest.json"}},"MTCH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTCH2","identifiers":{"aliases":["SLC25A50","MIMP"],"approved_symbol":"MTCH2","ensembl_gene_id":"ENSG00000109919","hgnc_id":"HGNC:17587","ncbi_gene_id":23788,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTCH2","release_manifest":"api/v1.1/release_manifest.json"}},"MTCL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTCL1","identifiers":{"aliases":[],"approved_symbol":"MTCL1","ensembl_gene_id":"ENSG00000168502","hgnc_id":"HGNC:29121","ncbi_gene_id":23255,"previous_symbols":["KIAA0802","CCDC165","SOGA2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTCL1","release_manifest":"api/v1.1/release_manifest.json"}},"MTCP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTCP1","identifiers":{"aliases":["P13MTCP1","p8MTCP1","TCL1C"],"approved_symbol":"MTCP1","ensembl_gene_id":"ENSG00000214827","hgnc_id":"HGNC:7423","ncbi_gene_id":4515,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTCP1","release_manifest":"api/v1.1/release_manifest.json"}},"MTDH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTDH","identifiers":{"aliases":["LYRIC","3D3","AEG-1"],"approved_symbol":"MTDH","ensembl_gene_id":"ENSG00000147649","hgnc_id":"HGNC:29608","ncbi_gene_id":92140,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTDH","release_manifest":"api/v1.1/release_manifest.json"}},"MTERF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTERF1","identifiers":{"aliases":[],"approved_symbol":"MTERF1","ensembl_gene_id":"ENSG00000127989","hgnc_id":"HGNC:21463","ncbi_gene_id":7978,"previous_symbols":["MTERF"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTERF1","release_manifest":"api/v1.1/release_manifest.json"}},"MTERF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTERF2","identifiers":{"aliases":["FLJ14062"],"approved_symbol":"MTERF2","ensembl_gene_id":"ENSG00000120832","hgnc_id":"HGNC:30779","ncbi_gene_id":80298,"previous_symbols":["MTERFD3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTERF2","release_manifest":"api/v1.1/release_manifest.json"}},"MTERF3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTERF3","identifiers":{"aliases":["CGI-12","FLJ10939"],"approved_symbol":"MTERF3","ensembl_gene_id":"ENSG00000156469","hgnc_id":"HGNC:24258","ncbi_gene_id":51001,"previous_symbols":["MTERFD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTERF3","release_manifest":"api/v1.1/release_manifest.json"}},"MTERF4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTERF4","identifiers":{"aliases":["MGC61716"],"approved_symbol":"MTERF4","ensembl_gene_id":"ENSG00000122085","hgnc_id":"HGNC:28785","ncbi_gene_id":130916,"previous_symbols":["MTERFD2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTERF4","release_manifest":"api/v1.1/release_manifest.json"}},"MTF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTF1","identifiers":{"aliases":[],"approved_symbol":"MTF1","ensembl_gene_id":"ENSG00000188786","hgnc_id":"HGNC:7428","ncbi_gene_id":4520,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTF1","release_manifest":"api/v1.1/release_manifest.json"}},"MTF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTF2","identifiers":{"aliases":["M96","PCL2","TDRD19A"],"approved_symbol":"MTF2","ensembl_gene_id":"ENSG00000143033","hgnc_id":"HGNC:29535","ncbi_gene_id":22823,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTF2","release_manifest":"api/v1.1/release_manifest.json"}},"MTFMT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTFMT","identifiers":{"aliases":["FMT1"],"approved_symbol":"MTFMT","ensembl_gene_id":"ENSG00000103707","hgnc_id":"HGNC:29666","ncbi_gene_id":123263,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTFMT","release_manifest":"api/v1.1/release_manifest.json"}},"MTFP1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTFP1","identifiers":{"aliases":["MTP18","HSPC242"],"approved_symbol":"MTFP1","ensembl_gene_id":"ENSG00000242114","hgnc_id":"HGNC:26945","ncbi_gene_id":51537,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTFP1","release_manifest":"api/v1.1/release_manifest.json"}},"MTFR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTFR1","identifiers":{"aliases":["CHPPR","KIAA0009","FAM54A2"],"approved_symbol":"MTFR1","ensembl_gene_id":"ENSG00000066855","hgnc_id":"HGNC:29510","ncbi_gene_id":9650,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTFR1","release_manifest":"api/v1.1/release_manifest.json"}},"MTFR1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTFR1L","identifiers":{"aliases":[],"approved_symbol":"MTFR1L","ensembl_gene_id":"ENSG00000117640","hgnc_id":"HGNC:28836","ncbi_gene_id":56181,"previous_symbols":["FAM54B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTFR1L","release_manifest":"api/v1.1/release_manifest.json"}},"MTFR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTFR2","identifiers":{"aliases":[],"approved_symbol":"MTFR2","ensembl_gene_id":"ENSG00000146410","hgnc_id":"HGNC:21115","ncbi_gene_id":113115,"previous_symbols":["DUFD1","FAM54A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTFR2","release_manifest":"api/v1.1/release_manifest.json"}},"MTG1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTG1","identifiers":{"aliases":[],"approved_symbol":"MTG1","ensembl_gene_id":"ENSG00000148824","hgnc_id":"HGNC:32159","ncbi_gene_id":92170,"previous_symbols":["GTPBP7"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTG1","release_manifest":"api/v1.1/release_manifest.json"}},"MTG2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTG2","identifiers":{"aliases":["FLJ10741","dJ1005F21.2","ObgH1"],"approved_symbol":"MTG2","ensembl_gene_id":"ENSG00000101181","hgnc_id":"HGNC:16239","ncbi_gene_id":26164,"previous_symbols":["GTPBP5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTG2","release_manifest":"api/v1.1/release_manifest.json"}},"MTHFD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTHFD1","identifiers":{"aliases":[],"approved_symbol":"MTHFD1","ensembl_gene_id":"ENSG00000100714","hgnc_id":"HGNC:7432","ncbi_gene_id":4522,"previous_symbols":["MTHFC","MTHFD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTHFD1","release_manifest":"api/v1.1/release_manifest.json"}},"MTHFD1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTHFD1L","identifiers":{"aliases":["DKFZP586G1517","FLJ21145"],"approved_symbol":"MTHFD1L","ensembl_gene_id":"ENSG00000120254","hgnc_id":"HGNC:21055","ncbi_gene_id":25902,"previous_symbols":["FTHFSDC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTHFD1L","release_manifest":"api/v1.1/release_manifest.json"}},"MTHFD2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTHFD2","identifiers":{"aliases":[],"approved_symbol":"MTHFD2","ensembl_gene_id":"ENSG00000065911","hgnc_id":"HGNC:7434","ncbi_gene_id":10797,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTHFD2","release_manifest":"api/v1.1/release_manifest.json"}},"MTHFD2L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTHFD2L","identifiers":{"aliases":["MGC72244"],"approved_symbol":"MTHFD2L","ensembl_gene_id":"ENSG00000163738","hgnc_id":"HGNC:31865","ncbi_gene_id":441024,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTHFD2L","release_manifest":"api/v1.1/release_manifest.json"}},"MTHFR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTHFR","identifiers":{"aliases":[],"approved_symbol":"MTHFR","ensembl_gene_id":"ENSG00000177000","hgnc_id":"HGNC:7436","ncbi_gene_id":4524,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTHFR","release_manifest":"api/v1.1/release_manifest.json"}},"MTHFS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTHFS","identifiers":{"aliases":["HsT19268"],"approved_symbol":"MTHFS","ensembl_gene_id":"ENSG00000136371","hgnc_id":"HGNC:7437","ncbi_gene_id":10588,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTHFS","release_manifest":"api/v1.1/release_manifest.json"}},"MTHFSD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTHFSD","identifiers":{"aliases":["FLJ12998"],"approved_symbol":"MTHFSD","ensembl_gene_id":"ENSG00000103248","hgnc_id":"HGNC:25778","ncbi_gene_id":64779,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTHFSD","release_manifest":"api/v1.1/release_manifest.json"}},"MTIF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTIF2","identifiers":{"aliases":["IF-2mt"],"approved_symbol":"MTIF2","ensembl_gene_id":"ENSG00000085760","hgnc_id":"HGNC:7441","ncbi_gene_id":4528,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTIF2","release_manifest":"api/v1.1/release_manifest.json"}},"MTIF3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTIF3","identifiers":{"aliases":["IF-3mt","IF3(mt)"],"approved_symbol":"MTIF3","ensembl_gene_id":"ENSG00000122033","hgnc_id":"HGNC:29788","ncbi_gene_id":219402,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTIF3","release_manifest":"api/v1.1/release_manifest.json"}},"MTLN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTLN","identifiers":{"aliases":["MOXI","LEMP","MPM","TILR"],"approved_symbol":"MTLN","ensembl_gene_id":"ENSG00000175701","hgnc_id":"HGNC:27339","ncbi_gene_id":205251,"previous_symbols":["NCRNA00116","LINC00116","SMIM37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTLN","release_manifest":"api/v1.1/release_manifest.json"}},"MTM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTM1","identifiers":{"aliases":[],"approved_symbol":"MTM1","ensembl_gene_id":"ENSG00000171100","hgnc_id":"HGNC:7448","ncbi_gene_id":4534,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/MTM1","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR1","identifiers":{"aliases":[],"approved_symbol":"MTMR1","ensembl_gene_id":"ENSG00000063601","hgnc_id":"HGNC:7449","ncbi_gene_id":8776,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR1","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR10","identifiers":{"aliases":["FLJ20313"],"approved_symbol":"MTMR10","ensembl_gene_id":"ENSG00000166912","hgnc_id":"HGNC:25999","ncbi_gene_id":54893,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTMR10","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR11","identifiers":{"aliases":["CRA"],"approved_symbol":"MTMR11","ensembl_gene_id":"ENSG00000014914","hgnc_id":"HGNC:24307","ncbi_gene_id":10903,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR11","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR12","identifiers":{"aliases":["3-PAP","FLJ20476","KIAA1682","3PAP"],"approved_symbol":"MTMR12","ensembl_gene_id":"ENSG00000150712","hgnc_id":"HGNC:18191","ncbi_gene_id":54545,"previous_symbols":["PIP3AP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR12","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR14","identifiers":{"aliases":["FLJ22405","FLJ90311","hJumpy","hEDTP"],"approved_symbol":"MTMR14","ensembl_gene_id":"ENSG00000163719","hgnc_id":"HGNC:26190","ncbi_gene_id":64419,"previous_symbols":["C3orf29"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR14","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR2","identifiers":{"aliases":["KIAA1073"],"approved_symbol":"MTMR2","ensembl_gene_id":"ENSG00000087053","hgnc_id":"HGNC:7450","ncbi_gene_id":8898,"previous_symbols":["CMT4B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR2","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR3","identifiers":{"aliases":["KIAA0371","ZFYVE10","FYVE-DSP1"],"approved_symbol":"MTMR3","ensembl_gene_id":"ENSG00000100330","hgnc_id":"HGNC:7451","ncbi_gene_id":8897,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR3","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR4","identifiers":{"aliases":["KIAA0647","ZFYVE11"],"approved_symbol":"MTMR4","ensembl_gene_id":"ENSG00000108389","hgnc_id":"HGNC:7452","ncbi_gene_id":9110,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR4","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR6","identifiers":{"aliases":[],"approved_symbol":"MTMR6","ensembl_gene_id":"ENSG00000139505","hgnc_id":"HGNC:7453","ncbi_gene_id":9107,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR6","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR7","identifiers":{"aliases":[],"approved_symbol":"MTMR7","ensembl_gene_id":"ENSG00000003987","hgnc_id":"HGNC:7454","ncbi_gene_id":9108,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR7","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR8","identifiers":{"aliases":["FLJ20126"],"approved_symbol":"MTMR8","ensembl_gene_id":"ENSG00000102043","hgnc_id":"HGNC:16825","ncbi_gene_id":55613,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTMR8","release_manifest":"api/v1.1/release_manifest.json"}},"MTMR9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTMR9","identifiers":{"aliases":["DKFZp434K171","LIP-STYX"],"approved_symbol":"MTMR9","ensembl_gene_id":"ENSG00000104643","hgnc_id":"HGNC:14596","ncbi_gene_id":66036,"previous_symbols":["C8orf9","MTMR8"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTMR9","release_manifest":"api/v1.1/release_manifest.json"}},"MTO1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTO1","identifiers":{"aliases":[],"approved_symbol":"MTO1","ensembl_gene_id":"ENSG00000135297","hgnc_id":"HGNC:19261","ncbi_gene_id":25821,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTO1","release_manifest":"api/v1.1/release_manifest.json"}},"MTOR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTOR","identifiers":{"aliases":["mTOR","RAFT1","RAPT1","FLJ44809"],"approved_symbol":"MTOR","ensembl_gene_id":"ENSG00000198793","hgnc_id":"HGNC:3942","ncbi_gene_id":2475,"previous_symbols":["FRAP","FRAP2","FRAP1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTOR","release_manifest":"api/v1.1/release_manifest.json"}},"MTPAP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTPAP","identifiers":{"aliases":["FLJ10486","SPAX4","TENT6"],"approved_symbol":"MTPAP","ensembl_gene_id":"ENSG00000107951","hgnc_id":"HGNC:25532","ncbi_gene_id":55149,"previous_symbols":["PAPD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTPAP","release_manifest":"api/v1.1/release_manifest.json"}},"MTPN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTPN","identifiers":{"aliases":["MYOTROPHIN","GCDP","V-1"],"approved_symbol":"MTPN","ensembl_gene_id":"ENSG00000105887","hgnc_id":"HGNC:15667","ncbi_gene_id":136319,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTPN","release_manifest":"api/v1.1/release_manifest.json"}},"MTR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTR","identifiers":{"aliases":["cblG"],"approved_symbol":"MTR","ensembl_gene_id":"ENSG00000116984","hgnc_id":"HGNC:7468","ncbi_gene_id":4548,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MTR","release_manifest":"api/v1.1/release_manifest.json"}},"MTRES1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTRES1","identifiers":{"aliases":["HSPC230","PRED31"],"approved_symbol":"MTRES1","ensembl_gene_id":"ENSG00000130349","hgnc_id":"HGNC:17971","ncbi_gene_id":51250,"previous_symbols":["C6orf203"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTRES1","release_manifest":"api/v1.1/release_manifest.json"}},"MTREX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTREX","identifiers":{"aliases":["Mtr4","Dob1","fSAP118"],"approved_symbol":"MTREX","ensembl_gene_id":"ENSG00000039123","hgnc_id":"HGNC:18734","ncbi_gene_id":23517,"previous_symbols":["KIAA0052","SKIV2L2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTREX","release_manifest":"api/v1.1/release_manifest.json"}},"MTRF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTRF1","identifiers":{"aliases":["RF1","MTTRF1","MGC47721"],"approved_symbol":"MTRF1","ensembl_gene_id":"ENSG00000120662","hgnc_id":"HGNC:7469","ncbi_gene_id":9617,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTRF1","release_manifest":"api/v1.1/release_manifest.json"}},"MTRF1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTRF1L","identifiers":{"aliases":["HMRF1L","mtRF1a"],"approved_symbol":"MTRF1L","ensembl_gene_id":"ENSG00000112031","hgnc_id":"HGNC:21051","ncbi_gene_id":54516,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTRF1L","release_manifest":"api/v1.1/release_manifest.json"}},"MTRNR2L5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTRNR2L5","identifiers":{"aliases":[],"approved_symbol":"MTRNR2L5","ensembl_gene_id":null,"hgnc_id":"HGNC:37162","ncbi_gene_id":100463289,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MTRNR2L5","release_manifest":"api/v1.1/release_manifest.json"}},"MTRR":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTRR","identifiers":{"aliases":["cblE"],"approved_symbol":"MTRR","ensembl_gene_id":"ENSG00000124275","hgnc_id":"HGNC:7473","ncbi_gene_id":4552,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTRR","release_manifest":"api/v1.1/release_manifest.json"}},"MTSS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTSS1","identifiers":{"aliases":["KIAA0429","MIMA","MIMB","MIM"],"approved_symbol":"MTSS1","ensembl_gene_id":"ENSG00000170873","hgnc_id":"HGNC:20443","ncbi_gene_id":9788,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTSS1","release_manifest":"api/v1.1/release_manifest.json"}},"MTSS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTSS2","identifiers":{"aliases":["ABBA-1","LOC92154","ABBA"],"approved_symbol":"MTSS2","ensembl_gene_id":"ENSG00000132613","hgnc_id":"HGNC:25094","ncbi_gene_id":92154,"previous_symbols":["MTSS1L"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTSS2","release_manifest":"api/v1.1/release_manifest.json"}},"MTTP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTTP","identifiers":{"aliases":["ABL"],"approved_symbol":"MTTP","ensembl_gene_id":"ENSG00000138823","hgnc_id":"HGNC:7467","ncbi_gene_id":4547,"previous_symbols":["MTP"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MTTP","release_manifest":"api/v1.1/release_manifest.json"}},"MTURN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTURN","identifiers":{"aliases":["FLJ25903","Ells1"],"approved_symbol":"MTURN","ensembl_gene_id":"ENSG00000180354","hgnc_id":"HGNC:25457","ncbi_gene_id":222166,"previous_symbols":["C7orf41"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTURN","release_manifest":"api/v1.1/release_manifest.json"}},"MTUS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTUS1","identifiers":{"aliases":["MTSG1","KIAA1288","DKFZp586D1519","FLJ14295","ATIP1","MP44","ATBP","ICIS","ATIP3"],"approved_symbol":"MTUS1","ensembl_gene_id":"ENSG00000129422","hgnc_id":"HGNC:29789","ncbi_gene_id":57509,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTUS1","release_manifest":"api/v1.1/release_manifest.json"}},"MTUS2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTUS2","identifiers":{"aliases":["TIP150","CAZIP","ICIS"],"approved_symbol":"MTUS2","ensembl_gene_id":"ENSG00000132938","hgnc_id":"HGNC:20595","ncbi_gene_id":23281,"previous_symbols":["KIAA0774"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MTUS2","release_manifest":"api/v1.1/release_manifest.json"}},"MTX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTX1","identifiers":{"aliases":["MTXN"],"approved_symbol":"MTX1","ensembl_gene_id":"ENSG00000173171","hgnc_id":"HGNC:7504","ncbi_gene_id":4580,"previous_symbols":["MTX"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTX1","release_manifest":"api/v1.1/release_manifest.json"}},"MTX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTX2","identifiers":{"aliases":[],"approved_symbol":"MTX2","ensembl_gene_id":"ENSG00000128654","hgnc_id":"HGNC:7506","ncbi_gene_id":10651,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTX2","release_manifest":"api/v1.1/release_manifest.json"}},"MTX3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MTX3","identifiers":{"aliases":[],"approved_symbol":"MTX3","ensembl_gene_id":"ENSG00000177034","hgnc_id":"HGNC:24812","ncbi_gene_id":345778,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MTX3","release_manifest":"api/v1.1/release_manifest.json"}},"MUC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC1","identifiers":{"aliases":["CD227","PEM","ADMCKD","ADMCKD1","MCKD","MCD","KL-6","EMA","Ca15-3"],"approved_symbol":"MUC1","ensembl_gene_id":"ENSG00000185499","hgnc_id":"HGNC:7508","ncbi_gene_id":4582,"previous_symbols":["PUM","MCKD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MUC1","release_manifest":"api/v1.1/release_manifest.json"}},"MUC12":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC12","identifiers":{"aliases":[],"approved_symbol":"MUC12","ensembl_gene_id":"ENSG00000205277","hgnc_id":"HGNC:7510","ncbi_gene_id":10071,"previous_symbols":["MUC11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MUC12","release_manifest":"api/v1.1/release_manifest.json"}},"MUC13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC13","identifiers":{"aliases":[],"approved_symbol":"MUC13","ensembl_gene_id":"ENSG00000173702","hgnc_id":"HGNC:7511","ncbi_gene_id":56667,"previous_symbols":["DRCC1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MUC13","release_manifest":"api/v1.1/release_manifest.json"}},"MUC19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC19","identifiers":{"aliases":["FLJ35746"],"approved_symbol":"MUC19","ensembl_gene_id":"ENSG00000205592","hgnc_id":"HGNC:14362","ncbi_gene_id":283463,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MUC19","release_manifest":"api/v1.1/release_manifest.json"}},"MUC20":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC20","identifiers":{"aliases":["FLJ14408","KIAA1359"],"approved_symbol":"MUC20","ensembl_gene_id":"ENSG00000176945","hgnc_id":"HGNC:23282","ncbi_gene_id":200958,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MUC20","release_manifest":"api/v1.1/release_manifest.json"}},"MUC3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC3A","identifiers":{"aliases":[],"approved_symbol":"MUC3A","ensembl_gene_id":"ENSG00000169894","hgnc_id":"HGNC:7513","ncbi_gene_id":4584,"previous_symbols":["MUC3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MUC3A","release_manifest":"api/v1.1/release_manifest.json"}},"MUC4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC4","identifiers":{"aliases":["ASGP","MUC-4"],"approved_symbol":"MUC4","ensembl_gene_id":"ENSG00000145113","hgnc_id":"HGNC:7514","ncbi_gene_id":4585,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MUC4","release_manifest":"api/v1.1/release_manifest.json"}},"MUC6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUC6","identifiers":{"aliases":["MUC-6"],"approved_symbol":"MUC6","ensembl_gene_id":"ENSG00000184956","hgnc_id":"HGNC:7517","ncbi_gene_id":4588,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MUC6","release_manifest":"api/v1.1/release_manifest.json"}},"MUL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUL1","identifiers":{"aliases":["FLJ12875","MULAN","RNF218","MAPL","GIDE"],"approved_symbol":"MUL1","ensembl_gene_id":"ENSG00000090432","hgnc_id":"HGNC:25762","ncbi_gene_id":79594,"previous_symbols":["C1orf166"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MUL1","release_manifest":"api/v1.1/release_manifest.json"}},"MUS81":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUS81","identifiers":{"aliases":["FLJ44872","SLX3"],"approved_symbol":"MUS81","ensembl_gene_id":"ENSG00000172732","hgnc_id":"HGNC:29814","ncbi_gene_id":80198,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MUS81","release_manifest":"api/v1.1/release_manifest.json"}},"MUSK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUSK","identifiers":{"aliases":[],"approved_symbol":"MUSK","ensembl_gene_id":"ENSG00000030304","hgnc_id":"HGNC:7525","ncbi_gene_id":4593,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MUSK","release_manifest":"api/v1.1/release_manifest.json"}},"MUSTN1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUSTN1","identifiers":{"aliases":["Mustang"],"approved_symbol":"MUSTN1","ensembl_gene_id":"ENSG00000272573","hgnc_id":"HGNC:22144","ncbi_gene_id":389125,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MUSTN1","release_manifest":"api/v1.1/release_manifest.json"}},"MUTYH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MUTYH","identifiers":{"aliases":["MYH"],"approved_symbol":"MUTYH","ensembl_gene_id":"ENSG00000132781","hgnc_id":"HGNC:7527","ncbi_gene_id":4595,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MUTYH","release_manifest":"api/v1.1/release_manifest.json"}},"MVB12A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MVB12A","identifiers":{"aliases":["FLJ32495"],"approved_symbol":"MVB12A","ensembl_gene_id":"ENSG00000141971","hgnc_id":"HGNC:25153","ncbi_gene_id":93343,"previous_symbols":["FAM125A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MVB12A","release_manifest":"api/v1.1/release_manifest.json"}},"MVB12B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MVB12B","identifiers":{"aliases":["FLJ00001"],"approved_symbol":"MVB12B","ensembl_gene_id":"ENSG00000196814","hgnc_id":"HGNC:23368","ncbi_gene_id":89853,"previous_symbols":["C9orf28","FAM125B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MVB12B","release_manifest":"api/v1.1/release_manifest.json"}},"MVD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MVD","identifiers":{"aliases":["MPD"],"approved_symbol":"MVD","ensembl_gene_id":"ENSG00000167508","hgnc_id":"HGNC:7529","ncbi_gene_id":4597,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MVD","release_manifest":"api/v1.1/release_manifest.json"}},"MVK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MVK","identifiers":{"aliases":["LRBP","MK"],"approved_symbol":"MVK","ensembl_gene_id":"ENSG00000110921","hgnc_id":"HGNC:7530","ncbi_gene_id":4598,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MVK","release_manifest":"api/v1.1/release_manifest.json"}},"MVP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MVP","identifiers":{"aliases":["LRP","VAULT1"],"approved_symbol":"MVP","ensembl_gene_id":"ENSG00000013364","hgnc_id":"HGNC:7531","ncbi_gene_id":9961,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MVP","release_manifest":"api/v1.1/release_manifest.json"}},"MX1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MX1","identifiers":{"aliases":["IFI-78K","MxA","lncMX1-215"],"approved_symbol":"MX1","ensembl_gene_id":"ENSG00000157601","hgnc_id":"HGNC:7532","ncbi_gene_id":4599,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MX1","release_manifest":"api/v1.1/release_manifest.json"}},"MX2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MX2","identifiers":{"aliases":["MXB"],"approved_symbol":"MX2","ensembl_gene_id":"ENSG00000183486","hgnc_id":"HGNC:7533","ncbi_gene_id":4600,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MX2","release_manifest":"api/v1.1/release_manifest.json"}},"MXD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MXD1","identifiers":{"aliases":["MAD1","bHLHc58"],"approved_symbol":"MXD1","ensembl_gene_id":"ENSG00000059728","hgnc_id":"HGNC:6761","ncbi_gene_id":4084,"previous_symbols":["MAD"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MXD1","release_manifest":"api/v1.1/release_manifest.json"}},"MXD3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MXD3","identifiers":{"aliases":["MAD3","bHLHc13"],"approved_symbol":"MXD3","ensembl_gene_id":"ENSG00000213347","hgnc_id":"HGNC:14008","ncbi_gene_id":83463,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MXD3","release_manifest":"api/v1.1/release_manifest.json"}},"MXD4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MXD4","identifiers":{"aliases":["MAD4","MSTP149","MST149","bHLHc12"],"approved_symbol":"MXD4","ensembl_gene_id":"ENSG00000123933","hgnc_id":"HGNC:13906","ncbi_gene_id":10608,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MXD4","release_manifest":"api/v1.1/release_manifest.json"}},"MXI1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MXI1","identifiers":{"aliases":["MXD2","MAD2","MXI","bHLHc11"],"approved_symbol":"MXI1","ensembl_gene_id":"ENSG00000119950","hgnc_id":"HGNC:7534","ncbi_gene_id":4601,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MXI1","release_manifest":"api/v1.1/release_manifest.json"}},"MXRA5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MXRA5","identifiers":{"aliases":["DKFZp564I1922"],"approved_symbol":"MXRA5","ensembl_gene_id":"ENSG00000101825","hgnc_id":"HGNC:7539","ncbi_gene_id":25878,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MXRA5","release_manifest":"api/v1.1/release_manifest.json"}},"MXRA7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MXRA7","identifiers":{"aliases":["FLJ46603","TMAP1","PS1TP1"],"approved_symbol":"MXRA7","ensembl_gene_id":"ENSG00000182534","hgnc_id":"HGNC:7541","ncbi_gene_id":439921,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MXRA7","release_manifest":"api/v1.1/release_manifest.json"}},"MXRA8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MXRA8","identifiers":{"aliases":["DKFZp586E2023"],"approved_symbol":"MXRA8","ensembl_gene_id":"ENSG00000162576","hgnc_id":"HGNC:7542","ncbi_gene_id":54587,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MXRA8","release_manifest":"api/v1.1/release_manifest.json"}},"MYADM":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYADM","identifiers":{"aliases":[],"approved_symbol":"MYADM","ensembl_gene_id":"ENSG00000179820","hgnc_id":"HGNC:7544","ncbi_gene_id":91663,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYADM","release_manifest":"api/v1.1/release_manifest.json"}},"MYB":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYB","identifiers":{"aliases":["c-myb"],"approved_symbol":"MYB","ensembl_gene_id":"ENSG00000118513","hgnc_id":"HGNC:7545","ncbi_gene_id":4602,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYB","release_manifest":"api/v1.1/release_manifest.json"}},"MYBBP1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBBP1A","identifiers":{"aliases":["P160","PAP2","FLJ37886","Pol5"],"approved_symbol":"MYBBP1A","ensembl_gene_id":"ENSG00000132382","hgnc_id":"HGNC:7546","ncbi_gene_id":10514,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYBBP1A","release_manifest":"api/v1.1/release_manifest.json"}},"MYBL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBL1","identifiers":{"aliases":["AMYB","A-myb"],"approved_symbol":"MYBL1","ensembl_gene_id":"ENSG00000185697","hgnc_id":"HGNC:7547","ncbi_gene_id":4603,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYBL1","release_manifest":"api/v1.1/release_manifest.json"}},"MYBL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBL2","identifiers":{"aliases":["BMYB","B-MYB"],"approved_symbol":"MYBL2","ensembl_gene_id":"ENSG00000101057","hgnc_id":"HGNC:7548","ncbi_gene_id":4605,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYBL2","release_manifest":"api/v1.1/release_manifest.json"}},"MYBPC1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBPC1","identifiers":{"aliases":["ssMyBP-C"],"approved_symbol":"MYBPC1","ensembl_gene_id":"ENSG00000196091","hgnc_id":"HGNC:7549","ncbi_gene_id":4604,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYBPC1","release_manifest":"api/v1.1/release_manifest.json"}},"MYBPC2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBPC2","identifiers":{"aliases":["MYBPCF","MGC163408","fsMyBP-C"],"approved_symbol":"MYBPC2","ensembl_gene_id":"ENSG00000086967","hgnc_id":"HGNC:7550","ncbi_gene_id":4606,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYBPC2","release_manifest":"api/v1.1/release_manifest.json"}},"MYBPC3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBPC3","identifiers":{"aliases":["FHC","cMyBP-C"],"approved_symbol":"MYBPC3","ensembl_gene_id":"ENSG00000134571","hgnc_id":"HGNC:7551","ncbi_gene_id":4607,"previous_symbols":["CMH4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYBPC3","release_manifest":"api/v1.1/release_manifest.json"}},"MYBPH":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBPH","identifiers":{"aliases":[],"approved_symbol":"MYBPH","ensembl_gene_id":"ENSG00000133055","hgnc_id":"HGNC:7552","ncbi_gene_id":4608,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYBPH","release_manifest":"api/v1.1/release_manifest.json"}},"MYBPHL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYBPHL","identifiers":{"aliases":[],"approved_symbol":"MYBPHL","ensembl_gene_id":"ENSG00000221986","hgnc_id":"HGNC:30434","ncbi_gene_id":343263,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYBPHL","release_manifest":"api/v1.1/release_manifest.json"}},"MYC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYC","identifiers":{"aliases":["c-Myc","bHLHe39","MYCC"],"approved_symbol":"MYC","ensembl_gene_id":"ENSG00000136997","hgnc_id":"HGNC:7553","ncbi_gene_id":4609,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYC","release_manifest":"api/v1.1/release_manifest.json"}},"MYCBP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCBP","identifiers":{"aliases":["AMY-1"],"approved_symbol":"MYCBP","ensembl_gene_id":"ENSG00000214114","hgnc_id":"HGNC:7554","ncbi_gene_id":26292,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L3a_external_context_screen","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"assessed","support_status":"context_evidence_present","hit":false,"effect_size":0.061793,"fdr":0.67954,"context":"GSE293514_myoblast_fusion_screen","interpretation":"assessed_no_current_hit"},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYCBP","release_manifest":"api/v1.1/release_manifest.json"}},"MYCBP2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCBP2","identifiers":{"aliases":["PAM","KIAA0916","FLJ10106","PHR1"],"approved_symbol":"MYCBP2","ensembl_gene_id":"ENSG00000005810","hgnc_id":"HGNC:23386","ncbi_gene_id":23077,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYCBP2","release_manifest":"api/v1.1/release_manifest.json"}},"MYCBP2-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCBP2-AS1","identifiers":{"aliases":[],"approved_symbol":"MYCBP2-AS1","ensembl_gene_id":"ENSG00000236051","hgnc_id":"HGNC:41023","ncbi_gene_id":100874212,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYCBP2-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MYCBPAP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCBPAP","identifiers":{"aliases":["AMAP-1","DKFZp434N1415"],"approved_symbol":"MYCBPAP","ensembl_gene_id":"ENSG00000136449","hgnc_id":"HGNC:19677","ncbi_gene_id":84073,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYCBPAP","release_manifest":"api/v1.1/release_manifest.json"}},"MYCL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCL","identifiers":{"aliases":["LMYC","bHLHe38"],"approved_symbol":"MYCL","ensembl_gene_id":"ENSG00000116990","hgnc_id":"HGNC:7555","ncbi_gene_id":4610,"previous_symbols":["MYCL1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYCL","release_manifest":"api/v1.1/release_manifest.json"}},"MYCN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCN","identifiers":{"aliases":["bHLHe37","N-myc","MYCNOT"],"approved_symbol":"MYCN","ensembl_gene_id":"ENSG00000134323","hgnc_id":"HGNC:7559","ncbi_gene_id":4613,"previous_symbols":["NMYC"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYCN","release_manifest":"api/v1.1/release_manifest.json"}},"MYCNUT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCNUT","identifiers":{"aliases":["lncUSMycN"],"approved_symbol":"MYCNUT","ensembl_gene_id":"ENSG00000223850","hgnc_id":"HGNC:32684","ncbi_gene_id":103752554,"previous_symbols":["MYCNUN"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYCNUT","release_manifest":"api/v1.1/release_manifest.json"}},"MYCT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYCT1","identifiers":{"aliases":["MTLC","FLJ21269"],"approved_symbol":"MYCT1","ensembl_gene_id":"ENSG00000120279","hgnc_id":"HGNC:23172","ncbi_gene_id":80177,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYCT1","release_manifest":"api/v1.1/release_manifest.json"}},"MYD88":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYD88","identifiers":{"aliases":[],"approved_symbol":"MYD88","ensembl_gene_id":"ENSG00000172936","hgnc_id":"HGNC:7562","ncbi_gene_id":4615,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYD88","release_manifest":"api/v1.1/release_manifest.json"}},"MYDGF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYDGF","identifiers":{"aliases":["R33729_1","IL25","SF20","IL-25","IL-27"],"approved_symbol":"MYDGF","ensembl_gene_id":"ENSG00000074842","hgnc_id":"HGNC:16948","ncbi_gene_id":56005,"previous_symbols":["IL27","IL27w","C19orf10"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYDGF","release_manifest":"api/v1.1/release_manifest.json"}},"MYEF2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYEF2","identifiers":{"aliases":["MEF-2","FLJ11213","KIAA1341","HsT18564"],"approved_symbol":"MYEF2","ensembl_gene_id":"ENSG00000104177","hgnc_id":"HGNC:17940","ncbi_gene_id":50804,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYEF2","release_manifest":"api/v1.1/release_manifest.json"}},"MYEOV":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYEOV","identifiers":{"aliases":["OCIM"],"approved_symbol":"MYEOV","ensembl_gene_id":"ENSG00000172927","hgnc_id":"HGNC:7563","ncbi_gene_id":26579,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MYEOV","release_manifest":"api/v1.1/release_manifest.json"}},"MYF5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYF5","identifiers":{"aliases":["bHLHc2"],"approved_symbol":"MYF5","ensembl_gene_id":"ENSG00000111049","hgnc_id":"HGNC:7565","ncbi_gene_id":4617,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYF5","release_manifest":"api/v1.1/release_manifest.json"}},"MYF6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYF6","identifiers":{"aliases":["MRF4","bHLHc4"],"approved_symbol":"MYF6","ensembl_gene_id":"ENSG00000111046","hgnc_id":"HGNC:7566","ncbi_gene_id":4618,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYF6","release_manifest":"api/v1.1/release_manifest.json"}},"MYH1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH1","identifiers":{"aliases":["MYHSA1","MYHa","MyHC-2X/D","MGC133384"],"approved_symbol":"MYH1","ensembl_gene_id":"ENSG00000109061","hgnc_id":"HGNC:7567","ncbi_gene_id":4619,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYH1","release_manifest":"api/v1.1/release_manifest.json"}},"MYH10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH10","identifiers":{"aliases":["NMMHCB"],"approved_symbol":"MYH10","ensembl_gene_id":"ENSG00000133026","hgnc_id":"HGNC:7568","ncbi_gene_id":4628,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYH10","release_manifest":"api/v1.1/release_manifest.json"}},"MYH11":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH11","identifiers":{"aliases":["SMMHC","SMHC","SMMS-1"],"approved_symbol":"MYH11","ensembl_gene_id":"ENSG00000133392","hgnc_id":"HGNC:7569","ncbi_gene_id":4629,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYH11","release_manifest":"api/v1.1/release_manifest.json"}},"MYH13":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH13","identifiers":{"aliases":["MyHC-eo"],"approved_symbol":"MYH13","ensembl_gene_id":"ENSG00000006788","hgnc_id":"HGNC:7571","ncbi_gene_id":8735,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYH13","release_manifest":"api/v1.1/release_manifest.json"}},"MYH14":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH14","identifiers":{"aliases":["FLJ13881","KIAA2034","MHC16","MYH17"],"approved_symbol":"MYH14","ensembl_gene_id":"ENSG00000105357","hgnc_id":"HGNC:23212","ncbi_gene_id":79784,"previous_symbols":["DFNA4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYH14","release_manifest":"api/v1.1/release_manifest.json"}},"MYH15":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH15","identifiers":{"aliases":["KIAA1000"],"approved_symbol":"MYH15","ensembl_gene_id":"ENSG00000144821","hgnc_id":"HGNC:31073","ncbi_gene_id":22989,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MYH15","release_manifest":"api/v1.1/release_manifest.json"}},"MYH2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH2","identifiers":{"aliases":["MYH2A","MYHSA2","MyHC-IIa","MYHas8","MyHC-2A"],"approved_symbol":"MYH2","ensembl_gene_id":"ENSG00000125414","hgnc_id":"HGNC:7572","ncbi_gene_id":4620,"previous_symbols":["IBM3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/MYH2","release_manifest":"api/v1.1/release_manifest.json"}},"MYH3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH3","identifiers":{"aliases":["MYHC-EMB","MYHSE1","HEMHC","SMHCE"],"approved_symbol":"MYH3","ensembl_gene_id":"ENSG00000109063","hgnc_id":"HGNC:7573","ncbi_gene_id":4621,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYH3","release_manifest":"api/v1.1/release_manifest.json"}},"MYH4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH4","identifiers":{"aliases":["MYH2B","MyHC-2B","MyHC-IIb"],"approved_symbol":"MYH4","ensembl_gene_id":"ENSG00000264424","hgnc_id":"HGNC:7574","ncbi_gene_id":4622,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MYH4","release_manifest":"api/v1.1/release_manifest.json"}},"MYH7":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH7","identifiers":{"aliases":["CMD1S"],"approved_symbol":"MYH7","ensembl_gene_id":"ENSG00000092054","hgnc_id":"HGNC:7577","ncbi_gene_id":4625,"previous_symbols":["CMH1","MPD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited; NMD scope support not supported current atlas","links":{"research_record":"gene/MYH7","release_manifest":"api/v1.1/release_manifest.json"}},"MYH7B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH7B","identifiers":{"aliases":["KIAA1512","dJ756N5.1","MYH14","MHC14","lncMYH7b"],"approved_symbol":"MYH7B","ensembl_gene_id":"ENSG00000078814","hgnc_id":"HGNC:15906","ncbi_gene_id":57644,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYH7B","release_manifest":"api/v1.1/release_manifest.json"}},"MYH8":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH8","identifiers":{"aliases":["MyHC-peri","MyHC-pn"],"approved_symbol":"MYH8","ensembl_gene_id":"ENSG00000133020","hgnc_id":"HGNC:7578","ncbi_gene_id":4626,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYH8","release_manifest":"api/v1.1/release_manifest.json"}},"MYH9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYH9","identifiers":{"aliases":["NMMHCA","NMHC-II-A","MHA","FTNS","EPSTS"],"approved_symbol":"MYH9","ensembl_gene_id":"ENSG00000100345","hgnc_id":"HGNC:7579","ncbi_gene_id":4627,"previous_symbols":["DFNA17"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYH9","release_manifest":"api/v1.1/release_manifest.json"}},"MYL1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL1","identifiers":{"aliases":["MLC1","MLC1F","MLC3F","MLC-1","MLC1/3"],"approved_symbol":"MYL1","ensembl_gene_id":"ENSG00000168530","hgnc_id":"HGNC:7582","ncbi_gene_id":4632,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL1","detailed_audit_record":"gene/MYL1/audit","legacy_api_record":"api/v1/genes/MYL1.json","release_manifest":"api/v1.1/release_manifest.json"}},"MYL10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL10","identifiers":{"aliases":["MGC3479","MYLC2PL","PLRLC"],"approved_symbol":"MYL10","ensembl_gene_id":"ENSG00000106436","hgnc_id":"HGNC:29825","ncbi_gene_id":93408,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYL10","release_manifest":"api/v1.1/release_manifest.json"}},"MYL12A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL12A","identifiers":{"aliases":["MLCB","MYL2B","MRLC3","MRCL3"],"approved_symbol":"MYL12A","ensembl_gene_id":"ENSG00000101608","hgnc_id":"HGNC:16701","ncbi_gene_id":10627,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL12A","release_manifest":"api/v1.1/release_manifest.json"}},"MYL12B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL12B","identifiers":{"aliases":["MRLC2"],"approved_symbol":"MYL12B","ensembl_gene_id":"ENSG00000118680","hgnc_id":"HGNC:29827","ncbi_gene_id":103910,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL12B","release_manifest":"api/v1.1/release_manifest.json"}},"MYL2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL2","identifiers":{"aliases":["CMH10"],"approved_symbol":"MYL2","ensembl_gene_id":"ENSG00000111245","hgnc_id":"HGNC:7583","ncbi_gene_id":4633,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL2","detailed_audit_record":"gene/MYL2/audit","legacy_api_record":"api/v1/genes/MYL2.json","release_manifest":"api/v1.1/release_manifest.json"}},"MYL3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL3","identifiers":{"aliases":["CMH8","VLC1","MLC1V","MLC1SB"],"approved_symbol":"MYL3","ensembl_gene_id":"ENSG00000160808","hgnc_id":"HGNC:7584","ncbi_gene_id":4634,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL3","release_manifest":"api/v1.1/release_manifest.json"}},"MYL4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL4","identifiers":{"aliases":["ALC1","AMLC","GT1","PRO1957"],"approved_symbol":"MYL4","ensembl_gene_id":"ENSG00000198336","hgnc_id":"HGNC:7585","ncbi_gene_id":4635,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL4","release_manifest":"api/v1.1/release_manifest.json"}},"MYL5":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL5","identifiers":{"aliases":[],"approved_symbol":"MYL5","ensembl_gene_id":"ENSG00000215375","hgnc_id":"HGNC:7586","ncbi_gene_id":4636,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL5","release_manifest":"api/v1.1/release_manifest.json"}},"MYL6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL6","identifiers":{"aliases":["ESMLC","MLC3NM","MLC1SM"],"approved_symbol":"MYL6","ensembl_gene_id":"ENSG00000092841","hgnc_id":"HGNC:7587","ncbi_gene_id":4637,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYL6","release_manifest":"api/v1.1/release_manifest.json"}},"MYL6B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL6B","identifiers":{"aliases":["MLC1SA"],"approved_symbol":"MYL6B","ensembl_gene_id":"ENSG00000196465","hgnc_id":"HGNC:29823","ncbi_gene_id":140465,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL6B","release_manifest":"api/v1.1/release_manifest.json"}},"MYL9":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYL9","identifiers":{"aliases":["MYRL2","MLC2","LC20","MRLC1"],"approved_symbol":"MYL9","ensembl_gene_id":"ENSG00000101335","hgnc_id":"HGNC:15754","ncbi_gene_id":10398,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYL9","release_manifest":"api/v1.1/release_manifest.json"}},"MYLIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYLIP","identifiers":{"aliases":["MIR","IDOL"],"approved_symbol":"MYLIP","ensembl_gene_id":"ENSG00000007944","hgnc_id":"HGNC:21155","ncbi_gene_id":29116,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYLIP","release_manifest":"api/v1.1/release_manifest.json"}},"MYLK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYLK","identifiers":{"aliases":["MLCK","smMLCK","MYLK1","MLCK1","KRP","Telokin","MLCK108","MLCK210","MYLK-L"],"approved_symbol":"MYLK","ensembl_gene_id":"ENSG00000065534","hgnc_id":"HGNC:7590","ncbi_gene_id":4638,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYLK","release_manifest":"api/v1.1/release_manifest.json"}},"MYLK-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYLK-AS1","identifiers":{"aliases":[],"approved_symbol":"MYLK-AS1","ensembl_gene_id":"ENSG00000239523","hgnc_id":"HGNC:42440","ncbi_gene_id":100506826,"previous_symbols":["MYLK-AS2"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYLK-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MYLK2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYLK2","identifiers":{"aliases":["skMLCK","KMLC","MLCK2"],"approved_symbol":"MYLK2","ensembl_gene_id":"ENSG00000101306","hgnc_id":"HGNC:16243","ncbi_gene_id":85366,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYLK2","release_manifest":"api/v1.1/release_manifest.json"}},"MYLK3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYLK3","identifiers":{"aliases":["caMLCK","MLCK"],"approved_symbol":"MYLK3","ensembl_gene_id":"ENSG00000140795","hgnc_id":"HGNC:29826","ncbi_gene_id":91807,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYLK3","release_manifest":"api/v1.1/release_manifest.json"}},"MYLK4":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYLK4","identifiers":{"aliases":["SgK085"],"approved_symbol":"MYLK4","ensembl_gene_id":"ENSG00000145949","hgnc_id":"HGNC:27972","ncbi_gene_id":340156,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYLK4","release_manifest":"api/v1.1/release_manifest.json"}},"MYLPF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYLPF","identifiers":{"approved_symbol":"MYLPF","symbol_status":"not_matched_to_frozen_hgnc_subset","hgnc_id":null,"aliases":[],"previous_symbols":[],"ensembl_gene_id":null,"ncbi_gene_id":null,"species":"Homo sapiens"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYLPF","detailed_audit_record":"gene/MYLPF/audit","legacy_api_record":"api/v1/genes/MYLPF.json","release_manifest":"api/v1.1/release_manifest.json"}},"MYMK":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYMK","identifiers":{"aliases":["TMEM226","MYOMAKER"],"approved_symbol":"MYMK","ensembl_gene_id":"ENSG00000187616","hgnc_id":"HGNC:33778","ncbi_gene_id":389827,"previous_symbols":["TMEM8C"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYMK","release_manifest":"api/v1.1/release_manifest.json"}},"MYMX":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYMX","identifiers":{"aliases":["MINION"],"approved_symbol":"MYMX","ensembl_gene_id":"ENSG00000262179","hgnc_id":"HGNC:52391","ncbi_gene_id":101929726,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYMX","release_manifest":"api/v1.1/release_manifest.json"}},"MYNN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYNN","identifiers":{"aliases":["SBBIZ1","ZBTB31","ZNF902"],"approved_symbol":"MYNN","ensembl_gene_id":"ENSG00000085274","hgnc_id":"HGNC:14955","ncbi_gene_id":55892,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYNN","release_manifest":"api/v1.1/release_manifest.json"}},"MYO10":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO10","identifiers":{"aliases":["KIAA0799","MyoX"],"approved_symbol":"MYO10","ensembl_gene_id":"ENSG00000145555","hgnc_id":"HGNC:7593","ncbi_gene_id":4651,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO10","release_manifest":"api/v1.1/release_manifest.json"}},"MYO15A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO15A","identifiers":{"aliases":[],"approved_symbol":"MYO15A","ensembl_gene_id":"ENSG00000091536","hgnc_id":"HGNC:7594","ncbi_gene_id":51168,"previous_symbols":["DFNB3","MYO15"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO15A","release_manifest":"api/v1.1/release_manifest.json"}},"MYO15B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO15B","identifiers":{"aliases":["MYO15BP"],"approved_symbol":"MYO15B","ensembl_gene_id":"ENSG00000266714","hgnc_id":"HGNC:14083","ncbi_gene_id":80022,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO15B","release_manifest":"api/v1.1/release_manifest.json"}},"MYO16":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO16","identifiers":{"aliases":["MYR8","KIAA0865","Myo16b","NYAP3","PPP1R107"],"approved_symbol":"MYO16","ensembl_gene_id":"ENSG00000041515","hgnc_id":"HGNC:29822","ncbi_gene_id":23026,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYO16","release_manifest":"api/v1.1/release_manifest.json"}},"MYO18A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO18A","identifiers":{"aliases":["KIAA0216","MysPDZ"],"approved_symbol":"MYO18A","ensembl_gene_id":"ENSG00000196535","hgnc_id":"HGNC:31104","ncbi_gene_id":399687,"previous_symbols":["TIAF1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO18A","release_manifest":"api/v1.1/release_manifest.json"}},"MYO18B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO18B","identifiers":{"aliases":["BK125H2.1"],"approved_symbol":"MYO18B","ensembl_gene_id":"ENSG00000133454","hgnc_id":"HGNC:18150","ncbi_gene_id":84700,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO18B","release_manifest":"api/v1.1/release_manifest.json"}},"MYO19":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO19","identifiers":{"aliases":["FLJ22865"],"approved_symbol":"MYO19","ensembl_gene_id":"ENSG00000278259","hgnc_id":"HGNC:26234","ncbi_gene_id":80179,"previous_symbols":["MYOHD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO19","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1A","identifiers":{"aliases":[],"approved_symbol":"MYO1A","ensembl_gene_id":"ENSG00000166866","hgnc_id":"HGNC:7595","ncbi_gene_id":4640,"previous_symbols":["MYHL","DFNA48","BBMI"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO1A","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1B","identifiers":{"aliases":["myr1"],"approved_symbol":"MYO1B","ensembl_gene_id":"ENSG00000128641","hgnc_id":"HGNC:7596","ncbi_gene_id":4430,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYO1B","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1C","identifiers":{"aliases":["myr2","NMI","MyoIC"],"approved_symbol":"MYO1C","ensembl_gene_id":"ENSG00000197879","hgnc_id":"HGNC:7597","ncbi_gene_id":4641,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO1C","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1D":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1D","identifiers":{"aliases":["KIAA0727","myr4","PPP1R108"],"approved_symbol":"MYO1D","ensembl_gene_id":"ENSG00000176658","hgnc_id":"HGNC:7598","ncbi_gene_id":4642,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO1D","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1E":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1E","identifiers":{"aliases":["MYO1C","HuncM-IC","MGC104638"],"approved_symbol":"MYO1E","ensembl_gene_id":"ENSG00000157483","hgnc_id":"HGNC:7599","ncbi_gene_id":4643,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO1E","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1F":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1F","identifiers":{"aliases":[],"approved_symbol":"MYO1F","ensembl_gene_id":"ENSG00000142347","hgnc_id":"HGNC:7600","ncbi_gene_id":4542,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO1F","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1G":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1G","identifiers":{"aliases":["HA-2"],"approved_symbol":"MYO1G","ensembl_gene_id":"ENSG00000136286","hgnc_id":"HGNC:13880","ncbi_gene_id":64005,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO1G","release_manifest":"api/v1.1/release_manifest.json"}},"MYO1H":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO1H","identifiers":{"aliases":["FLJ37587"],"approved_symbol":"MYO1H","ensembl_gene_id":"ENSG00000174527","hgnc_id":"HGNC:13879","ncbi_gene_id":283446,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO1H","release_manifest":"api/v1.1/release_manifest.json"}},"MYO3A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO3A","identifiers":{"aliases":[],"approved_symbol":"MYO3A","ensembl_gene_id":"ENSG00000095777","hgnc_id":"HGNC:7601","ncbi_gene_id":53904,"previous_symbols":["DFNB30"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO3A","release_manifest":"api/v1.1/release_manifest.json"}},"MYO3B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO3B","identifiers":{"aliases":[],"approved_symbol":"MYO3B","ensembl_gene_id":"ENSG00000071909","hgnc_id":"HGNC:15576","ncbi_gene_id":140469,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO3B","release_manifest":"api/v1.1/release_manifest.json"}},"MYO5A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO5A","identifiers":{"aliases":["MYO5","GS1","MYR12"],"approved_symbol":"MYO5A","ensembl_gene_id":"ENSG00000197535","hgnc_id":"HGNC:7602","ncbi_gene_id":4644,"previous_symbols":["MYH12"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO5A","release_manifest":"api/v1.1/release_manifest.json"}},"MYO5B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO5B","identifiers":{"aliases":["KIAA1119"],"approved_symbol":"MYO5B","ensembl_gene_id":"ENSG00000167306","hgnc_id":"HGNC:7603","ncbi_gene_id":4645,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO5B","release_manifest":"api/v1.1/release_manifest.json"}},"MYO5C":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO5C","identifiers":{"aliases":["MGC74969"],"approved_symbol":"MYO5C","ensembl_gene_id":"ENSG00000128833","hgnc_id":"HGNC:7604","ncbi_gene_id":55930,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO5C","release_manifest":"api/v1.1/release_manifest.json"}},"MYO6":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO6","identifiers":{"aliases":["KIAA0389"],"approved_symbol":"MYO6","ensembl_gene_id":"ENSG00000196586","hgnc_id":"HGNC:7605","ncbi_gene_id":4646,"previous_symbols":["DFNA22","DFNB37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO6","release_manifest":"api/v1.1/release_manifest.json"}},"MYO7A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO7A","identifiers":{"aliases":["NSRD2"],"approved_symbol":"MYO7A","ensembl_gene_id":"ENSG00000137474","hgnc_id":"HGNC:7606","ncbi_gene_id":4647,"previous_symbols":["USH1B","DFNB2","DFNA11"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO7A","release_manifest":"api/v1.1/release_manifest.json"}},"MYO7B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO7B","identifiers":{"aliases":[],"approved_symbol":"MYO7B","ensembl_gene_id":"ENSG00000169994","hgnc_id":"HGNC:7607","ncbi_gene_id":4648,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO7B","release_manifest":"api/v1.1/release_manifest.json"}},"MYO9A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO9A","identifiers":{"aliases":["FLJ11061","FLJ13244","MGC71859"],"approved_symbol":"MYO9A","ensembl_gene_id":"ENSG00000066933","hgnc_id":"HGNC:7608","ncbi_gene_id":4649,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO9A","release_manifest":"api/v1.1/release_manifest.json"}},"MYO9B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYO9B","identifiers":{"aliases":[],"approved_symbol":"MYO9B","ensembl_gene_id":"ENSG00000099331","hgnc_id":"HGNC:7609","ncbi_gene_id":4650,"previous_symbols":["CELIAC4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYO9B","release_manifest":"api/v1.1/release_manifest.json"}},"MYOC":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOC","identifiers":{"aliases":["TIGR","JOAG1"],"approved_symbol":"MYOC","ensembl_gene_id":"ENSG00000034971","hgnc_id":"HGNC:7610","ncbi_gene_id":4653,"previous_symbols":["GLC1A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOC","detailed_audit_record":"gene/MYOC/audit","legacy_api_record":"api/v1/genes/MYOC.json","release_manifest":"api/v1.1/release_manifest.json"}},"MYOCD":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOCD","identifiers":{"aliases":["MYCD"],"approved_symbol":"MYOCD","ensembl_gene_id":"ENSG00000141052","hgnc_id":"HGNC:16067","ncbi_gene_id":93649,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOCD","release_manifest":"api/v1.1/release_manifest.json"}},"MYOCOS":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOCOS","identifiers":{"aliases":[],"approved_symbol":"MYOCOS","ensembl_gene_id":"ENSG00000283683","hgnc_id":"HGNC:53429","ncbi_gene_id":110806290,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOCOS","release_manifest":"api/v1.1/release_manifest.json"}},"MYOD1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOD1","identifiers":{"aliases":["PUM","MYOD","bHLHc1"],"approved_symbol":"MYOD1","ensembl_gene_id":"ENSG00000129152","hgnc_id":"HGNC:7611","ncbi_gene_id":4654,"previous_symbols":["MYF3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOD1","release_manifest":"api/v1.1/release_manifest.json"}},"MYOF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOF","identifiers":{"aliases":["KIAA1207"],"approved_symbol":"MYOF","ensembl_gene_id":"ENSG00000138119","hgnc_id":"HGNC:3656","ncbi_gene_id":26509,"previous_symbols":["FER1L3"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOF","release_manifest":"api/v1.1/release_manifest.json"}},"MYOG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOG","identifiers":{"aliases":["bHLHc3"],"approved_symbol":"MYOG","ensembl_gene_id":"ENSG00000122180","hgnc_id":"HGNC:7612","ncbi_gene_id":4656,"previous_symbols":["MYF4"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"context_level_significant_rows_present","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOG","detailed_audit_record":"gene/MYOG/audit","legacy_api_record":"api/v1/genes/MYOG.json","release_manifest":"api/v1.1/release_manifest.json"}},"MYOM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOM1","identifiers":{"aliases":[],"approved_symbol":"MYOM1","ensembl_gene_id":"ENSG00000101605","hgnc_id":"HGNC:7613","ncbi_gene_id":8736,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOM1","release_manifest":"api/v1.1/release_manifest.json"}},"MYOM2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOM2","identifiers":{"aliases":[],"approved_symbol":"MYOM2","ensembl_gene_id":"ENSG00000036448","hgnc_id":"HGNC:7614","ncbi_gene_id":9172,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOM2","release_manifest":"api/v1.1/release_manifest.json"}},"MYOM3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOM3","identifiers":{"aliases":["FLJ35961"],"approved_symbol":"MYOM3","ensembl_gene_id":"ENSG00000142661","hgnc_id":"HGNC:26679","ncbi_gene_id":127294,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOM3","release_manifest":"api/v1.1/release_manifest.json"}},"MYORG":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYORG","identifiers":{"aliases":["NET37"],"approved_symbol":"MYORG","ensembl_gene_id":"ENSG00000164976","hgnc_id":"HGNC:19918","ncbi_gene_id":57462,"previous_symbols":["KIAA1161"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 3 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYORG","release_manifest":"api/v1.1/release_manifest.json"}},"MYOSLID":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOSLID","identifiers":{"aliases":[],"approved_symbol":"MYOSLID","ensembl_gene_id":"ENSG00000229647","hgnc_id":"HGNC:51821","ncbi_gene_id":105373853,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOSLID","release_manifest":"api/v1.1/release_manifest.json"}},"MYOT":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOT","identifiers":{"aliases":[],"approved_symbol":"MYOT","ensembl_gene_id":"ENSG00000120729","hgnc_id":"HGNC:12399","ncbi_gene_id":9499,"previous_symbols":["TTID","LGMD1A","LGMD1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted; NMD scope support not supported current atlas","links":{"research_record":"gene/MYOT","release_manifest":"api/v1.1/release_manifest.json"}},"MYOZ1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOZ1","identifiers":{"aliases":["FATZ","CS-2"],"approved_symbol":"MYOZ1","ensembl_gene_id":"ENSG00000177791","hgnc_id":"HGNC:13752","ncbi_gene_id":58529,"previous_symbols":["MYOZ"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOZ1","release_manifest":"api/v1.1/release_manifest.json"}},"MYOZ2":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOZ2","identifiers":{"aliases":["CS-1","FATZ-2"],"approved_symbol":"MYOZ2","ensembl_gene_id":"ENSG00000172399","hgnc_id":"HGNC:1330","ncbi_gene_id":51778,"previous_symbols":["C4orf5"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOZ2","release_manifest":"api/v1.1/release_manifest.json"}},"MYOZ3":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYOZ3","identifiers":{"aliases":["CS-3","CS3","FRP3","FATZ-3"],"approved_symbol":"MYOZ3","ensembl_gene_id":"ENSG00000164591","hgnc_id":"HGNC:18565","ncbi_gene_id":91977,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":3,"directional_sources":3,"proportion":0.6666666666666666},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYOZ3","release_manifest":"api/v1.1/release_manifest.json"}},"MYPN":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYPN","identifiers":{"aliases":["MYOP"],"approved_symbol":"MYPN","ensembl_gene_id":"ENSG00000138347","hgnc_id":"HGNC:23246","ncbi_gene_id":84665,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYPN","release_manifest":"api/v1.1/release_manifest.json"}},"MYPOP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYPOP","identifiers":{"aliases":["P42pop"],"approved_symbol":"MYPOP","ensembl_gene_id":"ENSG00000176182","hgnc_id":"HGNC:20178","ncbi_gene_id":339344,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYPOP","release_manifest":"api/v1.1/release_manifest.json"}},"MYRF":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYRF","identifiers":{"aliases":["Ndt80","pqn-47","MRF"],"approved_symbol":"MYRF","ensembl_gene_id":"ENSG00000124920","hgnc_id":"HGNC:1181","ncbi_gene_id":745,"previous_symbols":["C11orf9"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":3,"directional_sources":3,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"3_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYRF","release_manifest":"api/v1.1/release_manifest.json"}},"MYRFL":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYRFL","identifiers":{"aliases":["FLJ25056","bcm1377"],"approved_symbol":"MYRFL","ensembl_gene_id":"ENSG00000166268","hgnc_id":"HGNC:26316","ncbi_gene_id":196446,"previous_symbols":["C12orf15","C12orf28"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYRFL","release_manifest":"api/v1.1/release_manifest.json"}},"MYRIP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYRIP","identifiers":{"aliases":["DKFZp586F1018","exophilin-8","SLAC2-C","SLAC2C"],"approved_symbol":"MYRIP","ensembl_gene_id":"ENSG00000170011","hgnc_id":"HGNC:19156","ncbi_gene_id":25924,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYRIP","release_manifest":"api/v1.1/release_manifest.json"}},"MYSM1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYSM1","identifiers":{"aliases":["KIAA1915"],"approved_symbol":"MYSM1","ensembl_gene_id":"ENSG00000162601","hgnc_id":"HGNC:29401","ncbi_gene_id":114803,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MYSM1","release_manifest":"api/v1.1/release_manifest.json"}},"MYT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYT1","identifiers":{"aliases":["MTF1","MYTI","ZC2HC4A","NZF2","ZC2H2C1"],"approved_symbol":"MYT1","ensembl_gene_id":"ENSG00000196132","hgnc_id":"HGNC:7622","ncbi_gene_id":4661,"previous_symbols":["PLPB1"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":2,"directional_sources":2,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["multisource_direction_consistent"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module multisource direction consistent","links":{"research_record":"gene/MYT1","release_manifest":"api/v1.1/release_manifest.json"}},"MYT1L":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYT1L","identifiers":{"aliases":["KIAA1106","NZF1","ZC2HC4B","ZC2H2C2"],"approved_symbol":"MYT1L","ensembl_gene_id":"ENSG00000186487","hgnc_id":"HGNC:7623","ncbi_gene_id":23040,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module source limited","links":{"research_record":"gene/MYT1L","release_manifest":"api/v1.1/release_manifest.json"}},"MYZAP":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MYZAP","identifiers":{"aliases":["MYOZAP","Gup","Gup1","GCOM1"],"approved_symbol":"MYZAP","ensembl_gene_id":"ENSG00000263155","hgnc_id":"HGNC:43444","ncbi_gene_id":100820829,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MYZAP","release_manifest":"api/v1.1/release_manifest.json"}},"MZB1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MZB1","identifiers":{"aliases":["PACAP","MGC29506","HSPC190","pERp1","MEDA-7"],"approved_symbol":"MZB1","ensembl_gene_id":"ENSG00000170476","hgnc_id":"HGNC:30125","ncbi_gene_id":51237,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"consistent_down","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":1,"directional_sources":1,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["source_limited"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"1_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"incomplete_source_coverage","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module source limited","links":{"research_record":"gene/MZB1","release_manifest":"api/v1.1/release_manifest.json"}},"MZF1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MZF1","identifiers":{"aliases":["ZSCAN6","MZF1B","MZF-1","Zfp98"],"approved_symbol":"MZF1","ensembl_gene_id":"ENSG00000099326","hgnc_id":"HGNC:13108","ncbi_gene_id":7593,"previous_symbols":["ZNF42"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"consistent_up","source_direction_agreement":{"agreeing_sources":4,"assessed_sources":4,"directional_sources":4,"proportion":1},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["exploratory_multisource_core"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_consistent_not_formal_meta_analysis","conflict_reason":null,"integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module exploratory multisource core","links":{"research_record":"gene/MZF1","release_manifest":"api/v1.1/release_manifest.json"}},"MZF1-AS1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MZF1-AS1","identifiers":{"aliases":[],"approved_symbol":"MZF1-AS1","ensembl_gene_id":"ENSG00000267858","hgnc_id":"HGNC:51271","ncbi_gene_id":100131691,"previous_symbols":[],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"down","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"down_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior down in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MZF1-AS1","release_manifest":"api/v1.1/release_manifest.json"}},"MZT1":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MZT1","identifiers":{"aliases":["LOC440145","FLJ21869","MGC150539","RP11-11C5.2","MOZART1"],"approved_symbol":"MZT1","ensembl_gene_id":"ENSG00000204899","hgnc_id":"HGNC:33830","ncbi_gene_id":440145,"previous_symbols":["C13orf37"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":2,"assessed_sources":4,"directional_sources":4,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"2 source(s) positive and 2 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MZT1","release_manifest":"api/v1.1/release_manifest.json"}},"MZT2A":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MZT2A","identifiers":{"aliases":["MOZART2A"],"approved_symbol":"MZT2A","ensembl_gene_id":"ENSG00000173272","hgnc_id":"HGNC:33187","ncbi_gene_id":653784,"previous_symbols":["FAM128A"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":1,"assessed_sources":2,"directional_sources":2,"proportion":0.5},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"2_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"1 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MZT2A","release_manifest":"api/v1.1/release_manifest.json"}},"MZT2B":{"schema_version":"1.1","resource_release":"v1.0.0-database-resource","evidence_freeze":"2026-07-25","gene":"MZT2B","identifiers":{"aliases":["FLJ14346","MOZART2B"],"approved_symbol":"MZT2B","ensembl_gene_id":"ENSG00000152082","hgnc_id":"HGNC:25886","ncbi_gene_id":80097,"previous_symbols":["FAM128B"],"species":"Homo sapiens","symbol_status":"approved"},"highest_supported_level":"L1_resource_record","highest_assessed_level":"L1_resource_record","evidence_status":{"resource_record":{"assessment_status":"assessed","support_status":"supported"},"observed_hepg2_perturbation":{"assessment_status":"not_assessed"},"internal_model_support":{"assessment_status":"not_assessed","ood_status":"not_assessed"},"external_context_screen":{"assessment_status":"not_assessed","hit":null},"independent_perturbation_replication":{"assessment_status":"not_assessed"},"dmd_muscle_validation":{"assessment_status":"not_assessed"},"functional_validation":{"assessment_status":"not_assessed"},"therapeutic_utility":{"assessment_status":"not_assessed"}},"decision":{"current_numeric_rank":null,"formal_deprioritization":false,"historical_rank_is_current":false},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-01","label":"Direct target-level perturbation evidence is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation","secondary_gaps":["GAP-02 independent muscle-context perturbation","GAP-07 independent replication"]},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"not_assessed","variant_count":null,"evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","integration_method":"median signed score across significant context rows when present, otherwise across all available context rows; source-level directions are audited separately","uncertainty_state":"direction_conflict_retained","conflict_reason":"3 source(s) positive and 1 source(s) negative","integrated_direction_is_prior_not_ground_truth":true,"consensus_direction":"up_in_dmd","consensus_direction_deprecation":{"deprecated":true,"replacement":"integrated_prior_direction","policy":"retained for one schema cycle; do not interpret as study consensus"}},"context_metrics":{},"summary":"integrated DMD prior up in dmd; DMD-source module direction conflicted","links":{"research_record":"gene/MZT2B","release_manifest":"api/v1.1/release_manifest.json"}}}
