{
  "readiness_schema": "nmd-vcell-dataset-readiness/1.0",
  "interface_build": "EA-20260817-57",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "score_policy": "No scalar AI-readiness score is computed. Each axis is reported independently.",
  "axes": [
    "disease_context_state",
    "perturbation_outcome_state",
    "cell_level_outcome_state",
    "time_structure_state",
    "donor_or_batch_identity_state"
  ],
  "records": [
    {
      "dataset_id": "NMDVCELL-HEPG2-CRISPRI",
      "observation_unit": "governed candidate-level aggregate",
      "disease_context_state": "ABSENT_NOT_DMD",
      "perturbation_outcome_state": "AVAILABLE_SINGLE_CRISPRI",
      "cell_level_outcome_state": "PARTIAL_COMPONENT_RESOLVED",
      "time_structure_state": "SINGLE_FROZEN_ENDPOINT",
      "donor_or_batch_identity_state": "LIMITED_RELEASED_DIAGNOSTICS",
      "ai_readiness_state": "BASELINE_READY_SAME_CONTEXT_ONLY",
      "current_ai_role": "Train and audit the same-context baseline",
      "decision_blocker": "No matched muscle or DMD perturbation outcome"
    },
    {
      "dataset_id": "GSE293514",
      "observation_unit": "screen-level and selected validation objects",
      "disease_context_state": "MUSCLE_CONTEXT_NOT_DMD_RESCUE",
      "perturbation_outcome_state": "AVAILABLE_KNOCKOUT_SCREEN_ENDPOINT",
      "cell_level_outcome_state": "NOT_RELEASED_AS_CELL_POPULATION_TRUTH",
      "time_structure_state": "PUBLICATION_ENDPOINT",
      "donor_or_batch_identity_state": "NOT_QUALIFIED_FOR_CURRENT_MODEL",
      "ai_readiness_state": "CONTEXT_SCREEN_ONLY",
      "current_ai_role": "Qualify muscle-context coverage and endpoint compatibility",
      "decision_blocker": "Not an independent candidate perturbation in a DMD model"
    },
    {
      "dataset_id": "GSE272233",
      "observation_unit": "bulk sample",
      "disease_context_state": "AVAILABLE_DMD_CORRECTION_REFERENCE",
      "perturbation_outcome_state": "DMD_LOCUS_CORRECTION_NOT_CANDIDATE_PERTURBATION",
      "cell_level_outcome_state": "ABSENT_BULK_RNA",
      "time_structure_state": "SINGLE_STUDY_ENDPOINT",
      "donor_or_batch_identity_state": "GROUPED_SAMPLE_IDENTITIES_AVAILABLE",
      "ai_readiness_state": "ORTHOGONAL_REFERENCE_ONLY",
      "current_ai_role": "Check disease-correction direction and context",
      "decision_blocker": "Candidate transcripts are observed but candidates were not perturbed"
    },
    {
      "dataset_id": "GSE52529",
      "observation_unit": "single cell",
      "disease_context_state": "ABSENT_NON_DISEASE_REFERENCE",
      "perturbation_outcome_state": "ABSENT_UNPERTURBED",
      "cell_level_outcome_state": "AVAILABLE_SINGLE_CELL_REFERENCE",
      "time_structure_state": "AVAILABLE_0_24_48_72_HOURS",
      "donor_or_batch_identity_state": "NOT_SUITABLE_FOR_UNSEEN_DONOR_PERTURBATION",
      "ai_readiness_state": "TRAJECTORY_REFERENCE_ONLY",
      "current_ai_role": "Build an unperturbed human-myogenic state reference",
      "decision_blocker": "No perturbation-conditioned trajectory and no longitudinal DMD state"
    },
    {
      "dataset_id": "GSE133344",
      "observation_unit": "single cell",
      "disease_context_state": "ABSENT_K562_METHOD_REFERENCE",
      "perturbation_outcome_state": "AVAILABLE_CRISPRA_SINGLES_AND_PAIRS",
      "cell_level_outcome_state": "AVAILABLE_PUBLIC_METHOD_REFERENCE",
      "time_structure_state": "SINGLE_STUDY_ENDPOINT",
      "donor_or_batch_identity_state": "NOT_A_DONOR_GENERALIZATION_SET",
      "ai_readiness_state": "METHOD_CALIBRATION_ONLY",
      "current_ai_role": "Calibrate activation and combination task design",
      "decision_blocker": "No matched muscle or DMD activation response for current candidates"
    }
  ],
  "current_training_conclusion": "One same-context baseline substrate is available. No dataset qualifies a calibrated DMD candidate-perturbation model."
}