{"core_record_schema":"nmd-vcell-gene-core-record/1.2","core_schema":"nmd-vcell-gene-ssr-core/1.2","schema_version":"1.1","resource_release":"v1.2.0-measured-dmd-evidence","evidence_freeze":"2026-08-03","interface_build":"EA-20260817-57","record_count":17921,"gene":"ZNF133","identifiers":{"hgnc_id":"HGNC:12917","ensembl_gene_id":"ENSG00000125846","ncbi_gene_id":7692},"decision":{"current_action":"muscle_assay","current_display_label":"Muscle-context assay","formal_deprioritization":false},"highest_supported_level":"L2_observed_same_context_perturbation","highest_assessed_level":"L3a_external_context_screen","gene_evidence_tier":{"code":"G4","label":"G4 · muscle-context screen, not DMD replication","plain_language":"The gene has a muscle-context screen in addition to non-DMD perturbation evidence, but still lacks independent DMD muscle replication.","prediction_use":"evidence_depth_annotation_only_not_a_dmd_prediction","supports_calibrated_dmd_prediction":false},"prediction_readiness":{"code":"R2","label":"R2 · muscle-context bridge evidence","plain_language":"The gene has non-DMD perturbation evidence plus muscle-context screening evidence, but still lacks DMD-context perturbation outcome.","current_state":"context_bridge_ready_dmd_prediction_locked","next_upgrade_required":"Run an independent DMD/control myogenic perturbation with predeclared molecular, state and functional endpoints.","model_claim":"not_a_calibrated_dmd_prediction","supports_research_use_dmd_response_prediction":false,"supports_calibrated_dmd_prediction":false},"dmd_context":{"integrated_prior_direction":"up","source_direction_state":"conflicted","source_direction_agreement":{"agreeing_sources":3,"assessed_sources":4,"directional_sources":4,"proportion":0.75},"variant_stability_state":"sign_varied_across_variants","evidence_module_memberships":["direction_conflicted"],"statistical_support_state":"direction_only_no_significant_context_rows","coverage_state":"4_of_4_sources","uncertainty_state":"direction_conflict_retained"},"evidence_status":{"observed_hepg2_perturbation":{"assessment_status":"assessed","observed_cells":84},"external_context_screen":{"assessment_status":"assessed","hit":false,"effect_size":-0.003533,"fdr":0.999999,"context":"GSE293514_myoblast_fusion_screen"}},"context_metrics":{"skeletal_muscle_median_tpm":4.55781,"depmap_median_gene_effect":-0.0375505223925062,"moderate_dependency_flag":false,"observed_counteralignment":0.0638177433316608},"evidence_gaps":{"decision_blocking_gap":{"code":"GAP-02","label":"Independent muscle-context perturbation is absent"},"highest_missing_evidence_layer":"L4_dmd_functional_validation"},"has_detailed_audit_record":true,"links":{"stable_research_record":"/resource/gene/ZNF133","quantitative_evidence_bundle":"/resource/api/v1.1/gene-evidence/ZNF133","complete_typed_bucket":"/resource/api/v1.1/gene_buckets/Z.json","detailed_audit_record":"/resource/gene/ZNF133/audit","release_manifest":"/resource/api/v1.1/release_manifest.json"},"claim_boundary":"This is a bounded evidence record, not a causal, therapeutic or safety claim."}