{
  "schema": "nmd-vcell-applicability/1.1",
  "resource_release": "v1.2.0-measured-dmd-evidence",
  "interface_build": "EA-20260817-57",
  "release_scope": [
    "DMD",
    "FSHD",
    "DM1",
    "SMA"
  ],
  "dmd_axes": [
    {
      "axis": "disease_context_evidence",
      "state": "AVAILABLE",
      "evidence": [
        "measured_dmd_locus_induction",
        "measured_dmd_locus_correction",
        "patient_muscle_pathway_observation",
        "heterogeneity_and_sample_qc"
      ],
      "unsupported_inference": "candidate_gene_dmd_perturbation_response"
    },
    {
      "axis": "candidate_expression_and_pathway_background",
      "state": "PARTIAL_HETEROGENEOUS",
      "evidence": [
        "same_hepg2_observed_response",
        "skeletal_muscle_expression",
        "source_specific_dmd_prior",
        "selected_external_context_screen"
      ],
      "unsupported_inference": "efficacy_safety_or_calibrated_target_rank"
    },
    {
      "axis": "direct_dmd_candidate_perturbation_outcome",
      "state": "MISSING",
      "coverage": "0/21",
      "unsupported_inference": "validated_candidate_pathway_or_therapeutic_claim"
    }
  ],
  "disease_modules": {
    "DMD": {
      "context": "MEASURED_AND_CORRECTED",
      "prospective_candidate_validation": "MISSING_0_OF_21",
      "route": "/resource/disease/dmd/"
    },
    "FSHD": {
      "context": "MEASURED_PATIENT_STATE_AND_INDUCED_TIMING",
      "prospective_candidate_validation": "MISSING",
      "route": "/resource/disease/fshd/"
    },
    "DM1": {
      "context": "MEASURED_PATIENT_AND_CORRECTED_ISOGENIC",
      "prospective_candidate_validation": "MISSING",
      "route": "/resource/disease/dm1/"
    },
    "SMA": {
      "context": "MEASURED_NEURAL_RESPONSE_AND_RESIDUAL_MUSCLE",
      "prospective_candidate_validation": "MISSING",
      "route": "/resource/disease/sma/"
    }
  },
  "evidence_coverage": "/resource/api/v2/diseases/coverage.json",
  "policy": "MISSING is not zero; applicability states are not ranks."
}