{
  "status_schema": "nmd-vcell-adam10-pilot-execution-status/1.0",
  "generated_at": "2026-09-09",
  "target": "ADAM10",
  "execution_state": "TECHNICAL_PACKAGE_COMPLETE_WET_LAB_AND_PARAMETER_LOCK_EXTERNAL",
  "design_sensitivity": {
    "scenarios": 480,
    "simulations_per_scenario": 20000,
    "total_simulations": 9600000,
    "role": "prospective operating-characteristic sensitivity only"
  },
  "stage_a": "Two named model pairs can calibrate feasibility and endpoint variance only.",
  "stage_b": "Pair count cannot be frozen until endpoint-specific variance, minimum meaningful effect, equivalence margin and target operating characteristic are approved.",
  "independent_unit": "independent model pairs for generalization; cells, wells, guides and technical aliquots are not independent n",
  "formal_lock_blockers": 39,
  "registered_amendments": 0,
  "randomization_assignments": 0,
  "observed_outcomes": 0,
  "required_stage_a_inputs": [
    "endpoint-specific measured variance",
    "model-pair ICC or variance components",
    "minimum meaningful effect on the endpoint scale",
    "equivalence margin and target operating characteristic",
    "named model-pair identities, QC rules and missingness disposition"
  ],
  "next_transition": "Named authorities resolve and sign all formal-lock inputs, attach Stage A evidence, freeze a checksum and externally register the amendment before randomization generation.",
  "objects": {
    "formal_parameter_lock": "/resource/api/v1.1/adam10_formal_parameter_lock_template_v088.json",
    "study_amendment": "/resource/api/v1.1/adam10_pilot_preregistration_v088.json",
    "randomization_contract": "/resource/api/v1.1/adam10_randomization_contract_v088.json",
    "outcome_ingestion_contract": "/resource/api/v1.1/adam10_outcome_ingestion_contract_v088.json",
    "completion_workbench": "/resource/adam10-formal-lock/",
    "packet": "/resource/downloads/nmd_vcell_adam10_registration_scaffold_v088_20260906.zip",
    "prior_workbench_registry": "/resource/api/v1.1/adam10_formal_lock_workbench_v090.json",
    "workbench_registry": "/resource/api/v1.1/adam10_formal_lock_workbench_v091.json"
  },
  "claim_boundary": "No v08.8 amendment is registered; no randomization or outcome exists; wet-lab execution remains unauthorized."
}